公开(公告)号：US20120178715A1

公开(公告)日：2012-07-12

申请号：US13393767

申请日：2010-09-03

Applicant: Steven W. Andrews ,  Kevin Ronald Condroski ,  Lisa A. De Meese ,  Jay Bradford Fell ,  John P. Fischer ,  John A. Josey ,  Kevin Koch ,  Yvan Le Huerou ,  Gregory F. Miknis ,  Martha E. Rodriguez ,  George T. Topalov ,  Eli M. Wallace ,  Rui Xu

Inventor： Steven W. Andrews ,  Kevin Ronald Condroski ,  Lisa A. De Meese ,  Jay Bradford Fell ,  John P. Fischer ,  John A. Josey ,  Kevin Koch ,  Yvan Le Huerou ,  Gregory F. Miknis ,  Martha E. Rodriguez ,  George T. Topalov ,  Eli M. Wallace ,  Rui Xu

IPC: A61K31/519 ,  A61K31/5377 ,  A61P35/00 ,  A61K31/5386 ,  A61K31/675 ,  C07D487/04 ,  C07D498/08

CPC classification number: C07D487/04

Abstract: Compounds of Formula I: and salts thereof in which R1, R2, R2a, R3, n, X and ring B have the meanings given in the specification, are inhibitors of mTOR and are useful in the treatment of diseases which are sensitive to inhibition of mTOR, such as cancers.

Abstract translation: 式I化合物及其盐，其中R 1，R 2，R 2a，R 3，n，X和环B具有本说明书中给出的含义，是mTOR的抑制剂，可用于治疗对抑制作用敏感的疾病 mTOR，如癌症。

公开(公告)号：US20110245230A1

公开(公告)日：2011-10-06

申请号：US13160351

申请日：2011-06-14

Applicant: Ian S. Mitchell ,  James F. Blake ,  Rui Xu ,  Nicholas C. Kallan ,  Dengming Xiao ,  Keith Lee Spencer ,  Josef R. Bencsik ,  Eli M. Wallace ,  Stephen T. Schlachter ,  Anna L. Banka ,  Jun Liang ,  Brian Safina ,  Jun Li ,  Christine Chabot

Inventor： Ian S. Mitchell ,  James F. Blake ,  Rui Xu ,  Nicholas C. Kallan ,  Dengming Xiao ,  Keith Lee Spencer ,  Josef R. Bencsik ,  Eli M. Wallace ,  Stephen T. Schlachter ,  Anna L. Banka ,  Jun Liang ,  Brian Safina ,  Jun Li ,  Christine Chabot

IPC: A61K31/397 ,  A61K31/497 ,  A61K31/5377 ,  A61P29/00 ,  A61P35/00 ,  A61P19/02 ,  A61P25/00 ,  A61P1/00 ,  A61P3/04 ,  A61P25/28 ,  A61P11/00 ,  A61P31/00 ,  A61P25/16 ,  A61P37/06

CPC classification number: C07D409/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  C07D239/70 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12

Abstract: The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

公开(公告)号：US08003651B2

公开(公告)日：2011-08-23

申请号：US11773946

申请日：2007-07-05

Applicant: Ian S. Mitchell ,  James F. Blake ,  Rui Xu ,  Nicholas C. Kallan ,  Dengming Xiao ,  Keith Lee Spencer ,  Josef R. Bencsik ,  Eli M. Wallace ,  Stephen T. Schlachter ,  Anna L. Banka ,  Jun Liang ,  Brian Safina ,  Jun Li ,  Christine Chabot

Inventor： Ian S. Mitchell ,  James F. Blake ,  Rui Xu ,  Nicholas C. Kallan ,  Dengming Xiao ,  Keith Lee Spencer ,  Josef R. Bencsik ,  Eli M. Wallace ,  Stephen T. Schlachter ,  Anna L. Banka ,  Jun Liang ,  Brian Safina ,  Jun Li ,  Christine Chabot

IPC: C07D239/70 ,  A61K31/497 ,  A61P35/00 ,  A61P29/00 ,  A61P25/28 ,  A61P9/00

CPC classification number: C07D409/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  C07D239/70 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12

Abstract: The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Abstract translation: 本发明提供了式I化合物，包括互变异构体，拆分的对映异构体，非对映异构体，溶剂合物，代谢物，盐和药学上可接受的前药。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

公开(公告)号：US20100285370A1

公开(公告)日：2010-11-11

申请号：US12775158

申请日：2010-05-06

Applicant: Heng-Tao Xia ,  Feng-Gang Zhao ,  Rui Xu ,  Kai-Gui Cai ,  Kun-qing Zhu ,  Wei Chen ,  Yu-qun Zeng

