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    UV dosimetry system for measuring vitamin D production
    55.
    发明授权
    UV dosimetry system for measuring vitamin D production 有权
    用于测量维生素D生产的UV剂量测定系统

    公开(公告)号：US09086323B2

    公开(公告)日：2015-07-21

    申请号：US14575875

    申请日：2014-12-18

    申请人： Jie Lian ,  Nabyl Bennouri ,  Nattapon Chaimanonart

    发明人： Jie Lian ,  Nabyl Bennouri ,  Nattapon Chaimanonart

    IPC分类号： G01N21/33 ,  G01J1/42 ,  G01T1/02 ,  G01J1/44 ,  G01J1/04 ,  A61B5/00

    CPC分类号： G01J1/429 ,  A61B5/441 ,  G01J1/0219 ,  G01J1/0233 ,  G01J1/0403 ,  G01J1/44 ,  G01J2001/4266 ,  G01J2001/444 ,  G01T1/02 ,  G06F1/163

    摘要： A UV exposure dosimetry system includes at least one UV sensor that accurately measures the UV irradiance intensity. The UV dosimetry system integrates the measured UV irradiance intensity over time to calculate the real-time UV dosage and the vitamin D production by taking into account factors comprising UV sensor location, body surface area, clothing coverage, and sunscreen usage. Based on the measurement, the system can predict the time remaining to skin burn and the time remaining to reach daily goal of vitamin D production. The system also calculates the UV index in real-time, and can crowd source the measured data in a network. The UV dosimetry system supports multi-user control through an advanced and user friendly input and output interface.

    摘要翻译： UV曝光剂量测定系统包括至少一个UV传感器，其精确地测量紫外线辐照强度。 UV剂量测定系统通过考虑到UV传感器位置，体表面积，衣物覆盖率和防晒霜使用量的因素，将测量的紫外线辐照度随时间整合，以计算实时紫外线剂量和维生素D的生产。 基于测量，该系统可以预测皮肤灼伤的时间和剩余的时间达到维生素D生产的每日目标。 该系统还实时计算UV指数，并可以将网络中的测量数据聚集在一起。 UV剂量测定系统通过先进且用户友好的输入和输出接口支持多用户控制。

    UV dosimetry system
    56.
    发明授权
    UV dosimetry system 有权
    紫外线剂量测定系统

    公开(公告)号：US09068887B1

    公开(公告)日：2015-06-30

    申请号：US14257514

    申请日：2014-04-21

    申请人： Nabyl Bennouri ,  Jie Lian ,  Nattapon Chaimanonart

    发明人： Nabyl Bennouri ,  Jie Lian ,  Nattapon Chaimanonart

    IPC分类号： G01J1/44 ,  G01J1/42

    CPC分类号： G01W1/02 ,  A61B5/441 ,  G01J1/0219 ,  G01J1/0233 ,  G01J1/0247 ,  G01J1/42 ,  G01J1/429 ,  G01J1/44

    摘要： A UV dosimetry system comprises a wearable unit and a mobile computing device. The wearable unit measures the UV irradiance intensity and wirelessly communicates with the mobile computing device. The UV dosimetry system supports multi-user control and can link one mobile computing device with multiple wearable units. The UV dosimetry system processes the measured UV irradiance intensity to calculate the UV index (UVI) and the sensor site specific UV dose. It can also calculate the total absorbed UV dose and vitamin D production by taking into account user specific factors. The UVI data measured by a plurality of UV meters such as the disclosed UV dosimetry system are crowd sourced to a remote server together with the location and time data of the measurement. The remote server excludes invalid UVI measurement and generates UVI maps showing time-varying distribution of UVI data at different locations.

