利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

66 条记录 (耗时 0.019 秒)

    4R-Amino-1t-phenyl-1c-ethoxy-carbonylcyclohexenes-(2) and process for their preparation
    51.
    发明授权
    4R-Amino-1t-phenyl-1c-ethoxy-carbonylcyclohexenes-(2) and process for their preparation 失效
    4R-氨基-1t-苯基-1c-乙氧羰基环己烯 - （2）及其制备方法

    公开(公告)号：US4022818A

    公开(公告)日：1977-05-10

    申请号：US585439

    申请日：1975-06-10

    申请人： Gerhard Satzinger ,  Manfred Herrmann

    发明人： Gerhard Satzinger ,  Manfred Herrmann

    IPC分类号： C07D211/14 ,  C07D211/34 ,  C07D211/46 ,  C07C101/38

    CPC分类号： C07D211/34 ,  C07D211/14 ,  C07D211/46

    摘要： This invention relates to 4r-amino-1t-phenyl-1c-ethoxycarbonyl-cyclohexenes-(2) of formula I: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and are hydrogen or alkyl having 1 to 4 carbon atoms, or one of the two groups is allyl, phenalkyl having 7 to 9 carbon atoms or .alpha.-methyl-.beta.-hydroxyethyl; or R.sub.1 and R.sub.2 together form a morpholino group, piperazino group substituted at the 4- position by methyl, benzyl, phenyl, 3-chlorophenyl, 4-chlorophenyl, 2-phenethyl or benzoyl, or a piperidino group substituted at the 4- position by hydroxyl, phenyl, 2-methoxyphenyl, 4-methoxyphenyl, methyl or benzyl and medically acceptable addition compounds derived from inorganic and organic acids or lower alkyl halides. The compounds of the present invention are prepared by separation of 4-amino-1-phenyl-1-ethoxycarbonyl-cyclohexenes-(2), described in U.S. Pat. application Ser. No. 226,509, filed Feb. 15, 1972, now U.S. Pat. No. 3,957,851 into the two possible geometrical isomers. The instant compounds, the 4r-amino-1t-phenyl-1c-ethoxycarbonyl-cyclohexenes-(2) of formula I, exhibit marked analgesic and neuroleptic activities and are useful for the alleviation and reduction of pain.

    摘要翻译： 本发明涉及式I的4r-氨基-1t-苯基-c-乙氧基羰基 - 环己烯 - （2）：其中R 1和R 2相同或不同，为氢或具有1至4个碳原子的烷基，或 两个基团之一是烯丙基，具有7至9个碳原子的苯基烷基或α-甲基-β-羟乙基; 或R 1和R 2一起形成吗啉代基，在4-位上被甲基，苄基，苯基，3-氯苯基，4-氯苯基，2-苯乙基或苯甲酰基取代的哌嗪基或在4-位取代的哌啶子基， 羟基，苯基，2-甲氧基苯基，4-甲氧基苯基，甲基或苄基，以及衍生自无机和有机酸或低级烷基卤的医药上可接受的加成化合物。 本发明的化合物是通过分离美国专利No.4,657中描述的4-氨基-1-苯基-1-乙氧基羰基 - 环己烯 - （2）来制备的。 应用程序 1972年2月15日提交的现在的美国专利第226,509号。 编号3,957,851成两种可能的几何异构体。 本发明化合物，式I的4r-氨基-1t-苯基1c-乙氧基羰基 - 环己烯 - （2）表现出明显的镇痛和精神安定活性，并且可用于缓解和减轻疼痛。

    Closed coolant loop with expansion device for a fuel cell system
    54.
    发明授权
    Closed coolant loop with expansion device for a fuel cell system 有权
    封闭的冷却液回路与燃料电池系统的膨胀装置

    公开(公告)号：US08431282B2

    公开(公告)日：2013-04-30

    申请号：US11735253

    申请日：2007-04-13

    申请人： Manfred Herrmann

    发明人： Manfred Herrmann

    IPC分类号： H01M8/04

    CPC分类号： H01M8/04029 ,  H01M8/04044 ,  H01M8/04089 ,  H01M8/0444 ,  H01M8/04485 ,  H01M8/04768 ,  H01M8/04783 ,  H01M2250/20 ,  Y02T90/32

    摘要： A fuel cell system that employs a closed coolant loop. The system includes an expansion device having a flexible membrane, where a cooling fluid side of the membrane is in fluid communication with the cooling fluid in the coolant loop and an air side of the membrane is in communication with an air pocket. The air side of the expansion device is in air communication with an air compressor so that the pressure of the cooling fluid within the coolant loop changes as the stack pressure changes. The fuel cell system also includes a coolant reservoir that is in fluid communication with the cooling fluid in the coolant loop. Air and hydrogen bubbles within the cooling fluid are vented to the coolant reservoir where they accumulate. The coolant reservoir includes a level sensor indicating the level of the cooling fluid therein.

