摘要:
Oligonucleotide inhibitors that inhibit expression of a mammalian MBD2/DNA demethylase (MBD2/dMTase) are provided. The oligonucleotide inhibitors can be used to inhibit the growth or proliferation of tumour cells in vitro and in vivo. The use of the oligonucleotide inhibitors in the treatment of cancer and methods of identifying potential target genes for cancer therapy or diagnosis using the oligonucleotide inhibitors are also provided.
摘要:
A computer is disclosed. The computer has a general register file of registers, a RISC instruction decoder, and a CISC instruction decoder. The RISC instruction decoder is exposed for execution of user-state programs in a RISC instruction set, being an instruction set having fixed-length instructions and a load/store/operate organization. The hardware CISC instruction decoder is exposed for execution by user-state programs in a CISC instruction set, being an instruction set with variable-length instructions and many instructions having multiple side-effects. The CISC decoder is designed to decode a portion of an instruction set for the computer, and to deliver the decoded instructions to an instruction execution pipeline designed to execute the output of both the RISC instruction decoder and the CISC instruction decoder. A software emulator is programmed to implement a remainder of the instruction set. The CISC instruction set provides accessibility to only a subset of the registers of the general register file, intermediate results of instructions of the instruction set being stored in registers of the general register file that are inaccessible in the CISC instruction set.
摘要:
This invention pertains to heterojunction bipolar transistors containing a semiconductor substrate, a buffer layer of an antimony-based material deposited on the substrate, a sub-collector layer of an antimony-based material deposited on the buffer layer, a collector layer of an antimony-based material deposited on the sub-collector layer, a base layer of an antimony-based material deposited on the collector layer, an emitter layer of an antimony-based material deposited on the base layer, and a cap layer of an antimony-based material deposited on the emitter layer.
摘要:
A retaining-locking system for chain link fence slats includes specially notched fence slat elements having a pointed upper or lower end. The slat elements are sized and shaped to be interwoven between consecutive links of a chain link fence. A retaining-locking strip is formed of resilient material, and has an inner surface and an outer surface and at least one securing protrusion. The securing protrusion is sized and shaped to fit slidably within the notch. The protrusion is located on the outer surface of the strip. When the slat elements are interwoven into between consecutive links of a chain link fence with each of the notches aligned with one another, the retaining-locking strip inserted between the slat elements and the links, with the securing protrusion disposed within the slats, the strip will urge the slats toward the links, thereby retaining the slats within the chain link fence.
摘要:
A method and apparatus is provided for providing communication with input/output devices without being bound by the limitations of an existing input/output bus while still providing compatibility with software intended to communicate with input/output devices using the existing input/output bus. The software image of the input/output devices as being associated with the input/output bus is preserved, but a technique is provided to allow communication with the input/output devices to bypass the existing input/output bus. A translation lookaside buffer is utilized to remap accesses to an internal input/output device from virtual address space for input/output-bus-based input/output devices to physical address space for the internal input/output device. Circuitry for interfacing with the input/output devices separately from the existing input/output bus may be fabricated as a single integrated circuit device along with other system components, such as a central processing unit.
摘要:
A method and apparatus for dependent segmentation and paging processing within a computer system include processing that begins by determining context of an operation supported by a native operating system. The context of an operation may correspond to performing an operation that is a native operating system operation or may be a legacy operating system operation. The processing then continues by setting within a corresponding segment descriptor a paging enable bit for a given segment that corresponds to the operation when the context of the operation corresponds to a legacy operating system. The setting of the paging enable bit is done in accordance with the processing of the native operating system. The processing then continues by processing the segment descriptor via segmentation processing in accordance with the legacy operating system to obtain a linear address. With the paging enable bitd, the linear address is processed to obtain a physical address.