公开(公告)号：US10255228B2

公开(公告)日：2019-04-09

申请号：US13312954

申请日：2011-12-06

申请人： Xiaogang Qiu ,  Jack Hilaire Choquette ,  Manuel Olivier Gautho ,  Ming Y. (Michael) Siu

发明人： Xiaogang Qiu ,  Jack Hilaire Choquette ,  Manuel Olivier Gautho ,  Ming Y. (Michael) Siu

IPC分类号： G06F9/30 ,  G06F15/167 ,  G06F9/38 ,  G06F9/345

摘要： One embodiment of the present invention sets forth a technique that provides an efficient way to retrieve operands from a register file. Specifically, the instruction dispatch unit receives one or more instructions, each of which includes one or more operands. Collectively, the operands are organized into one or more operand groups from which a shaped access may be formed. The operands are retrieved from the register file and stored in a collector. Once all operands are read and collected in the collector, the instruction dispatch unit transmits the instructions and corresponding operands to functional units within the streaming multiprocessor for execution. One advantage of the present invention is that multiple operands are retrieved from the register file in a single register access operation without resource conflict. Performance in retrieving operands from the register file is improved by forming shaped accesses that efficiently retrieve operands exhibiting recognized memory access patterns.

公开(公告)号：US08999998B2

公开(公告)日：2015-04-07

申请号：US13382145

申请日：2010-07-02

申请人： Paul Gibbons ,  Emily Hanan ,  Wendy Liu ,  Joseph P. Lyssikatos ,  Steven R. Magnuson ,  Rohan Mendonca ,  Richard Pastor ,  Thomas E. Rawson ,  Michael Siu ,  Mark Zak ,  Aihe Zhou ,  Bing-Yan Zhu

发明人： Paul Gibbons ,  Emily Hanan ,  Wendy Liu ,  Joseph P. Lyssikatos ,  Steven R. Magnuson ,  Rohan Mendonca ,  Richard Pastor ,  Thomas E. Rawson ,  Michael Siu ,  Mark Zak ,  Aihe Zhou ,  Bing-Yan Zhu

IPC分类号： C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04

摘要： A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

摘要翻译： 其中R 1，R 2和R 3在本文中定义的式I化合物，对映异构体，非对映异构体，互变异构体或其药学上可接受的盐可用作一种或多种Janus激酶的抑制剂。 公开了包含式I化合物和药学上可接受的载体，佐剂或媒介物的药物组合物，以及对患者中Janus激酶活性的抑制作出反应的疾病或病症的严重程度的治疗或减轻的方法。

公开(公告)号：US08609687B2

公开(公告)日：2013-12-17

申请号：US13471269

申请日：2012-05-14

申请人： Bing-Yan Zhu ,  Michael Siu ,  Steven R. Magnuson ,  Richard Pastor ,  He Haiying ,  Xiao Yisong ,  Zheng Jifu ,  Xu Xing ,  Zhao Junping ,  Christopher Hurley ,  Jun Liang ,  Wendy Liu ,  Joseph P. Lyssikatos

发明人： Bing-Yan Zhu ,  Michael Siu ,  Steven R. Magnuson ,  Richard Pastor ,  He Haiying ,  Xiao Yisong ,  Zheng Jifu ,  Xu Xing ,  Zhao Junping ,  Christopher Hurley ,  Jun Liang ,  Wendy Liu ,  Joseph P. Lyssikatos

IPC分类号： A61K31/437 ,  C07D471/02

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  C07D487/04

摘要： A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.

摘要翻译： 其中R 1，R 2，R 3，R 4和R 5在本文中定义的式I化合物，对映异构体，非对映异构体，互变异构体或其药学上可接受的盐可用作JAK激酶抑制剂。 公开了包含式I化合物和药学上可接受的载体，佐剂或载体的药物组合物，以及治疗或减轻对患者中JAK激酶活性的抑制作用的疾病或病症的严重程度的方法。

公开(公告)号：US08399690B2

公开(公告)日：2013-03-19

申请号：US13018068

申请日：2011-01-31

申请人： Steven Do ,  Richard Goldsmith ,  Tim Heffron ,  Aleksandr Kolesnikov ,  Steven Staben ,  Alan G. Olivero ,  Michael Siu ,  Daniel P. Sutherlin ,  Bing-Yan Zhu ,  Paul Goldsmith ,  Tracy Bayliss ,  Adrian Folkes ,  Neil Pegg

