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    9H-pyrimido[4,5-B]indoles, 9H-pyrido[4',3':4,5]pyrrolo[2,3-D]pyridines, and 9H 1,3,6,9 tetraaza-fluorenes as CHK1 kinase function inhibitors
    51.
    发明授权
    9H-pyrimido[4,5-B]indoles, 9H-pyrido[4',3':4,5]pyrrolo[2,3-D]pyridines, and 9H 1,3,6,9 tetraaza-fluorenes as CHK1 kinase function inhibitors 有权
    9H-嘧啶并[4,5-B]吲哚，9H-吡啶并[4'，3'：4,5]吡咯并[2,3-D]吡啶，和9H 1,3,6,9四氮杂芴作为CHK1 激酶功能抑制剂

    公开(公告)号：US08618121B2

    公开(公告)日：2013-12-31

    申请号：US12665961

    申请日：2008-07-01

    申请人： Ian Collins ,  John Charles Reader ,  Suki Klair ,  Jane Scanlon ,  Glynn Addison ,  Michael Cherry

    发明人： Ian Collins ,  John Charles Reader ,  Suki Klair ,  Jane Scanlon ,  Glynn Addison ,  Michael Cherry

    IPC分类号： A01N43/54 ,  A61K31/505 ,  C07D239/00 ,  C07D471/00 ,  C07D487/00 ,  C07D491/00

    CPC分类号： C07D471/14 ,  C07D487/04 ,  C07D487/14

    摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain tricyclic compounds (referred to herein as TC compounds), and especially certain 9H-pyrimido[4,5-b]indole, 9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyridine, and 9H-1,3,6,9-tetraaza-fluorene compounds, which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc., optionally in combination with another agent, for example, (a) a DNA topoisomerase I or II inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or TS inhibitor; (d) a microtubule targeted agent; and (e) ionising radiation.

    摘要翻译： 本发明一般涉及治疗化合物领域，更具体地涉及某些三环化合物（本文称为TC化合物），特别是某些9H-嘧啶并[4,5-b]吲哚，9H-吡啶并[4' 3'：4,5]吡咯并[2,3-d]吡啶和9 H-1,3,6,9-四氮杂芴化合物，其特别地抑制检测点激酶1（CHK1）激酶功能。 本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制CHK1激酶功能，以及治疗由CHK1介导的疾病和病症，即 通过抑制CHK1激酶功能等改善，包括增殖条件如癌症等，任选地与另一种试剂组合，例如（a）DNA拓扑异构酶I或II抑制剂; （b）DNA损伤剂; （c）抗代谢物或TS抑制剂; （d）微管靶向剂; 和（e）电离辐射。

    Antibacterial agents
    53.
    发明授权
    Antibacterial agents 有权
    抗菌剂

    公开(公告)号：US08492414B2

    公开(公告)日：2013-07-23

    申请号：US12678767

    申请日：2008-09-22

    申请人： David John Haydon ,  Ian Collins ,  Lloyd George Czaplewski

    发明人： David John Haydon ,  Ian Collins ,  Lloyd George Czaplewski

    IPC分类号： A61K31/41

    CPC分类号： C07D285/08

    摘要： Compounds of formula (IA) or (IB) have antibacterial activity: wherein W is ═CH— or ═N—; Ri and R2 are independently selected from hydrogen, fluoro and chloro, provided that Ri and R2 are not each hydrogen when W is ═CH—; n is 0 or 1; X is —O—, —S—, or —CH2—; and Q is (i) a phenyl radical, a naphthyl radical, a monocyclic carbocyclic or heteroaryl radical having 3 to 6 ring atoms, or a bicyclic heteroaryl radical having 5 to 10 ring atoms, any of which radicals being optionally substituted; or (ii) an optionally substituted C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl radical, which may optionally be interrupted by —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, —N(CH2CH3)—, —C—K═Oh or —C(═O)—O—.

    摘要翻译： 式（IA）或（IB）的化合物具有抗菌活性：其中W为= CH-或= N-; R 1和R 2独立地选自氢，氟和氯，条件是当W = CH-时，R 1和R 2不是氢。 n为0或1; X是-O - ， - S-或-CH 2 - ; Q为（i）具有3〜6个环原子的苯基，萘基，单环碳环或杂芳基，或环原子数为5〜10的双环杂芳基，其中任意一个为任选被取代的基团; 或（ⅱ）任选被-O - ， - S - ， - S（O） - ， - S（O 2））间隔的任选取代的C 1 -C 6烷基，C 2 -C 6烯基或C 2 -C 6炔基， - ， - NH - ， - N（CH 3） - ， - N（CH 2 CH 3） - ， - K = O或-C（= O）-O-。

    Automatic connection to an online service provider from a backup system
    55.
    发明授权
    Automatic connection to an online service provider from a backup system 有权
    从备份系统自动连接到在线服务提供商

