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公开(公告)号:US20220323371A1
公开(公告)日:2022-10-13
申请号:US17734132
申请日:2022-05-02
发明人: AHARON M. EYAL , NOA RAZ
IPC分类号: A61K31/015 , A61K31/01 , A61K31/352 , A61K47/10 , A61K47/38 , A61K47/06 , A61P25/14 , A61P21/04 , A61P25/28 , A61P25/30 , A61P11/06 , A61P25/22 , A61P25/18 , A61P25/24 , A61P25/00 , A61P25/08 , A61P25/16 , A61P35/00 , A61K31/05
摘要: Terpene-ensiched cannabinoid composition. Cannabinoid compositions are described including at least one cannabinoid in a specific amount, a primary terpene in a specific amount, at least 5% by weight of a non-cannabinoid, non-terpene, carrier, optionally at least three secondary terpenes; less than 5% by weight glycol; and less than 20% by weight water, where said non-cannabinoid, non-terpene carrier comprises cellulose and the terpenes to cannabinoids weight/weight ratio in said composition is about 0.1 to about 1.0. Also described are the above compositions where said non-cannabinoid, non-terpene carrier comprise less than 5% by weight cellulose and the terpenes to cannabinoids weight/weight ratio in said compositions is about 0.05 to about 1.0, forming terpene-enriched cannabinoid compositions with enhanced therapeutic effect compared with that of a composition comprising the same cannabinoids amounts and one half the amount of said primary terpene.
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公开(公告)号:US20220323366A1
公开(公告)日:2022-10-13
申请号:US17737700
申请日:2022-05-05
申请人: XWPHARMA LTD.
IPC分类号: A61K9/50 , A61K9/00 , A61K31/195 , A61K47/02 , A61K47/38
摘要: Granulations with granules having a high loading of an active pharmaceutical ingredient are disclosed. The active pharmaceutical ingredient has a high aqueous water solubility. The granules have a narrow particle size distribution and a smooth exterior surface.
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公开(公告)号:US11464769B2
公开(公告)日:2022-10-11
申请号:US16933642
申请日:2020-07-20
申请人: Vyluma Inc.
摘要: The inventive subject matter is directed to compositions and methods for sterile and storage stable low-dose atropine formulations with improved stability. Most preferably, the compositions presented herein are substantially preservative free and exhibit less than 0.35% tropic acid from degradation of atropine. Advantageously, contemplated formulations are also substantially free of preservatives.
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公开(公告)号:US11464736B2
公开(公告)日:2022-10-11
申请号:US16947224
申请日:2020-07-23
IPC分类号: A61K9/00 , A61K47/38 , A61K31/192 , A61K31/4748 , A61K31/496
摘要: Orodispersible films (ODFs) and methods for making the same.
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公开(公告)号:US20220313717A1
公开(公告)日:2022-10-06
申请号:US17629048
申请日:2020-08-13
发明人: Raphael J. MANNINO , Ruying LU , Theresa MATKOVITS
IPC分类号: A61K31/7048 , A61K31/513 , A61K9/00 , A61K31/4196 , A61K9/127 , A61K47/18 , A61K47/24 , A61K47/22 , A61K47/38 , A61K47/14 , A61K47/02
摘要: The present disclosure is directed to a method of treating or preventing a fungal infection in a subject including a Cryptococcus spp., which method includes an induction treatment phase and a consolidation treatment phase, wherein the induction treatment phase includes: administering amphotericin B (cAMB) and 5-Flucytosine or an azole to the subject, wherein the cAMB and the 5-Flucytosine or the azole are mucosally administered. cAMB formulations are also disclosed.
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公开(公告)号:US20220313668A1
公开(公告)日:2022-10-06
申请号:US17662979
申请日:2022-05-11
申请人: ChemoCentryx, Inc.
发明人: Zhenhua MIAO , Israel Charo
摘要: A method of treating liver fibrosis with CCR2 antagonists is provided. The liver fibrosis may be associated with non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), emerging cirrhosis, non-cirrhotic hepatic fibrosis, type 2 diabetes mellitus (T2DM) or metabolic syndrome (MS).
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公开(公告)号:US20220306643A1
公开(公告)日:2022-09-29
申请号:US17827064
申请日:2022-05-27
申请人: AbbVie Inc.
发明人: Aileen L. Pangan , Henrique D. Teixeira , Mohamed-Eslam F. Mohamed , Ahmed A. Othman , Ben Klünder
IPC分类号: C07D487/14 , A61K47/38 , A61K47/12 , A61K31/4985 , A61K9/00 , A61K9/20
摘要: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3Himidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.
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58.
公开(公告)号:US20220305084A1
公开(公告)日:2022-09-29
申请号:US17640133
申请日:2020-02-19
发明人: Teresita de Jesus RODRÍGUEZ OBAYA , Daniel Enrique AMARO GONZÁLEZ , Judey Aymed GARCÍA ARTALEJO , Iliana Maria SOSA TESTÉ , Yanara SARMIENTO CONDE , Lourdes HERNÁNDEZ DE LA ROSA , Dayli DÍAZ GOIRE , Estela GIMÉNEZ LÓPEZ
摘要: The present invention relates to the fields of Biotechnology and Medicine and describes a pharmaceutical composition of recombinant human erythropoietin which is characterized by having a microheterogeneity of fucosylated N-glycans formed by bi, tri and tetra-antennary structures with mono and bi-sialylated sialic acid residues that represent 40-60% of the total glycans, trisialylated ones that represent 40-43% of the total glycans and tetrasialylated ones that represent 10-13% of the total glycans. This glycosylation pattern confers properties to said composition that allow for its use in disorders of the nervous system. The method of obtaining the pharmaceutical composition described herein is also described.
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公开(公告)号:US11452732B2
公开(公告)日:2022-09-27
申请号:US17018040
申请日:2020-09-11
申请人: Randal Davis
发明人: Randal Davis
IPC分类号: A61K31/573 , A61K31/4709 , A61K31/196 , A61K47/18 , A61K9/08 , A61K47/38 , A61K47/10 , A61K9/00
摘要: This application is directed to a homogeneous solution of an aqueous, topical composition useful for the treatment of infection and/or for the treatment of inflammation due to trauma to tissue. Specifically, this application relates to a homogeneous, aqueous composition of a quinolone antibiotic and an anti-inflammatory agent.
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公开(公告)号:US20220298114A1
公开(公告)日:2022-09-22
申请号:US17806033
申请日:2022-06-08
申请人: Cytokinetics, Inc.
发明人: Mingda BI , Robert KUEHL
IPC分类号: C07D213/75 , A61K9/20 , A61K31/496 , A61K47/38
摘要: Provided are certain pharmaceutical formulations of omecamtiv mecarbil and methods for their preparation and use.
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