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    Solution-based method of making oligonucleotides via phosphoramidite coupling
    1.
    发明授权
    Solution-based method of making oligonucleotides via phosphoramidite coupling 有权
    通过亚磷酰胺偶联制备寡核苷酸的基于溶液的方法

    公开(公告)号：US09029528B2

    公开(公告)日：2015-05-12

    申请号：US13473884

    申请日：2012-05-17

    申请人： Kunihiro Hirai ,  Satoshi Katayama

    发明人： Kunihiro Hirai ,  Satoshi Katayama

    IPC分类号： C07H21/00 ,  C07C41/16

    CPC分类号： C07H21/00 ,  C07C41/16 ,  C07H1/00 ,  Y02P20/55 ,  C07C43/23

    摘要： A method of producing an n+p-mer oligonucleotide efficiently in a high yield, which includes use of, as a starting material, an n-mer oligonucleotide wherein the 3′-terminal hydroxyl group is protected, and the 5′-terminal hydroxyl group is protected by a temporary protecting group, and continuously performing, in a solution, (1) a deprotection step of the 5′-terminal hydroxyl group, (2) a 5′-terminal elongation step by the addition of a p-mer oligonucleotide wherein the 3′-position is phosphoramidited, and (3) an oxidation step or a sulfurization step of a phosphite triester moiety. The 3′-hydroxyl group of the n-mer oligonucleotide is protected by a solubilizing protecting group represented by formula: -L-Y—Z, where L is a group represented by formula (a1): Y is an oxygen atom, or NR wherein R is a hydrogen atom, an alkyl group or an aralkyl group, and Z is a group represented by formula (a2):

    摘要翻译： 以高产率有效地制备n +对聚物寡核苷酸的方法，其包括使用保护3'末端羟基的n-mer寡核苷酸作为起始原料，使用5'-末端羟基 基团被临时保护基团保护，并且在溶液中连续进行（1）5'-末端羟基的脱保护步骤，（2）通过加入对聚体的5'-末端伸长步骤 其中3'-位是磷酰胺化的寡核苷酸，和（3）亚磷酸三酯部分的氧化步骤或硫化步骤。 n-mer寡核苷酸的3'-羟基被由式-LL-Z表示的增溶保护基保护，其中L是由式（a1）表示的基团：Y是氧原子，或NR，其中R 是氢原子，烷基或芳烷基，Z是由式（a2）表示的基团：

    Board layout structure of digital broadcast receiving portion
    2.
    发明申请
    Board layout structure of digital broadcast receiving portion 审中-公开
    数字广播接收部分的板布局结构

    公开(公告)号：US20070149165A1

    公开(公告)日：2007-06-28

    申请号：US11634272

    申请日：2006-12-06

    申请人： Satoshi Katayama

    发明人： Satoshi Katayama

    IPC分类号： H04B1/08

    CPC分类号： H04B1/08

    摘要： The invention provides a board layout structure of a digital broadcast receiving portion, wherein mutual positional relation between a digital signal demodulation unit and a digital tuner is interchangeable between right and left. An IF input terminal of a digital signal demodulation unit is placed at a center of a connector so that the IF input terminal can be electrically connected to a digital tuner by pattern wiring of fixed length whether the digital tuner is placed to the right or to the left of the digital signal demodulation unit so as to give even digital broadcast receiving performance in either case.

    摘要翻译： 本发明提供一种数字广播接收部分的电路板布局结构，其中数字信号解调单元和数字调谐器之间的相互位置关系在左右互换。 数字信号解调单元的IF输入端放置在连接器的中心，使得IF输入端可以通过固定长度的图案布线电连接到数字调谐器，无论数字调谐器是放置在右边还是位于 数字信号解调单元的左侧，以便在任一种情况下给出均匀的数字广播接收性能。

    PLL frequency synthesizer with lock detection circuit
    3.
    发明授权
    PLL frequency synthesizer with lock detection circuit 失效
    PLL频率合成器带锁定检测电路

    公开(公告)号：US06757349B1

    公开(公告)日：2004-06-29

    申请号：US09106715

    申请日：1998-06-29

    申请人： Satoshi Katayama ,  Takehito Doi ,  Shinji Saito

    发明人： Satoshi Katayama ,  Takehito Doi ,  Shinji Saito

    IPC分类号： H04L706

    CPC分类号： H03L7/095

    摘要： A PLL frequency synthesizer including a lock detection circuit which detects whether or not the PLL is locked. First and second phase difference signals are generated from a reference signal and a compared signal by a phase comparator. The lock detection circuit determines the locked condition and generates a clock detection signal using only the first and second phase difference signals and does not require an external clock signal. The lock detection signal is generated independently of the frequencies of the reference signal and the compared signal.

