-
公开(公告)号:US06518423B1
公开(公告)日:2003-02-11
申请号:US09230852
申请日:1999-04-05
申请人: Toshihiko Kaneko , Richard Clark , Norihito Ohi , Fumihiro Ozaki , Tetsuya Kawahara , Atsushi Kamada , Kazuo Okano , Hiromitsu Yokohama , Kenzo Muramoto , Tohru Arai , Masayoshi Ohkuro , Osamu Takenaka , Jiro Sonoda
发明人: Toshihiko Kaneko , Richard Clark , Norihito Ohi , Fumihiro Ozaki , Tetsuya Kawahara , Atsushi Kamada , Kazuo Okano , Hiromitsu Yokohama , Kenzo Muramoto , Tohru Arai , Masayoshi Ohkuro , Osamu Takenaka , Jiro Sonoda
IPC分类号: C07D51300
CPC分类号: C07D487/04 , C07D513/04
摘要: Benzopiperidine derivatives represented by formula (I), salts thereof or hydrates thereof, processes for producing the same and drugs comprising the same: wherein the variables are as described in the specification. These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and rejection reaction accompanying organ transplantation.
摘要翻译: 由式(I)表示的苯并哌啶衍生物,其盐或其水合物,其制备方法和包含其的药物:其中变量如说明书中所述。 这些化合物可用作预防和治疗各种炎性疾病和免疫疾病,如类风湿性关节炎,特应性皮炎,牛皮癣,哮喘和伴随器官移植排斥反应的药物。
-
公开(公告)号:US20060276465A1
公开(公告)日:2006-12-07
申请号:US11474225
申请日:2006-06-23
IPC分类号: A61K31/5377 , A61K31/538 , A61K31/496 , A61K31/495 , C07D413/02 , C07D403/02
CPC分类号: C07D295/096 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/12 , C07D207/273 , C07D207/335 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/62 , C07D211/70 , C07D211/74 , C07D211/76 , C07D211/88 , C07D213/38 , C07D213/64 , C07D223/04 , C07D241/08 , C07D243/08 , C07D257/04 , C07D261/08 , C07D263/56 , C07D265/30 , C07D265/36 , C07D271/10 , C07D277/28 , C07D277/64 , C07D279/12 , C07D295/033 , C07D295/067 , C07D295/073 , C07D295/088 , C07D295/108 , C07D295/116 , C07D295/13 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/192 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D307/52 , C07D309/04 , C07D309/14 , C07D317/66 , C07D319/18 , C07D333/20 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/12 , C07D417/12 , C07D487/08 , C07D491/10
摘要: A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R10 represents optionally substituted cycloalkyl, etc., R20-23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc. And A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R10 represents 5- to 10-membered cycloalkyl etc. optionally substituted with hydroxyl etc., R30, R31 and R32 may be the same or different and each represents hydrogen etc., R40 represents C1-10 alkyl etc. optionally substituted with hydroxyl etc., n represents an integer of 0, 1 or 2, X1 represents CH or nitrogen, and R20, R21, R22 and R23 may be the same or different and each represents hydrogen etc.
-
3.
公开(公告)号:US20090156589A1
公开(公告)日:2009-06-18
申请号:US11917542
申请日:2006-06-14
IPC分类号: A61K31/496 , C07D295/14 , C07D295/096 , C07D211/46 , C07D401/10 , C07D403/10 , C07D405/12 , A61P29/00 , A61P1/00 , C07D413/10 , C07D417/10 , A61K31/538 , A61K31/5377 , A61K31/495 , A61K31/451
CPC分类号: C07D211/22 , C07D207/08 , C07D207/27 , C07D207/408 , C07D211/46 , C07D211/58 , C07D211/62 , C07D211/74 , C07D211/76 , C07D211/88 , C07D213/643 , C07D263/56 , C07D265/36 , C07D277/64 , C07D295/033 , C07D295/096 , C07D295/116 , C07D295/135 , C07D295/155 , C07D295/215 , C07D295/24 , C07D309/04 , C07D309/14 , C07D317/48 , C07D319/18 , C07D491/113
摘要: A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action and cell infiltration inhibitory action. wherein R10 represents 5- to 10-membered cycloalkyl etc. optionally substituted with hydroxyl etc., R30, R31 and R32 may be the same or different and each represents hydrogen etc., R40 represents C1-10 alkyl etc. optionally substituted with hydroxyl etc., n represents an integer of 0, 1 or 2, X1 represents CH or nitrogen, and R20, R21, R22 and R23 may be the same or different and each represents hydrogen etc.
