公开(公告)号：US11554110B2

公开(公告)日：2023-01-17

申请号：US17708740

申请日：2022-03-30

Applicant: Kowa Company, Ltd.

Inventor： Ryu Oshima ,  Masatoshi Ito ,  Chisato Nagai

IPC: A61K31/423 ,  A61K31/34 ,  A61K31/4152 ,  A61K31/427 ,  A61K31/4353 ,  A61K31/4402 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/513 ,  A61K31/7034 ,  A61K38/13 ,  A61P3/06 ,  A61K31/7048 ,  A61K45/06

Abstract: To provide a medicament for safely treating a patient in need of treatment with pemafibrate, a salt thereof, or a solvate of any of these (hereinafter also referred to as pemafibrate therapy).
A medicament for treating a patient in need of pemafibrate therapy, the medicament comprising the step of avoiding or suspending concomitant use of pemafibrate, a salt thereof, or a solvate of any of these as an active ingredient in order to suppress an increase in plasma concentration of pemafibrate when the treatment is combined with a medicament containing an OATP1B inhibitor, or the step of reducing the dose of pemafibrate, a salt thereof, or a solvate of any of these.

公开(公告)号：US11514570B2

公开(公告)日：2022-11-29

申请号：US16637216

申请日：2018-08-06

Applicant: KOWA COMPANY, LTD.

Inventor： Reiko Arita ,  Katsumi Yabusaki

IPC: G06K9/00 ,  G06T7/00 ,  A61B3/00 ,  A61B5/00

Abstract: Provided are a method, a computer program and a device for noninvasively evaluating a state of a tear fluid and a tear fluid amount of a tear meniscus.
Included are a binarization step of binarizing a tear meniscus image, obtained by capturing at least a part of a tear meniscus of a subject, using a predetermined threshold value; an extraction step of extracting a high luminance region indicating a tear meniscus part from the binarized image; and an evaluation step of evaluating a tear fluid state on the basis of the high luminance region.

公开(公告)号：US11426064B2

公开(公告)日：2022-08-30

申请号：US16633548

申请日：2018-07-23

Applicant: Tohoku University ,  Kowa Company, Ltd.

Inventor： Toru Nakazawa ,  Satoshi Shimada ,  Takuya Hara

IPC: A61B3/024 ,  A61B3/00 ,  A61B3/06

Abstract: In examining a patient for progression of glaucoma, a perimeter capable of appropriately assessing visual field progression in a short period of time, therefore lessening the physical burden of testing on the examinee.

公开(公告)号：US20220244568A1

公开(公告)日：2022-08-04

申请号：US17659401

申请日：2022-04-15

Applicant: KOWA COMPANY, LTD.

Inventor： Haruo Ishikawa

IPC: G02C7/02 ,  A61F2/16 ,  G02C7/04

Abstract: An ophthalmic lens has a cross-sectional shape in an arbitrary meridian direction on a lens surface of the ophthalmic lens. The cross-sectional shape is expressed by the following formula (1), Z = c ⁢ r 2 1 + [ 1 - c 2 ⁢ r 2 ⁡ ( k + 1 ) ] 1 / 2 + A ⁡ ( θ ) ⁢ r 2 + B ⁡ ( θ ) ⁢ r 4 . In the formula, c is a paraxial curvature of the ophthalmic lens, r is a distance from a lens center of the ophthalmic lens, k is a conic constant of a surface which is in rotation symmetry with respect to an optical axis of the lens in the ophthalmic lens. The variables c, r and k are used in common in the meridian direction on the lens surface, and A(θ) and B(θ) are parameters expressed by functions depending on an angle in the meridian direction.

公开(公告)号：US20220127768A1

公开(公告)日：2022-04-28

申请号：US17437667

申请日：2020-03-13

Applicant: NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION ,  KOWA COMPANY, LTD.

