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51.发明申请Amide compounds with MCH antagonistic activity and medicaments comprising these compounds 有权具有MCH拮抗活性的酰胺化合物和包含这些化合物的药物公开(公告)号：US20050267093A1
公开(公告)日：2005-12-01
申请号：US11021897
申请日：2004-12-23
申请人： Thorsten Lehmann-Lintz , Ralf Lotz , Philipp Lustenberger , Stephan Mueller , Gerald Roth , Klaus Rudolf , Marcus Schindler , Dirk Stenkamp , Leo Thomas
发明人： Thorsten Lehmann-Lintz , Ralf Lotz , Philipp Lustenberger , Stephan Mueller , Gerald Roth , Klaus Rudolf , Marcus Schindler , Dirk Stenkamp , Leo Thomas
IPC分类号： A61K31/397 , A61K31/4025 , A61K31/454 , A61K31/4545 , A61K31/537 , A61K31/54
CPC分类号： C07C255/24 , C07C233/29 , C07C233/44 , C07C233/55 , C07C237/20 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/12 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/58 , C07D213/36 , C07D213/56 , C07D221/20 , C07D231/12 , C07D233/60 , C07D249/08 , C07D263/56 , C07D295/155 , C07D309/14 , C07D401/12
摘要： Compounds of formula (I) wherein A, B, b, W, X, Y, Z, R1, R2, and R3 have the meanings given in claim 1, pharmaceutical compositions these compounds, and methods of preventing or treating metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia, and diabetes using these compounds.
摘要翻译： 其中A，B，b，W，X，Y，Z，R 1，R 2和R 3的式（I）化合物 具有权利要求1中给出的含义，这些化合物的药物组合物，以及使用这些化合物预防或治疗代谢紊乱和/或进食障碍，特别是肥胖症，食欲过剩，厌食，食欲过盛和糖尿病的方法。
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52.发明申请Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds 审中-公开具有MCH拮抗活性的炔烃化合物和包含这些化合物的药物公开(公告)号：US20050239826A1
公开(公告)日：2005-10-27
申请号：US11104915
申请日：2005-04-13
申请人： Dirk Stenkamp , Stephan Mueller , Philipp Lustenberger , Thorsten Lehmann-Lintz , Gerald Roth , Klaus Rudolf , Marcus Schindler , Leo Thomas , Ralf Lotz
发明人： Dirk Stenkamp , Stephan Mueller , Philipp Lustenberger , Thorsten Lehmann-Lintz , Gerald Roth , Klaus Rudolf , Marcus Schindler , Leo Thomas , Ralf Lotz
IPC分类号： A61K31/44 , A61K31/4439 , A61K31/4709 , C07D43/02 , C07D45/02
CPC分类号： C07D213/53 , C07D213/36 , C07D213/38 , C07D213/61 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/14
摘要： The present invention relates to alkyne compounds of general formula I wherein the groups and radicals A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one alkyne according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.
摘要翻译： 本发明涉及通式I的炔化合物，其中基团A，B，W，X，Y，Z，R 1和R 2具有如下含义： 此外，本发明涉及含有至少一种根据本发明的炔的药物组合物。 由于其MCH-受体拮抗活性，根据本发明的药物组合物适用于治疗代谢紊乱和/或进食障碍，特别是肥胖症和糖尿病。
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公开(公告)号：US07605176B2
公开(公告)日：2009-10-20
申请号：US11071797
申请日：2005-03-03
申请人： Gerald Juergen Roth , Philipp Lustenberger , Dirk Stenkamp , Stephan Georg Mueller , Thorsten Lehmann-Lintz , Marcus Schindler , Leo Thomas , Ralf R. H. Lotz , Marco Santagostino
发明人： Gerald Juergen Roth , Philipp Lustenberger , Dirk Stenkamp , Stephan Georg Mueller , Thorsten Lehmann-Lintz , Marcus Schindler , Leo Thomas , Ralf R. H. Lotz , Marco Santagostino
IPC分类号： A01N43/36 , C07D207/00 , C07D295/00
CPC分类号： C07D207/08 , C07C235/74 , C07D205/04 , C07D207/20 , C07D209/08 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/62 , C07D221/20 , C07D263/56 , C07D295/088 , C07D295/135 , C07D401/12
摘要： Compounds of formula I wherein the groups and residues A, B, b, X, Y, Z, R1, R2, R3, R5a and R5b have the meanings given in claim 1. The invention further relates to pharmaceutical compositions containing at least one amide according to the invention. As a result of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia, and diabetes.
