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    INDIVIDUALIZED VACCINES FOR CANCER
    63.
    发明申请
    INDIVIDUALIZED VACCINES FOR CANCER 审中-公开
    癌症个体化疫苗

    公开(公告)号：US20160058853A1

    公开(公告)日：2016-03-03

    申请号：US14647577

    申请日：2013-11-26

    Applicant: BIONTECH AG ,  TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTEN-BERG-UNIVER

    Inventor： Ugur Sahin ,  Claudia Paret ,  Kirsten Vormbrock ,  Christian Bender ,  Jan Diekmann

    IPC: A61K39/00

    CPC classification number: A61K39/0011 ,  A61K2039/53 ,  A61K2039/55561 ,  A61K2039/572 ,  A61K2039/605 ,  A61K2039/627

    Abstract: The present invention relates to a patient-specific tumor treatment targeting individual expression patterns of tumor antigens, in particular shared tumor antigens, and individual tumor mutations. In one aspect, the present invention relates to a method for preventing or treating cancer in a patient comprising the steps of: (i) inducing a first immune response against one or more tumor antigens in the patient, and (ii) inducing a second immune response against one or more tumor antigens in the patient wherein the second immune response is specific for cancer specific somatic mutations present in cancer cells of the patient.

    Abstract translation: 本发明涉及靶向肿瘤抗原，特别是共享的肿瘤抗原的个体表达模式的患者特异性肿瘤治疗和个体肿瘤突变。 一方面，本发明涉及一种用于预防或治疗患者癌症的方法，包括以下步骤：（i）诱导针对患者中一种或多种肿瘤抗原的第一免疫应答，和（ii）诱导第二免疫 对患者中一种或多种肿瘤抗原的反应，其中第二免疫应答对存在于患者的癌细胞中的癌症特异性体细胞突变是特异性的。

    Identification of tumor-associated cell surface antigens for diagnosis and therapy
    65.
    发明授权
    Identification of tumor-associated cell surface antigens for diagnosis and therapy 有权
    鉴定肿瘤相关细胞表面抗原进行诊断和治疗

    公开(公告)号：US09139880B2

    公开(公告)日：2015-09-22

    申请号：US13863780

    申请日：2013-04-16

    Applicant: BioNTech AG

    Inventor： Özlem Türeci ,  Ugur Sahin ,  Gerd Helftenbein ,  Volker Schlüter

    IPC: C12Q1/68 ,  C07K14/47 ,  C07K14/705 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00

    CPC classification number: G01N33/57492 ,  A61K2039/505 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/30 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N2800/56

    Abstract: The present invention provides agents with tumor-inhibiting activity, and which are selective for cells expressing or abnormally expressing a tumor-associated antigen. Said tumor-associated antigen has a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence selected from the specific sequences set forth herein, or a 6-50 contiguous nucleotide residue portion thereof; (b) a nucleotide sequence of a nucleic acid which hybridizes with a nucleic acid having the nucleotide sequence of (a) under stringent conditions; (c) a nucleotide sequence which is degenerate with respect to the nucleotide sequence of (a) or (b); and (d) a nucleotide sequence which is complementary to the nucleotide sequence of (a), (b) or (c). Pharmaceutical compositions and kits comprising the agents are also provided, as well as methods treating, diagnosing or monitoring a disease characterized by expression or abnormal expression of the tumor-associated antigen.

    Abstract translation: 本发明提供具有肿瘤抑制活性的药剂，并且其对表达或异常表达肿瘤相关抗原的细胞是选择性的。 所述肿瘤相关抗原具有选自以下的核苷酸序列：（a）选自本文所述的特定序列的核苷酸序列或其6-50个连续核苷酸残基部分; （b）在严格条件下与具有（a）的核苷酸序列的核酸杂交的核酸的核苷酸序列; （c）相对于（a）或（b）的核苷酸序列退化的核苷酸序列; 和（d）与（a），（b）或（c）的核苷酸序列互补的核苷酸序列。 还提供了包含这些试剂的药物组合物和试剂盒，以及治疗，诊断或监测以肿瘤相关抗原的表达或异常表达为特征的疾病的方法。

    Polynucleotides encoding an intracellular segment of CD40 and a constant region of an immunoglobulin heavy chain
    66.
    发明授权
    Polynucleotides encoding an intracellular segment of CD40 and a constant region of an immunoglobulin heavy chain 有权
    编码CD40细胞内区段和免疫球蛋白重链恒定区的多核苷酸

    公开(公告)号：US09139639B2

    公开(公告)日：2015-09-22

    申请号：US14571425

    申请日：2014-12-16

    Applicant: BioNTech AG ,  Universitatsmedizin der Johannes Gutenberg-Universitat Mainz

    Inventor： Ugur Sahin ,  Ozlem Tureci ,  Torsten Seppmann ,  Holger Hoff ,  Jens Schumacher

    IPC: C12N15/12 ,  C12N15/11 ,  C12N15/63 ,  C07K14/705 ,  C07K16/00 ,  C12N5/0781

    CPC classification number: C07K14/70578 ,  C07K16/00 ,  C07K2319/30 ,  C12N5/0635

    Abstract: The present invention provides recombinant proteins comprising the amino acid sequence of an intracellular segment of CD40 and an amino acid sequence mediating the association of the recombinant protein with the constant region of an immunoglobulin heavy chain. The recombinant proteins according to the present invention are—useful for inducing clonal expansion of a B cell having a predetermined antigen-specificity without the need for T cell or CD40L mediated co-stimulation. Thus, the present invention provides tools for clonal expansion of B cells specific for an antigen of interest and the production of B cells secreting antibodies specific for an antigen of interest. The recombinant proteins of the present invention may also be used for generating fully human monoclonal antibodies with a predetermined antigen-specificity from the B cell repertoire of a human subject.

    Abstract translation: 本发明提供重组蛋白，其包含CD40的细胞内节段的氨基酸序列和介导重组蛋白与免疫球蛋白重链的恒定区的缔合的氨基酸序列。 根据本发明的重组蛋白质可用于诱导具有预定抗原特异性的B细胞的克隆扩增，而不需要T细胞或CD40L介导的共刺激。 因此，本发明提供了用于针对感兴趣的抗原特异性的B细胞的克隆扩增的工具，以及产生分泌针对感兴趣的抗原的抗体的B细胞。 本发明的重组蛋白还可用于从人受试者的B细胞库中产生具有预定抗原特异性的完全人单克隆抗体。

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