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    Systems and methods for delivering electric current for spinal cord stimulation
    1.
    发明授权
    Systems and methods for delivering electric current for spinal cord stimulation 有权
    用于输送脊髓刺激电流的系统和方法

    公开(公告)号：US09259568B2

    公开(公告)日：2016-02-16

    申请号：US12431607

    申请日：2009-04-28

    申请人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

    发明人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0551 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/36071 ,  A61N1/36114

    摘要： Various system embodiments comprise a lead having a distal end and a proximal end. The distal end includes a plurality of electrodes. The lead is configured to be fed into a dorsal epidural space of a human to a desired region of a spinal column and to be fed laterally to at least partially encircle a spinal cord in the desired region to place at least one stimulation electrode in position to stimulate a dorsal nerve root and at least another stimulation electrode in position to stimulate a ventral nerve root. The desired region may include cervical vertebrae, thoracic vertebrae, or lumbar vertebrae. Some embodiments stimulate the spinal cord in the T1-T5 region.

    摘要翻译： 各种系统实施例包括具有远端和近端的引线。 远端包括多个电极。 引线被配置为被馈送到人的背部硬膜外区域到脊柱的期望区域，并且被横向地供给至少部分地包围所需区域中的脊髓，以将至少一个刺激电极置于适当位置 刺激背神经根和至少另一个刺激电极，以刺激腹侧神经根。 所需区域可包括颈椎，胸椎或腰椎。 一些实施方案刺激T1-T5区域中的脊髓。

    SYSTEMS AND METHODS FOR DELIVERING ELECTRIC CURRENT FOR SPINAL CORD STIMULATION
    2.
    发明申请
    SYSTEMS AND METHODS FOR DELIVERING ELECTRIC CURRENT FOR SPINAL CORD STIMULATION 有权
    用于输送脊髓刺激电流的系统和方法

    公开(公告)号：US20090270960A1

    公开(公告)日：2009-10-29

    申请号：US12431607

    申请日：2009-04-28

    申请人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

    发明人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

    IPC分类号： A61N1/00

    CPC分类号： A61N1/0551 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/36071 ,  A61N1/36114

    摘要： Various system embodiments comprise a lead having a distal end and a proximal end. The distal end includes a plurality of electrodes. The lead is configured to be fed into a dorsal epidural space of a human to a desired region of a spinal column and to be fed laterally to at least partially encircle a spinal cord in the desired region to place at least one stimulation electrode in position to stimulate a dorsal nerve root and at least another stimulation electrode in position to stimulate a ventral nerve root. The desired region may include cervical vertebrae, thoracic vertebrae, or lumbar vertebrae. Some embodiments stimulate the spinal cord in the T1-T5 region.

    摘要翻译： 各种系统实施例包括具有远端和近端的引线。 远端包括多个电极。 引线被配置为被馈送到人的背部硬膜外空间到脊柱的期望区域，并且被横向馈送以至少部分地环绕所需区域中的脊髓，以将至少一个刺激电极置于适当位置 刺激背神经根和至少另一个刺激电极，以刺激腹侧神经根。 所需区域可包括颈椎，胸椎或腰椎。 一些实施方案刺激T1-T5区域中的脊髓。

    SYSTEMS AND METHODS FOR SELECTIVELY STIMULATING NERVE ROOTS
    3.
    发明申请
    SYSTEMS AND METHODS FOR SELECTIVELY STIMULATING NERVE ROOTS 有权
    用于选择性刺激神经病变的系统和方法

    公开(公告)号：US20090270935A1

    公开(公告)日：2009-10-29

    申请号：US12431621

    申请日：2009-04-28

    申请人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

    发明人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36117 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/36057 ,  A61N1/36071 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/37241

    摘要： Various system embodiments comprise an implantable lead, an implantable housing, a neural stimulation circuit in the housing, and a controller in the housing and connected to the neural stimulation circuit. The lead has a proximal end and a distal end. The distal end is adapted to deliver neural stimulation pulses to the ventral nerve root and the dorsal nerve root. The proximal end of the lead is adapted to connect to the housing. The neural stimulation circuit is adapted to generate neural stimulation pulses to stimulate the ventral nerve root or the dorsal nerve root using the implantable lead. The controller is adapted to control the neural stimulation circuit to deliver a neural stimulation treatment.