摘要翻译： 式I化合物，其中基团和残基A，B，b，X，Y，Z，R 1，R 2，R 3，R 5a和R 5b具有权利要求1中给出的含义。本发明还涉及含有至少一种酰胺 根据本发明。 由于它们的MCH受体拮抗活性，根据本发明的药物组合物适用于治疗代谢紊乱和/或进食障碍，特别是肥胖症，贪食症，厌食症，食欲过盛和糖尿病。
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54.发明授权Substituted cycloalkyl derivatives, process for the manufacture thereof and use thereof as medicament 有权取代的环烷基衍生物，其制备方法及其作为药物的用途公开(公告)号：US07423035B2
公开(公告)日：2008-09-09
申请号：US11125757
申请日：2005-05-10
申请人： Ingo Konetzki , Thierry Bouyssou , Philipp Lustenberger , Andreas Schnapp , Christoph Hoenke , Klaus Rudolf , Marco Santagostino
发明人： Ingo Konetzki , Thierry Bouyssou , Philipp Lustenberger , Andreas Schnapp , Christoph Hoenke , Klaus Rudolf , Marco Santagostino
IPC分类号： C07D265/36 , A61K31/538 , A61K31/138
CPC分类号： C07D265/36 , C07C215/60 , C07C215/68 , C07C217/74 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D215/227
摘要： The present invention relates to compounds of formula 1 wherein the groups R1, R2, R3, R4, R5, R6, R7, R8, n, m and X may have the meanings given in the claims and in the specification, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
摘要翻译： 本发明涉及式1化合物，其中基团R 1，R 2，R 3，R 4， >，R 5，R 6，R 7，R 8，n，m和X可以具有 在权利要求和说明书中给出的含义，以及作为药物组合物的用途，特别是用于治疗炎性和阻塞性呼吸道疾病。
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55.发明授权Amide compounds with MCH antagonistic activity and medicaments comprising these compounds 有权具有MCH拮抗活性的酰胺化合物和包含这些化合物的药物公开(公告)号：US07592373B2
公开(公告)日：2009-09-22
申请号：US11021897
申请日：2004-12-23
申请人： Thorsten Lehmann-Lintz , Ralf R. H. Lotz , Philipp Lustenberger , Stephan Georg Mueller , Gerald Juergen Roth , Klaus Rudolf , Marcus Schindler , Dirk Stenkamp , Leo Thomas
发明人： Thorsten Lehmann-Lintz , Ralf R. H. Lotz , Philipp Lustenberger , Stephan Georg Mueller , Gerald Juergen Roth , Klaus Rudolf , Marcus Schindler , Dirk Stenkamp , Leo Thomas
IPC分类号： C07C233/29 , C07C235/24 , C07D209/18 , A61K31/40 , A61K31/167 , A61K31/404 , A61P3/04
CPC分类号： C07C255/24 , C07C233/29 , C07C233/44 , C07C233/55 , C07C237/20 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/12 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/58 , C07D213/36 , C07D213/56 , C07D221/20 , C07D231/12 , C07D233/60 , C07D249/08 , C07D263/56 , C07D295/155 , C07D309/14 , C07D401/12
摘要： Compounds of formula (I) wherein A, B, b, W, X, Y, Z, R1, R2, and R3 have the meanings given in claim 1, pharmaceutical compositions these compounds, and methods of preventing or treating metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia, and diabetes using these compounds.
