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公开(公告)号：US09603741B2
公开(公告)日：2017-03-28
申请号：US14028460
申请日：2013-09-16
申请人： Michael S. Berlin
发明人： Michael S. Berlin
CPC分类号： A61F9/00781 , A61F9/00736 , A61F9/00802 , A61F2009/00868 , A61F2009/00891
摘要： A method and delivery system are disclosed for creating an aqueous flow pathway in the trabecular meshwork, juxtacanalicular trabecular meshwork and Schlemm's canal of an eye for reducing elevated intraocular pressure. Pulsed laser radiation is delivered from the distal end of a fiber-optic probe sufficient to cause photoablation of selected portions of the trabecular meshwork, the juxtacanalicular trabecular meshwork and an inner wall of Schlemm's canal in the target site. The fiber-optic probe may be advanced so as to create an aperture in the inner wall of Schlemm's canal in which fluid from the anterior chamber of the eye flows. The method and delivery system may further be used on any tissue types in the body.
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公开(公告)号：US20170020732A1
公开(公告)日：2017-01-26
申请号：US15288993
申请日：2016-10-07
申请人： Michael S. BERLIN
发明人： Michael S. BERLIN
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F9/00736 , A61F9/00802 , A61F2009/00868 , A61F2009/00891
摘要： A method and delivery system are disclosed for creating an aqueous flow pathway in the trabecular meshwork, juxtacanalicular trabecular meshwork and Schlemm's canal of an eye for reducing elevated intraocular pressure. Pulsed laser radiation is delivered from the distal end of a fiber-optic probe sufficient to cause photoablation of selected portions of the trabecular meshwork, the juxtacanalicular trabecular meshwork and an inner wall of Schlemm's canal in the target site. The fiber-optic probe may be advanced so as to create an aperture in the inner wall of Schlemm's canal in which fluid from the anterior chamber of the eye flows. The method and delivery system may further be used on any tissue types in the body.
摘要翻译： 公开了一种方法和输送系统，用于在小梁网，并肩关节小梁网和眼睛的施莱姆氏管中创建水流动通道，以降低眼内压升高。 脉冲激光辐射从纤维光学探针的远端传送，足以引起小梁网的选定部分，近端棘突小梁网和目标部位的施莱姆氏管内壁的光消融。 可以推进光纤探针，以便在施莱姆氏管的内壁中形成一个孔，其中来自眼睛前房的流体流动。 该方法和递送系统还可以用于身体中的任何组织类型。
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公开(公告)号：US06251103B1
公开(公告)日：2001-06-26
申请号：US08237221
申请日：1994-05-02
申请人： Michael S. Berlin
发明人： Michael S. Berlin
IPC分类号： A61M506
CPC分类号： A61F9/00802 , A61B2018/2277 , A61F2009/00868 , A61F2009/0087 , A61F2009/00874 , A61F2009/00887
摘要： Transocular and periocular laser delivery system for treatment of eye diseases wherein a fiberoptic element is passed through a perforation made either by paracentesis of eyeball encapsulating tissue (i.e.—cornea, sclera) or by the fiberoptic element itself so that the fiber actually penetrates into a chamber therein. The penetrating fiber end is then juxtaposed to the tissue to be treated while the external fiberoptic end is coupled either to an excimer laser emitting ultraviolet radiation (in the range of 193 to 351 nanometers) or to certain lasers emitting infrared radiation, the radiated pulses therefrom being directed through the transocularly-positioned fiber to be absorbed by chromophores in the target tissue (cataractous lens, trabecular meshwork, vitreous membranes, tear duct occlusion) where removal by photoablation is effected. Photoablation by way of the fiberoptic element creates a portal for filtration of aqueous fluid in the case of glaucoma or allows removal of cataractous lens tissue, vitreous hemorrhage or membranes or other tissue occluding tear duct passages in a manner promoting controlled healing, minimizing inflammation and scarring.