发明人： Steven Do ,  Richard Goldsmith ,  Tim Heffron ,  Aleksandr Kolesnikov ,  Steven Staben ,  Alan G. Olivero ,  Michael Siu ,  Daniel P. Sutherlin ,  Bing-Yan Zhu ,  Paul Goldsmith ,  Tracy Bayliss ,  Adrian Folkes ,  Neil Pegg

IPC分类号： C07D313/00 ,  C07D333/00

CPC分类号： C07F5/02 ,  A61K31/381 ,  A61K31/4155 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/4436 ,  A61K31/496 ,  A61K31/53 ,  C07D495/04 ,  C07D495/14 ,  C07D513/14

摘要： Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formulas I and II for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

摘要翻译： 式I和II的苯并吡喃和苯并辛菌素化合物，包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐，可用于抑制脂质激酶，包括p110α和PI3K的其他同种型，并用于治疗疾病如癌症 由脂质激酶介导。 公开了使用式I和II的化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：US20120225855A1

公开(公告)日：2012-09-06

申请号：US13471269

申请日：2012-05-14

申请人： Bing-Yan Zhu ,  Michael Siu ,  Steven R. Magnuson ,  Richard Pastor ,  He Haiying ,  Xiao Yisong ,  Zheng Jifu ,  Xu Xing ,  Zhao Junping ,  Christopher Hurley ,  Jun Liang ,  Wendy Liu ,  Joseph P. Lyssikatos

发明人： Bing-Yan Zhu ,  Michael Siu ,  Steven R. Magnuson ,  Richard Pastor ,  He Haiying ,  Xiao Yisong ,  Zheng Jifu ,  Xu Xing ,  Zhao Junping ,  Christopher Hurley ,  Jun Liang ,  Wendy Liu ,  Joseph P. Lyssikatos

IPC分类号： C07D471/04 ,  A61K31/496 ,  A61K31/5377 ,  A61P9/00 ,  A61P3/10 ,  A61P37/00 ,  A61P25/00 ,  A61P1/16 ,  A61P37/08 ,  A61P25/28 ,  A61P19/08 ,  A61P31/00 ,  A61P35/04 ,  A61P35/02 ,  A61P9/10 ,  A61P25/16 ,  A61P17/00 ,  A61K31/437

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  C07D487/04

摘要： A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.

公开(公告)号：US20120065195A1

公开(公告)日：2012-03-15

申请号：US13077477

申请日：2011-03-31

申请人： Christopher T. Clark ,  Adam Cook ,  Indrani W. Gunawardana ,  Kevin W. Hunt ,  Nicholas C. Kallan ,  Michael Siu ,  Allen A. Thomas ,  Matthew Volgraf

发明人： Christopher T. Clark ,  Adam Cook ,  Indrani W. Gunawardana ,  Kevin W. Hunt ,  Nicholas C. Kallan ,  Michael Siu ,  Allen A. Thomas ,  Matthew Volgraf

IPC分类号： A61K31/547 ,  A61K31/527 ,  A61K31/4439 ,  A61K31/423 ,  A61K31/4184 ,  C07D279/08 ,  C07D413/10 ,  C07D401/14 ,  C07D263/52 ,  C07D235/02 ,  C07D417/10 ,  A61P25/28 ,  C07D403/10 ,  C07D401/10 ,  C07D491/107 ,  A61K31/506

CPC分类号： C07D401/14 ,  C07D263/64 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10

摘要： The invention provides novel spirotetrahydronaphthalene compounds of Formula α that inhibit β-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.

摘要翻译： 本发明提供抑制APP分解酶切割的新颖的式α的四氢四氢化合物，可用作治疗神经变性疾病的治疗剂。

公开(公告)号：US07722283B2

公开(公告)日：2010-05-25

申请号：US11537478

申请日：2006-09-29

申请人： Kin Wai Michael Siu

发明人： Kin Wai Michael Siu

IPC分类号： E01F13/00 ,  E01F9/00

CPC分类号： E01F13/024 ,  E01F9/623

摘要： A bollard with connecting mechanism for connecting railings, comprising: a bollard body which is provided with at least two receiving parts concave inwardly on each of opposite surfaces thereof; at least two connectors, each of which includes a base and an ear extending from the base and having a connecting hole thereon for connecting the railing; wherein the base is accommodated in the receiving part, and the ear is selectively accommodated in the receiving part or exposed out of the receiving part according to whether railings need to be connected.

