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51.发明申请Aminoacyl Prodrug Derivatives and Medicaments for the Treatment of Thromboembolitic Disorders 有权氨基酰基前体药物和药物用于治疗血栓栓塞性疾病公开(公告)号：US20110034453A1
公开(公告)日：2011-02-10
申请号：US12224007
申请日：2007-02-06
申请人： Hans-Georg Lerchen , Ursula Krenz , Karl-Heinz Schlemmer , Elisabeth Perzborn , Joerg Keldenich
发明人： Hans-Georg Lerchen , Ursula Krenz , Karl-Heinz Schlemmer , Elisabeth Perzborn , Joerg Keldenich
IPC分类号： A61K31/5377 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本申请涉及5-氯-N - （{（5S）-2-氧代-3- [4-（3-氧代吗啉-4-基）苯基] -1,3-恶唑烷-5-基的前药衍生物 ）甲基）噻吩-2-甲酰胺，其制备方法，它们用于治疗和/或预防疾病的用途，以及它们用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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52.发明申请Aminoacyl prodrug derivatives and medicaments for treatment of thromboembolic disorders 有权氨基酰基前药衍生物和治疗血栓栓塞障碍的药物公开(公告)号：US20100292230A1
公开(公告)日：2010-11-18
申请号：US12438097
申请日：2007-08-23
IPC分类号： A61K31/5377 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本申请涉及5-氯-N - （{（5S）-2-氧代-3- [4-（3-氧代吗啉-4-基）苯基] -1,3-恶唑烷-5-基的前药衍生物 ）甲基）噻吩-2-甲酰胺，其制备方法，它们用于治疗和/或预防疾病的用途，以及它们用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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53.发明申请公开(公告)号：US20100016323A1
公开(公告)日：2010-01-21
申请号：US12569720
申请日：2009-09-29
申请人： Ulrich Niewöhner , Maria Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
发明人： Ulrich Niewöhner , Maria Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
IPC分类号： A61K31/53 , C07D487/04 , A61P15/10
CPC分类号： C07D487/04 , C07F9/6561
摘要： The application claims a compound of the formula or a salt, a hydrate, or a hydrate of a salt thereof. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of erectile dysfunction.
摘要翻译： 本申请要求具有下式的化合物或其盐，水合物或其盐的水合物。 该化合物抑制cGMP代谢磷酸二酯酶，适用于药物中的活性化合物，用于治疗勃起功能障碍。
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![Imidazo[1,3,5]triazinones and their use](/abs-image/US/2006/08/15/US07091203B2/abs.jpg.150x150.jpg)
公开(公告)号：US07091203B2
公开(公告)日：2006-08-15
申请号：US10892984
申请日：2004-07-15
申请人： Ulrich Niewöhner , Helmut Haning , Thomas Lampe , Mazen Es-Sayed , Gunter Schmidt , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn , Karl-Heinz Schlemmer
发明人： Ulrich Niewöhner , Helmut Haning , Thomas Lampe , Mazen Es-Sayed , Gunter Schmidt , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn , Karl-Heinz Schlemmer
IPC分类号： A01N43/66 , A61K31/53 , A61K31/535
CPC分类号： C07D487/04
摘要： The invention relates to imidazo[1,3,5]triazinones, a method for their production and methods of use, in particular as inhibitors of cyclic GMP metabolizing phosphodiesterases.
摘要翻译： 本发明涉及咪唑并[1,3,5]三嗪酮，其制备方法和使用方法，特别是作为环状GMP代谢磷酸二酯酶的抑制剂。
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![Imidazo[1,3,5]triazinones and the use thereof](/abs-image/US/2004/10/12/US06803365B2/abs.jpg.150x150.jpg)
公开(公告)号：US06803365B2
公开(公告)日：2004-10-12
申请号：US10168194
申请日：2002-11-04
申请人： Ulrich Niewöhner , Helmut Haning , Thomas Lampe , Mazen Es-Sayed , Gunter Schmidt , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn , Karl-Heinz Schlemmer
发明人： Ulrich Niewöhner , Helmut Haning , Thomas Lampe , Mazen Es-Sayed , Gunter Schmidt , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn , Karl-Heinz Schlemmer
IPC分类号： C07D48704
CPC分类号： C07D487/04
摘要： The invention relates to imidazo[1.3.5]triazinones, a method for their production and methods of use, in particular as inhibitors of cyclic GMP metabolizing phosphodiesterases.
