公开(公告)号：US09358384B2

公开(公告)日：2016-06-07

申请号：US14479066

申请日：2014-09-05

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： Jodi Townsley Dubuclet

IPC: A61N1/05

CPC classification number: A61N1/0553

Abstract: A neurostimulation system is disclosed herein. The neurostimulation system includes an implantable pulse generator and an implantable therapy lead configured to be electrically coupled to the implantable pulse generator. The implantable therapy lead includes a flexible paddle electrode array with flexible electrodes. Each flexible electrode has a segmented configuration having first and second electrode segments and a flexible bridge or living hinge joining together the first and second electrode segments.

Abstract translation: 本文公开了一种神经刺激系统。 神经刺激系统包括可植入脉冲发生器和被配置为电耦合到可植入脉冲发生器的可植入治疗引线。 可植入治疗引线包括具有柔性电极的柔性桨电极阵列。 每个柔性电极具有分段构造，其具有第一和第二电极段以及将第一和第二电极段接合在一起的柔性桥或活动铰链。

公开(公告)号：US09144679B2

公开(公告)日：2015-09-29

申请号：US13716968

申请日：2012-12-17

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： Patrick M. Cullen ,  John H. Erickson

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/05 ,  A61N1/372 ,  G06F19/00

CPC classification number: A61N1/36128 ,  A61N1/05 ,  A61N1/0553 ,  A61N1/36178 ,  A61N1/37247 ,  G06F19/00 ,  G16H40/63

Abstract: In one embodiment, a method for defining a stimulation program for electrical stimulation of a patient, the method comprising: providing a single screen user interface that comprises a first plurality of controls and a second plurality of controls, the first plurality of controls allowing selection of multiple stimulation parameters for a plurality of stimulation sets, the second plurality of controls allowing selection of multiple stimulation parameters defining burst stimulation and tonic stimulation; receiving user input in one or more of the second plurality of controls; and automatically modifying parameters for one or more stimulation sets in response to receiving the user input in one or more of the second plurality of controls and modifying values displayed in one or more controls of the first plurality of controls according to the modified parameters, the modified parameters reflecting a stimulation program that includes an interleaved pattern of burst stimulation and tonic stimulation for delivery to the patient.

Abstract translation: 在一个实施例中，一种用于定义用于电刺激患者的刺激程序的方法，所述方法包括：提供包括第一多个控制和第二多个控制的单个屏幕用户界面，所述第一多个控件允许选择 用于多个刺激组的多个刺激参数，所述第二多个控制允许选择限定突发刺激和强直刺激的多个刺激参数; 在所述第二多个控制中的一个或多个中接收用户输入; 以及响应于在所述第二多个控制中的一个或多个控制中接收到所述用户输入并根据所述修改的参数修改显示在所述第一多个控件的一个或多个控制中的值，自动修改针对一个或多个刺激集的参数， 反映刺激程序的参数，其包括突发刺激的交替模式和用于递送给患者的补品刺激。

公开(公告)号：US20150231330A1

公开(公告)日：2015-08-20

申请号：US14703725

申请日：2015-05-04

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： Andres M. Lozano ,  Helen S. Mayberg

IPC: A61M5/142 ,  A61N1/05

CPC classification number: A61M5/14276 ,  A61B5/4848 ,  A61N1/0534 ,  A61N1/36096 ,  A61N1/36185

Abstract: The present application involves a method and a system for using electrical stimulation and/or chemical stimulation to treat depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.

Abstract translation: 本申请涉及使用电刺激和/或化学刺激来治疗抑郁症的方法和系统。 更具体地，该方法包括手术植入电刺激引线和/或导管，所述电刺激引线和/或导管与预定位置通信，所述预定部位耦合到信号发生器和/或输注泵，所述信号发生器和/或输注泵释放导致刺激的电信号和/或药物 的预定位置，从而治疗心情和/或焦虑。

公开(公告)号：US20150229139A1

公开(公告)日：2015-08-13

申请号：US14175642

申请日：2014-02-07

Applicant: Advanced Neuromodulation Systems, Inc. d/b/a St. Jude Medical Neuromodulation Division

Inventor： John C. Greene

IPC: H02J7/00 ,  H02J7/02

CPC classification number: H02J7/008 ,  A61N1/36125 ,  A61N1/3787 ,  H02J5/005 ,  H02J7/0047 ,  H02J7/0077 ,  H02J7/025 ,  H02J50/10 ,  H02J50/80 ,  H02J2007/005

Abstract: A charging energy control system may include an implantable medical device (IMD) and an external charger. The IMD receives charging energy to recharge the battery during a charging energy acceptance period and rejects the charging energy during an actual charging energy rejection period. The external charger transmits the charging energy to the IMD in order to recharge the battery. The external charger may include a charging controller configured to determine the charging energy rejection period, and regulate the charging energy during which the charging controller predicts a predicted charging energy rejection period of the IMD based on the actual recharging energy rejection period. The charging controller is configured to cease or reduce transmission of the charging energy during a charging energy conservation period that is at least a portion of the predicted charging energy rejection period.

