公开(公告)号：US6090988A

公开(公告)日：2000-07-18

申请号：US40967

申请日：1998-03-18

Applicant: Hideyuki Kambe ,  Hitoshi Yano ,  Yuuji Shimasaki

Inventor： Hideyuki Kambe ,  Hitoshi Yano ,  Yuuji Shimasaki

IPC: C07C41/42 ,  C07C41/00

CPC classification number: C07C41/42

Abstract: A reaction mixture in a gas form which is obtained by intramolecular dehydration of glycol ether in a gas phase is liquidized and collected by using as a collecting agent the glycol ether which is a raw material of the reaction mixture. The collected liquid thus obtained is continuously distilled by using a continuous distillation column so that a distillate containing alkyl vinyl ether and water is obtained, while a bottom product containing glycol ether is obtained. The distillate is left to stand in a separation vessel whereby separating into an oleaginous layer and an aqueous layer, so that alkyl vinyl ether is collected as the oleaginous layer. On the other hand, in the case where the bottom product contains water, the bottom product is continuously distilled together with an azeotrope former by using a continuous distillation column whereby a distillate containing an azeotrope of water and the azeotrope former, so that glycol ether is collected as a bottom product. By doing so, a method whereby alkyl vinyl ether as well as glycol ether which is the raw material and the collecting agent are efficiently collected, purified, and recovered is realized.

Abstract translation: 通过在气相中通过二醇醚的分子内脱水获得的气体形式的反应混合物通过使用作为反应混合物的原料的二醇醚作为收集剂进行液化和收集。 通过使用连续蒸馏塔将得到的收集液连续蒸馏，得到含有烷基乙烯基醚和水的馏出物，得到含有二醇醚的底物。 将馏出物置于分离容器中，由此分离成油层和水层，从而收集烷基乙烯基醚作为含油层。 另一方面，在底部产品含有水的情况下，通过使用连续蒸馏塔将底部产物与共沸物一起连续蒸馏，由此得到含有共沸物和共沸物的馏出物，使得乙二醇醚为 作为底部产品收集。 通过这样做，实现了作为原料的烷基乙烯基醚以及作为原料的二醇醚和收集剂被有效收集，纯化和回收的方法。

公开(公告)号：US5833813A

公开(公告)日：1998-11-10

申请号：US737207

申请日：1996-11-07

Applicant: Hitoshi Yano ,  Yoshinari Yamaguchi ,  Hirokazu Ito ,  Ryuichi Ishikawa ,  Yukihiro Matsumoto ,  Teruhisa Kaziwara

Inventor： Hitoshi Yano ,  Yoshinari Yamaguchi ,  Hirokazu Ito ,  Ryuichi Ishikawa ,  Yukihiro Matsumoto ,  Teruhisa Kaziwara

IPC: B01D3/14 ,  C07D331/02 ,  B01D3/00

CPC classification number: C07D331/02 ,  B01D3/146

Abstract: A method of recovering ethylene sulfide from a hydrous stock solution (solution) containing ethylene sulfide, toluene (hydrophobic organic compound) having a higher boiling point than ethylene sulfide, and a compound having a higher boiling point than toluene, by distilling the stock solution continuously using a continuous fractionating tower 2, a fractionating tower 4, and a rectifying tower 5. Ethylene sulfide is distilled out with toluene and water from the continuous fractionating tower 2, and the distillate is allowed to separate into an oil layer and a water layer in a separating tank 3. The oil layer is distilled continuously by the fractionating tower 4 without being subjected to a reflux operation to distill out water with a part of ethylene sulfide. The bottom product from the fractionating tower 4 is rectified by the rectifying tower 5 to recover ethylene sulfide. Consequently, the polymerization reaction of ethylene sulfide can be suppressed and ethylene sulfide can be separated and recovered continuously in an efficient and stable manner. Also, the clogging of fractionating towers and pipes can be prevented.

Abstract translation: PCT No.PCT / JP96 / 00890 Sec。 371日期：1996年11月7日 102（e）1996年11月7日PCT PCT 1996年4月2日PCT公布。 出版物WO96 / 31495 日期：1996年10月10日从含有环硫乙烷，沸点高于环硫乙烷的甲苯（疏水性有机化合物）和沸点高于甲苯的化合物的含水储备溶液（溶液）中回收环硫乙烷的方法， 使用连续分馏塔2，分馏塔4和精馏塔5连续蒸馏储备溶液。将来自连续分馏塔2的甲苯和水蒸馏出乙烯硫醚，使馏出物分离成油层 和分离罐3中的水层。油层通过分馏塔4连续蒸馏而不进行回流操作，以用一部分环硫乙烷蒸馏出水。 来自分馏塔4的底部产物由精馏塔5精馏，以回收硫化亚乙烯。 因此，可以抑制环硫乙烷的聚合反应，并且可以以有效且稳定的方式连续分离和回收环硫乙烷。 此外，可以防止分馏塔和管道的堵塞。

公开(公告)号：US5604120A

公开(公告)日：1997-02-18

申请号：US517792

申请日：1995-08-22

Applicant: Hitoshi Yano ,  Teruyo Sugiura ,  Yasuyuki Koizumi ,  Naoyuki Yoshida

Inventor： Hitoshi Yano ,  Teruyo Sugiura ,  Yasuyuki Koizumi ,  Naoyuki Yoshida

IPC: C12N11/08 ,  C07C35/30 ,  C07C69/24 ,  C07C69/614 ,  C07C69/74 ,  C07C69/76 ,  C12N11/10 ,  C12P7/02 ,  C12P41/00 ,  C12R1/72 ,  C12P7/62

CPC classification number: C12P7/02 ,  C12P41/004

Abstract: The present invention provides a method for producing optically active endo-2-norborneols, represented by the following formula: ##STR1## and the antipodes, it comprises asymmetrically hydrolysing racemic endo-2-acyloxynorbornane or endo-2-acyloxynorbornane, whose (R)-compound is in excess, having an optical purity of 50-95% ee with lipase derived from Candida genus. The optically active endo-2-norborneol useful for synthesizing intermediates of pharmaceutical preparations in large quantities.

Abstract translation: 本发明提供了一种由下式表示的光学活性的内-2-降冰片烯的方法：＆lt; IMAGE＆gt;和对映体，包括不对称水解的外消旋内-2-酰氧基降冰片烷或内-2-酰氧基降冰片烷，其（R） 化合物过量，具有50-95％ee的光学纯度，并且衍生自念珠菌属的脂肪酶。 用于大量合成药物制剂中间体的光学活性内-2-羟基吲哚类。