    公开(公告)号：US08050905B2

    公开(公告)日：2011-11-01

    申请号：US12917335

    申请日：2010-11-01

    申请人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li

    发明人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li

    IPC分类号： G06F9/455 ,  G06F3/00 ,  G06F5/00 ,  G06F13/12 ,  G06F13/38

    CPC分类号： G06F11/1456 ,  G06F11/1451 ,  G06F11/1458 ,  G06F11/1461 ,  G07F17/0014

    摘要： A software application is provided for a user to select a backed up data file and specify a task to be performed by an online service provider on the selected file. The application automatically connects to the online service provider and uploads the selected file for the online service provider to perform the task. Tasks that can be performed include printing, sharing, viewing, playing and archiving the selected file. Task preferences, user settings and user information can also be specified by the user and uploaded to the online service provider. Automatic connection to the online service provider can be via default setting, selected file type, or specified task. Alternatively, the user can designate which service provider is to perform the task. Payment for the task can be accomplished via bundled credits or by other payment mechanisms.

    摘要翻译： 提供软件应用程序供用户选择备份的数据文件，并指定由所选文件上的在线服务提供商执行的任务。 应用程序自动连接到在线服务提供商，并上传所选文件以供在线服务提供商执行任务。 可执行的任务包括打印，共享，查看，播放和归档所选文件。 任务首选项，用户设置和用户信息也可以由用户指定并上传到在线服务提供商。 可以通过默认设置，选定的文件类型或指定的任务自动连接到在线服务提供商。 或者，用户可以指定哪个服务提供者要执行任务。 任务的付款可以通过捆绑信用或其他支付机制来完成。

    Data Backup Devices and Methods for Backing Up Data
    56.
    发明申请
    Data Backup Devices and Methods for Backing Up Data 审中-公开
    用于备份数据的数据备份设备和方法

    公开(公告)号：US20110004459A1

    公开(公告)日：2011-01-06

    申请号：US12881603

    申请日：2010-09-14

    申请人： Ian Collins ,  Eric Li ,  Yousuf Chowdhary ,  Jeffrey Brunet

    发明人： Ian Collins ,  Eric Li ,  Yousuf Chowdhary ,  Jeffrey Brunet

    IPC分类号： G06F9/455 ,  G06F17/00

    CPC分类号： G06F3/065 ,  G06F3/0605 ,  G06F3/0632 ,  G06F3/0676 ,  G06F3/0677 ,  G06F3/0679 ,  G06F11/1451 ,  G06F11/1456 ,  G06F11/1461

    摘要： A data backup system comprises an emulation component and a storage device having logical storage areas. The emulation component is configured to represent a first logical storage area of the storage device, such as a solid state memory or a disk drive partition, as if it were an auto-launch device. Accordingly, a data source, such as a personal computer, will interact with the first logical storage area as if it were the auto-launch device. As some operating systems are configured to recognize auto-launch devices upon connection and automatically execute applications stored thereon, merely connecting the data backup system to a data source running such an operating system can cause a backup application stored by the first logical storage area to automatically execute on the data source to selectively back up data to a second logical storage area of the storage device.

    摘要翻译： 数据备份系统包括具有逻辑存储区域的仿真部件和存储装置。 仿真部件被配置为表示诸如固态存储器或磁盘驱动器分区之类的存储设备的第一逻辑存储区域，如同它是自动发射设备。 因此，诸如个人计算机的数据源将与第一逻辑存储区域交互，如同它是自动发射设备。 由于一些操作系统被配置为在连接时识别自动发射设备并且自动执行存储在其上的应用，仅将数据备份系统连接到运行这样的操作系统的数据源可以使由第一逻辑存储区域存储的备份应用自动地 在数据源上执行选择性地将数据备份到存储设备的第二逻辑存储区域。

    BICYCLYLARYL-ARYL-AMINE COMPOUNDS AND THEIR USE
    57.
    发明申请
    BICYCLYLARYL-ARYL-AMINE COMPOUNDS AND THEIR USE 有权
    双氰胺 - 氨基化合物及其用途

    公开(公告)号：US20100331328A1

    公开(公告)日：2010-12-30

    申请号：US12918266

    申请日：2009-02-19

    申请人： Ian Collins ,  John Charles Reader ,  David Hugh Williams ,  Sukhbinder Singh Klair ,  Jane Elizabeth Scanlon ,  Nelly Piton ,  Michael Cherry

    发明人： Ian Collins ,  John Charles Reader ,  David Hugh Williams ,  Sukhbinder Singh Klair ,  Jane Elizabeth Scanlon ,  Nelly Piton ,  Michael Cherry

    IPC分类号： A61K31/5377 ,  C07D487/04 ,  A61K31/497 ,  A61P35/00 ,  C12N5/00 ,  C07D241/26 ,  A61K31/4965 ,  C07D413/12

    CPC分类号： C07D471/04

    摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain bicyclylaryl-aryl-amines compounds of the following formula (referred to herein as BCAA compounds), which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc., optionally in combination with another agent, for example, (a) a DNA topoisomerase I or II inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or TS inhibitor; (d) a microtubule targeted agent; and (e) ionising radiation:

    摘要翻译： 本发明一般涉及治疗化合物领域，更具体地涉及下列通式的某些双环芳基 - 芳基胺化合物（本文称为BCAA化合物），其特别地抑制检测点激酶1（CHK1）激酶功能 。 本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制CHK1激酶功能，以及治疗由CHK1介导的疾病和病症，即 通过抑制CHK1激酶功能等改善，包括增殖条件如癌症等，任选地与另一种试剂组合，例如（a）DNA拓扑异构酶I或II抑制剂; （b）DNA损伤剂; （c）抗代谢物或TS抑制剂; （d）微管靶向剂; 和（e）电离辐射：

    SUBSTITUTED BENAMIDINES AS ANTIBACTERIAL AGENTS
    58.
    发明申请
    SUBSTITUTED BENAMIDINES AS ANTIBACTERIAL AGENTS 有权

    公开(公告)号：US20100298388A1

    公开(公告)日：2010-11-25

    申请号：US12679334

    申请日：2008-09-22

    申请人： David John Haydon ,  Ian Collins ,  Lloyd George Czaplewski

    发明人： David John Haydon ,  Ian Collins ,  Lloyd George Czaplewski

    IPC分类号： A61K31/4245 ,  A61K31/433 ,  A61K31/428 ,  A61K31/427 ,  C07D285/08 ,  C07D413/12 ,  C07D277/64 ,  C07D413/04 ,  A01N43/78 ,  A01N43/836 ,  A01P1/00 ,  A61P31/04

    CPC分类号： C07D277/34 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/429 ,  A61K31/433 ,  C07D271/07 ,  C07D277/64 ,  C07D285/08 ,  C07D417/12

    摘要： Compounds of formula (IA) or (IB) have antibacterial activity: wherein W is ═C(H)— or ═N—; R3 is a radical of formula -(Alk1)m-(Z1)p-(Alk2)n-Q wherein m, p and n are independently 0 or 1, provided that at least one of m, p and n is 1, Z1 is —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, —N(CH2CH3)—, —C(—O)—, —O—(C═O)—, —C(═O)—O—, or an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted divalent bicyclic carbocyclic or heterocyclic radical having 5 to 10 ring atoms; Alk1 and Alk2 are optionally substituted C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radicals, which may optionally terminate with or be interrupted by —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, Or —N(CH2CH3)—; and Q is hydrogen, halogen, nitrile, or hydroxyl, or an optionally substituted monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted bicyclic carbocyclic or heterocyclic radical having 5 to 10 ring atoms; R4 and R5 are optional substituents; and R2, R6 and R7 are independently hydrogen or a radical of formula -(Alk3)x-(Z2)y-(Alk4)z-H wherein x, y and z are independently 0 or 1, Z2 is —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, —N(CH2CH3)—, —C(—O)—, —O—(C═O)— or —C(═O)—O—; Alk3 and Alk4 are optionally substituted C1-C3 alkylene, C2-C3 alkenylene, or C2-C3 alkynylene radicals, which may optionally terminate with or be interrupted by —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, or —N(CH2CH3)—.

    Emulation component for data backup applications
    59.
    发明授权
    Emulation component for data backup applications 有权
    用于数据备份应用程序的仿真组件

    公开(公告)号：US07813913B2

    公开(公告)日：2010-10-12

    申请号：US11492380

    申请日：2006-07-24

    申请人： Ian Collins ,  Eric Li ,  Yousuf Chowdhary ,  Jeffrey Brunet

    发明人： Ian Collins ,  Eric Li ,  Yousuf Chowdhary ,  Jeffrey Brunet

    IPC分类号： G06F9/455 ,  G06F9/00 ,  G06F13/12

    CPC分类号： G06F3/065 ,  G06F3/0605 ,  G06F3/0632 ,  G06F3/0676 ,  G06F3/0677 ,  G06F11/1451 ,  G06F11/1458 ,  G06F11/1461

    摘要： An emulation component for a data backup system is provided. The emulation component represents a storage device, such as a flash memory device or a partition of a disk drive, as if it were an auto-launch device, that will trigger applications to execute automatically. Accordingly, other computing systems, such as personal computers, interact with the storage device, through the emulation component, as if the storage device were the auto-launch device. Because the emulation component makes this representation, merely connecting the emulation component between the storage device and the computing system can cause a backup application stored on the storage device to automatically execute on the computing system. A data backup appliance including an emulation component and a storage device is also provided. The backup system can also include an interface for connecting another removable device, such as a disk drive, for storing backup content from the data source.

    摘要翻译： 提供了一种用于数据备份系统的仿真组件。 仿真组件表示存储设备，例如闪存设备或磁盘驱动器的分区，就像它是自动启动设备一样，将触发应用程序自动执行。 因此，诸如个人计算机的其他计算系统通过仿真组件与存储设备交互，就像存储设备是自动发射设备一样。 由于仿真组件做出这种表示，只需将存储设备和计算系统之间的仿真组件连接起来，就能够使存储在存储设备上的备份应用程序在计算系统上自动执行。 还提供了包括仿真组件和存储设备的数据备份设备。 备份系统还可以包括用于连接另一个可移动设备（如磁盘驱动器）的接口，用于从数据源存储备份内容。