    摘要翻译： 一种PLL频率合成器，包括检测PLL是否被锁定的锁定检测电路。 通过相位比较器从参考信号和比较信号产生第一和第二相位差信号。 锁定检测电路确定锁定状态，并且仅使用第一和第二相位差信号产生时钟检测信号，并且不需要外部时钟信号。 独立于参考信号和比较信号的频率产生锁定检测信号。

    Electrophotographic photoreceptor, process for production thereof, and image-forming apparatus using same
    4.
    发明授权
    Electrophotographic photoreceptor, process for production thereof, and image-forming apparatus using same 有权
    电子照相感光体及其制造方法以及使用其的图像形成装置

    公开(公告)号：US06696214B2

    公开(公告)日：2004-02-24

    申请号：US10336761

    申请日：2003-01-06

    申请人： Satoshi Katayama ,  Mikio Kakui ,  Masayuki Sakamoto ,  Tatsuhiro Morita ,  Sayaka Fujita ,  Tadashi Nakamura

    发明人： Satoshi Katayama ,  Mikio Kakui ,  Masayuki Sakamoto ,  Tatsuhiro Morita ,  Sayaka Fujita ,  Tadashi Nakamura

    IPC分类号： G03G5047

    CPC分类号： G03G5/0696 ,  G03G5/144

    摘要： The invention provides an electrophotographic photoreceptor, in which suppression of image defects and high sensitivity are compatible, and a method for production thereof. The invention also provides a coating fluid for forming a photosensitive layer and a method for production thereof, as well as an image-forming apparatus using said electrophoto-graphic photoreceptor. Briefly, the electrophoto-graphic photoreceptors may be constructed by forming an undercoating layer on a conductive support, and then forming a photosensitive layer on the undercoating layer. The undercoating layer contains titanium oxide particles in at least either needle shape or dendrite shape. The photosensitive layer contains an electric charge-generating material of which the primary particle size and cohesive particle size are in a range of 0.01 &mgr;m-10 &mgr;m. Accordingly, in the electrophotographic photoreceptors, it is possible to maintain high sensitivity and excellent durability and to form an image with no defect. The photosensitive layer in the electrophotographic photoreceptor has a multilayer structure consisting of a charge-generating layer and a charge-transporting layer. The charge-generating material is a phthalocyanine pigment.

    摘要翻译： 本发明提供一种电子照相感光体及其制造方法，其中图像缺陷的抑制和高灵敏度相容。 本发明还提供了用于形成感光层的涂布液及其制造方法，以及使用所述电子照相感光体的图像形成装置。 简而言之，电子照相感光体可以通过在导电载体上形成底涂层，然后在底涂层上形成感光层来构造。 底涂层含有至少针状或枝晶形状的氧化钛粒子。 感光层含有一次粒径和粘性粒径在0.01μm〜10μm的范围内的电荷产生材料。 因此，在电子照相感光体中，可以保持高灵敏度和优异的耐久性，并形成没有缺陷的图像。 电子照相感光体中的感光层具有由电荷产生层和电荷输送层组成的多层结构。 电荷产生材料是酞菁颜料。

    Methods for producing nucleoside derivatives and intermediates therefor
    6.
    发明授权
    Methods for producing nucleoside derivatives and intermediates therefor 失效
    制备核苷衍生物的方法及其中间体

    公开(公告)号：US6090937A

    公开(公告)日：2000-07-18

    申请号：US267789

    申请日：1999-03-15

    申请人： Satoshi Takamatsu ,  Satoshi Katayama ,  Naoko Hirose ,  Kunisuke Izawa ,  Tokumi Maruyama

    发明人： Satoshi Takamatsu ,  Satoshi Katayama ,  Naoko Hirose ,  Kunisuke Izawa ,  Tokumi Maruyama

    IPC分类号： C07D473/00 ,  C07H19/16 ,  C07H19/167 ,  C07H19/19

    CPC分类号： C07D473/00 ,  C07H19/16

    摘要： Novel intermediates of nucleoside derivatives, of which the 6-position of the nucleic acid base moiety is substituted with a halogen atom, are produced. Using those novel intermediates, even substrates, of which the 3'-position of the saccharide moiety is deoxylated, can be substituted at the 2'-position at an extremely high yield. Specifically, by subjecting a 3'-deoxy derivative of inosine to 6-halogenation to give a 6-halide of the derivative, and then subjecting it to 2'-deoxylation/substitution with a fluorine atom or the like, followed by further subjecting it to substitution with an amino group, a hydroxyl group or any other intended substituent at the 6-positioned halogen atom, nucleoside derivatives are produced at a high yield.Methods for producing nucleoside derivatives including 9-(2,3-dideoxy-2-fluoro-.beta.-D-threo-pentofuranosyl)adenine (FddA) and their related compounds, in a simplified manner, at a high yield and at low costs, and especially Economical methods for substituting substrates, of which the 3'-position of the saccharide moiety is deoxylated, at the 2'-position to produce those nucleoside derivatives on an industrial scale are also provided.