Abstract translation: 充电能量控制系统可以包括可植入医疗装置（IMD）和外部充电器。 在充电能量接受期间，IMD接收充电能量以对电池进行充电，并在实际的充电能量抑制期间拒绝充电能量。 外部充电器将充电能量发送到IMD，以便为电池充电。 外部充电器可以包括充电控制器，其被配置为确定充电能量抑制周期，并且调节充电控制器根据实际充电能量抑制周期预测IMD的预测充电能量抑制周期的充电能量。 充电控制器被配置为在作为预测的充电能量抑制期间的至少一部分的充电节能期间停止或减少充电能量的传输。

公开(公告)号：US09020608B2

公开(公告)日：2015-04-28

申请号：US13734280

申请日：2013-01-04

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： John Swanson

IPC: A61N1/00 ,  A61N1/05

CPC classification number: A61N1/0553 ,  Y10T29/49124 ,  Y10T29/49128

Abstract: In one embodiment, a paddle-style lead for implantation in the epidural space through an insertion tool, the paddle-style lead comprises: a paddle structure that comprises: (i) a frame of rigid material, the frame comprising a spring member adapted to bias the frame to assume a first width and a first length, the frame being adapted to elongate to assume a second width and a second length under application of a compressive force; and (ii) elastic material disposed across an interior surface area defined the frame, wherein a plurality of electrodes and a plurality of electrical traces are provided on the elastic material, wherein the plurality of electrical traces are electrically coupled to a plurality of lead conductors and the plurality of electrodes; wherein the plurality of electrical traces comprises a plurality of alternating curves that elongate when the elastic material is stretched.

Abstract translation: 在一个实施例中，桨式引线用于通过插入工具植入硬膜外腔中，桨式引线包括：桨结构，其包括：（i）刚性材料框架，所述框架包括适于 将框架偏置成呈现第一宽度和第一长度，该框架适于在施加压缩力的情况下伸长以呈现第二宽度和第二长度; 和（ii）穿过限定框架的内表面区域布置的弹性材料，其中多个电极和多个电迹线设置在弹性材料上，其中多个电迹线电耦合到多个引线导体， 多个电极; 其中所述多个电迹线包括当所述弹性材料被拉伸时延伸的多个交替曲线。

公开(公告)号：US08903508B2

公开(公告)日：2014-12-02

申请号：US13789027

申请日：2013-03-07

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： Claudio Feler

IPC: A61N1/05

CPC classification number: A61N1/0553

Abstract: An implantable stimulation system including an epidural lead for spinal cord stimulation that includes a paddle having an array of electrodes coupled to conductors within the lead body. The paddle includes score lines that extend along the length and width of either the front or back facets of the paddle portion. The score lines increase the flexibility of the paddle in both the length and width directions which facilitate the implantation of the paddle within the epidural space of the spinal cord, and further permits the paddle to conform more uniformly to the target area of implantation to minimize the gap between the electrodes and targeted fibers.

Abstract translation: 一种植入式刺激系统，包括用于脊髓刺激的硬膜外引线，其包括具有耦合到引线体内的导体的电极阵列的桨叶。 桨叶包括沿桨叶部分的前面或后面的长度和宽度延伸的刻痕线。 刻痕线增加了桨叶在长度和宽度方向上的灵活性，这有助于将桨植入脊髓的硬膜外腔内，并且还允许桨更均匀地符合植入的目标区域，以最小化 电极和目标纤维之间的间隙。

公开(公告)号：US08831744B2

公开(公告)日：2014-09-09

申请号：US13873010

申请日：2013-04-29

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： John Swanson

IPC: A61N1/00 ,  A61N1/05 ,  H01R13/66 ,  H01R24/58

CPC classification number: A61N1/05 ,  A61N1/0551 ,  A61N1/0553 ,  H01R13/6658 ,  H01R24/58 ,  H01R2201/12 ,  Y10T29/49169 ,  Y10T29/53204

Abstract: In one embodiment, a stimulation lead for applying electrical pulses to tissue of a patient, the stimulation lead comprises: a plurality of electrodes on a first end of the lead body; a plurality of terminals on a second end of the lead body; a lead body comprising a flex film component disposed within insulative material, wherein (i) the flex film component comprises a plurality of electrical traces, (ii) the plurality of electrical traces electrically couple the plurality of electrodes with the plurality of terminals, and (iii) the flex film component comprises a plurality of bends along a substantial length of the lead body; wherein the stimulation lead is adapted to elastically elongate under application of stretching forces to the lead body without disconnection of the electrical connections between the plurality of electrodes and the plurality of terminals through the electrical traces of the flex film component.

