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61.发明申请公开(公告)号：US20220387576A1
公开(公告)日：2022-12-08
申请号：US17824295
申请日：2022-05-25
申请人： Pfizer Inc.
发明人： Annaliesa Sybil Anderson , Caitlyn Gallagher , Jianxin Gu , Isis Kanevsky , Jin-Hwan Kim , Justin Keith Moran , Suddham Singh , Naveen Surendran
摘要： The present invention relates to new conjugated capsular saccharide antigens (glycoconjugates), immunogenic compositions comprising said glycoconjugates and uses thereof.
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公开(公告)号：US20220370606A1
公开(公告)日：2022-11-24
申请号：US17415348
申请日：2019-12-18
申请人： Pfizer Inc.
IPC分类号： A61K39/395 , C07K16/28 , A61P35/00 , A61K31/713 , A61K31/7125
摘要： The present disclosure describes combination therapies and uses thereof for the treatment of cancer. The combinations therapies include at least a first therapeutic agent and a second therapeutic agent.
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公开(公告)号：US20220362372A1
公开(公告)日：2022-11-17
申请号：US17733566
申请日：2022-04-29
申请人： PFIZER INC.
发明人： Philip Ralph Dormitzer , Advait Vijay Badkar , Christina Van Geen Hoven , Kathrin Ute Jansen , Pirada Suphaphiphat Allen , Ramin Darvari , Mark Duda
IPC分类号： A61K39/145 , A61P31/16
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines comprising polynucleotide molecules encoding one or more influenza antigens, such as hemagglutinin antigens.
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公开(公告)号：US11472850B2
公开(公告)日：2022-10-18
申请号：US17060067
申请日：2020-09-30
申请人： PFIZER INC.
发明人： Annaliesa Sybil Anderson , Susan Kay Hoiseth , Kathrin Ute Jansen , Justin Keith Moran , Mark Edward Ruppen
IPC分类号： C07K14/22 , A61K39/095 , A61K39/00
摘要： In one aspect, the invention relates to a non-lipidated and non-pyruvylated Neisseria meningitidis serogroup B polypeptide and methods of use thereof. In another aspect, the invention relates to an immunogenic composition including an isolated non-lipidated, non-pyruvylated ORF2086 polypeptide from Neisseria meningitidis serogroup B, and at least one conjugated capsular saccharide from a meningococcal serogroup, and methods of use thereof.
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![Pyrazolo[1,5-a]pyrazin-4-yl derivatives](/abs-image/US/2022/10/18/US11472809B2/abs.jpg.150x150.jpg)
公开(公告)号：US11472809B2
公开(公告)日：2022-10-18
申请号：US17014533
申请日：2020-09-08
申请人： Pfizer Inc.
发明人： Matthew Frank Brown , Alpay Dermenci , Andrew Fensome , Brian Stephen Gerstenberger , Matthew Merrill Hayward , Dafydd Rhys Owen , Stephen Wayne Wright , Li Huang Xing , Xiaojing Yang
IPC分类号： A61K31/4985 , C07D487/04
摘要： There is a method for treating a psoriasis. A compound is administered in a therapeutically effective amount to a subject suffering therefrom. The compound has the structure or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof.
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公开(公告)号：US20220323558A1
公开(公告)日：2022-10-13
申请号：US17319395
申请日：2021-05-13
申请人： Pfizer Inc.
发明人： Joseph John Binder , Paul Jason Cockle , Derek John Falconer , Siradanahalli Guru , Karin Ute Jooss , Marianne Marcela Andrea Martinic , Kenneth Nelson Wills , Helen Kim Cho
摘要： The present disclosure provides (i) isolated immunogenic TAA polypeptides (i.e., an immunogenic MUC1 polypeptides, an immunogenic MSLN polypeptides, and an immunogenic TERT polypeptides), (ii) isolated nucleic acid molecules encoding one or more immunogenic TAA polypeptides, (iii) compositions comprising an immunogenic TAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic TAA polypeptide, and (iv) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions.
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公开(公告)号：US20220306641A1
公开(公告)日：2022-09-29
申请号：US17693197
申请日：2022-03-11
申请人： PFIZER INC.
发明人： Ketan Satish GAJIWALA , Chan Woo HUH , Mehran JALAIE , Ryan Lloyd PATMAN , Eugene Yuanjin RUI , Jianmin SUN , Martin James WYTHES
IPC分类号： C07D487/04 , C07D471/04
摘要： Provided herein are compounds of the general formula (I): and pharmaceutically acceptable salts thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US11452711B2
公开(公告)日：2022-09-27
申请号：US17660270
申请日：2022-04-22
申请人： Pfizer Inc.
发明人： Dafydd Rhys Owen , Matthew Richard Reese , Matthew Forrest Sammons , Jamison Bryce Tuttle , Patrick Robert Verhoest , Qingyi Yang
IPC分类号： C07D403/12 , A61K31/403 , A61P31/14 , A61K31/427 , A61K31/401
摘要： The invention relates to compounds of Formula I″ wherein R, R1, R2, R3, p, q and q′ are as defined herein, pharmaceutical compositions comprising the compounds, methods of treating coronavirus infection such as COVID-19 in a patient by administering therapeutically effective amounts of the compounds, and methods of inhibiting or preventing replication of coronaviruses such as SARS-CoV-2 with the compounds.
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公开(公告)号：US20220251066A1
公开(公告)日：2022-08-11
申请号：US17458862
申请日：2021-08-27
申请人： Pfizer Inc.
发明人： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC分类号： C07D401/12 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D241/20 , C07D475/00
摘要： The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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公开(公告)号：US20220235141A1
公开(公告)日：2022-07-28
申请号：US17613304
申请日：2020-05-21
申请人： Pfizer Inc.
IPC分类号： C07K16/28 , C07K14/705 , A61K45/06 , A61P35/00
摘要： This invention relates to a method for treating cancer by administering a CDK4/6 inhibitor or CDK2/4/6 inhibitor in combination with a 4-1BB agonist and/or an OX40 agonist to a subject in need thereof.
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