公开(公告)号：US20150239881A1

公开(公告)日：2015-08-27

申请号：US14626749

申请日：2015-02-19

Applicant: Xin Chen ,  Peng Cheng ,  L. Edward Clemens ,  Jeffrey D. Johnson ,  Jingyuan Ma ,  Alison Murphy ,  Imad Nashashibi ,  Christopher J. Rabbat ,  Jiangao Song ,  Maria E. Wilson ,  Yan Zhu ,  Zuchun Zhao

Inventor： Xin Chen ,  Peng Cheng ,  L. Edward Clemens ,  Jeffrey D. Johnson ,  Jingyuan Ma ,  Alison Murphy ,  Imad Nashashibi ,  Christopher J. Rabbat ,  Jiangao Song ,  Maria E. Wilson ,  Yan Zhu ,  Zuchun Zhao

IPC: C07D417/14 ,  C07D277/42 ,  C07D413/14 ,  C07D417/04 ,  C07D413/04

CPC classification number: A61K31/506 ,  A61K31/454 ,  C07D277/42 ,  C07D401/04 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.

公开(公告)号：US20150161143A1

公开(公告)日：2015-06-11

申请号：US14415629

申请日：2012-08-02

Applicant: Yan Zhu ,  Jianxiu Wang ,  Sheng Zhong ,  Zhenzhi Zhang

Inventor： Yan Zhu ,  Jianxiu Wang ,  Sheng Zhong ,  Zhenzhi Zhang

IPC: G06F17/30

CPC classification number: G06F16/3322 ,  G06F3/018 ,  G06F3/0236 ,  G06F3/0237 ,  G06F3/04886

Abstract: An input processing method and device are provided. The method includes: detecting that at least one input character is deleted; obtaining a group of candidate characters corresponding to a last input character in one or more input characters that are not deleted; and displaying the group of candidate characters. The solution solves the problem that a candidate word of a character cannot be reselected if the character is not re-input in the related art, thereby improving the input efficiency of characters and facilitating improvement of user experience.

Abstract translation: 提供了一种输入处理方法和装置。 该方法包括：检测至少一个输入字符被删除; 获取与未被删除的一个或多个输入字符中的最后输入字符对应的一组候选字符; 并显示候选人物组。 该解决方案解决了如果在现有技术中没有重新输入字符的情况下不能重新选择字符的候选词的问题，从而提高字符的输入效率并促进用户体验的改善。

公开(公告)号：US08999998B2

公开(公告)日：2015-04-07

申请号：US13382145

申请日：2010-07-02

Applicant: Paul Gibbons ,  Emily Hanan ,  Wendy Liu ,  Joseph P. Lyssikatos ,  Steven R. Magnuson ,  Rohan Mendonca ,  Richard Pastor ,  Thomas E. Rawson ,  Michael Siu ,  Mark Zak ,  Aihe Zhou ,  Bing-Yan Zhu

Inventor： Paul Gibbons ,  Emily Hanan ,  Wendy Liu ,  Joseph P. Lyssikatos ,  Steven R. Magnuson ,  Rohan Mendonca ,  Richard Pastor ,  Thomas E. Rawson ,  Michael Siu ,  Mark Zak ,  Aihe Zhou ,  Bing-Yan Zhu

IPC: C07D487/04 ,  A61K31/519

CPC classification number: C07D487/04

Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

Abstract translation: 其中R 1，R 2和R 3在本文中定义的式I化合物，对映异构体，非对映异构体，互变异构体或其药学上可接受的盐可用作一种或多种Janus激酶的抑制剂。 公开了包含式I化合物和药学上可接受的载体，佐剂或媒介物的药物组合物，以及对患者中Janus激酶活性的抑制作出反应的疾病或病症的严重程度的治疗或减轻的方法。

公开(公告)号：US08720271B2

公开(公告)日：2014-05-13

申请号：US12694001

申请日：2010-01-26

Applicant: Yan Zhu ,  Xiaoying Zhu

Inventor： Yan Zhu ,  Xiaoying Zhu

IPC: G01M1/16

CPC classification number: G01M1/06 ,  G01M1/16

Abstract: A device to balance a disc, comprising a shaft disposed for rotation about an axis having one end adapted to coaxially receive the disc and an opposite end including rotor structure stator structure to magnetically drive the rotor structure, shaft and disc about the axis; and structure for determining imbalance in the disc.