摘要翻译： 一种具有用于连接栏杆的连接机构的系杆，包括：柱柱体，其具有在其每个相对表面上向内凹入的至少两个接收部分; 至少两个连接器，每个连接器包括基座和从基座延伸的耳部，并且在其上具有用于连接栏杆的连接孔; 其中所述基座容纳在所述接收部分中，并且所述耳朵根据是否需要连接栏杆选择性地容纳在所述接收部分中或者从所述接收部分露出。

公开(公告)号：US20070295656A1

公开(公告)日：2007-12-27

申请号：US11707195

申请日：2007-02-13

申请人： Kin Wai Michael Siu

发明人： Kin Wai Michael Siu

IPC分类号： B01D39/10 ,  B01D35/16 ,  B01D29/07 ,  B01D39/14

CPC分类号： B01D29/03

摘要： A filter comprises at least one filtration unit with a filtration passage having an inlet and an outlet, wherein the filtration unit includes at least one groove formed in an inlet side surface of the filtration unit, said at least one groove extending to the inlet and dimensioned to hold back substances which may clog the filtration passage, by means of upper edges of said at least one groove. According to the present invention, by forming at least one groove in an inlet side surface of the filtration unit, the filtration passages of the filter can be effectively prevented from being clogged.

摘要翻译： 过滤器包括至少一个具有过滤通道的过滤单元，过滤通道具有入口和出口，其中过滤单元包括形成在过滤单元的入口侧表面中的至少一个凹槽，所述至少一个凹槽延伸到入口和尺寸 通过所述至少一个凹槽的上边缘阻挡可能堵塞过滤通道的物质。 根据本发明，通过在过滤单元的入口侧表面形成至少一个槽，可以有效地防止过滤器的过滤通道堵塞。

公开(公告)号：US20070061203A1

公开(公告)日：2007-03-15

申请号：US11513903

申请日：2006-08-30

申请人： Richard Ellis ,  Christopher Newcombe ,  Michael Siu ,  Michael Stradley ,  Chris Oje

发明人： Richard Ellis ,  Christopher Newcombe ,  Michael Siu ,  Michael Stradley ,  Chris Oje

IPC分类号： G06Q30/00

CPC分类号： A63F13/61 ,  A63F13/12 ,  A63F13/30 ,  A63F13/35 ,  A63F2300/535 ,  A63F2300/5506 ,  A63F2300/5593 ,  G06Q30/02 ,  G06Q30/0243 ,  G06Q30/0252 ,  G06Q30/0264 ,  G06Q30/0267 ,  G06Q30/0272 ,  G06Q30/0273 ,  G07F17/32 ,  G07F17/3227

摘要： Methods and systems for dynamically incorporating advertising content into multimedia environments, such as games, are provided. Example embodiments include a dynamic inserter, which selects content, based upon a set of criteria, to deliver to a receiving client system, such as a game client. The receiving client system typically dynamically determines locations within the game where advertisements are desirably inserted. Associated with these locations are ad tags that specify criteria for the ads including, for example ad type, ad genre, and scheduling information which are sent by the client system to the dynamic inserter to select appropriate ads. The dynamic inserter selects ads based upon the criteria and sends them to the client system, which selects them for ad tags with conforming criteria. The client system then renders the selected ad in the appropriate location.

摘要翻译： 提供了将广告内容动态地结合到诸如游戏等多媒体环境中的方法和系统。 示例性实施例包括动态插入器，其基于一组标准来选择内容以递送到诸如游戏客户端的接收客户端系统。 接收客户端系统通常动态地确定游戏中希望插入广告的位置。 与这些位置相关联的是指定广告标准的广告代码，例如广告类型，广告类型和计划信息，由客户端系统发送给动态插入器以选择适当的广告。 动态插入器根据标准选择广告，并将其发送到客户端系统，客户端系统将其选择为符合标准的广告标签。 然后，客户端系统将所选广告呈现在适当的位置。

公开(公告)号：US20060095458A1

公开(公告)日：2006-05-04

申请号：US10976463

申请日：2004-10-29

申请人： Michael Siu ,  Clifford Strom ,  Brian Evans

发明人： Michael Siu ,  Clifford Strom ,  Brian Evans

IPC分类号： G06F7/00

CPC分类号： G06F21/10 ,  Y10S707/99932 ,  Y10S707/99942 ,  Y10S707/99943

摘要： A method for storing data. A method for storing data comprising arranging a plurality of data buckets in a logical inverted tree structure having a plurality of levels; and performing nested hashing at each level of the plurality of levels.

摘要翻译： 一种存储数据的方法。 一种用于存储数据的方法，包括以具有多个级别的逻辑倒置树结构布置多个数据桶; 以及在所述多个级别的每个级别执行嵌套散列。