公开(公告)号：US20100228310A1

公开(公告)日：2010-09-09

申请号：US12715862

申请日：2010-03-02

申请人： Allan C. Shuros ,  Weiying Zhao ,  Jason J. Hamann ,  Stephen Ruble

发明人： Allan C. Shuros ,  Weiying Zhao ,  Jason J. Hamann ,  Stephen Ruble

IPC分类号： A61N1/36

CPC分类号： A61N1/0551 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36185 ,  A61N1/36585

摘要： According to various embodiments of a method for modulating autonomic neural activity in a body having a spinal cord, a subclavian vein and thoracic lymphatic vessels that include a thoracic duct and a right lymphatic duct, at least one programmed therapy is implemented using an implanted medical device to modulate autonomic neural activity. Implementing the therapy includes increasing or decreasing sympathetic activity in sympathetic nerves branching from a first region of the spinal cord using a first electrode in the thoracic duct, and further includes increasing or decreasing parasympathetic activity in parasympathetic nerves adjacent to the desired thoracic lymphatic vessel or sympathetic activity in sympathetic nerves branching from a second region of the spinal cord using a second electrode in the desired thoracic lymphatic vessel.

摘要翻译： 根据用于调节具有脊髓，锁骨下静脉和包括胸导管和右淋巴管的胸部淋巴管的身体中的自主神经活动的方法的各种实施例，至少一个程序化治疗使用植入的医疗装置 调节自主神经活动。 实施治疗包括使用胸导管中的第一电极从脊髓的第一区域分支的交感神经中增加或减少交感神经活动，并且还包括增加或减少邻近所需胸部淋巴管或交感神经的副交感神经中的副交感神经活动 在所需胸廓淋巴管中使用第二电极从脊髓的第二区域分支的交感神经中的活动。

公开(公告)号：US09259568B2

公开(公告)日：2016-02-16

申请号：US12431607

申请日：2009-04-28

申请人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

发明人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

IPC分类号： A61N1/05

CPC分类号： A61N1/0551 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/36071 ,  A61N1/36114

摘要： Various system embodiments comprise a lead having a distal end and a proximal end. The distal end includes a plurality of electrodes. The lead is configured to be fed into a dorsal epidural space of a human to a desired region of a spinal column and to be fed laterally to at least partially encircle a spinal cord in the desired region to place at least one stimulation electrode in position to stimulate a dorsal nerve root and at least another stimulation electrode in position to stimulate a ventral nerve root. The desired region may include cervical vertebrae, thoracic vertebrae, or lumbar vertebrae. Some embodiments stimulate the spinal cord in the T1-T5 region.

摘要翻译： 各种系统实施例包括具有远端和近端的引线。 远端包括多个电极。 引线被配置为被馈送到人的背部硬膜外区域到脊柱的期望区域，并且被横向地供给至少部分地包围所需区域中的脊髓，以将至少一个刺激电极置于适当位置 刺激背神经根和至少另一个刺激电极，以刺激腹侧神经根。 所需区域可包括颈椎，胸椎或腰椎。 一些实施方案刺激T1-T5区域中的脊髓。

公开(公告)号：US20100010556A1

公开(公告)日：2010-01-14

申请号：US12487266

申请日：2009-06-18

申请人： Weiying Zhao ,  Quan Ni ,  Stephen Ruble ,  Jason J. Hamann

发明人： Weiying Zhao ,  Quan Ni ,  Stephen Ruble ,  Jason J. Hamann

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/0551 ,  A61N1/36053 ,  A61N1/36117 ,  A61N1/36592 ,  A61N1/3712

摘要： According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.

摘要翻译： 根据各种方法实施例，指示一个人用于治疗心血管疾病的治疗，并且将该治疗递送给该人以治疗心血管疾病。 提供治疗包括将迷走神经刺激治疗（VST）以对于心血管疾病的治疗有效强度的人的迷走神经递送，所述心血管疾病低于VST在VST期间的上边界降低内在心率的上边界 。

公开(公告)号：US20090270960A1

公开(公告)日：2009-10-29

申请号：US12431607

申请日：2009-04-28

申请人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

发明人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

IPC分类号： A61N1/00

CPC分类号： A61N1/0551 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/36071 ,  A61N1/36114

摘要： Various system embodiments comprise a lead having a distal end and a proximal end. The distal end includes a plurality of electrodes. The lead is configured to be fed into a dorsal epidural space of a human to a desired region of a spinal column and to be fed laterally to at least partially encircle a spinal cord in the desired region to place at least one stimulation electrode in position to stimulate a dorsal nerve root and at least another stimulation electrode in position to stimulate a ventral nerve root. The desired region may include cervical vertebrae, thoracic vertebrae, or lumbar vertebrae. Some embodiments stimulate the spinal cord in the T1-T5 region.

摘要翻译： 各种系统实施例包括具有远端和近端的引线。 远端包括多个电极。 引线被配置为被馈送到人的背部硬膜外空间到脊柱的期望区域，并且被横向馈送以至少部分地环绕所需区域中的脊髓，以将至少一个刺激电极置于适当位置 刺激背神经根和至少另一个刺激电极，以刺激腹侧神经根。 所需区域可包括颈椎，胸椎或腰椎。 一些实施方案刺激T1-T5区域中的脊髓。