公开(公告)号：US20210369169A1

公开(公告)日：2021-12-02

申请号：US17394355

申请日：2021-08-04

Applicant: Medtronic, Inc.

Inventor： Dwight E. Nelson ,  Jianping Wu ,  Rahul Gupta ,  Yan Zhao

IPC: A61B5/316 ,  A61N1/36 ,  A61B5/00 ,  A61B5/374

Abstract: In some examples, a processor determines a patient state based on activity of a bioelectrical brain signal of a patient in one or more frequency sub-bands of a frequency band of interest. For example, a processor may determine a patient state based on the power level of a bioelectrical brain signal of the patient in one or more frequency sub-bands of a frequency band, or based on a spectral pattern of a bioelectrical brain signal in a frequency band, such as a shift in a power distribution between sub-bands, a change in the peak frequency within one or more sub-bands, a pattern of the power distribution over one or more frequency sub-bands, or a width or a variability of one or more sub-bands exhibiting a relatively high or low level of activity.

公开(公告)号：US20210299442A1

公开(公告)日：2021-09-30

申请号：US17344826

申请日：2021-06-10

Applicant: Medtronic, Inc.

Inventor： Xuan K. Wei ,  Ryan D. Willemsen ,  Dwight E. Nelson ,  Sudha B. Iyer ,  Kira Stolen ,  Xin Su

IPC: A61N1/36 ,  A61N1/372 ,  A61N1/05

Abstract: In some examples, a technique for delivering electrical stimulation therapy to a patient includes determining, by processing circuitry, one or more cycle settings associated with delivery of the electrical stimulation therapy, determining, by the processing circuitry, a cycle time period associated with each cycle setting, and delivering, by a medical device, electrical stimulation therapy based on the determined cycle settings and the determined cycle time periods. Each cycle setting may define an on-cycle, during which electrical stimulation is delivered, and an off-cycle, during which electrical stimulation is not delivered. The technique further may include delivering electrical stimulation to the patient to provide one or more reminders to the patient, such as a reminder to void or a reminder of the existence of electrical stimulation.

公开(公告)号：US20200281649A1

公开(公告)日：2020-09-10

申请号：US16880524

申请日：2020-05-21

Applicant: Medtronic, Inc.

Inventor： Thaddeus S. Brink ,  Blake A. Hedstrom ,  Dwight E. Nelson ,  Ashish Singal ,  Xin Su

IPC: A61B18/14 ,  A61B5/20 ,  A61B5/0488 ,  A61B8/08 ,  A61B5/11

Abstract: The disclosure describes devices, systems, and techniques for identifying and treating bladder dysfunction. In one example, a method includes identifying one or more focal points at respective locations of bladder tissue of a bladder of a patient, the one or more focal points initiating coordinated contractions of a detrusor muscle. The method may also, or alternatively, include ablating, for each of the one or more focal points, a respective portion of the bladder tissue at the respective location of the focal point. Ablation of these targeted portions of the bladder tissue may reduce the coordinated contractions of the detrusor muscle and alleviate overactive bladder symptoms.

公开(公告)号：US10765355B2

公开(公告)日：2020-09-08

申请号：US15964739

申请日：2018-04-27

Applicant: Medtronic, Inc.

Inventor： Dwight E. Nelson ,  Thaddeus S. Brink ,  Lance Zirpel ,  Adam P. Steiner

IPC: A61B5/20 ,  A61N1/36 ,  G16H20/40 ,  G16H50/30 ,  A61B5/0488 ,  A61B5/00

Abstract: This disclosure describes methods, systems, and devices configured to determine a timing of a future bladder related event of a patient. For example, a system includes processing circuitry configured to identify a timing of a plurality of bladder related events of a patient, determine, based on the timing of the plurality of bladder related events of the patient, a probability to experience a bladder related event function for the patient, the probability to experience a bladder related event function indicating a probability that the patient will experience a bladder related event at an elapsed time after a previous bladder related event, predict, based on the probability to experience a bladder related event function, a timing of a future bladder related event, and control delivery of a therapy to the patient based on the predicted timing of the future bladder related event.

公开(公告)号：US20200147375A1

公开(公告)日：2020-05-14

申请号：US16730253

申请日：2019-12-30

Applicant: Medtronic, Inc.