    摘要翻译： UV剂量测定系统包括可穿戴单元和移动计算设备。 可穿戴单元测量紫外线辐射强度，并与移动计算设备进行无线通信。 UV剂量测定系统支持多用户控制，并且可以将一个移动计算设备与多个可穿戴单元相连接。 紫外线剂量测定系统处理测量的紫外线辐射强度以计算UV指数（UVI）和传感器位置特异性UV剂量。 还可以通过考虑用户的具体因素来计算吸收的紫外线剂量和维生素D的总产量。 通过诸如所公开的UV剂量测定系统的多个UV测量仪测量的UVI数据与测量的位置和时间数据一起聚集到远程服务器。 远程服务器排除无效的UVI测量，并生成显示UVI数据在不同位置的时变分布的UVI映射。

    Method and device for noise detection in physiological signals
    57.
    发明授权
    Method and device for noise detection in physiological signals 有权
    生理信号中噪声检测的方法和装置

    公开(公告)号：US09026198B2

    公开(公告)日：2015-05-05

    申请号：US13155690

    申请日：2011-06-08

    申请人： Jie Lian ,  Dirk Muessig

    发明人： Jie Lian ,  Dirk Muessig

    IPC分类号： A61B5/04 ,  A61B5/0452 ,  A61B5/00

    CPC分类号： A61B5/0452 ,  A61B5/7221 ,  Y10S128/901

    摘要： A method for determining the signal quality of samples in a physiological signal, in particular an electrocardiogram (ECG) signal, is provided. A supra-threshold sample sum, a noise threshold crossing sum, or both are calculated in a noise detection window including the sample to be evaluated, and low signal quality is indicated if either or both of the sums exceed respective values. ECG beat detections can then be labeled as unreliable based on the determination of low signal quality for one or more samples between the detections.

    摘要翻译： 提供了一种用于确定生理信号，特别是心电图（ECG）信号中的样本的信号质量的方法。 在包括要评估的样本的噪声检测窗口中计算超阈值采样和，噪声阈值交叉和或两者，并且如果这些和之一或两者都超过相应值，则指示低信号质量。 然后可以基于检测之间的一个或多个样本的低信号质量的确定，将ECG拍摄检测标记为不可靠。

    HEART STIMULATOR AND METHOD FOR A-V DELAY OPTIMIZATION
    58.
    发明申请
    HEART STIMULATOR AND METHOD FOR A-V DELAY OPTIMIZATION 有权
    用于A-V延迟优化的心脏刺激器和方法

    公开(公告)号：US20120302904A1

    公开(公告)日：2012-11-29

    申请号：US13462134

    申请日：2012-05-02

    申请人： Jie Lian ,  J. Christopher Moulder ,  Dirk Muessig

    发明人： Jie Lian ,  J. Christopher Moulder ,  Dirk Muessig

    IPC分类号： A61N1/365 ,  A61B5/0452

    CPC分类号： A61N1/3684 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/36578 ,  A61N1/36592 ,  A61N1/3682

    摘要： Exemplary methods and apparatuses are disclosed that provide for determination of an atrio-ventricular delay on a beat-to-beat basis by determining a P-wave duration from electric signals corresponding to electric potentials in a heart, and determining the atrio-ventricular delay on a beat-to-beat basis such that the atrio-ventricular delay for an individual heart cycle depends on the P-wave duration of a same or an immediately preceding heart cycle.

    摘要翻译： 公开了示例性方法和装置，其通过从对应于心脏中的电位的电信号确定P波持续时间来提供基于节拍的心室延迟的确定，并且确定心室上的心室延迟 以心跳为基础，使得个体心脏周期的心室延迟取决于相同或紧接在前的心脏周期的P波持续时间。

    APPARATUS AND METHOD TO ASSESS THE RISK OF R-ON-T EVENT
    59.
    发明申请
    APPARATUS AND METHOD TO ASSESS THE RISK OF R-ON-T EVENT 有权
    评估R-ON事件风险的装置和方法