    摘要翻译： 各种系统实施例包括可植入引线，可植入壳体，壳体中的神经刺激电路以及壳体中的控制器并连接到神经刺激电路。 引线具有近端和远端。 远端适于将神经刺激脉冲输送到腹侧神经根和背神经根。 引线的近端适于连接到外壳。 神经刺激电路适于产生神经刺激脉冲，以使用可植入引线刺激腹侧神经根或背神经根。 控制器适于控制神经刺激电路以递送神经刺激治疗。

    Systems and methods for selectively stimulating nerve roots
    4.
    发明授权
    Systems and methods for selectively stimulating nerve roots 有权
    选择性刺激神经根的系统和方法

    公开(公告)号：US08386045B2

    公开(公告)日：2013-02-26

    申请号：US12431621

    申请日：2009-04-28

    申请人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

    发明人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36117 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/36057 ,  A61N1/36071 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/37241

    摘要： Various system embodiments comprise an implantable lead, an implantable housing, a neural stimulation circuit in the housing, and a controller in the housing and connected to the neural stimulation circuit. The lead has a proximal end and a distal end. The distal end is adapted to deliver neural stimulation pulses to the ventral nerve root and the dorsal nerve root. The proximal end of the lead is adapted to connect to the housing. The neural stimulation circuit is adapted to generate neural stimulation pulses to stimulate the ventral nerve root or the dorsal nerve root using the implantable lead. The controller is adapted to control the neural stimulation circuit to deliver a neural stimulation treatment.

    摘要翻译： 各种系统实施例包括可植入引线，可植入壳体，壳体中的神经刺激电路以及壳体中的控制器并连接到神经刺激电路。 引线具有近端和远端。 远端适于将神经刺激脉冲输送到腹侧神经根和背神经根。 引线的近端适于连接到外壳。 神经刺激电路适于产生神经刺激脉冲，以使用可植入引线刺激腹侧神经根或背神经根。 控制器适于控制神经刺激电路以递送神经刺激治疗。

    SYSTEMS AND METHODS FOR AUTONOMIC NERVE MODULATION
    5.
    发明申请
    SYSTEMS AND METHODS FOR AUTONOMIC NERVE MODULATION 审中-公开
    用于自动神经调制的系统和方法

    公开(公告)号：US20100228310A1

    公开(公告)日：2010-09-09

    申请号：US12715862

    申请日：2010-03-02

    申请人： Allan C. Shuros ,  Weiying Zhao ,  Jason J. Hamann ,  Stephen Ruble

    发明人： Allan C. Shuros ,  Weiying Zhao ,  Jason J. Hamann ,  Stephen Ruble

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0551 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36185 ,  A61N1/36585

    摘要： According to various embodiments of a method for modulating autonomic neural activity in a body having a spinal cord, a subclavian vein and thoracic lymphatic vessels that include a thoracic duct and a right lymphatic duct, at least one programmed therapy is implemented using an implanted medical device to modulate autonomic neural activity. Implementing the therapy includes increasing or decreasing sympathetic activity in sympathetic nerves branching from a first region of the spinal cord using a first electrode in the thoracic duct, and further includes increasing or decreasing parasympathetic activity in parasympathetic nerves adjacent to the desired thoracic lymphatic vessel or sympathetic activity in sympathetic nerves branching from a second region of the spinal cord using a second electrode in the desired thoracic lymphatic vessel.

    摘要翻译： 根据用于调节具有脊髓，锁骨下静脉和包括胸导管和右淋巴管的胸部淋巴管的身体中的自主神经活动的方法的各种实施例，至少一个程序化治疗使用植入的医疗装置 调节自主神经活动。 实施治疗包括使用胸导管中的第一电极从脊髓的第一区域分支的交感神经中增加或减少交感神经活动，并且还包括增加或减少邻近所需胸部淋巴管或交感神经的副交感神经中的副交感神经活动 在所需胸廓淋巴管中使用第二电极从脊髓的第二区域分支的交感神经中的活动。

    INTERMITTENT PACING THERAPY FOR ANGINA AND DISEASE PREVENTION
    8.
    发明申请
    INTERMITTENT PACING THERAPY FOR ANGINA AND DISEASE PREVENTION 审中-公开
    用于治疗和预防疾病的间歇性治疗

    公开(公告)号：US20100016913A1

    公开(公告)日：2010-01-21

    申请号：US12504602

    申请日：2009-07-16

    申请人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Robert Shipley ,  Jason J. Hamann

    发明人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Robert Shipley ,  Jason J. Hamann

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61N1/3601 ,  A61N1/36528 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36571 ,  A61N1/3684

    摘要： A pacing system delivers cardiac protective pacing therapy (CPPT) to protect the heart from injuries and/or to treat existing injuries. The pacing system receives a set of inputs and delivers optimized cardiac protection pacing tailored for each of different purposes. The system delivers electrical stimulation to provide therapy for angina and/or to provide therapy for co-morbidities related to neural imbalance. In one embodiment, a method for treating angina is provided. A signal is sensed indicative of an incidence of angina and an angina region being a myocardial region affected by the angina. The incidence of angina is detected and the angina region is located. A pacing location is selected remote from the angina region, and CPPT is initiated at the pacing location. The CPPT is adapted to create increased stress at the angina region, to promote mass-redistribution and angiogenesis at the angina region to treat the angina.

