公开(公告)号：US20220017491A1

公开(公告)日：2022-01-20

申请号：US17292699

申请日：2019-11-08

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Hwan Jung LIM ,  Seong Jun PARK ,  Chang Hoon LEE ,  Kyoung Tai NO ,  Jiwon CHOI ,  Hei-Cheul JEUNG ,  You-keun SHIN ,  Jong Wan KIM ,  Xuemei JIN

IPC: C07D401/14 ,  C07D401/12 ,  C07D409/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to a compound which inhibits the binding of Yes associated protein (YAP) and transcriptional enhancer associate domain (TEAD), a prodrug of same, a hydrate of same, a solvate of same or a pharmaceutically acceptable salt of same, and a composition comprising same as an active ingredient, the compound according to the present invention being able to be applied as an inhibitor which can directly inhibit YAP-TEAD binding in the Hippo pathway which plays a crucial role in the occurrence of cancer.

公开(公告)号：US20210388313A1

公开(公告)日：2021-12-16

申请号：US17283516

申请日：2019-11-12

Applicant: Korea Research Institute of Chemical Technology

Inventor： Sun Woong Kang ,  Hye Eun Shim

IPC: C12N5/00 ,  G01N33/50

Abstract: The present invention relates to an organoid and, more specifically, to an organoid and a use thereof, the organoid being produced using a carrier for cell culture which comprises microcapsules containing gelatin, a natural polymer, an oil, and an oil thickener. When used as a carrier for cell culture in culturing cells, the microcapsules containing a natural oil, according to the present invention, have the effects of improving adhesion and survival of the cells and inducing maturation of the cultured cells. The organoid produced by culturing cells using the carrier for cell culture has been confirmed to have the function of the organ concerned and, when treated with a drug, react to the toxicity of the drug and thus may be variously employed in the development of new drugs, disease research, and the field of artificial organ development.

公开(公告)号：US20210378286A1

公开(公告)日：2021-12-09

申请号：US17338206

申请日：2021-06-03

Applicant: Korea Research Institute of Chemical Technology

Inventor： Yong-Hyun Kim ,  Sung-Hwan Kim ,  Min-Seok Kim

IPC: A24C5/34 ,  G01N1/24 ,  G01N1/22

Abstract: The techniques disclosed in the present specification relate to devices, systems, and methods using the same that generate cigarette smoke and then separate and collect substances of the cigarette smoke generated into particulate and gaseous substances for the preparation of a whole cigarette smoke condensate, which may comprise: a cigarette mount on which one or more cigarettes are mounted; an automatic ignition device for igniting the one or more cigarettes; a cigarette smoke collection unit for collecting substances of cigarette smoke generated from the ignited one or more cigarettes; one or more cigarette smoke intake lines configured to suck the cigarette smoke; one or more cigarette smoke exhaust lines configured to discharge the cigarette smoke; and one or more collection unit connecting lines connected to the cigarette smoke collection unit.

公开(公告)号：US11177403B2

公开(公告)日：2021-11-16

申请号：US16627123

申请日：2018-06-29

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Jaemin Lee ,  Hye Jin Na ,  Nam Joong Jeon ,  Tae Youl Yang ,  Jang Won Seo

IPC: H01L31/0256 ,  H01L51/00 ,  H01L51/42 ,  H01L51/44

Abstract: A perovskite solar cell adopts a compound having a specific central backbone having a carbazolylamino group as a substituent, and more particularly, to the perovskite solar cell adopts a compound, as a hole transport material, having a specific central backbone having a carbazolylamino group as a substituent, and a spirobifluorene compound having a carbazolylphenylamino group. The perovskite solar cell has very excellent high-temperature stability while having a high power generation efficiency.

公开(公告)号：US11168108B2

公开(公告)日：2021-11-09

申请号：US16473365

申请日：2018-08-03

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Ki-Suk Kim ,  Sun Hyun Park ,  Dae-hwan Nam

IPC: C07J41/00 ,  A61L27/36 ,  G01N33/483

Abstract: The present invention provides a composition for adjusting biological tissue size and a method for adjusting the size of biological tissue using the said composition. The composition for adjusting the size of biological tissue according to the present invention can adjust the size of biological tissue according to the specifications of a microscope and the needs of a researcher, and can be used as a mounting solution to easily acquire an image of the biological tissue. Therefore, the composition can be usefully used to reveal the causes of and find treatment methods for various disorders.

