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1.发明申请公开(公告)号：US20100016323A1
公开(公告)日：2010-01-21
申请号：US12569720
申请日：2009-09-29
申请人： Ulrich Niewöhner , Maria Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
发明人： Ulrich Niewöhner , Maria Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
IPC分类号： A61K31/53 , C07D487/04 , A61P15/10
CPC分类号： C07D487/04 , C07F9/6561
摘要： The application claims a compound of the formula or a salt, a hydrate, or a hydrate of a salt thereof. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of erectile dysfunction.
摘要翻译： 本申请要求具有下式的化合物或其盐，水合物或其盐的水合物。 该化合物抑制cGMP代谢磷酸二酯酶，适用于药物中的活性化合物，用于治疗勃起功能障碍。
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2.发明授权公开(公告)号：US07704999B2
公开(公告)日：2010-04-27
申请号：US12004933
申请日：2007-12-21
申请人： Ulrich Niewöhner , Maria Niewöhner, legal representative , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
发明人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
CPC分类号： C07D487/04 , C07F9/6561
摘要： The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
摘要翻译： 通过氯磺化和随后与胺的反应，由相应的2-苯基 - 咪唑并三嗪酮制备在9-位上具有短的非支链烷基的2-苯基取代的咪唑并三嗪酮。 所述化合物抑制cGMP代谢磷酸二酯酶，并且适合用作药物中的活性化合物，用于治疗心血管和脑血管障碍和/或泌尿生殖系统疾病，特别是用于治疗勃起功能障碍。
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3.发明申请2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS 审中-公开作为磷酸二酯酶抑制剂的2-苯基取代的咪达唑仑公开(公告)号：US20110009367A1
公开(公告)日：2011-01-13
申请号：US12717443
申请日：2010-03-04
申请人： Ulrich Niewöhner , Maria Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
发明人： Ulrich Niewöhner , Maria Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
IPC分类号： A61K31/53 , C07D487/04 , A61K31/5377 , C07D491/113 , A61K31/683 , A61K31/551 , A61P9/00 , A61P13/00
CPC分类号： C07D487/04 , C07F9/6561
摘要： The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
摘要翻译： 通过氯磺化和随后与胺的反应，由相应的2-苯基 - 咪唑并三嗪酮制备在9-位上具有短的非支链烷基的2-苯基取代的咪唑并三嗪酮。 所述化合物抑制cGMP代谢磷酸二酯酶，并且适合用作药物中的活性化合物，用于治疗心血管和脑血管障碍和/或泌尿生殖系统疾病，特别是用于治疗勃起功能障碍。
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4.发明授权公开(公告)号：US06362178B1
公开(公告)日：2002-03-26
申请号：US09554162
申请日：2000-07-21
申请人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
发明人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
IPC分类号： A01N4362
CPC分类号： C07D487/04 , C07F9/6561
摘要： The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
摘要翻译： 通过氯磺化和随后与胺的反应，由相应的2-苯基 - 咪唑并三嗪酮制备在9-位上具有短的非支链烷基的2-苯基取代的咪唑并三嗪酮。 所述化合物抑制cGMP代谢磷酸二酯酶，并且适合用作药物中的活性化合物，用于治疗心血管和脑血管障碍和/或泌尿生殖系统疾病，特别是用于治疗勃起功能障碍。
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5.发明授权公开(公告)号：US06566360B1
公开(公告)日：2003-05-20
申请号：US09943530
申请日：2001-08-30
申请人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
发明人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Karl-Heinz Schlemmer , Jörg Keldenich , Erwin Bischoff , Elisabeth Perzborn , Klaus Dembowsky , Peter Serno , Marc Nowakowski
IPC分类号： A61P1308
CPC分类号： C07D487/04 , C07F9/6561
摘要： The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
摘要翻译： 通过氯磺化和随后与胺的反应，由相应的2-苯基 - 咪唑并三嗪酮制备在9-位上具有短的非支链烷基的2-苯基取代的咪唑并三嗪酮。 所述化合物抑制cGMP代谢磷酸二酯酶，并且适合用作药物中的活性化合物，用于治疗心血管和脑血管障碍和/或泌尿生殖系统疾病，特别是用于治疗勃起功能障碍。
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![1,5-dihydro-pyrazolo[34-D]-pyrimidinone derivatives](/abs-image/US/2001/01/16/US06174884B1/abs.jpg.150x150.jpg)
公开(公告)号：US06174884B1
公开(公告)日：2001-01-16
申请号：US09367538
申请日：1999-08-16