    摘要翻译： 起搏系统提供心脏保护起搏治疗（CPPT），以保护心脏免受伤害和/或治疗现有的伤害。 起搏系统接收一组输入，并提供针对不同目的量身定制的优化的心脏保护起搏。 该系统提供电刺激以提供心绞痛治疗和/或为与神经不平衡相关的并发症提供治疗。 在一个实施方案中，提供了治疗心绞痛的方法。 感测到的信号指示心绞痛的发生率，心绞痛区域是受心绞痛影响的心肌区域。 发现心绞痛发生，心绞痛区域位于。 从心绞痛区域选择起搏位置，并在起搏位置启动CPPT。 CPPT适应于在心绞痛区域产生增加的压力，以促进心绞痛区域的质量再分配和血管生成以治疗心绞痛。

    APPARATUS AND METHODS FOR TREATMENT OF ATHEROSCLEROSIS AND INFARCTION
    9.
    发明申请
    APPARATUS AND METHODS FOR TREATMENT OF ATHEROSCLEROSIS AND INFARCTION 审中-公开
    用于治疗角膜移植和感染的装置和方法

    公开(公告)号：US20100016916A1

    公开(公告)日：2010-01-21

    申请号：US12504593

    申请日：2009-07-16

    申请人： Shantha Arcot-Krishnamurthy ,  Joseph M. Pastore ,  Allan C. Shuros ,  Scott A. Meyer ,  Robert Shipley ,  Jason J. Hamann

    发明人： Shantha Arcot-Krishnamurthy ,  Joseph M. Pastore ,  Allan C. Shuros ,  Scott A. Meyer ,  Robert Shipley ,  Jason J. Hamann

    IPC分类号： A61N1/368

    CPC分类号： A61N1/36564 ,  A61N1/36528 ,  A61N1/36571 ,  A61N1/368

    摘要： A pacing system delivers cardiac protective pacing therapy (CPPT) to protect the heart from injuries and/or to treat existing injuries. The pacing system receives a set of inputs and delivers optimized cardiac protection pacing tailored for different purposes. The system delivers electrical stimulation to modulate myocardial strain for anti-atherosclerosis therapy and/or to provide therapy for myocardial infarction (MI). In one embodiment, a medical device for treating atherosclerosis is provided. The medical device includes a sensing circuit to receive sensed signals to identify areas of coronary artery disease (CAD) or areas at risk for CAD using the sensed signals. The device also includes a pacemaker circuit adapted to deliver an electrical signal through at least one electrode to a myocardial target adjacent to the identified areas. According to various embodiments, a controller communicates with the sensing circuit and controls the pacemaker circuit to provide intermittent electrical stimulation to the myocardial target to induce periods of stretch on the vessel due to induce myocardial strain changes. The stimulation is targeted to attenuate or prevent atherosclerosis associated with the CAD, according to various embodiments.

    摘要翻译： 起搏系统提供心脏保护起搏治疗（CPPT），以保护心脏免受伤害和/或治疗现有的伤害。 起搏系统接收一组输入，并为不同目的提供优化的心脏保护起搏。 该系统提供电刺激以调节用于抗动脉粥样硬化治疗的心肌应变和/或提供心肌梗塞（MI）治疗。 在一个实施方案中，提供了用于治疗动脉粥样硬化的医疗装置。 医疗设备包括感测电路，用于接收感测到的信号，以使用感测到的信号来识别冠状动脉疾病（CAD）或CAD风险区域。 该装置还包括起搏器电路，其适于将电信号通过至少一个电极传递到与所识别的区域相邻的心肌靶。 根据各种实施例，控制器与感测电路通信并控制起搏器电路，以向心肌靶标提供间歇性电刺激，以诱导由于诱发心肌应变变化而在血管上延伸的时间段。 根据各种实施方案，刺激旨在减弱或预防与CAD相关的动脉粥样硬化。