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61.发明授权公开(公告)号：US11605172B2
公开(公告)日：2023-03-14
申请号：US16770793
申请日：2018-12-07
发明人： Stanley Pau , Rongguang Liang
摘要： Methods and systems are described that enable three-dimensional (3D) imaging of objects. One example system includes a light source that produces multiple light beams having specific spectral content and polarization states. The system also includes phase masks that modify the intensity or phase of the light, and projection optics that allow simultaneously projection of at least three fringe patterns onto an object having particular phase, polarization and spectral characteristics. The detection system includes a camera that simultaneously receives light associated with the at the fringe patterns upon reflection from the object, and a processing unit coupled to the camera unit that determines one or both of a phase or a depth information associated with the object. The system and associated methods can efficiency produce 2D images of the object and allow determination of characteristics such as surface profile. The disclosed systems and methods can be effectively implemented with moving objects.
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公开(公告)号：US20230028487A1
公开(公告)日：2023-01-26
申请号：US17949866
申请日：2022-09-21
发明人： Russell Witte , Hao Xin , Diego Martin
摘要： A method and system capable of applying microwave therapy guided by thermoacoustic imaging and/or thermoacoustic thermometry is disclosed. The system includes a thermoacoustic imaging system and/or a thermoacoustic thermometry system that generate(s) a map of a region of interest; and a microwave therapy system that targets the region of interest using the map, and that applies the microwave therapy to the targeted region of interest. Treatment of the targeted region of interest may be employed by the microwave therapy system using real-time feedback from the thermoacoustic imaging system and/or the thermoacoustic thermometry system. Imaging and therapy may be automatically co-registered.
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公开(公告)号：US20230023607A1
公开(公告)日：2023-01-26
申请号：US17790831
申请日：2021-02-04
发明人： Wei Wang
IPC分类号： C07D493/04 , C07D493/14 , C07D413/06 , C07D263/26
摘要： Disclosed are a deuterated compound of fomula (I), or a salt thereof, and methods for preparation thereof. The present disclosure may provide a mild, versatile organophotoredox method for the preparation of diverse, enantioenriched α-deuterated α-amino acids. In particular, the present disclosure may address the long-standing challenge of installing sterically demanding side chains into α-amino acids, including late-stage modifications on medicinal agents and natural products.
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公开(公告)号：US11542302B2
公开(公告)日：2023-01-03
申请号：US16876683
申请日：2020-05-18
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , THE TEXAS A&M UNIVERSITY SYSTEM
发明人： Victor J. Hruby , Minying Cai , Caurnel Morgan
IPC分类号： A61K38/12 , A61K38/34 , C07K14/68 , A61K38/00 , A61P25/18 , A61P25/22 , A61P25/24 , A61K38/08 , A61K38/06 , A61K38/07 , C07K5/02 , A61K9/00 , A61K9/70
摘要： Compositions and methods for treating a depressive disorder or an anxiety disorder in a subject in need of such treatment are described herein. A therapeutically effective amount of a composition comprising a melanocortin 5 receptor (MC5R) peptide ligand according to the following: in a pharmaceutically acceptable carrier is administered to the subject. Xaa can be Cha or Pro. The MC5R peptide is a selective MC5R antagonist, and administration thereof to the subject can treat the depressive or anxiety disorder with clinical improvement observed in a relatively short time.
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公开(公告)号：US11530953B2
公开(公告)日：2022-12-20
申请号：US17157355
申请日：2021-01-25
发明人： Stanley Pau
IPC分类号： G01J4/04
摘要： Methods and devices for measuring full or partial Mueller matrix information in a single shot are described. One single shot polarimeter includes a polarization filter that is positioned to receive collimated light from a light source and to produce light having different polarization states. The polarization filter includes at least four sections, where each section receives a portion of the collimated light and produces light of a particular polarization state, which is spatially separated from light produced by other sections of the polarization filter. An imaging component images the sections of the polarization filter onto a plane of a sample object. One or more optical elements receive the light from the sample object and image a section of the sample object onto a detector. The disclosed devices and methods enable the measurement of the Mueller matrix of the sample with high signal-to-noise ratios.
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公开(公告)号：US20220362002A1
公开(公告)日：2022-11-17
申请号：US17876302
申请日：2022-07-28
摘要： An implantable medical device and methods for making and using the same are provided. In various embodiments, the device comprises a central hub structure in communication with at least one housing or pod capable of containing cells and therapeutic materials. Also provided are membrane structures and methods of forming the same, the membranes comprising a gradient of varying porosity for use with devices of the present disclosure, as well as other uses.
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公开(公告)号：US20220358384A1
公开(公告)日：2022-11-10
申请号：US17736683
申请日：2022-05-04
发明人： Mithun Paul , Mihai Surdeanu , Sandeep Suntwal , Rebecca Sharp
摘要： A domain fact verification system is described having a computer programmed with a model trained using a process of data distillation and model distillation to improve model learning of the underlying semantics of a dataset rather than relying on statistical and lexical nuances in a domain-specific dataset. The computer thus programmed can accurately perform fact verification across multiple domains without the labor-intensive process of encoding a dataset of human-annotated, domain-specific information for each domain. Moreover, by combining data distillation with model distillation techniques, which may be seen as an inverse of well-established ensemble strategies (which train individual models separately and applies them jointly) the present domain transferable fact verification system scales better at inference time due to its reliance on a single trained model.
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公开(公告)号：US11496213B2
公开(公告)日：2022-11-08
申请号：US15780865
申请日：2016-12-05
申请人： Arizona Board of Regents on Behalf of the University of Arizona , THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
IPC分类号： H04B10/07 , H04B10/077 , H04J14/02 , H04Q11/00
摘要： A method of interrogating a WDM optical communication system is provided to obtain one or more performance parameters. In accordance with the method, an optical probe wavelength is generated and possibly modulated in a prescribed manner. The probe signal is transmitted along a selected optical path through the WDM optical communication system for a duration of time that is less than a response time of network elements that impact signal quality along the selected optical path.
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公开(公告)号：US20220332683A1
公开(公告)日：2022-10-20
申请号：US17724125
申请日：2022-04-19
发明人： Jun Wang
IPC分类号： C07D207/273 , C07D207/46 , A61K31/16 , A61P11/00 , A61P31/14 , C07D209/02 , A61K9/00
摘要： This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a pyrrolidinone-acetamide (or similar) structure (e.g., Formula I) which function as inhibitors of the SARS-CoV-2 papain-like protease (PLpro), which function as inhibitors of the SARS-CoV-2 related viral 3CL protease (MPpro), which function as therapeutics for the treatment of viral infection characterized with PLPpro and/or Mpro protease activity and/or expression (e.g., COVID-19), and which function as therapeutics for the treatment of other conditions characterized with PLPpro and/or Mpro protease activity and/or expression.
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70.发明授权公开(公告)号：US11454759B2
公开(公告)日：2022-09-27
申请号：US16641297
申请日：2018-08-22
摘要： In accordance with a method of forming a waveguide in a polymer film disposed on a substrate, a plurality of regions on a polymer film are selectively exposed to a first dosage of radiation. The polymer film is formed from a material having a refractive index that decreases by exposure to the radiation and subsequent heating. At least one region of the polymer film that was not previously exposed to the radiation is selectively exposing to a second dosage of radiation. The second dosage of radiation is less than the first dosage of radiation. The polymer film is heated to complete curing of the polymer film.
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