摘要翻译： 其中A，B，b，W，X，Y，Z，R 1，R 2和R 3具有权利要求1中给出的含义的式（I）化合物，这些化合物的药物组合物，以及预防或治疗代谢紊乱和/ 或进食障碍，特别是肥胖症，食欲过剩，厌食症，食欲过盛和糖尿病。
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56.发明申请Substituted Cycloalkyl Derivatives, Process for the Manufacture thereof and Use thereof as Medicament 有权取代的环烷基衍生物，其制造方法及其作为药物的用途公开(公告)号：US20080146554A1
公开(公告)日：2008-06-19
申请号：US12034409
申请日：2008-02-20
申请人： Ingo Konetzki , Thierry Bouyssou , Philipp Lustenberger , Andreas Schnapp , Christoph Hoenke , Klaus Rudolf , Marco Santagostino
发明人： Ingo Konetzki , Thierry Bouyssou , Philipp Lustenberger , Andreas Schnapp , Christoph Hoenke , Klaus Rudolf , Marco Santagostino
IPC分类号： A61K31/538 , C07D265/36 , C07C211/01 , A61K31/135 , C07D215/00 , A61K31/47 , A61P11/06
CPC分类号： C07D265/36 , C07C215/60 , C07C215/68 , C07C217/74 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D215/227
摘要： The present invention relates to compounds of formula 1 wherein the groups R1, R2, R3, R4, R5, R6, R7, R8, n, m and X may have the meanings given in the claims and in the specification, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
摘要翻译： 本发明涉及式1化合物，其中基团R 1，R 2，R 3，R 4， >，R 5，R 6，R 7，R 8，n，m和X可以具有 在权利要求和说明书中给出的含义，以及作为药物组合物的用途，特别是用于治疗炎性和阻塞性呼吸道疾病。
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57.发明申请Substituted cycloalkyl derivatives, process for the manufacture thereof and use thereof as medicament 有权取代的环烷基衍生物，其制备方法及其作为药物的用途公开(公告)号：US20050261286A1
公开(公告)日：2005-11-24
申请号：US11125757
申请日：2005-05-10
申请人： Ingo Konetzki , Thierry Bouyssou , Philipp Lustenberger , Andreas Schnapp , Christoph Hoenke , Klaus Rudolf , Marco Santagostino
发明人： Ingo Konetzki , Thierry Bouyssou , Philipp Lustenberger , Andreas Schnapp , Christoph Hoenke , Klaus Rudolf , Marco Santagostino
IPC分类号： A61K31/138 , A61K31/538 , C07C215/60 , C07C215/68 , C07C217/74 , C07C311/08 , C07D215/22 , C07D215/227 , C07D265/36
CPC分类号： C07D265/36 , C07C215/60 , C07C215/68 , C07C217/74 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D215/227
摘要： The present invention relates to compounds of formula 1 wherein the groups R1, R2, R3, R4, R5, R6, R7, R8, n, m and X may have the meanings given in the claims and in the specification, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
摘要翻译： 本发明涉及式1化合物，其中基团R 1，R 2，R 3，R 4， >，R 5，R 6，R 7，R 8，n，m和X可以具有 在权利要求和说明书中给出的含义，以及作为药物组合物的用途，特别是用于治疗炎性和阻塞性呼吸道疾病。
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58.发明授权Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds 有权具有MCH拮抗活性的炔烃化合物和包含这些化合物的药物公开(公告)号：US08618132B2
公开(公告)日：2013-12-31
申请号：US12121251
申请日：2008-05-15
申请人： Dirk Stenkamp , Stephan Georg Mueller , Gerald Juergen Roth , Thorsten Lehmann-Lintz , Klaus Rudolf , Philipp Lustenberger , Kristen Arndt , Ralf R. H. Lotz , Martin Lenter
发明人： Dirk Stenkamp , Stephan Georg Mueller , Gerald Juergen Roth , Thorsten Lehmann-Lintz , Klaus Rudolf , Philipp Lustenberger , Kristen Arndt , Ralf R. H. Lotz , Martin Lenter