摘要翻译： 本发明涉及咪唑并[1.3.5]三嗪酮，其制备方法和使用方法，特别是作为环状GMP代谢磷酸二酯酶的抑制剂。
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公开(公告)号：US06476029B1
公开(公告)日：2002-11-05
申请号：US09720051
申请日：2001-03-23
申请人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Gunter Schmidt , Karl-Heinz Schlemmer , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn
发明人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Gunter Schmidt , Karl-Heinz Schlemmer , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn
IPC分类号： C07D48704
CPC分类号： C07D487/04 , C07F9/6561
摘要： The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.
摘要翻译： 本发明涉及7-烷基 - 和环烷基取代的咪唑并三嗪酮，其制备方法和用作药物，特别是作为cGMP代谢磷酸二酯酶的抑制剂。
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57.发明授权Aminoacyl prodrug derivatives and medicaments for the treatment of thromboembolitic disorders 有权用于治疗血栓栓塞性疾病的氨基酰基前药衍生物和药物公开(公告)号：US08334284B2
公开(公告)日：2012-12-18
申请号：US13328532
申请日：2011-12-16
申请人： Hans-Georg Lerchen , Ursula Krenz , Karl-Heinz Schlemmer , Elisabeth Perzborn , Joerg Keldenich
发明人： Hans-Georg Lerchen , Ursula Krenz , Karl-Heinz Schlemmer , Elisabeth Perzborn , Joerg Keldenich
IPC分类号： A61K31/5375
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本申请涉及5-氯-N - （{（5S）-2-氧代-3- [4-（3-氧代吗啉-4-基）苯基] -1,3-恶唑烷-5-基的前药衍生物 ）甲基）噻吩-2-甲酰胺，其制备方法，它们用于治疗和/或预防疾病的用途，以及它们用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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58.发明授权Aminoacyl prodrug derivatives and medicaments for the treatment of thromboembolitic disorders 有权用于治疗血栓栓塞性疾病的氨基酰基前药衍生物和药物公开(公告)号：US08101601B2
公开(公告)日：2012-01-24
申请号：US12224007
申请日：2007-02-06
申请人： Hans-Georg Lerchen , Ursula Krenz , Karl-Heinz Schlemmer , Elisabeth Perzborn , Joerg Keldenich
发明人： Hans-Georg Lerchen , Ursula Krenz , Karl-Heinz Schlemmer , Elisabeth Perzborn , Joerg Keldenich
IPC分类号： A61K31/5377 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-morpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本申请涉及5-氯-N - （{（5S）-2-氧代-3- [4-（3-氧代 - 吗啉-4-基）苯基] -1,3-恶唑烷-5-酮 - 基}甲基）噻吩-2-甲酰胺，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途 。
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59.发明授权公开(公告)号：US07704999B2
公开(公告)日：2010-04-27
申请号：US12004933
申请日：2007-12-21
申请人： Ulrich Niewöhner , Maria Niewöhner, legal representative , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
发明人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
CPC分类号： C07D487/04 , C07F9/6561
摘要： The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
摘要翻译： 通过氯磺化和随后与胺的反应，由相应的2-苯基 - 咪唑并三嗪酮制备在9-位上具有短的非支链烷基的2-苯基取代的咪唑并三嗪酮。 所述化合物抑制cGMP代谢磷酸二酯酶，并且适合用作药物中的活性化合物，用于治疗心血管和脑血管障碍和/或泌尿生殖系统疾病，特别是用于治疗勃起功能障碍。
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60.发明授权公开(公告)号：US07696206B2
公开(公告)日：2010-04-13
申请号：US12569720
申请日：2009-09-29
申请人： Ulrich Niewöhner , Maria Niewöhner, legal representative , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jorg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
发明人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jorg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
IPC分类号： C07D403/12 , A61K31/53 , A61P15/10
CPC分类号： C07D487/04 , C07F9/6561
摘要： The application claims a compound of the formula or a salt, a hydrate, or a hydrate of a salt thereof. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of erectile dysfunction.
摘要翻译： 本申请要求具有下式的化合物或其盐，水合物或其盐的水合物。 该化合物抑制cGMP代谢磷酸二酯酶，适用于药物中的活性化合物，用于治疗勃起功能障碍。
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