公开(公告)号：US20140036262A1

公开(公告)日：2014-02-06

申请号：US13562567

申请日：2012-07-31

Applicant: Shih-Yuan Wang ,  Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Huei Pei Kuo ,  Zhang-Lin Zhou ,  R Stanley Williams

Inventor： Shih-Yuan Wang ,  Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Huei Pei Kuo ,  Zhang-Lin Zhou ,  R Stanley Williams

IPC: G01J3/44

CPC classification number: G01N21/658

Abstract: An apparatus for surface enhanced Raman spectroscopy includes a substrate, a nanostructure and a plasmonic material. The nanostructure and the plasmonic material are integrated together to provide electronic and plasmonic enhancement to a Raman signal produced by electromagnetic radiation scattering from an analyte.

Abstract translation: 用于表面增强拉曼光谱的装置包括底物，纳米结构和等离子体激元材料。 将纳米结构和等离子体激元材料集成在一起，以对由分析物的电磁辐射散射产生的拉曼信号提供电子和等离子体增强。

公开(公告)号：US20140029002A1

公开(公告)日：2014-01-30

申请号：US13561561

申请日：2012-07-30

Applicant: Shih-Yuan Wang ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Gary Gibson ,  Huei Pei Kuo ,  Zhang-Lin Zhou ,  Steven J. Barcelo ,  Ansoon Kim ,  R Stanley Williams

Inventor： Shih-Yuan Wang ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Gary Gibson ,  Huei Pei Kuo ,  Zhang-Lin Zhou ,  Steven J. Barcelo ,  Ansoon Kim ,  R Stanley Williams

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y15/00

Abstract: A sensor for surface enhanced Raman spectroscopy (SERS) sensor includes surfaces and an actuator to adjust an intersurface spacing between the surfaces to contain an analyte and allow the analyte to be released from containment.

Abstract translation: 用于表面增强拉曼光谱（SERS）传感器的传感器包括表面和致动器，以调节表面之间的表面间隔，以包含分析物并允许分析物从容纳物释放。

公开(公告)号：US08559003B2

公开(公告)日：2013-10-15

申请号：US13384456

申请日：2009-09-17

Applicant: Huei Pei Kuo ,  Shih-Yuan Wang ,  Min Hu ,  Zhiyong Li ,  Alexandre M. Bratkovski

Inventor： Huei Pei Kuo ,  Shih-Yuan Wang ,  Min Hu ,  Zhiyong Li ,  Alexandre M. Bratkovski

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y15/00 ,  B82Y30/00

Abstract: An electrically driven device for surface enhanced Raman spectroscopy includes a first electrode, a substrate positioned proximate to the first electrode, a plurality of cone shaped protrusions formed integrally with or on a substrate surface, a Raman signal-enhancing material coated on each protrusion, and a second electrode positioned relative to the first electrode at a predetermined distance. Each of the protrusions has a tip with a radius of curvature ranging from about 0.1 nm to about 100 nm. The second electrode is positioned relative to the first electrode such that the electrodes together produce an electric field when a voltage bias is applied therebetween. The electric field has a field distribution that creates a stronger field gradient at a region proximate to the tips than at other portions of the substrate.

Abstract translation: 用于表面增强拉曼光谱的电驱动装置包括第一电极，靠近第一电极定位的基板，与基底表面一体地形成的多个锥形突起，涂覆在每个突起上的拉曼信号增强材料，以及 相对于第一电极以预定距离定位的第二电极。 每个突起具有具有约0.1nm至约100nm范围的曲率半径的尖端。 第二电极相对于第一电极定位，使得当在其之间施加电压偏置时，电极一起产生电场。 电场具有场分布，其在靠近尖端的区域处产生比在衬底的其它部分更强的场梯度。

公开(公告)号：US08208137B2

公开(公告)日：2012-06-26

申请号：US12696853

申请日：2010-01-29

Applicant: Min Hu ,  Alexandre M. Bratkovski ,  Jingjing Li ,  Huei Pei Kuo ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

Inventor： Min Hu ,  Alexandre M. Bratkovski ,  Jingjing Li ,  Huei Pei Kuo ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

IPC: G01J3/44

CPC classification number: G01J3/44

Abstract: An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.