    摘要翻译： 采用封闭冷却剂回路的燃料电池系统。 该系统包括具有柔性膜的膨胀装置，其中膜的冷却流体侧与冷却剂回路中的冷却流体流体连通，并且膜的空气侧与气穴连通。 膨胀装置的空气侧与空气压缩机空气连通，使得冷却剂回路内的冷却液的压力随堆压变化而变化。 燃料电池系统还包括与冷却剂回路中的冷却流体流体连通的冷却剂储存器。 冷却流体内的空气和氢气气体被排放到冷却剂储存器，在那里它们积聚。 冷却剂储存器包括液位传感器，其指示其中的冷却流体的水平。

    Pressure driven hermetically sealed pump for fuel cell system
    55.
    发明授权
    Pressure driven hermetically sealed pump for fuel cell system 有权
    用于燃料电池系统的压力驱动密封泵

    公开(公告)号：US06706439B2

    公开(公告)日：2004-03-16

    申请号：US10028758

    申请日：2001-12-20

    申请人： Manfred Herrmann

    发明人： Manfred Herrmann

    IPC分类号： H01M804

    CPC分类号： H01M8/04089 ,  F04B9/115 ,  F04B43/0736

    摘要： A hydrogen feed system for a fuel cell arrangement in which the hydrogen can be taken at a higher pressure from a supply tank standing under pressure or under pressure from a reforming device and can be fed after relaxation to a lower pressure into the fuel cell arrangement, with a return flow loop being provided in the hydrogen circuit, so that a part of the non-consumed hydrogen emerging from the fuel cell arrangement can be fed back into the latter, is characterized in that a pump is provided which brings about the recirculation of the hydrogen and which can be driven from the pressure energy of the hydrogen taken from the tank or coming from a reforming unit.

    摘要翻译： 一种用于燃料电池装置的氢气供给系统，其中氢气可以在来自重压装置的压力下或在压力下从供应罐获得的较高压力下被采取，并且可以在松弛到低压进入燃料电池装置之后进料， 在氢气回路中设置有回流回路，使得从燃料电池装置排出的部分未消耗的氢能被反馈到后者，其特征在于，提供一种泵， 氢气，其可以从从罐中取出或来自重整单元的氢气的压力能量驱动。

    3-aryl-3-pyrroline derivatives
    59.
    发明授权
    3-aryl-3-pyrroline derivatives 失效
    3-芳基-3-吡咯啉衍生物

    公开(公告)号：US4626546A

    公开(公告)日：1986-12-02

    申请号：US637351

    申请日：1984-08-03

    申请人： Gerhard Satzinger ,  Karl Mannhardt ,  Johannes Hartenstein ,  Manfred Herrmann ,  Edgar Fritschi ,  Wolfgang Steinbrecher

    发明人： Gerhard Satzinger ,  Karl Mannhardt ,  Johannes Hartenstein ,  Manfred Herrmann ,  Edgar Fritschi ,  Wolfgang Steinbrecher

    IPC分类号： A61K31/40 ,  A61P9/08 ,  A61P9/10 ,  C07D207/20

    CPC分类号： C07D207/20

    摘要： The invention is concerned with partially new compounds of the general formula ##STR1## wherein R.sup.1 is a hydrogen atom or an alkyl group with up to four carbon atoms and R.sup.2 a substituted phenyl radical and the pharmacologically acceptable salts thereof.The compounds can be prepared according to known procedures and show surprisingly a cardiovascular efficacy. They are capable of decompensating cardiac insufficiencies to a large extent. In addition to the new compounds, claim is also made for pharmaceutical compositions which contain compounds according to the general formula and their application for controlling cardiac and vascular diseases.

    摘要翻译： 本发明涉及通式“IMAGE”的部分新化合物，其中R 1为氢原子或具有至多4个碳原子的烷基，R 2为取代的苯基及其药理学上可接受的盐。 这些化合物可以根据已知的方法制备并令人惊奇地显示出心血管功能。 它们能够在很大程度上失代偿心脏功能不全。 除了新化合物之外，还提出了含有根据通式的化合物及其用于控制​​心脏和血管疾病的应用的药物组合物。