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公开(公告)号：US20210330234A1
公开(公告)日：2021-10-28
申请号：US17366397
申请日：2021-07-02
Applicant: Medtronic, Inc.
Inventor： Dwight E. Nelson , Jianping Wu , Rahul Gupta , Yan Zhao
Abstract: In some examples, a processor determines a patient state based on activity of a bioelectrical brain signal of a patient in one or more frequency sub-bands of a frequency band of interest. For example, a processor may determine a patient state based on the power level of a bioelectrical brain signal of the patient in one or more frequency sub-bands of a frequency band, or based on a spectral pattern of a bioelectrical brain signal in a frequency band, such as a shift in a power distribution between sub-bands, a change in the peak frequency within one or more sub-bands, a pattern of the power distribution over one or more frequency sub-bands, or a width or a variability of one or more sub-bands exhibiting a relatively high or low level of activity.
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2.发明申请公开(公告)号：US20200338353A1
公开(公告)日：2020-10-29
申请号：US16395320
申请日：2019-04-26
Applicant: Medtronic, Inc.
Inventor： Jadin C. Jackson , Yizi Xiao , Paula Andrea Elma Dassbach Green , Jianping Wu , Christopher L. Pulliam , Eric J. Panken , Robert S. Raike , Scott R. Stanslaski
Abstract: Techniques are described determining electrodes that are proximate or distal to location of an oscillatory signal source in a patient based on current source densities (CSDs). Processing circuitry may determine, for one or more electrodes of a plurality of electrodes, respective time-varying measurements of CSDs, aggregate, for the one or more electrodes of the plurality electrodes, the respective time-varying measurements of the CSDs to generate respective average level values for the one or more electrodes of the plurality of electrodes, determine, for one or more electrodes of the plurality of electrodes, respective phase-magnitude representations of the time-varying measurements of the CSDs. The respective phase-magnitude representations are indicative of respective magnitudes and phases of a particular frequency component of respective time-varying measurements of the CSDs. The particular frequency component is a frequency component having a largest transform coefficient in a time-varying measurement of a CSD having a largest average level value.
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公开(公告)号：US10165977B2
公开(公告)日：2019-01-01
申请号：US15651850
申请日：2017-07-17
Applicant: Medtronic, Inc.
Inventor： Jianping Wu , Gregory F. Molnar , Gabriela C. Molnar , Timothy J. Denison
IPC: A61N1/00 , A61N1/08 , A61B5/00 , A61B5/04 , A61B5/048 , A61M21/02 , A61B5/0205 , A61B5/0402 , A61B5/0478 , A61B5/11 , A61M5/172 , A61N1/36 , A61M21/00 , G06F19/00 , A61B5/01 , A61B5/024 , G16H40/63
Abstract: Therapy delivery to a patient may be controlled based on a determined sleep stage of the patient. In examples, the sleep stage may be determined based on a frequency characteristic of a biosignal indicative of brain activity of the patient. A frequency characteristic may include, for example, a power level within one or more frequency bands of the biosignal, a ratio of the power level in two or more frequency bands, or a pattern in the power level of one or more frequency bands over time. A therapy program may be selected or modified based on the sleep stage determination. Therapy may be delivered during the sleep stage according to the selected or modified therapy program. In some examples, therapy delivery may be controlled after making separate determinations of a sleep stage based on the biosignal and another physiological parameter, and confirming that the sleep stage determinations are consistent.
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公开(公告)号：US20140135869A1
公开(公告)日：2014-05-15
申请号：US14161363
申请日：2014-01-22
Applicant: Medtronic, Inc.
Inventor： David L. Carlson , Randy M. Jensen , Timothy J. Denison , Jianping Wu , Gabriela C. Molnar , Scott R. Stanslaski , William J. Marks, JR.
IPC: A61N1/36
CPC classification number: A61N1/36067 , A61N1/0529 , A61N1/0534 , A61N1/36082 , A61N1/36185 , A61N1/37247
Abstract: Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.
Abstract translation: 可以在具有多个感测电极组合的患者的脑内感测生物电信号。 可以基于感测信号的频带特性来选择用于将刺激递送给患者以管理患者状况的刺激电极组合。 在一些示例中，可以选择与检测到具有相对较高的相对β带功率水平的生物电脑信号的感测电极组合相关联的刺激电极组合，以向患者传递刺激治疗。 也可以使用其他频带特性来选择刺激电极组合。
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公开(公告)号：US11931581B2
公开(公告)日：2024-03-19
申请号：US17028489
申请日：2020-09-22
Applicant: Medtronic, Inc.
Inventor： Jianping Wu , Dwight E. Nelson , Gabriela C. Molnar
CPC classification number: A61N1/36139 , A61B5/4076 , A61N1/0534 , A61N1/36067 , A61N1/36185 , A61B5/4082
Abstract: In some examples, a system may include a plurality of electrodes, electrical stimulation circuitry, and a controller. The controller may be configured to select one or more parameters of therapy to be delivered to a brain of a patient and to control the electrical stimulation circuitry to deliver the therapy to the brain of the patient based on the selected parameters and via a first one or more electrodes of the plurality of electrodes. The parameters may be defined based on a first plurality of electrical signals sensed at a plurality of different positions within the brain of the patient when electrical stimulation is not delivered at each of the positions and a second plurality of electrical signals sensed at each of the plurality of different positions within the brain of the patient in response to electrical stimulation delivered at each of the positions at a plurality of different intensities.
