Glycogen synthase kinase-3 inhibitors

    公开(公告)号:US07157422B2

    公开(公告)日:2007-01-02

    申请号:US10810578

    申请日:2004-03-29

    IPC分类号: A61K38/03 C07K4/00

    摘要: Peptide inhibitors of glycogen synthase kinase-3 (GSK-3) having an amino acid sequence motif of XZXXXS(p)X, wherein S(p)=phosphorylated serine or phosphorylated threonine, X=any amino acid, and Z=any amino acid except serine or threonine. These inhibitors, which are about 7 to 20 amino acids long, are specific for GSK-3 and strongly inhibit the enzyme with an IC50 of about 150 μM. Also provided are methods of treating biological conditions mediated by GSK-3 activity, such as potentiating insulin signaling in a subject, treating or preventing type 2 diabetes in a patient, and treating Alzheimer's Disease by administering peptide inhibitors. Compositions of these peptide inhibitors and pharmaceutically acceptable carriers are also provided, as is a method for identifying inhibitors of GSK-3. The invention further relates to a computer-assisted method of structure based drug design of GSK-3 inhibitors using a three-dimensional structure of a peptide substrate of GSK-3.

    Apparatus for monitoring CHF patients using bio-impedance technique
    54.
    发明授权
    Apparatus for monitoring CHF patients using bio-impedance technique 有权
    使用生物阻抗技术监测CHF患者的装置

    公开(公告)号:US07096061B2

    公开(公告)日:2006-08-22

    申请号:US10189161

    申请日:2002-07-03

    申请人: Shimon Arad

    发明人: Shimon Arad

    IPC分类号: A61B5/05

    摘要: A method is described for generating an impedance image of the chest, in which electrical data of the chest is acquired, and a finite volume method is used to calculate an impedance image from the electrical data, using an analytical expression for the Jacobian.

    摘要翻译: 描述了一种用于产生胸部的电气数据的胸部的阻抗图像的方法,并且使用有限体积方法来使用雅可比的解析表达式从电数据计算阻抗图像。