公开(公告)号：US20200063167A1

公开(公告)日：2020-02-27

申请号：US16671683

申请日：2019-11-01

申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES - INSA ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Thomas WALTHER ,  Yvan CAM ,  Jean-Marie FRANCOIS ,  Ceren ALKIM

IPC分类号： C12P7/42 ,  C12P7/18

摘要： Disclosed is a process for producing at least one metabolite of interest by conversion of a pentose in a microorganism. The process includes at least: (i) an operation of culturing a recombinant microorganism expressing a synthetic pathway for pentose assimilation which includes at least the following steps: a) phosphorylation in position 1 of a pentose chosen from (D)-xylulose and/or (L)-ribulose, b) cleavage of the pentose-1-phosphate obtained at the end of step a), in order to obtain glycolaldehyde and dihydroxyacetone phosphate (DHAP), and (ii) an operation of recovering the at least one metabolite of interest obtained at the end of the culturing operation (i). Also disclosed is an associated microorganism.

公开(公告)号：US20200063156A1

公开(公告)日：2020-02-27

申请号：US16676927

申请日：2019-11-07

申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) ,  VILMORIN ET CIE

发明人： Abdelhafid BENDAHMANE ,  Christelle TROADEC ,  Adnane BOUALEM ,  Daniele HOSEMANS ,  Julie FAUVE

IPC分类号： C12N15/82 ,  A01H6/34 ,  A01H5/08 ,  A01H1/04

摘要： Plants of the Cucurbitaceae family and seeds of such plants with an androecious phenotype, whereas this sexual type is not natural in the plants, and the use of the plants and of the plant seeds of the invention. Moreover, the nucleic acid sequence responsible for androecy in the plants of the invention and on the polypeptide encoded by the nucleic acid sequence. Finally, methods of identifying the plants and the seeds.

公开(公告)号：US20200024307A1

公开(公告)日：2020-01-23

申请号：US16470962

申请日：2017-12-20

申请人： INSTITUT PASTEUR ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) ,  THE UNITED STATES OF AMERICA, AS REPREESENTED BY THE SECRETARY, AGRICULTURE

发明人： John P. BANNANTINE ,  Gilles ETIENNE ,  Sylvie BAY ,  Franck BIET

IPC分类号： C07K5/087 ,  A61K47/54 ,  A61K47/60 ,  G01N33/569 ,  A61K39/04 ,  C12Q1/689 ,  C07K7/06

摘要： The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.

公开(公告)号：US20190241984A1

公开(公告)日：2019-08-08

申请号：US16318581

申请日：2017-07-11

申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE ,  IFP Energies nouvelles ,  AGRO INDUSTRIES RECHERCHE ET DEVELOPPEMENT

发明人： Damien HUDEBINE ,  Romain ROUSSET ,  Olivier CARNNOT

IPC分类号： C13K1/02 ,  C08H8/00

CPC分类号： C13K1/02 ,  C08H8/00

摘要： The invention concerns a continuous method for treating a lignocellulosic biomass before enzymatic hydrolysis, said method comprising a transfer of crushed then pressed biomass to a step of impregnation by an acid liquor, the impregnated biomass dripping over the area containing the impregnation liquor, then the resulting wet biomass is pressed and sent to a steam explosion step. The impregnation liquor is prepared in a dedicated area from the used liquor from the dripping operation and/or that from the pressing operation, prior to the explosion step. The invention also concerns the facility for implementing the method.

公开(公告)号：US20190224337A1

公开(公告)日：2019-07-25

申请号：US16235559

申请日：2018-12-28

申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Pierre FAFOURNOUX ,  Alain BRUHAT ,  Celine JOUSSE ,  Anne-Catherine MAURIN ,  Julien AVEROUS

IPC分类号： A61K48/00 ,  C12N15/85 ,  C12N15/86

摘要： An expression cassette including a gene of interest under the control of an inducible promoter, characterized in that said inducible promoter includes at least one CARE regulatory sequence (C/EBP-ATF responsive element) and a minimal promoter. Also, a vector and a host cell, as well as to a pharmaceutical composition including such a cassette, and to the use thereof for treating diseases by gene therapy.

公开(公告)号：US10328132B2

公开(公告)日：2019-06-25

申请号：US15501587

申请日：2015-08-10

申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE ,  MUSEUM NATIONAL D'HISTOIRE NATURELLE ,  ECOLE NATIONALE VETERINAIRE D'ALFORT

发明人： Luis G. Bermudez-Humaran ,  Thibault Allain ,  Isabelle Florent ,  Philippe Langella ,  Philippe Grellier ,  Marie-Agnes Travers ,  Bruno Polack

IPC分类号： A61K48/00 ,  A61K35/747 ,  A61K38/50 ,  A61K38/00 ,  A61K38/16 ,  A61K38/46 ,  A61K35/741 ,  A61K35/744 ,  A23L33/135 ,  C12N9/80

摘要： The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said composition comprising a bile-salt hydrolase (BSH) enzyme, a bacterium able to secrete a BSH, a recombinant host cell able to secrete a BSH, or a combination thereof. The present invention also relates to the use of a composition exhibiting a BSH activity for the treatment or the prevention of giardiasis, and to a pharmaceutical composition or a food composition comprising, as an active principle, a BSH, a lactic acid bacterium able to secrete a BSH, or a recombinant host cell able to secrete a BSH.