Abstract translation: 用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源， 以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光 以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

公开(公告)号：US20120113419A1

公开(公告)日：2012-05-10

申请号：US13383387

申请日：2009-07-30

Applicant: Shih-Yuan Wang ,  Jingjing Li ,  Huei Pei Kuo ,  David A. Fattal ,  Nobuhiko Kobayashi ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  Jingjing Li ,  Huei Pei Kuo ,  David A. Fattal ,  Nobuhiko Kobayashi ,  Zhiyong Li

IPC: G01J3/44 ,  B82Y99/00

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/44

Abstract: Embodiments of the present invention are directed to nanowire-based systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system comprises a substrate (102) having a surface and a plurality of tapered nanowires (104) disposed on the surface. Each nanowire has a tapered end directed away from the surface. The system also includes a plurality of nanoparticles (110) disposed near the tapered end of each nanowire. When each nanowire is illuminated with light of a pump wavelength, Raman excitation light is emitted from the tapered end of the nanowire to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles.

Abstract translation: 本发明的实施方案涉及用于进行表面增强拉曼光谱的基于纳米线的系统。 在一个实施例中，系统包括具有表面的基板（102）和设置在表面上的多个锥形纳米线（104）。 每个纳米线具有远离表面的锥形端。 该系统还包括在每个纳米线的锥形端附近设置的多个纳米颗粒（110）。 当每个纳米线被泵浦波长的光照射时，拉曼激发光从纳米线的锥形端发射以与纳米颗粒相互作用，并从位于紧邻纳米颗粒的分子产生增强的拉曼散射光。

公开(公告)号：US20120105841A1

公开(公告)日：2012-05-03

申请号：US12915148

申请日：2010-10-29

Applicant: Min Hu ,  Michael Josef Stuke ,  Zhiyong Li ,  Wei Wu ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Lars Helge Thylen

Inventor： Min Hu ,  Michael Josef Stuke ,  Zhiyong Li ,  Wei Wu ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Lars Helge Thylen

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: An apparatus for performing surface enhanced Raman spectroscopy (SERS) includes a substrate and a plurality of nano-pillars, each of the plurality of nano-pillars having a first end attached to the substrate, a second end located distally from the substrate, and a body portion extending between the first end and the second end, in which the plurality of nano-pillars are arranged in an array on the substrate, and in which each of the plurality of nano-pillars is formed of a polymer material that is functionalized to expand in the presence of a fluid to cause gaps between the plurality of nano-pillars to shrink when the fluid is supplied onto the nano-pillars.

Abstract translation: 用于进行表面增强拉曼光谱（SERS）的设备包括基底和多个纳米柱，多个纳米柱中的每一个具有连接到基底的第一端，位于远离基底的第二端，以及 主体部分在所述第一端和所述第二端之间延伸，其中所述多个纳米柱以阵列布置在所述基底上，并且所述多个纳米柱中的每一个由聚合物材料形成，所述聚合物材料被官能化为 在存在流体的情况下膨胀，以便当将流体供应到纳米支柱上时，使多个纳米柱之间的间隙收缩。

公开(公告)号：US20120105840A1

公开(公告)日：2012-05-03

申请号：US12914655

申请日：2010-10-28

Applicant: Michael Josef Stuke ,  Shih-Yuan Wang ,  Zhiyong Li

Inventor： Michael Josef Stuke ,  Shih-Yuan Wang ,  Zhiyong Li

IPC: G01J3/44 ,  B82Y15/00

CPC classification number: B82Y15/00 ,  G01N21/65 ,  G01N21/658

Abstract: A sensing device that produces a Raman signal includes micro-rods or nano-rods arranged on a substrate in a two-dimensional (2D) array, each of the rods having a length in a single row being substantially the same, with the rod length of each row being different from the rod length of each other row. Each row of rods has a respective resonant vibration frequency that varies from row to row. A source of vibration energy, operatively connected to the substrate, excites vibration in each of the rods such that a responding row resonates when an exciting frequency approaches the resonant vibration frequency of the responding row. A method includes exposing the 2D array to a light source and analyzing Raman scattering at each rod of the 2D array to render a Raman map.