IPC分类号： A61K31/444 , C07D401/12
CPC分类号： C07D471/10 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/48 , C07D213/53 , C07D213/55 , C07D213/56 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/85 , C07D215/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D333/16 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/06 , C07D453/02 , C07D471/04 , C07D487/08 , C07D487/10 , C07D495/04
摘要： The present invention relates to alkyne compounds of general formula I wherein the groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. The invention further relates to pharmaceutical compositions containing at least one alkyne according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
摘要翻译： 本发明涉及通式I的炔化合物，其中基团和残基A，B，W，X，Y，Z，R 1和R 2具有权利要求1中给出的含义。本发明还涉及含有至少一种 炔根据本发明。 鉴于其MCH受体拮抗活性，根据本发明的药物组合物适用于治疗代谢紊乱和/或进食障碍，特别是肥胖症，食欲过剩，厌食症，食欲过盛和糖尿病。
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59.发明授权Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds 有权具有MCH拮抗活性的炔烃化合物和包含这些化合物的药物公开(公告)号：US07524862B2
公开(公告)日：2009-04-28
申请号：US11104914
申请日：2005-04-13
申请人： Dirk Stenkamp , Stephan Georg Mueller , Philipp Lustenberger , Thorsten Lehmann-Lintz , Gerald Juergen Roth , Klaus Rudolf , Marcus Schindler , Leo Thomas , Ralf Lotz
发明人： Dirk Stenkamp , Stephan Georg Mueller , Philipp Lustenberger , Thorsten Lehmann-Lintz , Gerald Juergen Roth , Klaus Rudolf , Marcus Schindler , Leo Thomas , Ralf Lotz
IPC分类号： A61K31/47 , A61K31/44 , C07D215/38 , C07D491/02 , C07D405/00
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14
摘要： Alkyne compounds of formula I wherein A, B, W, X, Y, Z, R1, and R2 have the meanings given herein, which have MCH-receptor antagonistic activity and are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.
摘要翻译： 式I的炔烃化合物，其中A，B，W，X，Y，Z，R 1和R 2具有本文给出的含义，其具有MCH受体拮抗活性并且可用于制备用于治疗代谢紊乱和/ 或进食障碍，特别是肥胖和糖尿病。
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60.发明授权Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds 有权具有MCH拮抗活性的炔烃化合物和包含这些化合物的药物公开(公告)号：US07592358B2
公开(公告)日：2009-09-22
申请号：US11104889
申请日：2005-04-13
申请人： Dirk Stenkamp , Stephan Georg Mueller , Philipp Lustenberger , Thorsten Lehmann-Lintz , Gerald Juergen Roth , Klaus Rudolf , Marcus Schindler , Leo Thomas , Ralf Lotz
发明人： Dirk Stenkamp , Stephan Georg Mueller , Philipp Lustenberger , Thorsten Lehmann-Lintz , Gerald Juergen Roth , Klaus Rudolf , Marcus Schindler , Leo Thomas , Ralf Lotz
IPC分类号： A61K31/47 , A61K31/44 , A61K31/445 , C07D211/68 , C07D215/00 , C07D401/00
CPC分类号： C07D213/30 , C07D213/38 , C07D213/74 , C07D213/75 , C07D401/06 , C07D401/10 , C07D401/12 , C07D409/10 , C07D409/14 , C07D451/06
摘要： Alkyne compounds having MCH-receptor antagonistic activity, which are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.
摘要翻译： 具有MCH受体拮抗活性的炔烃化合物，其可用于制备用于治疗代谢紊乱和/或进食障碍，特别是肥胖和糖尿病的药物组合物。
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