公开(公告)号：US12234519B2

公开(公告)日：2025-02-25

申请号：US18339400

申请日：2023-06-22

Applicant: TORAY INDUSTRIES, INC. ,  NATIONAL CANCER CENTER

Inventor： Makiko Yoshimoto ,  Hiroko Sudo ,  Satoko Kozono ,  Junpei Kawauchi ,  Takahiro Ochiya ,  Hiroyuki Fujimoto ,  Wataru Usuba ,  Juntaro Matsuzaki

IPC: C12Q1/6886

Abstract: An embodiment according to the present invention provides a kit or device for detection of bladder cancer, and a method for detecting bladder cancer. An embodiment according to the present invention relates to: a kit or device for detection of bladder cancer, including a nucleic acid(s) capable of specifically binding to an miRNA(s) or a complementary strand(s) thereof in a sample from a subject; and a method for detecting bladder cancer, including measuring the miRNA(s) in vitro.

公开(公告)号：US12174174B2

公开(公告)日：2024-12-24

申请号：US17285710

申请日：2018-12-06

Applicant: NATIONAL CANCER CENTER

Inventor： Hyonchol Jang ,  Dong Keon Kim

IPC: G01N33/50 ,  C07K14/47 ,  G01N33/68

Abstract: The present invention relates to a composition for repressing the sternness of stem cells, which comprises a material for regulating OCT4 modification. The material for regulating OCT4 modification according to the present invention may regulate the phosphorylation or methylation of OCT4 and inhibit Wnt signaling, thereby effectively reducing the sternness of various stem cells. Therefore, since it can be effectively used in inhibition of proliferation, recurrence and metastasis of cancer, and inhibition of resistance to an anticancer agent, and can reduce sternness even in normal stem cells, it is expected that the time for differentiation of embryonic stem cells into specific cells is shortened, and efficiency is increased.

公开(公告)号：US12157919B2

公开(公告)日：2024-12-03

申请号：US18361440

申请日：2023-07-28

Applicant: TORAY INDUSTRIES, INC. ,  NATIONAL CANCER CENTER

Inventor： Junpei Kawauchi ,  Hitoshi Nobumasa ,  Satoko Kozono ,  Satoshi Kondou ,  Hiroko Sudo ,  Atsushi Ochiai ,  Motohiro Kojima

IPC: C12Q1/68 ,  C12N15/09 ,  C12P19/34 ,  C12Q1/6886 ,  G01N33/53 ,  G01N33/566 ,  G01N37/00

Abstract: The present invention provides a kit or device for the detection of biliary tract cancer, and a method for detecting biliary tract cancer. The present invention relates to a kit or device for the detection of biliary tract cancer, comprising a nucleic acid capable of specifically binding to miRNA in a sample of a subject, and a method for detecting biliary tract cancer, comprising measuring the miRNA in vitro.

公开(公告)号：US20240350542A1

公开(公告)日：2024-10-24

申请号：US18622113

申请日：2024-03-29

Applicant: NATIONAL CANCER CENTER ,  Eutilex Co., Ltd.

Inventor： Beom Kyu CHOI ,  Seon Hee Kim ,  Byoung Se Kwon ,  Young Ho Kim

IPC: A61K35/17 ,  A61K31/675 ,  A61K31/7076 ,  A61K38/20 ,  A61P35/00 ,  C07K16/28

CPC classification number: A61K35/17 ,  A61K31/675 ,  A61K31/7076 ,  A61K38/2013 ,  A61P35/00 ,  C07K16/2812

Abstract: The present invention relates to an anticancer T cell therapy product-assisting composition comprising a depleting anti-CD4 monoclonal antibody and a use thereof. Accordingly, the composition comprising a depleting anti-CD4 monoclonal antibody according to the present invention is able to maximize the anticancer effect of a cancer antigen-specific anticancer T cell therapy product by maintaining an immunodeficient state and is thus effective. In addition, when administered twice or more times at regular intervals of 5 to 8 days, the composition exhibits a far superior effect.

公开(公告)号：US12117462B2

公开(公告)日：2024-10-15

申请号：US17977377

申请日：2022-10-31

Applicant: TORAY INDUSTRIES, INC. ,  NATIONAL CANCER CENTER

Inventor： Hiroko Sudo ,  Hitoshi Nobumasa ,  Satoko Kozono ,  Satoshi Kondou ,  Junpei Kawauchi ,  Atsushi Ochiai ,  Motohiro Kojima

IPC: C12Q1/68 ,  C12M1/00 ,  C12N15/09 ,  C12P19/34 ,  G01N37/00

CPC classification number: G01N37/00 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: It is intended to provide a kit or a device for the detection of lung cancer and a method for detecting lung cancer. The present invention provides a kit or a device for the detection of lung cancer, comprising a nucleic acid capable of specifically binding to a miRNA in a sample from a subject, and a method for detecting lung cancer, comprising measuring the miRNA in vitro.