公开(公告)号：US20210338784A1

公开(公告)日：2021-11-04

申请号：US17081853

申请日：2020-10-27

Applicant: Korea Research Institute of Chemical Technology

Inventor： Sun-Hyun PARK ,  Ki-Suk KIM ,  Jae-Meun LEE ,  Jae-Hyeok LEE

IPC: A61K38/48 ,  A61K31/235 ,  A61K8/66 ,  A61K8/37 ,  A61K47/62 ,  A61K47/54 ,  A61K47/26 ,  A61Q19/08

Abstract: The present invention relates to a botulinum toxin pharmaceutical composition comprising tannic acid as an active ingredient. The botulinum toxin pharmaceutical composition comprising tannic acid provided in one aspect of the present invention improves the activity of the botulinum neurotoxin itself, allows the botulinum neurotoxin to stay in the injected place, and prevents the botulinum neurotoxin from spreading to the blood due to the properties of tannic acid. Therefore, the composition of the present invention has an effect of minimizing the side effects of the conventional Botox caused by the spread of the botulinum neurotoxin.

公开(公告)号：US20210324471A1

公开(公告)日：2021-10-21

申请号：US17006889

申请日：2020-08-30

Applicant: Korea Research Institute of Chemical Technology

Inventor： Jieon LEE ,  Woo-keun KIM ,  Seokjoo YOON

IPC: C12Q1/6883

Abstract: The present invention provides a complex of LNA probe and graphene oxide, and a nucleic acid detection method using the same. In the present invention, LNA-containing molecular beacon is conjugated through covalent bonding with graphene oxide, a single strand of the molecular beacon binds to a target nucleic acid to form a complex, and the complex is separated from graphene oxide to induce a fluorescence signal. The molecular beacon and graphene oxide can be covalently bonded to minimize non-specific signals, and a LNA-added molecular beacon is designed in a double strand to detect a very low concentration of target nucleic acid with high sensitivity, as well as a fluorescent signal, and the multiple target nucleic acids can be detected simultaneously through diversification of the fluorescent signal to enable easy and accurate detection of a nucleic acid biomarker whose specific expression level is specifically changed according to diseases and disease progression.

公开(公告)号：US20210323947A1

公开(公告)日：2021-10-21

申请号：US17235120

申请日：2021-04-20

Applicant: Novartis AG ,  Katholieke Universiteit Leuven ,  Korea Research Institute of Chemical Technology

Inventor： Johan NEYTS ,  Daniel POON ,  Keith Bruce PFISTER

IPC: C07D405/12 ,  C07D405/14 ,  C07D307/93 ,  A61K45/06 ,  A61P31/14

Abstract: The invention provides compounds of Formula (I): as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

公开(公告)号：US20210315879A1

公开(公告)日：2021-10-14

申请号：US16321631

申请日：2017-07-27

Applicant: NATIONAL CANCER CENTER ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kyung Chae JEONG ,  Hwan Jung LIM ,  Seong Jun PARK ,  Ho Kyung SEO ,  Kyung Ohk AHN ,  Sang Jin LEE ,  Eun Sook LEE

IPC: A61K31/47 ,  A61K31/4709 ,  A61P35/00

Abstract: Provided is a method for treating or preventing cancer, containing, as an active ingredient, a compound having a specific chemical structure and an activity of inhibiting the formation of a c-Myc/Max/DNA complex, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11110061B2

公开(公告)日：2021-09-07

申请号：US16760995

申请日：2018-11-01

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  KOREA PHARMA CO., LTD.

Inventor： Byung Chul Shin ,  Sun Hang Cho ,  Tae Kyung Yang ,  Seok Hee Kang ,  Eun Hee Park

IPC: A61K9/16 ,  A61K31/343 ,  A61K9/00

Abstract: The present invention relates to a biodegradable polymer microsphere-containing sustained-release injection containing escitalopram as an active ingredient, and to a method for manufacturing the same. In the case of escitalopram microspheres, there is a problem of low encapsulation rate, fracture due to weak strength, and initial over-release due to the phase separation of the liquid drug and the polymer inside the microspheres. In order to solve the problem, it is possible to maximize the encapsulation amount and the encapsulation efficiency of the escitalopram adding a hydrophobic solidifying agent to uniformize the non-uniform phase, to overcome the cracking of the microspheres at high loading conditions, and to properly control the initial release and release delay of the microspheres.