公开(公告)号：US11090288B2

公开(公告)日：2021-08-17

申请号：US16141092

申请日：2018-09-25

Applicant: Canadian Blood Services ,  University Health Network

Inventor： Donald R. Branch ,  Lakshmi P. Kotra

IPC: A61K31/4155 ,  A61K45/06 ,  C07D231/12 ,  C07D231/20 ,  C07D231/22 ,  C07D231/46 ,  C07D403/06 ,  C07D403/12

Abstract: The present disclosure relates to a compound of formula or a pharmaceutically acceptable salt thereof; wherein U, R1, R2, R3 and Q are as defined herein. The disclosure also provides a method for treating or preventing a method for the prevention, treatment and/or alleviation of one or more autoimmune or alloimmune disease, pharmaceutical compositions and combination comprising a therapeutically effective amount of a compound, as defined herein.

公开(公告)号：US11052173B2

公开(公告)日：2021-07-06

申请号：US16419221

申请日：2019-05-22

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ren-Ke Li

IPC: A61K9/10 ,  A61L27/18 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58

Abstract: The present disclosure relates to a biocompatible, electrically conductive polymer capable of carrying the electrical potential of a cardiac impulse. The present disclosure also relates to treatments using the electrically conductive polymer, such as for atrial fibrillation.

公开(公告)号：US20210198633A1

公开(公告)日：2021-07-01

申请号：US17057130

申请日：2019-05-30

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Maria Cristina NOSTRO ,  Farida SARANGI ,  Roman KORYTNIKOV ,  Emily MCGAUGH ,  Frankie Hoi Chun POON

IPC: C12N5/071

Abstract: Methods and compositions are provided for producing PDX1+/NKX6-1+ pancreatic progenitor cells from a PDX1+ endodermal cell population. The method comprises contacting the endodermal cell population with an EGF component and tankyrase inhibitor that binds to an adenosine subsite of a tankyrase enzyme, to induce the differentiation of at least a portion of the PDX1+ endodermal cell population into PDX1+NKX6-1+ pancreatic progenitor cells.

公开(公告)号：US20210188956A1

公开(公告)日：2021-06-24

申请号：US17127719

申请日：2020-12-18

Applicant: PROTHENA BIOSCIENCES LIMITED ,  UNIVERSITY HEALTH NETWORK

Inventor： Tarlochan S. Nijjar ,  Avijit Chakrabartty ,  Jeffrey N. Higaki

IPC: C07K16/18 ,  G01N33/68

Abstract: The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.

公开(公告)号：US11028158B2

公开(公告)日：2021-06-08

申请号：US16584634

申请日：2019-09-26

Applicant: PROTHENA BIOSCIENCES LIMITED ,  UNIVERSITY HEALTH NETWORK

Inventor： Yue Liu ,  Tarlochan S. Nijjar ,  Avijit Chakrabartty ,  Jeffrey N. Higaki

IPC: G01N33/38 ,  A61K39/00 ,  C07K16/46 ,  C07K16/18 ,  A61K51/10

Abstract: The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.

公开(公告)号：US20210087336A1

公开(公告)日：2021-03-25

申请号：US16634026

申请日：2018-07-27

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ren-Ke Li

IPC: C08G69/48 ,  A61L31/16 ,  A61L31/14 ,  A61L31/04 ,  A61L31/06 ,  C08L89/06 ,  A61N1/375 ,  A61N1/05

Abstract: The present disclosure relates to a biocompatible, electrically conductive biomaterial capable of carrying the electrical potential of a cardiac impulse. The biomaterial comprises a conductive polymer and a biocompatible component. The conductive polymer comprising an aminomethoxybenzoic acid (AMBA) polymer. The present disclosure also relates to treatments, uses and devices using the biocompatible, electrically conductive biomaterial.

公开(公告)号：US10906967B2

公开(公告)日：2021-02-02

申请号：US16669375

申请日：2019-10-30

Applicant: PROTHENA BIOSCIENCES LIMITED ,  UNIVERSITY HEALTH NETWORK

Inventor： Tarlochan S. Nijjar ,  Avijit Chakrabartty ,  Jeffrey N. Higaki

IPC: A01K67/027 ,  C12P21/08 ,  C12Q1/68 ,  C07K16/18 ,  G01N33/68 ,  A61K39/00

Abstract: The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.

公开(公告)号：US20210009595A1

公开(公告)日：2021-01-14

申请号：US16880192

申请日：2020-05-21

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Radoslaw Laufer ,  Grace Ng ,  Sze-Wan Li ,  Heinz W. Pauls ,  Yong Liu ,  Narendra Kumar B. Patel

IPC: C07D487/04 ,  C07D519/00

Abstract: The present teachings provide a compound represented by the following structural formula: (Formula (I)); or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

公开(公告)号：US10772992B2

公开(公告)日：2020-09-15

申请号：US15999308

申请日：2017-02-16

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO ,  UNIVERSITY HEALTH NETWORK

Inventor： Paul Santerre ,  Soror Sharifpoor ,  Wey Liang Leong

IPC: A61L27/58 ,  A61L27/18 ,  A61L27/56 ,  A61K9/16

Abstract: A soft tissue filler comprising a biodegradable amino-acid derived polycarbonate-urethanes and methods of repairing soft tissue defects are provided. The biodegradable soft tissue filler comprises a porous scaffold that is the reaction product of: a) a divinyl oligomer component that comprises a carbonate-derived divinyl oligomer that is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and a polycarbonate and, optionally, an ether-derived divinyl oligomer, wherein the ether-derived divinyl oligomer is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and an ether; b) at least one anionic monomer; and c) at least one hydrophobic monomer. The molar ratio of (a):(b+c) is between about 1:≥21 and about 1:30, the soft tissue filler has a porosity of >75%; and a compressive moduli of between about 1 kPa and about 50 kPa.

公开(公告)号：US10685461B1

公开(公告)日：2020-06-16

申请号：US16228512

申请日：2018-12-20

Applicant: CANON MEDICAL SYSTEMS CORPORATION ,  UNIVERSITY HEALTH NETWORK

Inventor： Chung Chan ,  Zhou Yu ,  Jian Zhou ,  Patrik Rogalla ,  Bernice Hoppel ,  Kurt Walter Schultz

IPC: G06K9/00 ,  G06T11/00 ,  G06K9/62 ,  G06T7/11 ,  G06T5/00 ,  A61B6/03 ,  A61B6/00 ,  G01N23/046

Abstract: A method and apparatus is provided to iteratively reconstruct a computed tomography (CT) image using a spatially-varying content-oriented regularization parameter, thereby achieving uniform statistical properties within respective organs/regions and different statistical properties (e.g., degree of smoothing and noise level) among the respective organs/regions. For example, less smoothing and sharper features/resolution can be applied within a lung region than within a soft-tissue region by using a smaller regularization parameter value in the lung region than in the soft-tissue region. This can be achieved, e.g., using a minimum intensity projection to suppress/eliminate sub-solid nodules in the lung region. The content-oriented regularization parameter can be generated by reconstructing an initial CT image, which is then segmented/classified according to organs and/or tissue type. Segmenting the image and generating the content-oriented regularization parameter can be integrated into one process by applying an HU-to-β mapping to the CT image.