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公开(公告)号：US07437191B2
公开(公告)日：2008-10-14
申请号：US11458286
申请日：2006-07-18
申请人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. R. Vanagt
发明人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. R. Vanagt
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了以提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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公开(公告)号：US07295874B2
公开(公告)日：2007-11-13
申请号：US11030575
申请日：2005-01-06
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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53.发明授权Controlled delivery of intermittent stress augmentation pacing for cardioprotective effect 有权间歇性应激增加起搏的控制输送用于心脏保护作用公开(公告)号：US08611998B2
公开(公告)日：2013-12-17
申请号：US13239835
申请日：2011-09-22
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61N1/36557 , A61N1/3684 , A61N1/3688 , A61N1/3702
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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54.发明授权公开(公告)号：US08571655B2
公开(公告)日：2013-10-29
申请号：US12693660
申请日：2010-01-26
IPC分类号： A61N1/368
CPC分类号： A61N1/36114 , A61N1/3622 , A61N1/3627 , A61N1/368
摘要： A method and device for delivering multi-site ventricular pacing therapy in conjunction with parasympathetic stimulation for reducing ventricular wall stress. Such reduction in ventricular wall stress is useful in reversing or preventing the ventricular remodeling which can occur in heart failure patients.
摘要翻译： 结合副交感神经刺激减少心室壁应力的方法和装置，用于多局部心室起搏治疗。 心室壁应激的这种减少可用于逆转或预防心力衰竭患者发生的心室重塑。
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55.发明申请公开(公告)号：US20120010674A1
公开(公告)日：2012-01-12
申请号：US13239835
申请日：2011-09-22
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61N1/36557 , A61N1/3684 , A61N1/3688 , A61N1/3702
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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56.发明申请MULTI-SITE VENTRICULAR PACING THERAPY WITH PARASYMPATHETIC STIMULATION 有权多地面静脉注射治疗与PARASYMPATHETIC STIMULATION公开(公告)号：US20100125307A1
公开(公告)日：2010-05-20
申请号：US12693660
申请日：2010-01-26
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/3622 , A61N1/3627 , A61N1/368
摘要： A method and device for delivering multi-site ventricular pacing therapy in conjunction with parasympathetic stimulation for reducing ventricular wall stress. Such reduction in ventricular wall stress is useful in reversing or preventing the ventricular remodeling which can occur in heart failure patients.
摘要翻译： 结合副交感神经刺激减少心室壁应力的方法和装置，用于多局部心室起搏治疗。 心室壁应激的这种减少可用于逆转或预防心力衰竭患者发生的心室重塑。
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公开(公告)号：US07979123B2
公开(公告)日：2011-07-12
申请号：US11868767
申请日：2007-10-08
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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58.发明授权Controlled delivery of intermittent stress augmentation pacing for cardioprotective effect 有权间歇性应激增加起搏的控制输送用于心脏保护作用公开(公告)号：US07366568B2
公开(公告)日：2008-04-29
申请号：US11151015
申请日：2005-06-13
CPC分类号： A61N1/365 , A61N1/36557 , A61N1/3684 , A61N1/3688 , A61N1/3702
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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公开(公告)号：US08214040B2
公开(公告)日：2012-07-03
申请号：US12250868
申请日：2008-10-14
申请人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. Vanagt
发明人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. Vanagt
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了以提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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60.发明申请公开(公告)号：US20080215105A1
公开(公告)日：2008-09-04
申请号：US12109169
申请日：2008-04-24
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61N1/36557 , A61N1/3684 , A61N1/3688 , A61N1/3702
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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