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公开(公告)号：US07745479B2
公开(公告)日：2010-06-29
申请号：US11604412
申请日：2006-11-27
申请人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Valerie Runtz-Schmitt , Sven Taylor
发明人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Valerie Runtz-Schmitt , Sven Taylor
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/454 , A61K31/4545 , A61K31/4045 , C07D209/42 , C07D401/02 , C07D413/02 , C07D417/02
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
摘要： The present invention relates to compounds of formula I wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中R 1至R 4和G如说明书和权利要求及其药学上可接受的盐所定义。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20100076027A1
公开(公告)日：2010-03-25
申请号：US12563193
申请日：2009-09-21
申请人： Gregory Martin Benson , Konrad Bleicher , Uwe Grether , Bernd Kuhn , Hans Richter , Sven Taylor
发明人： Gregory Martin Benson , Konrad Bleicher , Uwe Grether , Bernd Kuhn , Hans Richter , Sven Taylor
IPC分类号： A61K31/4439 , C07D231/56 , A61K31/416 , C07D257/04 , A61K31/41 , C07D401/02 , A61P9/10 , A61P3/10 , A61P3/04 , A61P3/06 , A61P25/00 , A61P35/00
CPC分类号： C07D231/56 , C07D401/12 , C07D403/12
摘要： This invention relates to novel indazole or 4,5,6,7-tetrahydro-indazole derivatives of formula I wherein R1 to R8 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are FXR modulators and can be used as medicaments.
摘要翻译： 本发明涉及式I的新的吲唑或4,5,6,7-四氢 - 吲唑衍生物，其中R 1至R 8如说明书和权利要求书中所定义，以及其生理上可接受的盐。 这些化合物是FXR调节剂，可用作药物。
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公开(公告)号：US07622466B2
公开(公告)日：2009-11-24
申请号：US12093669
申请日：2006-11-08
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/4353
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein R1 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of 113 receptors.
摘要翻译： 本发明涉及其中R1至R5如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐。 所述化合物可用于治疗和/或预防与113受体的调节相关的疾病。
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公开(公告)号：US07601711B2
公开(公告)日：2009-10-13
申请号：US11784041
申请日：2007-04-05
IPC分类号： A61K31/55 , A61K31/496 , C07D243/08 , C07D243/00
CPC分类号： C07D401/06 , C07D209/42 , C07D401/14 , C07D403/06 , C07D405/12 , C07D487/04 , C07D491/113
摘要： The present invention relates to compounds of formula I wherein G and R1 to R5 and R12 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中G和R 1至R 5和R 12如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07579351B2
公开(公告)日：2009-08-25
申请号：US11605899
申请日：2006-11-29
IPC分类号： A01N43/60
CPC分类号： C07D487/04 , C07D471/14
摘要： The present invention relates to compounds of formula I wherein A, G, r and R1 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中A，G，r和R 1至R 5如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20090029976A1
公开(公告)日：2009-01-29
申请号：US12173888
申请日：2008-07-16
申请人： Peter Mohr , Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Tadakatsu Takahashi , Sven Taylor
发明人： Peter Mohr , Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Tadakatsu Takahashi , Sven Taylor
IPC分类号： A61K31/541 , C07D417/06 , C07D413/06 , A61K31/5377 , C07D403/06 , A61K31/497 , C07D401/06 , A61K31/4523
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of formula I wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中X，A和R 1至R 4如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20090005379A1
公开(公告)日：2009-01-01
申请号：US12093669
申请日：2006-11-08
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/4353
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein R1 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及其中R1至R5如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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58.发明申请公开(公告)号：US20080188487A1
公开(公告)日：2008-08-07
申请号：US12020637
申请日：2008-01-28
IPC分类号： A61K31/497 , C07D403/02
CPC分类号： C07D209/42 , C07D401/04 , C07D403/06
摘要： The present invention relates to compounds of formula I wherein A, G and R1 to R3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中A，G和R 1至R 3如在说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20070244125A1
公开(公告)日：2007-10-18
申请号：US11784041
申请日：2007-04-05
IPC分类号： A61K31/4045 , C07D209/02
CPC分类号： C07D401/06 , C07D209/42 , C07D401/14 , C07D403/06 , C07D405/12 , C07D487/04 , C07D491/113
摘要： The present invention relates to compounds of formula I wherein G and R1 to R5 and R12 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中G和R 1至R 5和R 12如在说明书和权利要求书中所定义， 及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20070135416A1
公开(公告)日：2007-06-14
申请号：US11605899
申请日：2006-11-29
IPC分类号： A61K31/551 , A61K31/498 , C07D487/14
CPC分类号： C07D487/04 , C07D471/14
摘要： The present invention relates to compounds of formula I wherein A, G, r and R1 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中A，G，r和R 1至R 5如在说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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