公开(公告)号：US20240347167A1

公开(公告)日：2024-10-17

申请号：US18595584

申请日：2024-03-05

Applicant: MESO SCALE TECHNOLOGIES, LLC. ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

Inventor： William F. BLAKELY ,  Eli N. GLEZER ,  John H. KENTEN ,  Sudeep KUMAR ,  Anu MATHEW ,  Natalia I. OSSETROVA ,  George SIGAL

IPC: G16H20/40 ,  G01N27/327 ,  G01N33/68 ,  G01N35/00 ,  G01T1/00 ,  G01T1/02

CPC classification number: G16H20/40 ,  G01N27/3273 ,  G01N33/6893 ,  G01N35/00 ,  G01T1/00 ,  G01T1/02 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US11904185B2

公开(公告)日：2024-02-20

申请号：US17289346

申请日：2019-11-15

Applicant: HITACHI, LTD. ,  NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

Inventor： Shusuke Hirayama ,  Rintarou Fujimoto ,  Masumi Umezawa ,  Yuusuke Fujii ,  Keiji Kobashi ,  Taeko Matsuura ,  Shinichi Shimizu

IPC: A61N5/10 ,  G01T1/02

CPC classification number: A61N5/1071 ,  G01T1/02 ,  A61N2005/1087

Abstract: A proton beam therapy system 1 includes an irradiation nozzle 25 for irradiating a target 31A with a particle beam, a proton beam irradiation control system 41 that controls the irradiation nozzle 25, a dose monitor 27B that measures an irradiation amount of the particle beam emitted to the target 31A, a position monitor 27A that measures a position of the particle beam emitted to the target 31A, and a dose distribution evaluation system during irradiation 55 that calculates a dose distribution of the particle beam emitted to the target 31A during irradiation. This system supports a medical staff to quickly and appropriately make an intervention determination for treatment such as discontinuation of particle therapy, a change in conditions thereof, or the like in the process of particle irradiation.

公开(公告)号：US11656369B2

公开(公告)日：2023-05-23

申请号：US17298743

申请日：2019-12-20

Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY

Inventor： Shirin Abbasi Nejad Enger ,  Jack Childress ,  Lilian Childress ,  Julien Megroureche

IPC: G01T1/02 ,  A61B6/00

CPC classification number: G01T1/02 ,  A61B6/4208

Abstract: Herein provided is a radiation dosimeter and associated systems and methods. The radiation dosimeter comprises a light source configured for producing an input optical signal; a resonant cavity coupled to the light source for receiving the input optical signal, the resonant cavity configured for containing a fluid and for producing an output optical signal from the input optical signal indicative of a radiation dose absorbed by the fluid; and a light detector coupled to the optical fiber for obtaining the output optical signal.

公开(公告)号：US20180299564A1

公开(公告)日：2018-10-18

申请号：US15952841

申请日：2018-04-13

Applicant: JEFFERSON SCIENCE ASSOCIATES, LLC

Inventor： CARL ZORN ,  ANDREW WEISENBERGER ,  WENZE XI

IPC: G01T1/06 ,  G01T3/08 ,  G01T1/02

CPC classification number: G01T1/06 ,  G01T1/02 ,  G01T3/00 ,  G01T3/08 ,  G01T5/08

Abstract: A radiation monitor apparatus and method based on wavelength-dependent optical absorption in fused silica optical fibers. The radiation monitor uses the radiation induced optical changes in fused silica optical fibers as a way to quantify and differentiate the large doses of radiation from high energy photons and neutrons as well as providing a method to extend the sensitivity over a large dynamic range of doses from 103 to beyond 106 rads. The radiation monitor enables dynamic monitoring of highly ionizing radiation environments. The radiation monitor reduces sensitivity saturation at high dose levels, provides increased sensitivity over a large dynamic range of doses, and enables differentiation between high energy photon and neutron contributions or poor signal to noise.

公开(公告)号：US20180246100A1

公开(公告)日：2018-08-30

申请号：US15902597

申请日：2018-02-22

Applicant: Meso Scale Technologies, LLC. ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

Inventor： William F. Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC: G01N33/569 ,  G01N33/566 ,  G01N33/68

CPC classification number: G01N33/56972 ,  G01N33/566 ,  G01N33/6893 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60 ,  G01T1/00 ,  G01T1/02

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US20180231753A1

公开(公告)日：2018-08-16

申请号：US15943595

申请日：2018-04-02

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G02B21/00 ,  G02B21/36 ,  G01N33/80 ,  G01N15/14 ,  G06K9/00 ,  G01T1/02 ,  G01N11/00 ,  G03H1/00 ,  G01B9/02 ,  G03H1/04 ,  G01N15/00 ,  C12M1/34 ,  G01N15/10 ,  G06T7/00

CPC classification number: G02B21/0008 ,  C12M41/36 ,  G01B9/02041 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1463 ,  G01N15/1475 ,  G01N33/80 ,  G01N2011/008 ,  G01N2015/0069 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2015/149 ,  G01T1/02 ,  G02B21/00 ,  G02B21/0004 ,  G02B21/361 ,  G02B21/365 ,  G03H2001/005 ,  G03H2001/045 ,  G06K9/00127 ,  G06K9/00147 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/30242 ,  Y10S435/808

Abstract: Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.