Inventor： Heng-Tao Xia ,  Feng-Gang Zhao ,  Rui Xu ,  Kai-Gui Cai ,  Kun-qing Zhu ,  Wei Chen ,  Yu-qun Zeng

IPC: H01M2/16

CPC classification number: H01M10/052 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/70 ,  H01M10/613 ,  H01M10/647 ,  H01M10/654

Abstract: An electrode group for use in lithium ion batteries includes an anode plate, a cathode plate and a separator disposed between the anode plate and the cathode plate. The anode plate includes an anode current collector and an anode film containing anode active material formed on the anode current collector. The cathode plate includes a cathode current collector and a cathode film containing cathode active material formed on the cathode current collector. The anode current collector is formed with a number of anode extending portions extending along a width direction thereof and the anode extending portions are coupled together to form an anode lead. The cathode current collector is formed with a number of cathode extending portions extending along a width direction thereof and the cathode extending portions are coupled together to form a cathode lead.

Abstract translation: 用于锂离子电池的电极组包括阳极板，阴极板和布置在阳极板和阴极板之间的隔膜。 阳极板包括负极集电体和阳极膜，阳极膜含有在阳极集电体上形成的负极活性物质。 阴极板包括阴极集电体和形成在阴极集电体上的阴极活性物质阴极膜。 阳极集电器形成有沿着其宽度方向延伸的多个阳极延伸部分，并且阳极延伸部分耦合在一起以形成阳极引线。 阴极集电器形成有沿着其宽度方向延伸的多个阴极延伸部分，并且阴极延伸部分耦合在一起以形成阴极引线。

公开(公告)号：US20060269373A1

公开(公告)日：2006-11-30

申请号：US11462574

申请日：2006-08-04

Applicant: Rod Duncan ,  Joel Witt ,  Mark Quadling ,  Henley Quadling ,  Jeffrey Prince ,  Branko Bem ,  Rui Xu ,  Kirk Ray ,  Basil Haymann ,  Anthony Starfield

Inventor： Rod Duncan ,  Joel Witt ,  Mark Quadling ,  Henley Quadling ,  Jeffrey Prince ,  Branko Bem ,  Rui Xu ,  Kirk Ray ,  Basil Haymann ,  Anthony Starfield

IPC: B23Q1/28

CPC classification number: A61C13/0009 ,  A61C13/0004 ,  Y10T409/30 ,  Y10T409/301792 ,  Y10T409/303976 ,  Y10T483/1733

Abstract: The improved milling machine makes use of individually controlled x-axis, y-axis, and z-axis carriages. These carriages provide positive and precise control of the position of the cutting tools and the blank to be cut. A tool changer allows the tools to be changed to accommodate other materials. A camera is used to detect wear on the tools.

Abstract translation: 改进的铣床使用单独控制的x轴，y轴和z轴支架。 这些托架可以对切割工具和要切割的坯料的位置提供正确和精确的控制。 刀具更换器允许更换工具以适应其他材料。 相机用于检测工具上的磨损。

公开(公告)号：US20060035775A1

公开(公告)日：2006-02-16

申请号：US10917069

申请日：2004-08-12

Applicant: Rod Duncan ,  Joel Witt ,  Mark Quadling ,  Henley Quadling ,  Jeffrey Prince ,  Branko Bem ,  Rui Xu ,  Kirk Ray ,  Basil Haymann ,  Anthony Starfield

Inventor： Rod Duncan ,  Joel Witt ,  Mark Quadling ,  Henley Quadling ,  Jeffrey Prince ,  Branko Bem ,  Rui Xu ,  Kirk Ray ,  Basil Haymann ,  Anthony Starfield

IPC: B23Q3/157 ,  B23C1/16

CPC classification number: A61C13/0009 ,  A61C13/0004 ,  Y10T409/30 ,  Y10T409/301792 ,  Y10T409/303976 ,  Y10T483/1733

Abstract: The improved milling machine makes use of individually controlled x-axis, y-axis, and z-axis carriages. These carriages provide positive and precise control of the position of the cutting tools and the blank to be cut. A tool changer allows the tools to be changed to accommodate other materials. A camera is used to detect wear on the tools.

Abstract translation: 改进的铣床使用单独控制的x轴，y轴和z轴支架。 这些托架可以对切割工具和要切割的坯料的位置提供正确和精确的控制。 刀具更换器允许更换工具以适应其他材料。 相机用于检测工具上的磨损。