摘要翻译: 由以下通式(1)或(100)表示的化合物,其盐或其水合物具有优异的细胞粘附抑制作用和细胞浸润抑制作用。 其中R 10表示任选被羟基等取代的5-至10-元环烷基等,R 30,R 31和R 32可以相同或不同,各自表示氢等,R 40表示任选被羟基取代的C 1-10烷基等 n表示0,1或2的整数,X1表示CH或氮,R20,R21,R22和R23可以相同或不同,表示氢等。
-
公开(公告)号:US07425554B2
公开(公告)日:2008-09-16
申请号:US11022702
申请日:2004-12-27
IPC分类号: A61K31/535 , A61K31/4965 , A01N43/40 , A01N57/00 , C07D413/00 , C07D241/04 , C07D295/00
CPC分类号: C07D257/04 , C07D207/12 , C07D211/42 , C07D211/46 , C07D211/62 , C07D213/64 , C07D241/18 , C07D277/28 , C07D295/03 , C07D295/067 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/205 , C07D307/52 , C07D309/14
摘要: In one aspect, the present invention provides compounds having formula (1) or (100), a salt thereof or a hydrate of the foregoing, which compounds exhibit excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and are useful as therapeutic or prophylactic agents for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome; rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R10 represents optionally substituted cycloalkyl, etc., R20-23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc.
摘要翻译: 一方面,本发明提供具有式(1)或(100)的化合物,其盐或前述的水合物,其表现出优异的细胞粘附抑制作用或细胞浸润抑制作用,可用作治疗或预防 与炎性肠病(特别是溃疡性结肠炎或克罗恩病)等白细胞的粘连和浸润有关的各种炎性疾病和自身免疫性疾病的药剂,肠易激综合征; 类风湿性关节炎,牛皮癣,多发性硬化,哮喘和特应性皮炎。 其中R 10表示任选取代的环烷基等,R 20-23表示氢,烷基,烷氧基等,R 30-32表示氢,烷基,氧代等,R 40表示任意取代的烷基等。
-
公开(公告)号:US20060281747A1
公开(公告)日:2006-12-14
申请号:US11453194
申请日:2006-06-14
IPC分类号: A61K31/5377 , A61K31/496 , A61K31/4747 , A61K31/4439 , C07D413/14 , C07D403/02
CPC分类号: C07D211/22 , C07D207/08 , C07D207/27 , C07D207/408 , C07D211/46 , C07D211/58 , C07D211/62 , C07D211/74 , C07D211/76 , C07D211/88 , C07D213/643 , C07D263/56 , C07D265/36 , C07D277/64 , C07D295/033 , C07D295/096 , C07D295/116 , C07D295/135 , C07D295/155 , C07D295/215 , C07D295/24 , C07D309/04 , C07D309/14 , C07D317/48 , C07D319/18 , C07D491/113
摘要: A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action and cell infiltration inhibitory action. wherein R10 represents 5- to 10-membered cycloalkyl etc. optionally substituted with hydroxyl etc., R30, R31 and R32 may be the same or different and each represents hydrogen etc., R40 represents C1-10 alkyl etc. optionally substituted with hydroxyl etc., n represents an integer of 0, 1 or 2, X1 represents CH or nitrogen, and R20, R21, R22 and R23 may be the same or different and each represents hydrogen etc.
摘要翻译: 由以下通式(1)或(100)表示的化合物,其盐或其水合物具有优异的细胞粘附抑制作用和细胞浸润抑制作用。 其中R 10表示任选被羟基取代的5-至10-元环烷基等,R 30,R 31和R SUP > 32可以相同或不同,各自表示氢等,R 40代表任选被羟基取代的C 1-10烷基等,n表示0,1或2的整数 或2,X 1表示CH或氮,R 20,R 21,R 22和R 22, SUP> 23可以相同或不同,各自表示氢等。
-
公开(公告)号:US07410971B2
公开(公告)日:2008-08-12
申请号:US10581591
申请日:2004-12-24
IPC分类号: A61K31/4965 , A61K31/445 , A01N43/40 , C07D241/04 , C07D295/00 , C07D211/60 , C07D211/06 , C07D211/30 , C07D211/32 , C07D211/22
CPC分类号: C07D295/096 , C07D207/12 , C07D211/42 , C07D211/46 , C07D211/62 , C07D213/64 , C07D241/18 , C07D257/04 , C07D277/28 , C07D295/03 , C07D295/067 , C07D295/073 , C07D295/088 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/205 , C07D307/52 , C07D309/14
摘要: A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R10 represents optionally substituted cycloalkyl, etc., R20-23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc.