Inventor： Taiyo YOSHIOKA ,  Tsunenori KAMEDA ,  Akimune ASANUMA ,  Norhiko FUKUOKA

IPC: D04H1/4266 ,  C08J5/04

Abstract: An object of the present invention is to develop and provide a fiber-reinforced composite material having a bagworm silk thread(s) as a reinforcing fiber and being isotropic in terms of elastic modulus and strength. A fiber-reinforced composite material having nonwoven fabric(s) including bagworm silk thread as a reinforcing fiber is also provided.

公开(公告)号：US11215904B2

公开(公告)日：2022-01-04

申请号：US16964309

申请日：2019-02-08

Applicant: KOWA COMPANY, LTD.

Inventor： Shuichi Tominaga

IPC: G03B17/08 ,  G02B7/02 ,  G03B17/14 ,  G03B17/56 ,  H04N5/225

Abstract: A waterproof wall 60 is provided to be interposed between an end face 31 of a base end section of a waterproof lens unit 20 and a mount face 13 of a camera body 10, thereby shutting off the front surface of the camera body 10 from a space in front of the front surface of the camera body 10 by the waterproof wall 60.

公开(公告)号：US20210069157A1

公开(公告)日：2021-03-11

申请号：US16323374

申请日：2017-02-24

Applicant: Kowa Company, Ltd

Inventor： Mitsumasa NAKAMURA ,  Satoshi Kojima ,  Ryohei Tanigawa

IPC: A61K31/423 ,  A61P1/16

Abstract: The present invention relates to a pharmaceutical composition for the treatment of primary biliary cirrhosis (PBC), in which containing a therapeutically effective amount of (R)-2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy] butyric acid, a salt thereof, or a solvate thereof.

公开(公告)号：US10914964B2

公开(公告)日：2021-02-09

申请号：US16374849

申请日：2019-04-04

Applicant: KOWA COMPANY, LTD.

Inventor： Hirofumi Yagi

IPC: G02B7/02 ,  G02B27/64 ,  G03B9/02 ,  G03B15/00 ,  G03B17/14 ,  H04N5/225 ,  H04N5/232

Abstract: A lens barrel detachably attached to a camera body includes a fixed tube section that has a base end installed at the camera body, and a top end, a first pitch screw section being formed on an inner peripheral surface of the top end; a movable tube section that is a tube member configured to hold a plurality of lens and has a second pitch screw section on the movable tube side formed at an outer peripheral surface, and is located so as to be movable inside the fixed tube section in such a state that the second pitch screw section is threadedly engaged with the first pitch screw section, the plurality of lens including two group of lenses, a first group and a second group, held within the movable tube section. The movable tube section having a fixed diaphragm plate that is detachable.

公开(公告)号：US20200315446A1

公开(公告)日：2020-10-08

申请号：US16306398

申请日：2017-05-29

Applicant: KOWA COMPANY, LTD.

Inventor： Katsumi YABUSAKI

IPC: A61B3/10 ,  A61B3/14 ,  A61B3/00

Abstract: Provided are a method and a device for evaluating a tear fluid to objectively evaluate and determine the severity of dry eye or the like. Color information is acquired in a predetermined region of a tear fluid interference fringe image, a numerical value representing a color diversity is calculated from the color information acquired, and the numerical value representing the color diversity thus calculated is used as an index for evaluating a tear fluid state.

公开(公告)号：US10751224B2

公开(公告)日：2020-08-25

申请号：US15123601

申请日：2015-03-03

Applicant: KOWA COMPANY, LTD.

Inventor： Akiharu Tsuchiya ,  Hitoshi Ojima ,  Hidenori Kaseno

IPC: A61F13/00 ,  A61F13/06 ,  A61F5/01

Abstract: An ankle joint bandage includes a main body part of woven fabric in band shape, an anchor part of woven fabric joined to one end of the main body part and having a loop face of a touch fastener, and an engaging part joined to the other end of the main body part and having a hook face of a touch fastener. The main body part has a winding part which winds around an ankle of a wearer, a first supporting part which extends from an instep to the ankle, and a second supporting part which extends from the ankle to the instep of the wearer to cross the first supporting part at an upper portion of the instep of the wearer, the anchor part fastens around part corresponding to a metatarsal bone of the wearer, and the engaging part detachably sticks to the loop face of the anchor part.