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公开(公告)号：US20210395695A1
公开(公告)日：2021-12-23
申请号：US17283942
申请日：2019-12-20
Inventor： Eun-Mi Kim , Ki-Suk Kim , Hyang-Ae Lee
IPC: C12N5/071 , C12M3/00 , C12N5/0786
Abstract: The present invention relates to a method for fabrication of a three-dimensional lung organoid comprising human stem cell-derived alveolar macrophages. Specifically, a lung organoid is fabricated by co-culturing cells not expressing the definitive endoderm marker CRCX4 according to a fabrication method of the present disclosure. The lung organoid comprises type 1 and type 2 alveolar epithelial cells as well as alveolar macrophages and realizes infectious or inflammatory responses unlike conventional lung organoids that contain no immune cells and as such, can be advantageously used in studying mechanisms of related lung diseases, excavating biomarkers, developing therapeutic agents, and so on.
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公开(公告)号：US11041785B2
公开(公告)日：2021-06-22
申请号：US16332483
申请日：2018-07-31
Inventor： Ki-Suk Kim , Sun Hyun Park , Dae-hwan Nam
Abstract: An apparatus for observing image of living tissue having a first cover slip and a second cover slip; and one or more chambers interposed between the first cover slip and the second cover slip and having a cavity therein; in order to observe a living tissue loaded in the cavity of the chamber above is provided.
The apparatus for observing image of living tissue of the present invention can be easily prepared with a simple process and a low cost, and facilitates the observation of images of living tissues on both sides, so that an entire image of a huge living tissue at the level of several hundred micrometers can be obtained by using a tissue transparency technique, which is a distinguished advantage of the apparatus of the invention. In the apparatus of the invention, the outer wall part forming the chamber is strongly bound so that the leakage of the mounting solution and the bubble generation can be prevented, indicating the damage of the living tissue can also be prevented.-
公开(公告)号：US20180306687A1
公开(公告)日：2018-10-25
申请号：US15622529
申请日：2017-06-14
Inventor： SunHyun Park , Ki-Suk Kim
CPC classification number: G01N1/30 , C07J41/0061 , G01N1/34 , G01N2001/305
Abstract: The present invention relates to a composition for clearing biotissue and a clarity method for biotissue using the same. The composition for clearing biotissue and the clarity method for biotissue using the same of the present invention do not need a high price electrophoresis apparatus and expensive solutions, and can not only be applied to various biotissues including brain, liver, lung, kidney, intestine, heart, muscle, and blood vessel, without damaging any of them but also prevent bubble formation, color change, and dark sediment; improve the clarity of biotissues; and help antibody-staining of the cleared tissues. Therefore, it is useful to identify the reason of various diseases through structural imaging of biotissue and to establish a treatment method.
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公开(公告)号：US11446384B2
公开(公告)日：2022-09-20
申请号：US16482444
申请日：2019-03-12
Applicant: Korea Research Institute of Chemical Technology , Korea Advanced Institute of Science and Technology
Inventor： Ki-Suk Kim , Hyang-Ae Lee , Sun Hyun Park , Haeshin Lee , Mikyung Shin
Abstract: The present invention relates to a heart targeting agent comprising tannic acid, in which the agent aids a heart disease therapeutic drug to be delivered to the heart and bind to the cardiac myocardium by inducing tannylation of the drug so as to make heart targeting and accumulation of the drug possible. Unlike the conventional invasive method used for the traditional drugs to be able to target the heart, the agent of the present invention can help a drug to target the heart with high efficiency just via non-invasive intravenous administration.
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公开(公告)号：US11168108B2
公开(公告)日：2021-11-09
申请号：US16473365
申请日：2018-08-03
Inventor： Ki-Suk Kim , Sun Hyun Park , Dae-hwan Nam
IPC: C07J41/00 , A61L27/36 , G01N33/483
Abstract: The present invention provides a composition for adjusting biological tissue size and a method for adjusting the size of biological tissue using the said composition. The composition for adjusting the size of biological tissue according to the present invention can adjust the size of biological tissue according to the specifications of a microscope and the needs of a researcher, and can be used as a mounting solution to easily acquire an image of the biological tissue. Therefore, the composition can be usefully used to reveal the causes of and find treatment methods for various disorders.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20200378876A1
公开(公告)日：2020-12-03
申请号：US16604113
申请日：2018-02-23
Inventor： Sun Hyun Park , Ki-Suk Kim , Dae-hwan Nam
IPC: G01N1/34
Abstract: The clarity method for biotissue using a biotissue clearing agent including CHAPS of the present invention enables fast tissue clarity without denaturation.
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公开(公告)号：US12173325B2
公开(公告)日：2024-12-24
申请号：US17283942
申请日：2019-12-20
Inventor： Eun-Mi Kim , Ki-Suk Kim , Hyang-Ae Lee
IPC: C12N5/071 , C12M3/00 , C12N5/0786
Abstract: The present invention relates to a method for fabrication of a three-dimensional lung organoid comprising human stem cell-derived alveolar macrophages. Specifically, a lung organoid is fabricated by co-culturing cells not expressing the definitive endoderm marker CRCX4 according to a fabrication method of the present disclosure. The lung organoid comprises type 1 and type 2 alveolar epithelial cells as well as alveolar macrophages and realizes infectious or inflammatory responses unlike conventional lung organoids that contain no immune cells and as such, can be advantageously used in studying mechanisms of related lung diseases, excavating biomarkers, developing therapeutic agents, and so on.
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8.发明授权公开(公告)号：US11834560B2
公开(公告)日：2023-12-05
申请号：US16934475
申请日：2020-07-21
Inventor： Jae-Hyeok Lee , Sun-Hyun Park , Ki-Suk Kim
CPC classification number: C08J5/18 , C08K5/13 , C08L5/08 , B82Y30/00 , B82Y40/00 , C08J2305/08 , C08L2201/06 , C08L2203/16
Abstract: The present invention relates to a water degradable film comprising hyaluronic acid or a salt thereof and polyphenol compounds. The film of the present invention can transcribe nanofilms in the form of CNT (carbon nanotube), graphene and magnetic particles to various places. The film of the present invention can be dissolved by an aqueous solution or body fluid, and can be effectively used in the medical field since it is non-toxic and biocompatible. The film of the present invention can also be effectively used as a transcript that does not degrade the quality and performance of the device because no residue remains in the electronic device and the existing photolithography process.
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公开(公告)号：US11365213B2
公开(公告)日：2022-06-21
申请号：US16967095
申请日：2019-02-01
Inventor： Ki-Suk Kim , Sun Hyun Park
Abstract: Disclosed are a composition for clearing spheroids, a method for clearing spheroids using same, and a kit comprising same. The composition for clearing spheroids can clear the spheroids in a convenient and rapid manner and thus may be usefully used for imaging of spheroids and in identifying the causes of various diseases, treating the diseases, and predicting the therapeutic effects and toxicity of drugs. In addition, the composition may be used in combination with various medical devices, and in particular, can be prepared as a kit and usefully used as an in vitro medical diagnostic device.
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10.发明授权公开(公告)号：US11022528B2
公开(公告)日：2021-06-01
申请号：US16604113
申请日：2018-02-23
Inventor： Sun Hyun Park , Ki-Suk Kim , Dae-hwan Nam
IPC: G01N1/34 , A61K31/575 , G01N1/30 , G01N33/483 , C07J41/00
Abstract: The clarity method for biotissue using a biotissue clearing agent including CHAPS of the present invention enables fast tissue clarity without denaturation.
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