摘要翻译: 由以下通式(1)或(100)表示的化合物,其盐或其水合物具有优异的细胞粘附抑制作用或细胞浸润抑制作用,可用作各种炎性疾病的治疗或预防剂 以及与白细胞的粘附和浸润相关的自身免疫性疾病,例如炎性肠病(特别是溃疡性结肠炎或克罗恩病),肠易激综合征,类风湿性关节炎,牛皮癣,多发性硬化,哮喘和特应性皮炎。 其中R 10表示任选取代的环烷基等,R 20-23表示氢,烷基,烷氧基等,R 30-32表示氢,烷基,氧代等,R 40表示任意取代的烷基等。
-
公开(公告)号:US20070112002A1
公开(公告)日:2007-05-17
申请号:US10581591
申请日:2004-12-24
IPC分类号: A61K31/5377 , A61K31/496 , C07D413/02 , C07D403/02
CPC分类号: C07D295/096 , C07D207/12 , C07D211/42 , C07D211/46 , C07D211/62 , C07D213/64 , C07D241/18 , C07D257/04 , C07D277/28 , C07D295/03 , C07D295/067 , C07D295/073 , C07D295/088 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/205 , C07D307/52 , C07D309/14
摘要: A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R10 represents optionally substituted cycloalkyl, etc., R20-23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc.
摘要翻译: 由以下通式(1)或(100)表示的化合物,其盐或其水合物具有优异的细胞粘附抑制作用或细胞浸润抑制作用,可用作各种炎性疾病的治疗或预防剂 以及与白细胞的粘附和浸润相关的自身免疫性疾病,例如炎性肠病(特别是溃疡性结肠炎或克罗恩病),肠易激综合征,类风湿性关节炎,牛皮癣,多发性硬化,哮喘和特应性皮炎。 其中R 10表示任选取代的环烷基等,R 20-23表示氢,烷基,烷氧基等,R 30-32表示氢,烷基,氧代等,R 40表示任意取代的烷基等。
-
公开(公告)号:US20050261291A1
公开(公告)日:2005-11-24
申请号:US11022702
申请日:2004-12-27
IPC分类号: A61K31/381 , A61K31/382 , A61K31/40 , A61K31/407 , A61K31/4418 , A61K31/451 , A61K31/452 , A61K31/4525 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/00 , A61P1/04 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/06 , C07D207/12 , C07D207/273 , C07D207/325 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/56 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/64 , C07D213/75 , C07D233/04 , C07D241/18 , C07D257/04 , C07D261/08 , C07D265/30 , C07D265/32 , C07D271/10 , C07D277/28 , C07D295/02 , C07D295/03 , C07D295/067 , C07D295/073 , C07D295/08 , C07D295/088 , C07D295/096 , C07D295/12 , C07D295/135 , C07D295/14 , C07D295/15 , C07D295/155 , C07D295/18 , C07D295/205 , C07D307/52 , C07D309/04 , C07D309/14 , C07D333/20 , C07D335/02 , C07D405/12 , C07D413/02 , C07D413/12 , C07D487/08 , C07D45/02
CPC分类号: C07D257/04 , C07D207/12 , C07D211/42 , C07D211/46 , C07D211/62 , C07D213/64 , C07D241/18 , C07D277/28 , C07D295/03 , C07D295/067 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/205 , C07D307/52 , C07D309/14
摘要: In one aspect, the present invention provides compounds having formula (1) or (100), a salt thereof or a hydrate of the foregoing, which compounds exhibit excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and are useful as therapeutic or prophylactic agents for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome; rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R10 represents optionally substituted cycloalkyl, etc., R20-23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc.
摘要翻译: 一方面,本发明提供具有式(1)或(100)的化合物,其盐或前述的水合物,其表现出优异的细胞粘附抑制作用或细胞浸润抑制作用,可用作治疗或预防 与炎性肠病(特别是溃疡性结肠炎或克罗恩病)等白细胞的粘连和浸润有关的各种炎性疾病和自身免疫性疾病的药剂,肠易激综合征; 类风湿性关节炎,牛皮癣,多发性硬化,哮喘和特应性皮炎。 其中R 10表示任选取代的环烷基等,R 20-23表示氢,烷基,烷氧基等,R 30-32表示氢,烷基,氧代等,R 40表示任意取代的烷基等。
-
-
-
-
-
-
-