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公开(公告)号：US08623866B2
公开(公告)日：2014-01-07
申请号：US13151301
申请日：2011-06-02
申请人： Konrad Bleicher , Alexander Flohr , Katrin Groebke Zbinden , Felix Gruber , Matthias Koerner , Bernd Kuhn , Jens-Uwe Peters , Rosa Maria Rodriguez-Sarmiento
发明人： Konrad Bleicher , Alexander Flohr , Katrin Groebke Zbinden , Felix Gruber , Matthias Koerner , Bernd Kuhn , Jens-Uwe Peters , Rosa Maria Rodriguez-Sarmiento
IPC分类号： C07D239/42 , A01N43/54 , A61K31/5355 , C07D403/14 , A61K31/497 , A61P25/18
摘要： The invention is concerned with novel nitrogen-containing heteroaryl compounds of formula (I) wherein A1, A2, R1, R2, R3, R4, R5 and R6 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as therapeutics.
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公开(公告)号：US08309581B2
公开(公告)日：2012-11-13
申请号：US12885588
申请日：2010-09-20
申请人： Gregory Martin Benson , Konrad Bleicher , Song Feng , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Markus Rudolph , Sven Taylor
发明人： Gregory Martin Benson , Konrad Bleicher , Song Feng , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Markus Rudolph , Sven Taylor
IPC分类号： A61K31/4439 , A61K31/4184 , C07D401/04 , C07D235/18 , C07D403/12 , A61P3/06
CPC分类号： C07D401/04 , C07D235/18 , C07D403/10 , C07D403/12 , C07D405/14 , C07D417/14
摘要： The present invention relates to compounds of formula (I), as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions, wherein A, B, R1, R2, R3, R4, R5, n, m and p have the significance defined herein.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐可以药物组合物的形式使用，其中A，B，R 1，R 2，R 3，R 4，R 5，n，m和p具有 本文定义的意义。
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公开(公告)号：US08252826B2
公开(公告)日：2012-08-28
申请号：US13050031
申请日：2011-03-17
申请人： Gregory Martin Benson , Konrad Bleicher , Uwe Grether , Bernd Kuhn , Hans Richter , Sven Taylor
发明人： Gregory Martin Benson , Konrad Bleicher , Uwe Grether , Bernd Kuhn , Hans Richter , Sven Taylor
IPC分类号： A61K31/41 , A61K31/415 , C07D257/02 , C07D231/10
CPC分类号： C07D231/54 , A61K9/0019 , A61K9/0095 , A61K9/1623 , A61K9/1652 , A61K9/2018 , A61K9/2866 , A61K9/4825 , A61K9/4858 , C07D401/12 , C07D403/12
摘要： This invention relates to novel cyclopentyl- and cycloheptylpyrazole derivatives of the formula I wherein A and R1 to R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. The invention relates also to compositions including these compounds and methods of using the compounds.
摘要翻译： 本发明涉及式I的新的环戊基 - 和环庚基吡唑衍生物，其中A和R 1至R 4如说明书和权利要求书中所定义，以及其生理上可接受的盐。 本发明还涉及包括这些化合物的组合物和使用该化合物的方法。
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公开(公告)号：US08088930B2
公开(公告)日：2012-01-03
申请号：US12554023
申请日：2009-09-04
申请人： Gregory Martin Benson , Konrad Bleicher , Song Feng , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Sven Taylor
发明人： Gregory Martin Benson , Konrad Bleicher , Song Feng , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Sven Taylor
IPC分类号： A61K31/4184 , C07D235/12
CPC分类号： C07D235/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D495/04
摘要： The invention is concerned with novel benzimidazole derivatives of formula (I) wherein A, n and R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds can be used as medicaments.
摘要翻译： 本发明涉及新的式（I）的苯并咪唑衍生物，其中A，n和R 1至R 7如说明书和权利要求书中所定义，以及其生理上可接受的盐和酯。 这些化合物可以用作药物。
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公开(公告)号：US07825258B2
公开(公告)日：2010-11-02
申请号：US12265049
申请日：2008-11-05
申请人： Gregory Martin Benson , Konrad Bleicher , Uwe Grether , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Sven Taylor , Minmin Yang
发明人： Gregory Martin Benson , Konrad Bleicher , Uwe Grether , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Sven Taylor , Minmin Yang
IPC分类号： A61K31/4184 , C07D235/06
CPC分类号： C07D235/06 , C07D405/12 , C07D409/12
摘要： The invention is concerned with novel substituted benzimidazole derivatives of formula (I) wherein R1 to R10 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型取代的苯并咪唑衍生物，其中R 1至R 10如说明书和权利要求书中所定义，以及其生理学上可接受的盐和酯。 这些化合物可以用作药物。
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56.发明授权公开(公告)号：US07799806B2
公开(公告)日：2010-09-21
申请号：US12053781
申请日：2008-03-24
IPC分类号： A61K31/445
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04
摘要： This invention relates to compounds of the formula wherein A, R1 to R3 are as defined in the claims and G is benzoimidazole, quinoxaline, benzotriazole, dihydro-imidazo[4,5-c]pyridinone and dihydro-isoindolone group as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5 such as diabetes mellitus.