Abstract translation: 在一个实施例中，刺激引线用于向患者的组织施加电脉冲，刺激引线包括：引线本体的第一端上的多个电极; 所述引线体的第二端上的多个端子; 包括设置在绝缘材料内的柔性膜部件的引线主体，其中（i）柔性膜部件包括多个电迹线，（ii）多个电迹线将多个电极与多个端子电耦合，以及（ iii）柔性膜部件包括沿着引线主体的相当长度的多个弯曲部; 其中所述刺激引线适于在施加拉伸力的情况下弹性伸长到所述引线主体，而不断开所述多个电极与所述多个端子之间的电连接，通过所述柔性膜部件的电迹线。

公开(公告)号：US20130289684A1

公开(公告)日：2013-10-31

申请号：US13926612

申请日：2013-06-25

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： Richard B. North ,  Terry D. Daglow ,  Stephen L. Goldman

IPC: A61N1/05

CPC classification number: A61N1/0553 ,  A61N1/08 ,  A61N1/36071

Abstract: A paddle lead includes a plurality of electrodes configured in at least three rows of three electrodes with the second, intermediate row operable to provide anode guarding. The paddle lead further includes a plurality of grooves disposed on a surface opposite the electrodes to facilitate the insertion of the paddle lead within a patient by inhibiting the veering of the paddle lead to one side or the other of the dorsal column as the paddle lead is advanced along the dorsal column midline during implantation.

公开(公告)号：US20130116753A1

公开(公告)日：2013-05-09

申请号：US13663145

申请日：2012-10-29

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： John H. Erickson

IPC: A61N1/375 ,  A61N1/40

CPC classification number: A61N1/37 ,  A61N1/086 ,  A61N1/3718

Abstract: In one embodiment, a pulse generator for generating electrical stimulation for delivery to a patient, comprises: a hermetically sealed housing containing pulse generating circuitry; a header coupled to the housing for receiving one or more stimulation leads, wherein feedthrough wires are provided to conduct electrical pulses from the pulse generating circuitry to the header; the header comprising a plurality of connectors for electrically connecting to each terminal of the one or more stimulation leads, wherein an inductive winding is disposed around or adjacent to each of the connector structures and is electrically connected between the respective connector structure and a corresponding feedthrough wire to limit MRI induced heating of a respective electrode of the one or more stimulation leads.

Abstract translation: 在一个实施例中，用于产生用于递送给患者的电刺激的脉冲发生器包括：包含脉冲发生电路的密封外壳; 连接到所述壳体以用于接收一个或多个刺激引线的头部，其中提供穿通线以将电脉冲从所述脉冲发生电路传导到所述头部; 所述头部包括用于电连接到所述一个或多个刺激引线的每个端子的多个连接器，其中感应绕组设置在每个所述连接器结构的周围或附近，并且电连接在相应的连接器结构和相应的馈通线 以限制一个或多个刺激引线的相应电极的MRI诱导加热。

公开(公告)号：US20040243208A1

公开(公告)日：2004-12-02

申请号：US10448243

申请日：2003-05-29

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： Richard Jordan

IPC: A61N001/05

CPC classification number: A61N1/0553

Abstract: An implantable stimulation system including epidural lead for spinal cord stimulation that includes a paddle having a curved proximal end and lateral winged tips and an array of electrodes coupled to conductors within a lead body. The conductors couple to a pulse generator or other stimulation device. The curved and winged paddle provides more complete electrical stimulation coverage to targeted human tissue by minimizing the potential gap between electrodes and targeted fibers.

Abstract translation: 一种植入式刺激系统，包括用于脊髓刺激的硬膜外引线，其包括具有弯曲近端和侧翼翅尖的桨，以及耦合到引线体内导体的电极阵列。 导体耦合到脉冲发生器或其他刺激装置。 弯曲和翼状的桨通过最小化电极和目标纤维之间的潜在间隙来向目标人体组织提供更完整的电刺激覆盖。