公开(公告)号：US20180220923A1

公开(公告)日：2018-08-09

申请号：US15746145

申请日：2015-11-17

Applicant: LG ELECTRONICS INC.

Inventor： Hongjo SHIM ,  Sungho WOO ,  Hyunok LEE ,  Youngho SOHN ,  Seonghyok KIM ,  Mihyun PARK ,  Jisoo PARK

IPC: A61B5/053 ,  A61B5/00 ,  G04G21/02 ,  G04G17/06 ,  G04G17/04

CPC classification number: A61B5/0537 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0077 ,  A61B5/0097 ,  A61B5/0533 ,  A61B5/1032 ,  A61B5/681 ,  A61B5/721 ,  A61B5/742 ,  A61B5/7455 ,  A61B5/7475 ,  A61B2560/0214 ,  A61B2560/0247 ,  A61B2562/0204 ,  A61B2562/0209 ,  A61B2562/0219 ,  A61B2562/0247 ,  A61B2562/0257 ,  A61B2562/0271 ,  G01T1/00 ,  G01T1/02 ,  G04G17/04 ,  G04G17/06 ,  G04G21/025 ,  G06F1/163

Abstract: A watch-type terminal according to the present invention comprise: a main body; a band part connected to the main body and formed so as to be worn around the wrist; an electrode unit for generating a current by being disposed in one region among the main body or the band so as to make contact with the body of a user; and a control unit for calculating an impedance value on the basis of a voltage sensed by the electrode unit, wherein the electrode unit comprises: a first electrode member making contact with the wrist when the watch-type terminal is worn around the wrist; and a second electrode member exposed to the outside.

公开(公告)号：US20180045836A1

公开(公告)日：2018-02-15

申请号：US15675304

申请日：2017-08-11

Applicant: Korea Astronomy and Space Science Institute ,  Korea Meteorological Administration

Inventor： Junga HWANG

IPC: G01T1/02

CPC classification number: G01T1/02

Abstract: An analysis system for an aviation radiation dose according to the present invention includes: a proton spectrum generator which calculates a galactic cosmic ray incident on the Earth's atmosphere and a proton spectrum corresponding to a solar proton event; a global radiation dose map producer which calculates particle transport based on the proton spectrum and produces a radiation dose map; a global radiation dose map converter which converts the radiation dose map produced based on a standard atmosphere into a radiation dose map corresponding to current atmosphere conditions in real time; and a database in which data necessary for operations of the proton spectrum generator, the global radiation dose map producer and the global radiation dose map converter is previously calculated and stored, thereby having an effect on estimating a radiation dose of another route if another piece of information about an arbitrary path and time is given besides a previous given path.

公开(公告)号：US09893022B2

公开(公告)日：2018-02-13

申请号：US15596551

申请日：2017-05-16

Applicant: International Business Machines Corporation

Inventor： Qing Cao ,  Kangguo Cheng ,  Fei Liu

IPC: H01L23/29 ,  H01L23/00 ,  H01L21/56

CPC classification number: H01L23/573 ,  G01T1/02 ,  H01L21/56 ,  H01L23/295 ,  H01L23/57

Abstract: Circuits which self-destruct under radiation are provided. In one aspect, a method for creating a radiation-sensitive circuit is provided. The method includes the step of: connecting an integrated circuit to a power supply and to a ground in parallel with at least one dosimeter device, wherein the dosimeter device is configured to change from being an insulator to being a conductor under radiation. Radiation-sensitive circuits are also provided.

公开(公告)号：US20170299733A1

公开(公告)日：2017-10-19

申请号：US15323949

申请日：2016-02-24

Applicant: BOE TECHNOLOGY GROUP CO., LTD.

Inventor： Xuan HE

IPC: G01T1/16 ,  G02F1/1333 ,  G02F1/13

CPC classification number: G01T1/16 ,  G01T1/02 ,  G02F1/1303 ,  G02F1/1313 ,  G02F1/1333

Abstract: A terminal capable of detecting rays, an enclosure, and a method for fabricating terminal are provided. The terminal comprises a terminal body and a ray detector in communication with the terminal body. The terminal body comprises a display panel. The ray detector detects rays around the terminal, and transmits the detected signal to the terminal body. The terminal body analyzes the detected signal and transmits the detected signal to the display panel for displaying. In the present disclosure, the detector and the display panel are formed at the same time, and the detector is integrated in a same display panel, so that the process is simplified. The terminal stores and analyzes the data about the collected ionizing radiation dose. As a result, the radiation dose can be read in real time, and an alert can be issued instantaneously to reduce unnecessary damage.