Inventor： Xin Su ,  Dwight E. Nelson

IPC: A61N1/36 ,  A61B5/0488 ,  A61B5/20 ,  A61B5/00

Abstract: In some examples, electrical stimulation is delivered to a patient such that selective termination of the stimulation causes a therapeutic effect in the patient after termination of the electrical stimulation to the patient. The electrical stimulation may be insufficient to produce a desired therapeutic effect in the patient during stimulation, but sufficient to induce a post-stimulation desired therapeutic effect following termination of the stimulation. In some examples, the electrical stimulation may be sub-threshold electrical stimulation. In some examples, the desired therapeutic effect may alleviate bladder dysfunction, bowel dysfunction, or other disorders. The stimulation may be selectively terminated in response to one or more therapy trigger events to induce the post-stimulation therapeutic effect.

公开(公告)号：US20190269924A1

公开(公告)日：2019-09-05

申请号：US16344719

申请日：2017-09-14

Applicant: Medtronic, Inc.

Inventor： Xin SU ,  Thaddeus S. Brink ,  Dwight E. Nelson

IPC: A61N1/36 ,  A61N1/372

Abstract: This disclosure relates to devices, systems, and methods for autotitrating stimulation parameters. In one example, a method includes controlling an implantable medical device to deliver electrical stimulation to a patient according to a plurality of electrical stimulation parameter sets, each electrical stimulation parameter set of the plurality of electrical stimulation parameter sets defining a respective electrical stimulation signal deliverable to the patient, obtaining, by one or more processors and for each electrical stimulation parameter set of the plurality of electrical stimulation parameter sets, a respective signal representative of an electrical response sensed from the patient in response to the electrical stimulation delivered to the patient according to the respective electrical stimulation parameter set, and determining, by the one or more processors and based on the obtained respective signals, a primary electrical stimulation parameter set that defines electrical stimulation therapy deliverable to the patient by the implantable medical device.

公开(公告)号：US09707396B2

公开(公告)日：2017-07-18

申请号：US14063919

申请日：2013-10-25

Applicant: Medtronic, Inc.

Inventor： Xin Su ,  Dwight E. Nelson

IPC: A61N1/36 ,  A61B5/0484 ,  A61M5/172 ,  A61N1/372 ,  A61B5/00

CPC classification number: A61N1/36139 ,  A61B5/0484 ,  A61B5/4255 ,  A61M5/1723 ,  A61N1/36007 ,  A61N1/37241

Abstract: Techniques, devices, and systems may include screening effective therapies using cortical evoked potentials. In one example, a system may be configured to receive a first sensed cortical evoked potential of a patient that occurred in response to an induced sensation at an anatomical region different from a brain region of the patient and receive a second sensed cortical evoked potential that occurred in response to electrical stimulation delivered to one or more nerves associated with the anatomical region. The electrical stimulation may be at least partially defined by a set of therapy parameter values. The system may also compare a first value of a characteristic of the first sensed cortical evoked potential to a second value of the characteristic of the second sensed cortical evoked potential and determine, based on the comparison, efficacy of a therapy configured to treat a condition associated with the anatomical region.

公开(公告)号：US20160136420A1

公开(公告)日：2016-05-19

申请号：US14946431

申请日：2015-11-19

Applicant: Medtronic, Inc.

Inventor： Thaddeus S. Brink ,  Xin Su ,  Dwight E. Nelson

IPC: A61N1/36

CPC classification number: A61N1/36007

Abstract: In one example, a method including generating electrical stimulation therapy with a frequency of approximately 500 hertz or greater, and controlling delivery of the electrical stimulation therapy to a patient via a medical device between at least one of contractions of a bladder or contractions of a bowel of a patient, wherein the electrical stimulation therapy comprises electrical stimulation therapy configured to inhibit contraction of the bladder when the electrical stimulation is delivered between the contractions of the bladder, wherein the electrical stimulation therapy comprises electrical stimulation therapy configured to inhibit contraction of the bowel when the electrical stimulation is delivered between the contractions of the bowel, and wherein at least one of the generating and controlling is performed via one or more processors.

