专利检索 ap:("Michael J. South" OR "Brenda Case" OR "Danny J. Garland" OR "Michael J. Hayes" OR "Horng-Chih Huang" OR "Wei Huang" OR "Darin E. Jones" OR "William L. Neumann" OR "John J. Parlow" OR "David B. Reitz" OR "Melvin L. Rueppel" OR "Rondald K. Webber") AND inv:"Brenda Case" 第 1 页

1.

发明授权
Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade 失效
标题翻译：用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡啶

公开(公告)号：US06828338B2

公开(公告)日：2004-12-07

申请号：US10465125

申请日：2003-06-19

申请人： Michael J. South , Brenda Case , Danny J. Garland , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , William L. Neumann , John J. Parlow , David B. Reitz , Melvin L. Rueppel , Rondald K. Webber

发明人： Michael J. South , Brenda Case , Danny J. Garland , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , William L. Neumann , John J. Parlow , David B. Reitz , Melvin L. Rueppel , Rondald K. Webber

IPC分类号： A61K3144

CPC分类号： C07D213/74 , C07D213/89

摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

摘要翻译： 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。

2.

发明授权
Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade 失效

公开(公告)号：US06624180B2

公开(公告)日：2003-09-23

申请号：US09989634

申请日：2001-11-20

申请人： Michael J. South , Brenda Case , Danny J. Garland , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , William L. Neumann , John J. Parlow , David B. Reitz , Melvin L. Rueppel , Rondald K. Webber

发明人： Michael J. South , Brenda Case , Danny J. Garland , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , William L. Neumann , John J. Parlow , David B. Reitz , Melvin L. Rueppel , Rondald K. Webber

IPC分类号： C07D21306

CPC分类号： C07D213/74 , C07D213/89

摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

3.

发明授权
6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade 失效
标题翻译：可用于选择性抑制凝血级联的6元杂环化合物

公开(公告)号：US06969715B2

公开(公告)日：2005-11-29

申请号：US10263637

申请日：2002-10-03

申请人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes

发明人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes

IPC分类号： C07D249/12 , A61K31/451 , A61K31/495 , A61K31/50 , A61K31/513 , A61K31/53 , A61K31/535 , A61K45/00 , A61P7/02 , A61P9/10 , A61P43/00 , C07C257/18 , C07D207/32 , C07D211/56 , C07D211/98 , C07D213/74 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04

CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04

摘要： The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

摘要翻译： 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。

4.

发明授权
Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade 失效

公开(公告)号：US07105559B2

公开(公告)日：2006-09-12

申请号：US10263936

申请日：2002-10-03

申请人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes

发明人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes

IPC分类号： C07D23/10 , A61K31/415

CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D207/46 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04

摘要： The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

5.

发明授权
Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade 失效
标题翻译：用于选择性抑制凝血级联的取代的多环芳基和异齿酰基吡嗪酮

公开(公告)号：US07119094B1

公开(公告)日：2006-10-10

申请号：US10276174

申请日：2000-11-20

申请人： Michael S. South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Rick Fenton , Gary W. Franklin , Horng-Chih Huang , Wei Huang , Carrie Kusturin , Scott A. Long , William L. Neumann , David B. Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew W. Mahoney

发明人： Michael S. South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Rick Fenton , Gary W. Franklin , Horng-Chih Huang , Wei Huang , Carrie Kusturin , Scott A. Long , William L. Neumann , David B. Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew W. Mahoney

IPC分类号： A61K31/4965 , C07D241/02

CPC分类号： C07D417/12

摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基吡嗪酮化合物，以及用于治疗和预防各种血栓形成病症（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。

6.

发明授权
Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade 失效
标题翻译：用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡嗪酮

公开(公告)号：US06664255B1

公开(公告)日：2003-12-16

申请号：US09574752

申请日：2000-05-18

申请人： Michael South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Horng-Chih Huang , Wei Huang , Scott A. Long , Matthew Mahoney , William L. Neumann , David Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Rick Fenton , Gary W. Franklin , Carrie Kusturin

发明人： Michael South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Horng-Chih Huang , Wei Huang , Scott A. Long , Matthew Mahoney , William L. Neumann , David Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Rick Fenton , Gary W. Franklin , Carrie Kusturin

IPC分类号： C07D24120

CPC分类号： C07D417/12 , A61K38/00 , C07D241/20 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07K5/06139 , C07K5/06191

摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基吡嗪酮化合物，以及用于治疗和预防各种血栓形成病症（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。

7.

发明申请
Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade 审中-公开
标题翻译：用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡啶

公开(公告)号：US20050153965A1

公开(公告)日：2005-07-14

申请号：US11004437

申请日：2004-12-03

申请人： Michael South , Brenda Case , Danny Garland , Michael Hayes , Horng-Chih Huang , Wei Huang , Darin Jones , William Neumann , John Parlow , David Reitz , Melvin Rueppel , Ronald Webber

发明人： Michael South , Brenda Case , Danny Garland , Michael Hayes , Horng-Chih Huang , Wei Huang , Darin Jones , William Neumann , John Parlow , David Reitz , Melvin Rueppel , Ronald Webber

IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4436 , A61K31/4439 , A61K45/00 , A61P7/02 , A61P9/10 , A61P11/00 , A61P35/00 , A61P43/00 , C07D213/74 , C07D213/89 , C07D401/10 , C07D409/04 , C07D43/02 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , C07D41/02

CPC分类号： C07D213/74 , C07D213/89

摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

摘要翻译： 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。