Abstract translation: 一种用于平衡盘的装置，包括设置成用于围绕具有适于同轴地容纳盘的一端的轴线旋转的轴和包括转子结构定子结构的相对端，用于围绕轴线磁性驱动转子结构，轴和盘; 以及用于确定盘不平衡的结构。

公开(公告)号：US20140018380A1

公开(公告)日：2014-01-16

申请号：US14003174

申请日：2012-01-31

Applicant: Dengming Xiao ,  Yan Zhu ,  Yuandong Hu ,  Huting Wang ,  Yuliang Liu ,  Jijun Li ,  Deguang Sun ,  Zhe Wang ,  Yongheng Wei ,  Zanping Wang ,  Guojing Tang ,  Lutao Jing

Inventor： Dengming Xiao ,  Yan Zhu ,  Yuandong Hu ,  Huting Wang ,  Yuliang Liu ,  Jijun Li ,  Deguang Sun ,  Zhe Wang ,  Yongheng Wei ,  Zanping Wang ,  Guojing Tang ,  Lutao Jing

IPC: C07D401/04 ,  C07D471/04 ,  C07D413/14 ,  C07D401/14

CPC classification number: C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D451/14 ,  C07D471/04

Abstract: The present invention provides a new class of bicyclic heteroaryl compounds represented by Formula I, pharmaceutical compositions containing these compounds, and their use for modulating the activity of GPR119 in the treatment of metabolic disorders and complications thereof, as well as methods for the treatment of the metabolic disorders and complications thereof.

Abstract translation: 本发明提供了一类由式I表示的双环杂芳基化合物，含有这些化合物的药物组合物及其用于调节GPR119在治疗代谢紊乱及其并发症中的活性的用途，以及用于治疗 代谢紊乱及其并发症。

公开(公告)号：US08609687B2

公开(公告)日：2013-12-17

申请号：US13471269

申请日：2012-05-14

Applicant: Bing-Yan Zhu ,  Michael Siu ,  Steven R. Magnuson ,  Richard Pastor ,  He Haiying ,  Xiao Yisong ,  Zheng Jifu ,  Xu Xing ,  Zhao Junping ,  Christopher Hurley ,  Jun Liang ,  Wendy Liu ,  Joseph P. Lyssikatos

Inventor： Bing-Yan Zhu ,  Michael Siu ,  Steven R. Magnuson ,  Richard Pastor ,  He Haiying ,  Xiao Yisong ,  Zheng Jifu ,  Xu Xing ,  Zhao Junping ,  Christopher Hurley ,  Jun Liang ,  Wendy Liu ,  Joseph P. Lyssikatos

IPC: A61K31/437 ,  C07D471/02

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  C07D487/04

Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.

Abstract translation: 其中R 1，R 2，R 3，R 4和R 5在本文中定义的式I化合物，对映异构体，非对映异构体，互变异构体或其药学上可接受的盐可用作JAK激酶抑制剂。 公开了包含式I化合物和药学上可接受的载体，佐剂或载体的药物组合物，以及治疗或减轻对患者中JAK激酶活性的抑制作用的疾病或病症的严重程度的方法。

公开(公告)号：US08588044B2

公开(公告)日：2013-11-19

申请号：US12532822

申请日：2008-08-20

Applicant: Yan Zhu ,  BoWen Chen ,  ZengLian Liu ,  YaHui Dong

Inventor： Yan Zhu ,  BoWen Chen ,  ZengLian Liu ,  YaHui Dong

IPC: G11B5/09 ,  G11B7/00 ,  G11B5/58 ,  G11B5/55

CPC classification number: G11B19/02

Abstract: Circuitry for controlling mode selection of a CD/DVD reader is described. In one embodiment, the CD/DVD reader has a first device having at least one analog output, a second device having at least one digital input and at least one analog input, and an interface circuit coupling the analog output of the first device to the digital input and the analog input in the second device. The interface circuit includes a circuitry to use a single control signal from the analog output of the first device to control the digital input and the analog input in the second device. Other embodiments are also described.