摘要翻译： 用于治疗眼部疾病的透视和眼周激光递送系统，其中光纤元件穿过由眼球包封组织（即角膜，巩膜）的穿刺或纤维素元件本身制成的穿孔，使得纤维实际上穿透入室 其中。 然后将穿透纤维端和待处理的组织并置，同时将外部光纤端耦合到发射紫外线辐射（193至351纳米）范围内的准分子激光器或发射红外辐射的某些激光器，辐射脉冲 引导通过透视定位的纤维被靶组织（白内障透镜，小梁网，玻璃体膜，泪管闭塞）中的发色团吸收，其中通过光消除进行去除。 通过光纤元件进行光消融在青光眼的情况下产生过滤水溶液的门户，或者以促进受控愈合的方式，使炎症和瘢痕形成最小化，从而可以去除白内障晶状体组织，玻璃体出血或膜或其它组织阻塞撕裂通道。 。
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64.发明公开公开(公告)号：US20230355442A1
公开(公告)日：2023-11-09
申请号：US18356590
申请日：2023-07-21
申请人： Michael S. BERLIN
发明人： Michael S. BERLIN
CPC分类号： A61F9/00825 , A61F9/009 , A61F9/0084 , A61F2009/00851 , A61F2009/00865 , A61F2009/00868 , A61F2009/00891 , A61F2009/00897
摘要： Transcorneal and fiberoptic laser delivery systems and methods for the treatment of eye diseases wherein energy is delivered by wavelengths transparent to the cornea to effect target tissues in the eye for the control of intraocular pressure in diseases such as glaucoma by delivery systems both external to and within ocular tissues. External delivery may be affected under gonioscopic control. Internal delivery may be controlled endoscopically or fiberoptically, both systems utilizing femtosecond laser energy to excise ocular tissue. The femtosecond light energy is delivered to the target tissues to be treated to effect precisely controlled photodisruption to enable portals for the outflow of aqueous fluid in the case of glaucoma in a manner which minimizes target tissue healing responses, inflammation and scarring.
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公开(公告)号：US11583444B2
公开(公告)日：2023-02-21
申请号：US17656956
申请日：2022-03-29
申请人： Michael S. Berlin
发明人： Michael S. Berlin
IPC分类号： G06K9/00 , A61B18/18 , A61F9/007 , A61B90/00 , A61F9/008 , A61B34/20 , G06N20/00 , A61F2/14 , A61M27/00 , G02B23/24 , A61B1/00 , A61B34/00 , A61B1/04 , G06T3/40
摘要： An imaging probe comprises a camera or endoscope with an external detector array, in which the probe is sized and shaped for surgical placement in an eye to image the eye from an interior of the eye during treatment. The imaging probe and a treatment probe can be coupled together with a fastener or contained within a housing. The imaging probe and the treatment probe can be sized and shaped to enter the eye through an incision in the cornea and image one or more of the ciliary body band or the scleral spur. The treatment probe may comprise a treatment optical fiber or a surgical placement device to deliver an implant. A processor coupled to the detector can be configured with instructions to identify a location of one or more of the ciliary body band, the scleral spur, Schwalbe's line, or Schlemm's canal from the image.
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66.发明申请公开(公告)号：US20210353464A1
公开(公告)日：2021-11-18
申请号：US17302965
申请日：2021-05-17
申请人： Michael S. BERLIN
发明人： Michael S. BERLIN
摘要： Transcorneal and fiberoptic laser delivery systems and methods for the treatment of eye diseases wherein energy is delivered by wavelengths transparent to the cornea to effect target tissues in the eye for the control of intraocular pressure in diseases such as glaucoma by delivery systems both external to and within ocular tissues. External delivery may be affected under gonioscopic control. Internal delivery may be controlled endoscopically or fiberoptically, both systems utilizing femtosecond laser energy to excise ocular tissue. The femtosecond light energy is delivered to the target tissues to be treated to effect precisely controlled photodisruption to enable portals for the outflow of aqueous fluid in the case of glaucoma in a manner which minimizes target tissue healing responses, inflammation and scarring.