Abstract translation: 产生拉曼信号的感测装置包括以二维（2D）阵列布置在基底上的微棒或纳米棒，每根棒具有基本上相同的长度，其中棒长度 每行的距离与每隔一行的杆长度不同。 每排棒具有相应的谐振振动频率，其逐行变化。 可操作地连接到基板的振动能量源激发每个杆中的振动，使得当激励频率接近响应行的谐振振动频率时，响应行谐振。 一种方法包括将2D阵列暴露于光源并分析2D阵列的每个杆处的拉曼散射以呈现拉曼图。

公开(公告)号：US20120092660A1

公开(公告)日：2012-04-19

申请号：US12905891

申请日：2010-10-15

Applicant: Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Michael Josef Stuke ,  Lars Helge Thylen ,  Fung Suong Ou ,  Min Hu

Inventor： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Michael Josef Stuke ,  Lars Helge Thylen ,  Fung Suong Ou ,  Min Hu

IPC: G01J3/44

CPC classification number: G01N21/658

Abstract: An apparatus for performing SERS includes a substrate and flexible nano-fingers, each of the nano-fingers having a first end attached to the substrate, a free second end, and a body portion extending between the first end and the second end, in which the nano-fingers are arranged in an array on the substrate. The apparatus also includes an active material layer disposed on each of the second ends of the plurality of nano-fingers, in which the nano-fingers are to be in a substantially collapsed state in which the active layers on at least two of the nano-fingers contact each other under dominant attractive forces between the plurality of nano-fingers and in which the active material layers are to repel each other when the active material layers are electrostatically charged.

Abstract translation: 用于执行SERS的装置包括基底和柔性纳米指，每个纳米指具有连接到基底的第一端，自由的第二端和在第一端和第二端之间延伸的主体部分，其中 纳米手指以阵列排列在基板上。 该装置还包括设置在多个纳米手指的每个第二端上的活性材料层，其中纳米指状物将处于基本上塌陷的状态，其中在至少两个纳米手指上的活性层， 手指在多个纳米手指之间的主导吸引力下彼此接触，并且当活性材料层被静电充电时，活性材料层将彼此排斥。

公开(公告)号：US20080270042A1

公开(公告)日：2008-10-30

申请号：US11796455

申请日：2007-04-26

Applicant: Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Zhaoning Yu ,  R. Stanley Williams

Inventor： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Zhaoning Yu ,  R. Stanley Williams

IPC: G01J3/44

CPC classification number: G01N21/658

Abstract: An apparatus and related methods for facilitating surface-enhanced Raman spectroscopy (SERS) is described. A SERS-active structure near which a plurality of analyte molecules is disposed is periodically deformed at an actuation frequency. A synchronous measuring device synchronized with the actuation frequency receives Raman radiation scattered from the analyte molecules and generates therefrom at least one Raman signal measurement.

Abstract translation: 描述了用于促进表面增强拉曼光谱（SERS）的装置和相关方法。 多个分析物分子附近的SERS-活性结构以致动频率周期性地变形。 与致动频率同步的同步测量装置接收从分析物分子散射的拉曼辐射，并由此产生至少一个拉曼信号测量。

公开(公告)号：US20080094620A1

公开(公告)日：2008-04-24

申请号：US11584020

申请日：2006-10-20

Applicant: Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang

Inventor： Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: Raman spectroscopy systems include an analyte, a radiation source configured to emit incident radiation having a wavelength, and a detector that is capable of detecting only radiation having wavelengths within a detectable range that includes at least one wavelength corresponding to hyper Raman scattered radiation scattered by the analyte. The wavelength of the incident radiation is outside the detectable range. In particular systems, all wavelengths of radiation that are scattered in the direction of the detector impinge on the detector. Raman spectroscopy methods include providing an analyte and irradiating the analyte with incident radiation having a wavelength, providing a detector capable of detecting only wavelengths of radiation within a detectable range that does not include the wavelength of the incident radiation, and detecting Raman scattered radiation scattered by the analyte. A continuous path free of radiation filters may be provided between the analyte and the detector.