公开(公告)号：US12106847B2

公开(公告)日：2024-10-01

申请号：US17381200

申请日：2021-07-21

Applicant: NATIONAL CANCER CENTER ,  FUJIFILM Corporation

Inventor： Kazuma Kobayashi ,  Mototaka Miyake ,  Ryuji Hamamoto

IPC: G16H30/40 ,  G06F3/0486 ,  G16H30/20 ,  G16H50/20

CPC classification number: G16H30/40 ,  G06F3/0486 ,  G16H30/20 ,  G16H50/20

Abstract: An annotation support apparatus manages a medical image on the basis of an attribute of each medical image, using a hierarchical structure that has one medical image as a node and includes a medical image hierarchy to which a node of the medical image belongs and at least one of an upper hierarchy higher than the medical image hierarchy or a lower hierarchy lower than the medical image hierarchy. The annotation support apparatus includes: an image acquisition unit that acquires the medical image; a display unit; an annotation input receiving unit that receives designation of any one of the node of the medical image or a node associated with the node of the medical image in the hierarchical structure and an input of annotation information related to the designated node; and an annotation storage unit that stores the annotation information to be associated with the designated node.

公开(公告)号：US12098430B2

公开(公告)日：2024-09-24

申请号：US17743790

申请日：2022-05-13

Applicant: TORAY INDUSTRIES, INC. ,  NATIONAL CANCER CENTER

Inventor： Junpei Kawauchi ,  Hiroko Sudo ,  Satoko Kozono ,  Atsushi Ochiai ,  Motohiro Kojima

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: This application provides a kit or a device for the detection of early pancreatic cancer or a pancreatic cancer precursor lesion, comprising a nucleic acid(s) capable of specifically binding to a miRNA(s) in a sample from a subject, and a method for detecting early pancreatic cancer or a pancreatic cancer precursor lesion, comprising measuring an expression level(s) of the miRNA(s) in vitro.

公开(公告)号：US20240294671A1

公开(公告)日：2024-09-05

申请号：US18043469

申请日：2020-09-28

Applicant: NATIONAL CANCER CENTER ,  JP BIO A INC. ,  KOOKMIN UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION

Inventor： Yun Hee KIM ,  Kyun HEO ,  In Hoo KIM ,  Sun Il CHOI

IPC: C07K16/44

CPC classification number: C07K16/44 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/92

Abstract: The present invention relates to humanized antibodies having good binding ability to digoxigenin and uses thereof. When an antibody or antigen-binding fragment thereof specifically recognizing digoxigenin according to one aspect of the present invention is used, the concentration of the drug in the body is adjusted as needed through a complex (DOligobody) containing the same, or the concentration of the drug in vivo It is expected that the half-life can be increased.

公开(公告)号：US12077599B2

公开(公告)日：2024-09-03

申请号：US16767245

申请日：2018-03-06

Applicant: Seoul National University R&DB Foundation ,  NATIONAL CANCER CENTER ,  THE ASAN FOUNDATION ,  University of Ulsan Foundation For Industry Cooperation

Inventor： Junho Chung ,  Eugene C. Yi ,  Ji Eun Kim ,  Hwa Kyoung Lee ,  Junyeong Jin ,  Jong Bae Park ,  Hyori Kim

IPC: C07K16/40 ,  G01N33/574

CPC classification number: C07K16/40 ,  G01N33/57423 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622

Abstract: The present invention relates to an anti-ROS1 antibody improved in specificity for ROS1 and a use thereof and, more particularly, provides an anti-ROS1 antibody or an antigen-binding fragment thereof and a use thereof in cancer diagnosis.

公开(公告)号：US12075969B2

公开(公告)日：2024-09-03

申请号：US17274286

申请日：2019-09-12

Applicant: NEC CORPORATION ,  NATIONAL CANCER CENTER

Inventor： Ikuma Takahashi ,  Maki Sano ,  Kimiyasu Takoh ,  Motoyasu Okutsu ,  Chiemi Tanaka ,  Masahiro Saikou ,  Hitoshi Imaoka ,  Kenichi Kamijo ,  Ryuji Hamamoto ,  Yutaka Saito ,  Masayoshi Yamada

IPC: A61B1/00 ,  G06T7/00

CPC classification number: A61B1/00006 ,  A61B1/000094 ,  A61B1/00045 ,  G06T7/0012 ,  G06T2207/10016 ,  G06T2207/10068 ,  G06T2207/30204

Abstract: An information processing apparatus (2000) detects an abnormal region (30) in each of a plurality of video frames (14) constituting video data (12) in which the inside of a body is captured. The information processing apparatus (2000) outputs output information related to the detected abnormal region (30). Herein, the information processing apparatus (2000) starts outputting of the output information when a detection score based on a proportion of the number of the video frames (14) in which the abnormal region (30) is detected becomes equal to or more than a first threshold value in a state where outputting of the output information is not being performed. Further, the information processing apparatus (2000) ends outputting of the output information when the detection score becomes equal to or less than a second threshold value in a state where outputting of the output information is being performed.