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Patent Agency Ranking
公开(公告)号：US20210369169A1
公开(公告)日：2021-12-02
申请号：US17394355
申请日：2021-08-04
Applicant: Medtronic, Inc.
Inventor： Dwight E. Nelson , Jianping Wu , Rahul Gupta , Yan Zhao
Abstract: In some examples, a processor determines a patient state based on activity of a bioelectrical brain signal of a patient in one or more frequency sub-bands of a frequency band of interest. For example, a processor may determine a patient state based on the power level of a bioelectrical brain signal of the patient in one or more frequency sub-bands of a frequency band, or based on a spectral pattern of a bioelectrical brain signal in a frequency band, such as a shift in a power distribution between sub-bands, a change in the peak frequency within one or more sub-bands, a pattern of the power distribution over one or more frequency sub-bands, or a width or a variability of one or more sub-bands exhibiting a relatively high or low level of activity.
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公开(公告)号：US20150306391A1
公开(公告)日：2015-10-29
申请号：US14685690
申请日：2015-04-14
Applicant: Medtronic, Inc.
Inventor： Jianping Wu , Rahul Gupta , Dwight E. Nelson
IPC: A61N1/36
CPC classification number: A61N1/36078 , A61B5/048 , A61B5/4809 , A61B5/4812 , A61B5/4836 , A61N1/0534 , A61N1/36132 , A61N1/36139 , A61N1/36167
Abstract: In some examples, a medical device delivers electrical stimulation to the external portion of the globus pallidus of a brain of a patient in order to treat a sleep impairment of the patient. In some examples, the electrical stimulation may be delivered via one or more electrodes implanted in the GPe of the brain. In some examples, an electrical stimulation device is configured to deliver electrical stimulation therapy to the GPe based on detection of a sleep state of a patient. The sleep state may include, for example, a state in which the patient is awake and intending on sleeping, is awake and attempting to sleep or has initiated sleep. In addition, in some examples, an electrical stimulation device is configured to deliver electrical stimulation therapy to the GPe based on detection of an awake state of a patient.
Abstract translation: 在一些示例中，医疗装置向患者脑部的苍白球外部递送电刺激，以便治疗患者的睡眠障碍。 在一些示例中，电刺激可以通过植入在脑的GPe中的一个或多个电极递送。 在一些示例中，电刺激装置被配置为基于对患者的睡眠状态的检测将电刺激治疗递送给GPe。 睡眠状态可以包括例如患者清醒并打算睡觉的状态，清醒并尝试睡眠或已经开始睡眠。 此外，在一些示例中，电刺激装置被配置为基于检测到患者的清醒状态来向GPe递送电刺激治疗。
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公开(公告)号：US20220142513A1
公开(公告)日：2022-05-12
申请号：US17582903
申请日：2022-01-24
Applicant: Medtronic, Inc.
Inventor： Jianping Wu , Chih Lai , Dwight E. Nelson
Abstract: Devices, systems, and techniques for analyzing video information to objectively identify patient behavior are disclosed. A system may analyze obtained video information of patient motion during a period of time to track one or more anatomical regions through a plurality of frames of the video information and calculate one or more movement parameters of the one or more anatomical regions. The system may also compare the one or more movement parameters to respective criteria for each of a plurality of predetermined patient behaviors and identify the patient behaviors that occurred during the period of time. In some examples, a device may control therapy delivery according to the identified patient behaviors and/or sensed parameters previously calibrated based on the identified patient behaviors.
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公开(公告)号：US11083402B2
公开(公告)日：2021-08-10
申请号：US13955367
申请日：2013-07-31
Applicant: Medtronic, Inc.
Inventor： Dwight E. Nelson , Jianping Wu , Rahul Gupta , Yan Zhao
Abstract: In some examples, a processor determines a patient state based on activity of a bioelectrical brain signal of a patient in one or more frequency sub-bands of a frequency band of interest. For example, a processor may determine a patient state based on the power level of a bioelectrical brain signal of the patient in one or more frequency sub-bands of a frequency band, or based on a spectral pattern of a bioelectrical brain signal in a frequency band, such as a shift in a power distribution between sub-bands, a change in the peak frequency within one or more sub-bands, a pattern of the power distribution over one or more frequency sub-bands, or a width or a variability of one or more sub-bands exhibiting a relatively high or low level of activity.
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10.发明授权公开(公告)号：US11045652B2
公开(公告)日：2021-06-29
申请号：US16395320
申请日：2019-04-26
Applicant: Medtronic, Inc.
Inventor： Jadin C. Jackson , Yizi Xiao , Paula Andrea Elma Dassbach Green , Jianping Wu , Christopher L. Pulliam , Eric J. Panken , Robert S. Raike , Scott R. Stanslaski
Abstract: Techniques are described determining electrodes that are proximate or distal to location of an oscillatory signal source in a patient based on current source densities (CSDs). Processing circuitry may determine, for one or more electrodes of a plurality of electrodes, respective time-varying measurements of CSDs, aggregate, for the one or more electrodes of the plurality electrodes, the respective time-varying measurements of the CSDs to generate respective average level values for the one or more electrodes of the plurality of electrodes, determine, for one or more electrodes of the plurality of electrodes, respective phase-magnitude representations of the time-varying measurements of the CSDs. The respective phase-magnitude representations are indicative of respective magnitudes and phases of a particular frequency component of respective time-varying measurements of the CSDs. The particular frequency component is a frequency component having a largest transform coefficient in a time-varying measurement of a CSD having a largest average level value.
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