    公开(公告)号：US20090228061A1

    公开(公告)日：2009-09-10

    申请号：US12045142

    申请日：2008-03-10

    申请人： Jie Lian ,  Dirk Muessig ,  Volker Lang

    发明人： Jie Lian ,  Dirk Muessig ,  Volker Lang

    IPC分类号： A61N1/08 ,  A61B5/0456

    CPC分类号： A61B5/04011 ,  A61B5/0452 ,  A61B5/7275 ,  A61N1/3622 ,  A61N1/37282 ,  G06F19/00

    摘要： A medical device and a method is suggested for assessing the risk of R on T events. The device comprises a memory, input means for acquiring or receiving an electrogram signal and processing means. The processing means are adapted to detect R-wave and T-waves represented by said electrogram, establish a QT-RR regression model based detected R-waves and T-waves, estimate a vulnerable period, and store estimated vulnerable period data in said memory. Likewise, the method comprises the steps of to detecting R-wave and T-waves represented by an electrogram, establishing a QT-RR regression model based detected R-waves and T-waves, estimating a vulnerable period, and storing estimated vulnerable period data.

    摘要翻译： 建议使用医疗设备和方法来评估R on T事件的风险。 该装置包括存储器，用于获取或接收电描记图信号的输入装置和处理装置。 处理装置适于检测由所述电描记图表示的R波和T波，建立基于检测到的R波和T波的QT-RR回归模型，估计易受伤害的周期，并将估计的脆弱周期数据存储在所述存储器中 。 同样地，该方法包括以下步骤：检测由电描记图表示的R波和T波，建立基于检测的R波和T波的QT-RR回归模型，估计脆弱时期，以及存储估计的脆弱周期数据 。

    Adaptive ventricular rate smoothing during atrial fibrillation
    60.
    发明授权
    Adaptive ventricular rate smoothing during atrial fibrillation 有权
    心房颤动期间自适应心率平滑

    公开(公告)号：US07532929B2

    公开(公告)日：2009-05-12

    申请号：US11063240

    申请日：2005-02-22

    申请人： Dirk Mussig ,  Volker Lang ,  Jie Lian

    发明人： Dirk Mussig ,  Volker Lang ,  Jie Lian

    IPC分类号： A61N1/08

    CPC分类号： A61N1/3622 ,  A61N1/365

    摘要： An implantable cardiac device is provided for adaptive ventricular rate smoothing during atrial fibrillation (AF). When AF is detected, the operation of the device is switched to non-atrial synchronized pacing mode such as DDI, DDIR, VDI, VDIR, VVI, or VVIR. The ventricular escape interval (VEI) is beat-by-beat modulated around a physiological interval zone (PIZ), which is determined by the pre-arrhythmia ventricular rate or the output of rate responsive sensor. The VEI remains unchanged if the preceding ventricular event is sensed and its RR interval is within the PIZ. Otherwise, the VEI is decreased asymptotically toward a lower interval threshold if the preceding RR interval is longer than the upper limit of the PIZ, or the VEI is increased asymptotically toward an upper interval threshold if the preceding RR interval is shorter than the upper limit of the PIZ. The step of incrementing or decrementing the VEI is adaptive to the absolute difference value between the preceding RR interval and the asymptotic interval threshold to ensure fast recovery of deviant RR interval toward the PIZ and to reduce the amount of high rate ventricular paces after a ventricular sense with very short coupling interval.

    摘要翻译： 提供可植入的心脏装置，用于心房颤动（AF）期间的适应性心室率平滑。 当检测到AF时，设备的操作切换到非心率同步起搏模式，如DDI，DDIR，VDI，VDIR，VVI或VVIR。 心室逃逸间隔（VEI）围绕生理间隔区（PIZ）进行逐搏调制，其由心律失常心室率或速率响应传感器的输出决定。 如果检测到先前的心室事件并且其RR间期在PIZ内，则VEI保持不变。 否则，如果前一个RR间隔长于PIZ的上限，则VEI会逐渐减小到较低的间隔阈值，或者如果前一个RR间隔比上一个RR间隔的上限更短，VEI会渐近地向上限间隔增加 PIZ。 增加或减少VEI的步骤适应于前面的RR间隔和渐近间隔阈值之间的绝对差值，以确保偏离RR间隔向PIZ的快速恢复，并减少心室感觉后的高速率心室起搏量 具有非常短的耦合间隔。