    摘要翻译： 产生其核酸碱基部分的6位被卤素原子取代的核苷衍生物的新型中间体。 使用这些新型中间体，其中糖基部分的3'-位脱氧的偶联底物可以在2'-位以非常高的收率被取代。 具体来说，通过使肌苷的3'-脱氧衍生物进行6-卤化，得到该衍生物的6-卤化物，然后用氟原子等进行2'-脱氧/取代，然后进一步对其进行 以6-取代的卤素原子被氨基，羟基或任何其它目的取代基取代，以高产率生产核苷衍生物。 以简单的方式以高产率和低成本生产包括9-（2,3-二脱氧-2-氟-β-D-苏氨酸 - 呋喃鸟糖基）腺嘌呤（FddA）及其相关化合物的核苷衍生物的方法， 并且还提供了用于将2'-位上的糖部分的3'-位脱氧的底物替代为工业规模生产这些核苷衍生物的经济方法。

    Electrophotographic photoreceptor, process for producing the same, and image forming apparatus using same
    7.
    发明授权
    Electrophotographic photoreceptor, process for producing the same, and image forming apparatus using same 有权
    电子照相感光体及其制造方法以及使用其的成像装置

    公开(公告)号：US6054237A

    公开(公告)日：2000-04-25

    申请号：US210785

    申请日：1998-12-15

    申请人： Kazuya Ishida ,  Kiyofumi Morimoto ,  Satoshi Katayama ,  Takahiro Teramoto ,  Akihiko Kawahara ,  Kazushige Morita

    发明人： Kazuya Ishida ,  Kiyofumi Morimoto ,  Satoshi Katayama ,  Takahiro Teramoto ,  Akihiko Kawahara ,  Kazushige Morita

    IPC分类号： G03G5/00 ,  C08K5/56 ,  C08L27/06 ,  C08L31/04 ,  G03G5/05 ,  G03G5/06

    CPC分类号： G03G5/0539 ,  G03G5/0542 ,  G03G5/0696

    摘要： An object of the invention is to provide a highly characteristic image using an electrophotographic photoreceptor of which a charge-generating layer can be produced with a better coating property and which is highly sensitive and electrostatically highly stable in repeated use. The charge-generating layer of a function-separated type photoreceptor contains a n-type non-metallic phthalocyanine and a copolymer of vinyl chloride-vinyl acetate type. Particularly, the ratio of the .tau.-type non-metallic phthalocyanine to the copolymer of vinyl chloride-vinyl acetate type is fixed at 1/3-3/1 by weight. The thickness of the charge-generating layer is fixed at 0.1-0.6 .mu.m. As the copolymer of vinyl chloride-vinyl acetate type, copolymers of vinyl chloride-vinyl acetate, vinyl chloride-vinyl acetate-maleic acid, or vinyl chloride-vinyl acetate-vinyl alcohol are selected. Particularly, it is favorable to select those containing at least 10% by weight of the vinyl alcohol component. The charge-generating layer is formed with a liquid coating material using a ketone solvent as dispersant. The aforementioned photoreceptor is applied to an image-forming apparatus using an inversion development process.

    摘要翻译： 本发明的目的是提供使用电子照相感光体的高度特征的图像，其中可以制备具有更好涂层性能的电荷产生层，并且其在重复使用中是高度敏感的和静电性高度稳定的。 功能分离型感光体的电荷产生层含有n型非金属酞菁和氯乙烯 - 乙酸乙烯酯类共聚物。 特别地，将T型非金属酞菁与氯乙烯 - 乙酸乙烯酯类共聚物的比例固定为1 / 3-3 / 1重量比。 电荷产生层的厚度固定在0.1-0.6μm。 作为氯乙烯 - 乙酸乙烯酯型共聚物，选择氯乙烯 - 乙酸乙烯酯，氯乙烯 - 乙酸乙烯酯 - 马来酸或氯乙烯 - 乙酸乙烯酯 - 乙烯醇的共聚物。 特别地，选择含有至少10重量％的乙烯醇组分的那些。 电荷产生层由使用酮溶剂作为分散剂的液体涂料形成。 使用反转显影处理将上述感光体应用于图像形成装置。