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91 条记录 (耗时 0.061 秒)

    Tricyclopyrazole derivatives
    51.
    发明授权
    Tricyclopyrazole derivatives 有权
    三环吡唑衍生物

    公开(公告)号：US09127015B2

    公开(公告)日：2015-09-08

    申请号：US13512904

    申请日：2010-11-24

    申请人： Teresa Disingrini ,  Sergio Mantegani ,  Mario Varasi

    发明人： Teresa Disingrini ,  Sergio Mantegani ,  Mario Varasi

    IPC分类号： A61K31/437 ,  C07D471/14 ,  C07D487/14

    CPC分类号： C07D487/14 ,  C07D207/34 ,  C07D471/14

    摘要： Compounds which are tricyclopyrazole derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

    摘要翻译： 公开了作为三环吡唑衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性引起的和/或与其相关的疾病，例如癌症，病毒感染，HIV感染个体中的AIDS发展的预防，细胞增殖性疾病，自身免疫和神经变性疾病; 还公开了用于制备本发明化合物的固相合成条件和包含多个化合物的化学文库的方法。

    TRICYCLOPYRAZOLE DERIVATIVES
    52.
    发明申请
    TRICYCLOPYRAZOLE DERIVATIVES 有权
    三甲基吡唑衍生物

    公开(公告)号：US20120277214A1

    公开(公告)日：2012-11-01

    申请号：US13512904

    申请日：2010-11-24

    申请人： Teresa Disingrini ,  Sergio Mantegani ,  Mario Varasi

    发明人： Teresa Disingrini ,  Sergio Mantegani ,  Mario Varasi

    IPC分类号： C07D487/14 ,  C40B40/04 ,  A61K31/55 ,  A61K31/551 ,  A61K31/437 ,  A61P25/28 ,  A61K31/541 ,  A61P35/00 ,  A61P35/02 ,  A61P31/18 ,  A61P31/12 ,  A61P37/06 ,  C07D471/14 ,  A61K31/496

    CPC分类号： C07D487/14 ,  C07D207/34 ,  C07D471/14

    摘要： Compounds which are tricyclopyrazole derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

    摘要翻译： 公开了作为三环吡唑衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性引起的和/或与其相关的疾病，例如癌症，病毒感染，HIV感染个体中的AIDS发展的预防，细胞增殖性疾病，自身免疫和神经变性疾病; 还公开了用于制备本发明化合物的固相合成条件和包含多个化合物的化学文库的方法。

    Benzoxazine derivatives useful as integrin receptor antagonists
    59.
    发明授权
    Benzoxazine derivatives useful as integrin receptor antagonists 失效
    可用作整联蛋白受体拮抗剂的苯并恶嗪衍生物

    公开(公告)号：US06794385B2

    公开(公告)日：2004-09-21

    申请号：US09924732

    申请日：2001-08-08

    申请人： Paola Vianello ,  Tiziano Bandiera ,  Mario Varasi

    发明人： Paola Vianello ,  Tiziano Bandiera ,  Mario Varasi

    IPC分类号： A61K31538

    CPC分类号： C07D413/12

    摘要： The present invention relates to a class of compounds represented by the formula (I) or a pharmaceutical acceptable salt, prodrug or ester thereof, pharmaceutical compositions comprising compounds of the formula (I), and methods of selectively inhibiting or antagonizing &agr;v&bgr;3 integrin.

    摘要翻译： 本发明涉及一类由式（I）表示的化合物或其药学上可接受的盐，前药或酯，包含式（I）化合物的药物组合物，以及选择性抑制或拮抗α-角蛋白3整联蛋白的方法。

    4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity
    60.
    发明授权
    4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity 失效
    具有犬尿氨酸-3-羟化酶抑制活性的4-苯基-4-氧代 - 丁酸衍生物

    公开(公告)号：US06323240B1

    公开(公告)日：2001-11-27

    申请号：US09068016

    申请日：1998-05-01

    申请人： Antonio Giordani ,  Paolo Pevarello ,  Carmela Speciale ,  Mario Varasi

    发明人： Antonio Giordani ,  Paolo Pevarello ,  Carmela Speciale ,  Mario Varasi

    IPC分类号： A61K31195

    CPC分类号： C07C59/90 ,  C07C69/738 ,  C07C205/56

    摘要： 4-phenyl-4-oxo-butanoic acid derivatives for use in the treatment of the human or animal body by therepy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of a neurodegenerative disease wherein the inhibition of such an enyzme is needed. The present invention further comprises a selected class of the above mentioned 4-phenyl-4-oxo-butanoic acid derivatives, their pharmaceutically acceptable salts, a process for their preparation and pharmaceutical compositions containing them.

    摘要翻译： 4-苯基-4-氧代 - 丁酸衍生物，用于通过该药物治疗人体或动物体; 特别是作为犬尿氨酸-3-羟化酶抑制剂，在预防和/或治疗需要抑制这种乙烯的神经变性疾病中。 本发明还包括所选类别的上述4-苯基-4-氧代 - 丁酸衍生物，其药学上可接受的盐，其制备方法和含有它们的药物组合物。