公开(公告)号：US06518423B1

公开(公告)日：2003-02-11

申请号：US09230852

申请日：1999-04-05

申请人： Toshihiko Kaneko ,  Richard Clark ,  Norihito Ohi ,  Fumihiro Ozaki ,  Tetsuya Kawahara ,  Atsushi Kamada ,  Kazuo Okano ,  Hiromitsu Yokohama ,  Kenzo Muramoto ,  Tohru Arai ,  Masayoshi Ohkuro ,  Osamu Takenaka ,  Jiro Sonoda

发明人： Toshihiko Kaneko ,  Richard Clark ,  Norihito Ohi ,  Fumihiro Ozaki ,  Tetsuya Kawahara ,  Atsushi Kamada ,  Kazuo Okano ,  Hiromitsu Yokohama ,  Kenzo Muramoto ,  Tohru Arai ,  Masayoshi Ohkuro ,  Osamu Takenaka ,  Jiro Sonoda

IPC分类号： C07D51300

CPC分类号： C07D487/04 ,  C07D513/04

摘要： Benzopiperidine derivatives represented by formula (I), salts thereof or hydrates thereof, processes for producing the same and drugs comprising the same: wherein the variables are as described in the specification. These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and rejection reaction accompanying organ transplantation.

摘要翻译： 由式（I）表示的苯并哌啶衍生物，其盐或其水合物，其制备方法和包含其的药物：其中变量如说明书中所述。 这些化合物可用作预防和治疗各种炎性疾病和免疫疾病，如类风湿性关节炎，特应性皮炎，牛皮癣，哮喘和伴随器官移植排斥反应的药物。

公开(公告)号：US4929623A

公开(公告)日：1990-05-29

申请号：US207329

申请日：1988-06-16

申请人： Shinya Abe ,  Mitsuaki Miyamoto ,  Masayuki Tanaka ,  Kozo Akasaka ,  Kenji Hayashi ,  Tetsuya Kawahara ,  Satoshi Katayama ,  Yoshinori Sakuma ,  Takeshi Suzuki ,  Isao Yamatsu

发明人： Shinya Abe ,  Mitsuaki Miyamoto ,  Masayuki Tanaka ,  Kozo Akasaka ,  Kenji Hayashi ,  Tetsuya Kawahara ,  Satoshi Katayama ,  Yoshinori Sakuma ,  Takeshi Suzuki ,  Isao Yamatsu

IPC分类号： A61K31/428 ,  A61P11/06 ,  C07D277/82 ,  C07D277/84 ,  C07D417/04 ,  C07D417/12 ,  C07D513/04

CPC分类号： C07D417/04 ,  C07D277/82 ,  C07D277/84 ,  C07D417/12 ,  C07D513/04

摘要： A benzothiazol compound having the formula is disclosed and is effective to inhibit the production of leukotriene. It is useful against allergy, asthma, affections of the skin, allergic rhinitis and affection of a cardiovascular system. ##STR1## in which R20 is ester or amide and --NR5R6 is amino in variety.