公开(公告)号：US20190169669A1

公开(公告)日：2019-06-06

申请号：US16087312

申请日：2017-03-22

申请人： Institut National de la Recherche Agronomique ,  Sorbonne Universite ,  Centre National de la Recherche Scientifique (CNRS)

发明人： Emmanuelle Jacquin-Joly ,  Arthur De Fouchier ,  Nicolas Montagne

IPC分类号： C12Q1/02 ,  C07K14/435 ,  C07K14/705

摘要： The invention relates to a novel olfactory/pheromonal receptor (SlitOR5) of Spodoptera littoralis (Lepidoptera, Noctuidae) and the identification of the natural ligand of Slit OR5 and uses thereof.

公开(公告)号：US10287326B2

公开(公告)日：2019-05-14

申请号：US15326759

申请日：2015-07-07

申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) ,  INSTITUT PASTEUR DE LILLE (IPL)

发明人： Gwenael Jan ,  Benoit Foligne ,  Helene Falentin ,  Stephanie-Marie Deutsch

IPC分类号： A61K38/00 ,  C07K14/195 ,  A61K38/16 ,  C12Q1/04

摘要： Disclosed is a polypeptide including or consisting of the amino acid sequence SEQ id no:1, for use in the treatment or prevention of an inflammatory disease. It further encompasses a nucleic acid sequence encoding a polypeptide, a vector including a nucleic acid and a host cell including a nucleic acid sequence and/or a vector, for use in the treatment or prevention of an inflammatory disease. Also disclosed is a pharmaceutical composition or a food composition including a polypeptide, a nucleic acid sequence, a vector or a host cell and a pharmaceutically acceptable carrier or a dairy product, for the treatment of inflammatory disease. Additionally, a method for the screening of bacteria having immunomodulatory properties is disclosed.

公开(公告)号：US20190038681A1

公开(公告)日：2019-02-07

申请号：US16156576

申请日：2018-10-10

申请人： LESAFFRE ET COMPAGNIE ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE INRA ,  ECOLE NATIONALE SUPERIEURE DES SCIENCES AGRONOMIQUES DE BORDEAUX AQUITAINE

发明人： Marie Khuong Huu ,  Jean Fioramonti ,  Maria Urdaci

IPC分类号： A61K35/742 ,  G01N33/569 ,  C12R1/125 ,  G01N33/50 ,  G01N33/68 ,  A61K35/00

摘要： The present invention relates to a method of selecting or identifying probiotic strains capable of acting on the absorption of water in the colon, and use thereof as medicinal products in the treatment and/or prevention of diarrhea. The invention relates in particular to the strain of Bacillus subtilis CU1 for use in the treatment and/or prevention of diarrhea.

公开(公告)号：US20190029232A1

公开(公告)日：2019-01-31

申请号：US16074486

申请日：2017-01-31

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Institut National de la Recherche Agronomique

发明人： Emmanuel Dijoux ,  Laurent Legendre ,  Frédéric Sohm

IPC分类号： A01K61/17 ,  A01K63/00

摘要： Breeding system (1) for fish belonging to the Cyprinidae family, and more particularly for zebra fish of the species Danio rerio, the said system comprising a breeding tank (2) having a bottom (2a) and side walls (2b), a spawning support (3) placed in the breeding tank (2) and comprising a platform (4) forming a spawning zone positioned a distance away from the bottom (2a) of the breeding tank (2), and a water circulating system (17) configured to modify the water level in the breeding tank (2) and at least partially flood the platform (4) of the spawning support (3), in which breeding system the spawning support (3) comprises a funnel (7) comprising a truncated conical wall (8) having a lower orifice (9) extending near the bottom (2a) of the breeding tank (2) and in fluidic communication with the water circulating system (17) by means of a pipe (11), and an upper orifice (10) extending some distance away from the bottom (2a), the platform (4) being fixed near the upper orifice (10) of the funnel (7), and the breeding system further comprises a removable shut-off member (13) configured to at least partially block off the pipe (11) of the spawning support (3) so as to increase the water level in the breeding tank (2) so as to at least partially flood the platform (4), the shut-off member (13) comprising a pipe at the end of which through-holes are formed, the said pipe having a height that is greater than a distance between the lower orifice (9) and the upper orifice (10).