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公开(公告)号：US20180185491A1
公开(公告)日：2018-07-05
申请号：US15811040
申请日：2017-11-13
发明人： Raphael Mannino , Ruying Lu
IPC分类号： A61K47/24 , A61K45/06 , A61K9/127 , A61K47/02 , A61K9/19 , A61K31/122 , A61K31/12 , A61K31/685 , A61K31/7036 , A61K31/7048 , A61K33/06
摘要： Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
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公开(公告)号：US20180185308A1
公开(公告)日：2018-07-05
申请号：US15735708
申请日：2016-06-17
发明人： Raphael J. MANNINO , Ruying Lu
IPC分类号： A61K31/192 , A61K9/127 , A61K9/107
CPC分类号： A61K31/192 , A61K9/107 , A61K9/127
摘要： Disclosed are methods of treating anti-inflammatory disease or conditions, typically by orally administering encochleated anti-inflammatory agents, including NSAIDS. Orally administered cochleates have significantly reduced toxicity as compared to non-encochleated anti-inflammatory agents.
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公开(公告)号：US20240316204A1
公开(公告)日：2024-09-26
申请号：US18619502
申请日：2024-03-28
发明人： Raphael Mannino , Ruying Lu
IPC分类号： A61K47/24 , A61K9/127 , A61K9/19 , A61K31/12 , A61K31/122 , A61K31/685 , A61K31/7036 , A61K31/7048 , A61K33/06 , A61K45/06 , A61K47/02
CPC分类号： A61K47/24 , A61K9/1274 , A61K9/1277 , A61K9/19 , A61K31/12 , A61K31/122 , A61K31/685 , A61K31/7036 , A61K31/7048 , A61K33/06 , A61K45/06 , A61K47/02
摘要： Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
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4.发明申请公开(公告)号：US20180042849A1
公开(公告)日：2018-02-15
申请号：US15554921
申请日：2016-03-03
发明人： Raphael J. Mannino , Ruying Lu
IPC分类号： A61K9/127 , A61K31/122 , A61K31/7036 , C12N15/113 , A61K31/7048
CPC分类号： A61K9/1274 , A61K31/122 , A61K31/7036 , A61K31/7048 , C12N15/113 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： A cochleate composition is disclosed. Following oral administration of the cochleate composition, the pharmacologically active agent is found at higher concentrations in the tissue relative to plasma. Oral administration of these cochleate compositions also preferentially targets infected or inflamed tissue as compared to tissue in a healthy subject. The cochleate composition contains a size-regulating agent that reduces cochleate particle size, such as a lipid-anchored polynucleotide, a lipid-anchored sugar, a lipid-anchored polypeptide, or a bile salt (such as oxycholate or deoxycholate). Also disclosed are methods of treatment using the cochleate composition and methods of increasing the concentration of a pharmacologically active agent in an infected tissue relative to the concentration of the pharmacologically active agent in the plasma or the tissue of a healthy subject.
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公开(公告)号：US20220313717A1
公开(公告)日：2022-10-06
申请号：US17629048
申请日：2020-08-13
发明人： Raphael J. MANNINO , Ruying LU , Theresa MATKOVITS
IPC分类号： A61K31/7048 , A61K31/513 , A61K9/00 , A61K31/4196 , A61K9/127 , A61K47/18 , A61K47/24 , A61K47/22 , A61K47/38 , A61K47/14 , A61K47/02
摘要： The present disclosure is directed to a method of treating or preventing a fungal infection in a subject including a Cryptococcus spp., which method includes an induction treatment phase and a consolidation treatment phase, wherein the induction treatment phase includes: administering amphotericin B (cAMB) and 5-Flucytosine or an azole to the subject, wherein the cAMB and the 5-Flucytosine or the azole are mucosally administered. cAMB formulations are also disclosed.
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公开(公告)号：US11123295B2
公开(公告)日：2021-09-21
申请号：US16312047
申请日：2017-07-12
发明人： Raphael J. Mannino , Ruying Lu , Doug F. Kling
IPC分类号： A61K9/127 , A61P31/10 , A61K9/00 , A61K31/7048 , A61K47/24 , A61K31/513
摘要： The present application is directed to a cochleate composition including one or more cochleates and at least two antifungal compounds selected from amphotericin B, 5-flucytosine, fluconazole, ketoconazole, ravuconazole, albaconazole, itraconazole, posaconazole, isavuconazole and/or voriconazole. Methods of using the antifungal cochleate formulations are also disclosed.
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公开(公告)号：US20210038722A1
公开(公告)日：2021-02-11
申请号：US16904824
申请日：2020-06-18
发明人： Raphael MANNINO , Ruying LU
IPC分类号： A61K47/24 , A61K45/06 , A61K31/12 , A61K31/685 , A61K31/7036 , A61K31/7048 , A61K33/06 , A61K9/127 , A61K31/122 , A61K9/19 , A61K47/02
摘要： Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
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公开(公告)号：US11964019B2
公开(公告)日：2024-04-23
申请号：US16904824
申请日：2020-06-18
发明人： Raphael Mannino , Ruying Lu
IPC分类号： A61K47/24 , A61K9/127 , A61K9/19 , A61K31/12 , A61K31/122 , A61K31/685 , A61K31/7036 , A61K31/7048 , A61K33/06 , A61K45/06 , A61K47/02
CPC分类号： A61K47/24 , A61K9/1274 , A61K9/1277 , A61K9/19 , A61K31/12 , A61K31/122 , A61K31/685 , A61K31/7036 , A61K31/7048 , A61K33/06 , A61K45/06 , A61K47/02 , A61K31/685 , A61K2300/00 , A61K33/06 , A61K2300/00 , A61K31/7048 , A61K2300/00 , A61K31/12 , A61K2300/00 , A61K31/7036 , A61K2300/00
摘要： Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
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公开(公告)号：US20210393526A1
公开(公告)日：2021-12-23
申请号：US17463021
申请日：2021-08-31
发明人： Raphael J. Mannino , Ruying Lu , Doug F. Kling
IPC分类号： A61K9/127 , A61P31/10 , A61K9/00 , A61K31/7048 , A61K47/24
摘要： The present application is directed to a cochleate composition including one or more cochleates and at least two anti-fungal compounds selected from amphotericin B, 5-flucytosine, fluconazole, ketoconazole, ravuconazole, albaconazole, itraconazole, oposaconazole, isavuconazole and/or voriconazole. Methods of using the antifungal cochleate formulations are also disclosed.
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公开(公告)号：US10716860B2
公开(公告)日：2020-07-21
申请号：US15811040
申请日：2017-11-13
发明人： Raphael Mannino , Ruying Lu
IPC分类号： A61K47/24 , A61K45/06 , A61K9/127 , A61K47/02 , A61K9/19 , A61K31/122 , A61K31/12 , A61K31/685 , A61K31/7036 , A61K31/7048 , A61K33/06
摘要： Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
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