Abstract translation: 描述用于控制CD / DVD读取器的模式选择的电路。 在一个实施例中，CD / DVD阅读器具有具有至少一个模拟输出的第一装置，具有至少一个数字输入和至少一个模拟输入的第二装置，以及将第一装置的模拟输出耦合到 数字输入和第二个设备中的模拟输入。 接口电路包括使用来自第一装置的模拟输出的单个控制信号来控制第二装置中的数字输入和模拟输入的电路。 还描述了其它实施例。

公开(公告)号：US08399690B2

公开(公告)日：2013-03-19

申请号：US13018068

申请日：2011-01-31

Applicant: Steven Do ,  Richard Goldsmith ,  Tim Heffron ,  Aleksandr Kolesnikov ,  Steven Staben ,  Alan G. Olivero ,  Michael Siu ,  Daniel P. Sutherlin ,  Bing-Yan Zhu ,  Paul Goldsmith ,  Tracy Bayliss ,  Adrian Folkes ,  Neil Pegg

Inventor： Steven Do ,  Richard Goldsmith ,  Tim Heffron ,  Aleksandr Kolesnikov ,  Steven Staben ,  Alan G. Olivero ,  Michael Siu ,  Daniel P. Sutherlin ,  Bing-Yan Zhu ,  Paul Goldsmith ,  Tracy Bayliss ,  Adrian Folkes ,  Neil Pegg

IPC: C07D313/00 ,  C07D333/00

CPC classification number: C07F5/02 ,  A61K31/381 ,  A61K31/4155 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/4436 ,  A61K31/496 ,  A61K31/53 ,  C07D495/04 ,  C07D495/14 ,  C07D513/14

Abstract: Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formulas I and II for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract translation: 式I和II的苯并吡喃和苯并辛菌素化合物，包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐，可用于抑制脂质激酶，包括p110α和PI3K的其他同种型，并用于治疗疾病如癌症 由脂质激酶介导。 公开了使用式I和II的化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：US20120225855A1

公开(公告)日：2012-09-06

申请号：US13471269

申请日：2012-05-14

Applicant: Bing-Yan Zhu ,  Michael Siu ,  Steven R. Magnuson ,  Richard Pastor ,  He Haiying ,  Xiao Yisong ,  Zheng Jifu ,  Xu Xing ,  Zhao Junping ,  Christopher Hurley ,  Jun Liang ,  Wendy Liu ,  Joseph P. Lyssikatos

Inventor： Bing-Yan Zhu ,  Michael Siu ,  Steven R. Magnuson ,  Richard Pastor ,  He Haiying ,  Xiao Yisong ,  Zheng Jifu ,  Xu Xing ,  Zhao Junping ,  Christopher Hurley ,  Jun Liang ,  Wendy Liu ,  Joseph P. Lyssikatos

IPC: C07D471/04 ,  A61K31/496 ,  A61K31/5377 ,  A61P9/00 ,  A61P3/10 ,  A61P37/00 ,  A61P25/00 ,  A61P1/16 ,  A61P37/08 ,  A61P25/28 ,  A61P19/08 ,  A61P31/00 ,  A61P35/04 ,  A61P35/02 ,  A61P9/10 ,  A61P25/16 ,  A61P17/00 ,  A61K31/437

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  C07D487/04

Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.

公开(公告)号：US08065040B2

公开(公告)日：2011-11-22

申请号：US12093348

申请日：2005-12-19

Applicant: Mithun R. Kamat ,  Sara E. Atkinson ,  Aaron W. Morrow ,  David P. Lavigne ,  Guang-Yan Zhu

Inventor： Mithun R. Kamat ,  Sara E. Atkinson ,  Aaron W. Morrow ,  David P. Lavigne ,  Guang-Yan Zhu

IPC: G06F19/00

CPC classification number: F01K13/02 ,  Y02E20/14 ,  Y02P80/15

Abstract: An on-site power plant (24) has a controller (40) that selectively controls operation of prime movers (26, 28, 30). In one example, the controller (40) changes the number of operating prime movers responsive to a transient in a load (22) requirement while continuing to operate at least one of the prime movers. One example includes prioritizing the prime movers (26, 28, 30) for operation based upon the needs of a cogeneration unit (32, 34, 36) associated with the prime movers for providing a temperature control function within a facility. Another example includes controlling operation of the prime movers based upon a capacity for fueling the prime movers.

Abstract translation: 现场发电厂（24）具有选择性地控制原动机（26,28,30）的运行的控制器（40）。 在一个示例中，控制器（40）响应于负载（22）要求中的瞬态而改变操作原动机的数量，同时继续操作至少一个原动机。 一个示例包括基于与原动机相关联的热电联供单元（32,34,36）的需要来优先处理原动机（26,28,30），用于在设施内提供温度控制功能。 另一个例子包括基于对原动机进行加油的能力来控制原动机的操作。