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公开(公告)号：US20120185008A1
公开(公告)日：2012-07-19
申请号：US13353824
申请日：2012-01-19
申请人： Xiaohong Zhou , Robert Stadler , Richard Cornelussen , Lillian Kornet , Paul D. Ziegler , Karen J. Kleckner , Alberto Della Scala
发明人： Xiaohong Zhou , Robert Stadler , Richard Cornelussen , Lillian Kornet , Paul D. Ziegler , Karen J. Kleckner , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36114
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
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公开(公告)号：US07979123B2
公开(公告)日：2011-07-12
申请号：US11868767
申请日：2007-10-08
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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公开(公告)号：US20080269815A1
公开(公告)日：2008-10-30
申请号：US11742011
申请日：2007-04-30
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61N1/3682
摘要： An implantable medical device and associated method control the delivery of extra systolic stimulation by determining a coupling interval, setting an extra systolic interval in response to the coupling interval; and delivering a supraventricular stimulation pulse upon expiration of the extra systolic interval. The supraventricular stimulation pulse evokes a depolarization that is conducted to the ventricles occurring at a ventricular coupling interval relative to a ventricular event.
摘要翻译： 可植入医疗装置和相关方法通过确定耦合间隔来控制额外的收缩期刺激的输送，响应耦合间隔设定额外的收缩期间隔; 并且在额外的收缩期间隔期间递送室上的刺激脉冲。 室上刺激脉冲引起去极化，其进行到相对于心室事件的心室耦合间隔处发生的心室。
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公开(公告)号：US20120185007A1
公开(公告)日：2012-07-19
申请号：US13353802
申请日：2012-01-19
申请人： Paul D. Ziegler , Lillian Kornet , Xiaohong Zhou , Richard Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
发明人： Paul D. Ziegler , Lillian Kornet , Xiaohong Zhou , Richard Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3702 , A61N1/37235 , A61N1/3962
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
摘要翻译： 本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。 这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。
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5.发明申请公开(公告)号：US20060287684A1
公开(公告)日：2006-12-21
申请号：US11382849
申请日：2006-05-11
IPC分类号： A61N1/00
CPC分类号： A61N1/36557 , A61B5/026 , A61N1/3621 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702
摘要： A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. In one embodiment, the pacing system initiates a cardiac protection pacing sequence in response to the detection of the onset of an ischemic event, such that a pacing concurrent conditioning therapy is applied during the detected ischemic event.
摘要翻译： 起搏系统提供心脏保护起搏，以保护心脏免受与缺血事件相关的损伤。 起搏系统检测缺血事件，并作为响应启动一个或多个心脏保护起搏序列，每个起搏序列包括替代起搏和非起搏期。 在一个实施方案中，响应于检测到缺血事件的发作，起搏系统引发心脏保护起搏序列，使得在检测到的缺血事件期间应用起搏并发调节疗法。
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公开(公告)号：US20060259088A1
公开(公告)日：2006-11-16
申请号：US11129058
申请日：2005-05-13
申请人： Joseph Pastore , Andrew Kramer , Julio Spinelli , Rodney Salo , Tamara Baynham , Jeffrey Ross , Frits Prinzen , Ward Vanagt , Richard Cornelussen
发明人： Joseph Pastore , Andrew Kramer , Julio Spinelli , Rodney Salo , Tamara Baynham , Jeffrey Ross , Frits Prinzen , Ward Vanagt , Richard Cornelussen
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/3627 , A61N1/36557 , A61N1/37205 , A61N1/3787 , A61N2001/0585
摘要： An implantable cardiac protection pacing system delivers pacing pulses to protect the heart from injuries associated with ischemia and myocardial infarction. The system includes an implantable pulse generator (PG) that delivers the pacing pulses and a coronary stent electrically connected to the implantable PG to function as a pacing electrode through which the pacing pulses are delivered. In one embodiment, an intravascular lead provides the electrical connection between the coronary stent and the implantable PG to allow the implantable PG to be implanted in the femoral region. In another embodiment, the coronary stent and the implantable PG are integrated into an intravascular pulse generator-stent.
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公开(公告)号：US08620424B2
公开(公告)日：2013-12-31
申请号：US11742011
申请日：2007-04-30
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61N1/3682
摘要： An implantable medical device and associated method control the delivery of extra systolic stimulation by determining a coupling interval, setting an extra systolic interval in response to the coupling interval; and delivering a supraventricular stimulation pulse upon expiration of the extra systolic interval. The supraventricular stimulation pulse evokes a depolarization that is conducted to the ventricles occurring at a ventricular coupling interval relative to a ventricular event.
摘要翻译： 可植入医疗装置和相关方法通过确定耦合间隔来控制额外的收缩期刺激的输送，响应耦合间隔设定额外的收缩期间隔; 并且在额外的收缩期间隔期间递送室上的刺激脉冲。 室上刺激脉冲引起去极化，其进行到相对于心室事件的心室耦合间隔处发生的心室。
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公开(公告)号：US20080027495A1
公开(公告)日：2008-01-31
申请号：US11868767
申请日：2007-10-08
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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公开(公告)号：US20070021789A1
公开(公告)日：2007-01-25
申请号：US11458286
申请日：2006-07-18
IPC分类号： A61N1/00
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了以提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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公开(公告)号：US20060241704A1
公开(公告)日：2006-10-26
申请号：US11113828
申请日：2005-04-25
申请人： Allan Shuros , Tamara Baynham , Jihong Qu , Joseph Pastore , Andrew Kramer , Frits Prinzen , Ward Vanagt , Richard Cornelussen
发明人： Allan Shuros , Tamara Baynham , Jihong Qu , Joseph Pastore , Andrew Kramer , Frits Prinzen , Ward Vanagt , Richard Cornelussen
IPC分类号： A61N1/362
CPC分类号： A61N1/362 , A61B17/22 , A61B18/1492 , A61B2017/22001 , A61B2018/00214 , A61B2018/0041 , A61B2018/00422 , A61N1/056 , A61N1/3625 , A61N5/1001 , A61N2001/0585
摘要： Cardiac protection pacing is applied to prevent or reduce cardiac injury and/or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and/or after the ischemic event.
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