Abstract translation: 在一个实例中，一种方法包括产生具有大约500赫兹或更大频率的电刺激疗法，以及控制通过医疗装置在膀胱收缩或肠收缩中的至少一个之间向患者传递电刺激疗法 其中所述电刺激治疗包括电刺激治疗，所述电刺激治疗被配置为当在膀胱收缩之间递送电刺激时抑制膀胱的收缩，其中所述电刺激疗法包括电刺激治疗，其被配置为抑制肠的收缩， 电刺激在肠的收缩之间传递，并且其中通过一个或多个处理器执行生成和控制中的至少一个。

公开(公告)号：US09186509B2

公开(公告)日：2015-11-17

申请号：US14563677

申请日：2014-12-08

Applicant: Medtronic, Inc.

Inventor： Dwight E. Nelson ,  Xin Su ,  Thaddeus S. Brink ,  Blake A. Hedstrom

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/08 ,  A61N1/372 ,  A61B5/021 ,  A61B5/024 ,  A61B5/00

CPC classification number: A61N1/36132 ,  A61B5/021 ,  A61B5/024 ,  A61B5/4255 ,  A61B5/4368 ,  A61B5/4393 ,  A61N1/08 ,  A61N1/36007 ,  A61N1/3606 ,  A61N1/36107 ,  A61N1/3615 ,  A61N1/36171 ,  A61N1/37247

Abstract: Electrical stimulation therapy may be delivered to a patient to selectively and independently address different conditions of a pelvic floor disorder of the patient. The conditions of a pelvic floor disorder may include, for example, a lower urinary tract dysfunction (e.g., urinary or fecal incontinence) and sexual dysfunction (e.g., an impaired sexual reflex response to a sexual stimulus). In some examples, a system is configured to selectively deliver a first electrical stimulation therapy that is configured to elicit an inhibitory physiological response from the patient related to voiding, a second electrical stimulation therapy that is configured to improve a sexual reflex response of the patient to a sexual stimulus, and a third electrical stimulation therapy that is configured to both elicit the inhibitory physiological response from the patient related to voiding and increase a sexual response of the patient to a sexual stimulus.

Abstract translation: 电刺激治疗可以递送给患者以选择性且独立地解决患者盆底疾病的不同情况。 盆底疾病的状况可能包括例如下尿路功能障碍（例如尿或大便失禁）和性功能障碍（例如，对性刺激的性反射受损）。 在一些示例中，系统被配置为选择性地递送第一电刺激疗法，其被配置为引起患者与排尿相关的抑制性生理反应，第二电刺激治疗被配置为改善患者的性反射反应 性刺激和第三种电刺激疗法，其被配置为既引起来自患者的与排尿相关的抑制性生理反应并且增加患者对性刺激的性反应。

公开(公告)号：US20150306391A1

公开(公告)日：2015-10-29

申请号：US14685690

申请日：2015-04-14

Applicant: Medtronic, Inc.

Inventor： Jianping Wu ,  Rahul Gupta ,  Dwight E. Nelson

IPC: A61N1/36

CPC classification number: A61N1/36078 ,  A61B5/048 ,  A61B5/4809 ,  A61B5/4812 ,  A61B5/4836 ,  A61N1/0534 ,  A61N1/36132 ,  A61N1/36139 ,  A61N1/36167

Abstract: In some examples, a medical device delivers electrical stimulation to the external portion of the globus pallidus of a brain of a patient in order to treat a sleep impairment of the patient. In some examples, the electrical stimulation may be delivered via one or more electrodes implanted in the GPe of the brain. In some examples, an electrical stimulation device is configured to deliver electrical stimulation therapy to the GPe based on detection of a sleep state of a patient. The sleep state may include, for example, a state in which the patient is awake and intending on sleeping, is awake and attempting to sleep or has initiated sleep. In addition, in some examples, an electrical stimulation device is configured to deliver electrical stimulation therapy to the GPe based on detection of an awake state of a patient.

Abstract translation: 在一些示例中，医疗装置向患者脑部的苍白球外部递送电刺激，以便治疗患者的睡眠障碍。 在一些示例中，电刺激可以通过植入在脑的GPe中的一个或多个电极递送。 在一些示例中，电刺激装置被配置为基于对患者的睡眠状态的检测将电刺激治疗递送给GPe。 睡眠状态可以包括例如患者清醒并打算睡觉的状态，清醒并尝试睡眠或已经开始睡眠。 此外，在一些示例中，电刺激装置被配置为基于检测到患者的清醒状态来向GPe递送电刺激治疗。