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公开(公告)号：US20210022921A1
公开(公告)日：2021-01-28
申请号：US17070350
申请日：2020-10-14
发明人： Michael S. Berlin
摘要： Disclosed herein are systems and methods for aiding a surgeon to perform a surgical procedure on an eye. The surgical procedure includes inserting an elongate probe from an opening into the eye across an anterior chamber to a target tissue region comprising a trabecular meshwork and a Schlemm's canal. Exemplary systems include an optical microscope for the surgeon to view the eye with a microscope image during the procedure; an optical coherence tomography (OCT) apparatus configured to perform an OCT scan of a target location in the target tissue region during the procedure; and an image processing apparatus configured to generate an augmented image by overlaying an OCT image of target location and a graphical visual element identifying the locations, wherein the graphical visual element is registered with the microscope image to aid the surgeon in advancing a distal end of the elongate probe to the target location.
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公开(公告)号：US20200323687A1
公开(公告)日：2020-10-15
申请号：US16911988
申请日：2020-06-25
发明人： Michael S. Berlin
摘要： Disclosed herein are systems and methods for aiding a surgeon to perform a surgical procedure on an eye. The surgical procedure includes inserting an elongate probe from an opening into the eye across an anterior chamber to a target tissue region comprising a trabecular meshwork and a Schlemm's canal. Exemplary systems include an optical microscope for the surgeon to view the eye with a microscope image during the procedure; an optical coherence tomography (OCT) apparatus configured to perform an OCT scan of a target location in the target tissue region during the procedure; and an image processing apparatus configured to generate an augmented image by overlaying an OCT image of target location and a graphical visual element identifying the locations, wherein the graphical visual element is registered with the microscope image to aid the surgeon in advancing a distal end of the elongate probe to the target location.
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公开(公告)号：US20200281766A1
公开(公告)日：2020-09-10
申请号：US16880561
申请日：2020-05-21
发明人： Michael S. Berlin
摘要： Disclosed herein are systems and methods for aiding a surgeon to perform a surgical procedure on an eye. The surgical procedure includes inserting an elongate probe from an opening into the eye across an anterior chamber to a target tissue region comprising a trabecular meshwork and a Schlemm's canal. Exemplary systems include an optical microscope for the surgeon to view the eye with a microscope image during the procedure; an optical coherence tomography (OCT) apparatus configured to perform an OCT scan of a target location in the target tissue region during the procedure; and an image processing apparatus configured to generate an augmented image by overlaying an OCT image of target location and a graphical visual element identifying the locations, wherein the graphical visual element is registered with the microscope image to aid the surgeon in advancing a distal end of the elongate probe to the target location.
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公开(公告)号：US10517760B2
公开(公告)日：2019-12-31
申请号：US16011011
申请日：2018-06-18
申请人： Michael S. Berlin
发明人： Michael S. Berlin
IPC分类号： A61F9/00 , A61F9/008 , A61B3/00 , A61B3/10 , A61B3/13 , A61B3/14 , A61B34/20 , A61F9/007 , G06T11/60 , A61B90/00 , G06T7/00 , A61B34/00 , A61B90/20
摘要： Disclosed herein are systems and methods for aiding a surgeon to perform a surgical procedure on an eye. The surgical procedure includes inserting an elongate probe from an opening into the eye across an anterior chamber to a target tissue region comprising a trabecular meshwork and a Schlemm's canal. Exemplary systems include an optical microscope for the surgeon to view the eye with a microscope image during the procedure; an optical coherence tomography (OCT) apparatus configured to perform an OCT scan of a target location in the target tissue region during the procedure; and an image processing apparatus configured to generate an augmented image by overlaying an OCT image of target location and a graphical visual element identifying the locations, wherein the graphical visual element is registered with the microscope image to aid the surgeon in advancing a distal end of the elongate probe to the target location.
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