申请人： Helmut Haning , Ulrich Niewöhner , Ulrich Rosentreter , Thomas Schenke , Jörg Keldenich , Erwin Bischoff , Karl-Heinz Schlemmer , Helmuth Sch{umlaut over (u)}tz , G{umlaut over (u)}nter Thomas
发明人： Helmut Haning , Ulrich Niewöhner , Ulrich Rosentreter , Thomas Schenke , Jörg Keldenich , Erwin Bischoff , Karl-Heinz Schlemmer , Helmuth Sch{umlaut over (u)}tz , G{umlaut over (u)}nter Thomas
IPC分类号： A61K31519
CPC分类号： C07D487/04
摘要： The 1,5-dihydro-pyrazolo[3,4-d]-pyrimidinone derivatives are prepared by fusing the pyrimidone heterocycle with the suitably substituted pyrazoles. The compounds are suitable as active compounds in medicaments, in particular in medicaments for the treatment of cardiovascular and cerebrovascular diseases, diseases of the peripheral blood vessels and diseases of the urogenital tract.
摘要翻译： 1,5-二氢 - 吡唑并[3,4-d]嘧啶酮衍生物是通过将嘧啶酮杂环与适当取代的吡唑进行熔融混合来制备的。 该化合物适合用作药物中的活性化合物，特别是用于治疗心血管和脑血管疾病，外周血管疾病和泌尿生殖道疾病的药物。
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7.发明申请公开(公告)号：US20120088761A1
公开(公告)日：2012-04-12
申请号：US13328532
申请日：2011-12-16
IPC分类号： A61K31/5375 , A61P7/02
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本申请涉及5-氯-N - （{（5S）-2-氧代-3- [4-（3-氧代吗啉-4-基）苯基] -1,3-恶唑烷-5-基的前药衍生物 ）甲基）噻吩-2-甲酰胺，其制备方法，它们用于治疗和/或预防疾病的用途，以及它们用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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8.发明授权Dihydropyridine derivatives for use as human neutrophil elastase inhibitors 失效用作人嗜中性粒细胞弹性蛋白酶抑制剂的二氢吡啶衍生物公开(公告)号：US07691854B2
公开(公告)日：2010-04-06
申请号：US10525867
申请日：2003-08-18
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/44 , C07D213/72 , C07D401/02
CPC分类号： C07D401/04 , C07D211/90 , C07D405/04 , C07D413/04 , C07D417/04
摘要： The invention relates to novel dihydropyridine derivatives, of Formula (I) processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及式（I）的新型二氢吡啶衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。
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9.发明授权Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes 有权嘧啶酮衍生物作为抗急性和慢性炎性，缺血和重塑过程的治疗剂公开(公告)号：US07687510B2
公开(公告)日：2010-03-30
申请号：US10527391
申请日：2003-08-28
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： C07D239/22 , C07D401/04 , A61K31/5377
CPC分类号： C07D239/22 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12
摘要： The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases.
摘要翻译： 本发明涉及新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病。
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10.发明授权1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors 有权1,4-二芳基 - 二氢嘧啶-2-酮及其作为人嗜中性粒细胞弹性蛋白酶抑制剂的用途公开(公告)号：US08101615B2
公开(公告)日：2012-01-24
申请号：US10590770
申请日：2005-02-15
申请人： Heike Gielen-Haertwig , Barbara Albrecht , Jörg Keldenich , Volkhart Li , Josef Pernerstorfer , Karl-Heinz Schlemmer , Leila Telan
发明人： Heike Gielen-Haertwig , Barbara Albrecht , Jörg Keldenich , Volkhart Li , Josef Pernerstorfer , Karl-Heinz Schlemmer , Leila Telan
IPC分类号： C07D239/22 , C07D401/06 , C07D403/12 , A61K31/506
CPC分类号： C07D239/22 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/06 , C07D417/06
摘要： The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及通式（I）的新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗死和心力衰竭发展。
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