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公开(公告)号:US11426064B2
公开(公告)日:2022-08-30
申请号:US16633548
申请日:2018-07-23
发明人: Toru Nakazawa , Satoshi Shimada , Takuya Hara
摘要: In examining a patient for progression of glaucoma, a perimeter capable of appropriately assessing visual field progression in a short period of time, therefore lessening the physical burden of testing on the examinee.
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公开(公告)号:US20200205655A1
公开(公告)日:2020-07-02
申请号:US16633548
申请日:2018-07-23
发明人: Toru Nakazawa , Satoshi Shimada , Takuya Hara
摘要: A perimeter 2 capable of acquiring, as a threshold SV, a value corresponding to a response result of a subject 22 to an optotype presented with various brightness, for measurement points set across an entire measurement field of view of the ocular fundus, displaying the threshold SV as a threshold inspection result SHR and storing the same in a memory 13, comprises: a portion 15 for obtaining a pattern deviation PDV of the threshold SV relating to each measurement point RG, from the threshold inspection result SHR; a portion for 15 for obtaining a P value representing the obtained pattern deviation PDV for each measurement point RG as a probability variable, and generating a probability map image MAP4 indicating the measurement points RG separately for each P value; a portion 16 for selecting, from an abnormal measurement point group RG of points in the probability map image MAP4 in which at least a prescribed number of measurement points having a P value at most equal to 5% are continuous, and, of those, for which at least a prescribed number of points have a P value at most equal to 1%, measurement points to be used as subsequent measurement points, until ten points have been reached; and a memory 13 for storing the selected subsequent measurement points, wherein the selection of the subsequent measurement points is controlled in such a way that the measurement points RG are selected from the abnormal measurement point group in order of those having a good pattern deviation PDV.
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公开(公告)号:US10765316B2
公开(公告)日:2020-09-08
申请号:US15925922
申请日:2018-03-20
申请人: TOPCON CORPORATION , TOHOKU UNIVERSITY , RIKEN
发明人: Guangzhou An , Masahiro Akiba , Toru Nakazawa , Kazuko Omodaka , Hideo Yokota
摘要: An ophthalmic information processing system according to an embodiment includes a receiver and a processor. The receiver receives morphological data of an eye fundus of a subject. In addition, the receiver receives background data of the subject. The processor executes optic nerve head shape classification based on the morphological data and the background data received by the receiver.
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公开(公告)号:US10420736B2
公开(公告)日:2019-09-24
申请号:US15762726
申请日:2016-09-30
申请人: TOHOKU UNIVERSITY
发明人: Toru Nakazawa , Takaaki Akaike , Hiroshi Kunikata
IPC分类号: A61K31/16 , A61K38/00 , A61K31/198 , A61P27/02 , A61K31/4162 , A61K45/06 , A61P41/00 , A61P43/00 , A61K9/00 , A61K9/08
摘要: The present invention addresses the problem of providing an intraocular irrigating solution that allows the intraocular tissue to be sufficiently protected during ophthalmic surgery and further has high safety. The problem is solved by an intraocular irrigating solution containing at least one of active sulfur molecules of which examples include cysteine persulfide and glutathione persulfide.
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公开(公告)号:US20180162871A1
公开(公告)日:2018-06-14
申请号:US15553970
申请日:2016-02-29
发明人: Yasuteru Urano , Yuri Nagayo , Mako Kamiya , Toru Nakazawa
IPC分类号: C07D493/10 , C12Q1/37 , G01N33/58
CPC分类号: C07D493/10 , A61K49/0041 , C12Q1/37 , G01N21/78 , G01N33/582 , G01N2333/96466 , G01N2800/168
摘要: [Problem] To provide a fluorescent probe that detects calpain activity in cells at high sensitivity.[Solution] A compound represented by the following general formula (I) or a salt thereof.
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公开(公告)号:US10362939B2
公开(公告)日:2019-07-30
申请号:US15509421
申请日:2015-08-28
摘要: A fundus analysis apparatus includes a storage, an area setting unit, and a morphological information generating unit. The storage is configured to store OCT information acquired by applying optical coherence tomography to the fundus of an eye. The area setting unit is configured to set a front area corresponding to a front surface of the lamina cribrosa and a rear area corresponding to a rear surface of the lamina cribrosa in the OCT information. The morphological information generating unit is configured to generate morphological information indicating the morphology of the lamina cribrosa based on at least the front area and the rear area.
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公开(公告)号:US10321817B2
公开(公告)日:2019-06-18
申请号:US15717451
申请日:2017-09-27
申请人: TOHOKU UNIVERSITY
发明人: Kazuhiro Hane , Toru Nakazawa , Takashi Sasaki
摘要: An image display apparatus includes: a light source part generating a plurality of light rays corresponding to respective pixels in an image that changes over time; a projecting part defining an optical path from the light source part to an eye, and forming the image on a retina of the eye by projecting the generated light rays directly on the retina through the optical path; a splitting part splitting a plurality of reflection light rays from positions in a certain site of the eye on the optical path, the positions corresponding to the respective pixels; a detecting part detecting intensities of the reflection light rays that have been split; and a processing part obtaining parameters indicative of conditions of the site at the positions corresponding to the respective pixels, based on intensities of the generated light rays and the intensities of the reflection light rays, for the respective pixels.
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公开(公告)号:USRE49518E1
公开(公告)日:2023-05-02
申请号:US17327001
申请日:2021-05-21
发明人: Yasuteru Urano , Yuri Nagayo , Mako Kamiya , Toru Nakazawa
IPC分类号: C07D493/10 , A61K49/00 , C12Q1/37 , G01N21/78 , G01N33/58
摘要: [Problem] To provide a fluorescent probe that detects calpain activity in cells at high sensitivity.
[Solution] A compound represented by the following general formula (I) or a salt thereof.-
公开(公告)号:US10294240B2
公开(公告)日:2019-05-21
申请号:US15553970
申请日:2016-02-29
发明人: Yasuteru Urano , Yuri Nagayo , Mako Kamiya , Toru Nakazawa
IPC分类号: C12Q1/37 , A61K49/00 , G01N21/78 , G01N33/58 , C07D493/10
摘要: [Problem] To provide a fluorescent probe that detects calpain activity in cells at high sensitivity.[Solution] A compound represented by the following general formula (I) or a salt thereof.
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公开(公告)号:US20180296504A1
公开(公告)日:2018-10-18
申请号:US15762726
申请日:2016-09-30
申请人: TOHOKU UNIVERSITY
发明人: Toru Nakazawa , Takaaki Akaike , Hiroshi Kunikata
IPC分类号: A61K31/16 , A61K31/4162 , A61P27/02
CPC分类号: A61K31/16 , A61K9/0048 , A61K9/08 , A61K31/198 , A61K31/4162 , A61K38/00 , A61K45/06 , A61P27/02 , A61P41/00 , A61P43/00
摘要: The present invention addresses the problem of providing an intraocular irrigating solution that allows the intraocular tissue to be sufficiently protected during ophthalmic surgery and further has high safety. The problem is solved by an intraocular irrigating solution containing at least one of active sulfur molecules of which examples include cysteine persulfide and glutathione persulfide.
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