摘要翻译： 本发明涉及下式的化合物，其中A，R 1至R 3如权利要求中所定义，G为本说明书中定义的苯并咪唑，喹喔啉，苯并三唑，二氢 - 咪唑并[4,5-c]吡啶酮和二氢 - 异吲哚酮基 及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5如糖尿病有关的疾病的用途。
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公开(公告)号：US07786128B2
公开(公告)日：2010-08-31
申请号：US12114219
申请日：2008-05-02
IPC分类号： A61K31/415 , A61K31/40 , A61K31/497 , A01N43/52 , A01N43/38 , C07D209/42
CPC分类号： C07D235/12 , C07D209/12 , C07D401/06
摘要： Provided are compounds of the formula I: and pharmaceutically acceptable salts thereof, processes for making said compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said compound and pharmaceutically acceptable salts thereof, and methods of using said compounds. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors.
摘要翻译： 提供式I化合物及其药学上可接受的盐，制备所述化合物及其药学上可接受的盐的方法，包含所述化合物的药物组合物及其药学上可接受的盐以及使用所述化合物的方法。 该化合物可用于治疗和/或预防与调节CB1受体相关的疾病。
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公开(公告)号：US20100093818A1
公开(公告)日：2010-04-15
申请号：US12577765
申请日：2009-10-13
申请人： Gregory Martin Benson , Konrad Bleicher , Song Feng , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Sven Taylor
发明人： Gregory Martin Benson , Konrad Bleicher , Song Feng , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Sven Taylor
IPC分类号： A61K31/4184 , C07D235/12 , A61P9/00 , A61P9/10 , A61P35/00 , A61P17/06 , A61P25/00 , A61P25/28 , A61P25/16 , A61P3/10 , A61P3/06
CPC分类号： C07D235/18
摘要： The invention is concerned with novel benzimidazole derivatives of formula (I) wherein R1 to R6 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新的苯并咪唑衍生物，其中R 1至R 6如在说明书和权利要求书中所定义，以及其生理上可接受的盐和酯。 这些化合物可以用作药物。
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59.发明申请公开(公告)号：US20100076026A1
公开(公告)日：2010-03-25
申请号：US12563189
申请日：2009-09-21
申请人： Gregory Martin Benson , Konrad Bleicher , Song Feng , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Markus Rudolph , Sven Taylor
发明人： Gregory Martin Benson , Konrad Bleicher , Song Feng , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Markus Rudolph , Sven Taylor
IPC分类号： A61K31/4439 , C07D231/56 , A61K31/416 , C07D401/12
CPC分类号： C07D231/56 , C07D401/12 , C07D407/12
摘要： This invention relates to novel indazole derivatives of formula I: wherein R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are FXR modulators and can be used as medicaments.
摘要翻译： 本发明涉及式I的新型吲唑衍生物：其中R 1至R 7如说明书和权利要求书中所定义，以及其生理上可接受的盐。 这些化合物是FXR调节剂，可用作药物。
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公开(公告)号：US20100063101A1
公开(公告)日：2010-03-11
申请号：US12554023
申请日：2009-09-04
申请人： Gregory Martin Benson , Konrad Bleicher , Song Feng , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Sven Taylor
发明人： Gregory Martin Benson , Konrad Bleicher , Song Feng , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Sven Taylor
IPC分类号： A61K31/4439 , C07D235/12 , C07D401/02 , A61K31/4184 , A61P1/00
CPC分类号： C07D235/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D495/04
摘要： The invention is concerned with novel benzimidazole derivatives of formula (I) wherein A, n and R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds can be used as medicaments.
摘要翻译： 本发明涉及新的式（I）的苯并咪唑衍生物，其中A，n和R 1至R 7如说明书和权利要求书中所定义，以及其生理上可接受的盐和酯。 这些化合物可以用作药物。
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