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公开(公告)号：US11535616B2
公开(公告)日：2022-12-27
申请号：US17026763
申请日：2020-09-21
发明人： Amogh Boloor , Toufike Kanouni , Jeffrey Alan Stafford , James Marvin Veal , Michael Brennan Wallace
IPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
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公开(公告)号：US20210238161A1
公开(公告)日：2021-08-05
申请号：US17227570
申请日：2021-04-12
IPC分类号： C07D401/12 , C07D405/14 , A61P35/00 , C07D401/14 , C07D407/14 , C07D409/14 , C12N9/02
摘要： The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds, and compositions (including pharmaceutical compositions) that include these compounds. The subject compounds and compositions are useful for inhibition of at least one histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer or neoplastic disease, such as prostate cancer, breast cancer, bladder cancer, lung cancer, melanoma, retinoblastoma, or multiple endocrine neoplasia type 1.
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公开(公告)号：US10807956B2
公开(公告)日：2020-10-20
申请号：US16782275
申请日：2020-02-05
发明人： Young K. Chen , Toufike Kanouni , Zhe Nie , Jeffrey Alan Stafford , James Marvin Veal , Michael Brennan Wallace
IPC分类号： C07D213/79 , C07D213/74 , C07D213/81 , C07D237/24 , C07D401/04 , C07D401/12 , C07D405/14 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
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公开(公告)号：US10654830B2
公开(公告)日：2020-05-19
申请号：US16168753
申请日：2018-10-23
IPC分类号： C07D401/04 , C07D401/14
摘要： The present embodiments provide for substituted triazolylpyridine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for modulating the activity of histone demethylase enzymes. Additionally, the subject compounds and compositions are useful for the treatment of cancer or other neoplastic diseases, or maladies associated with abnormal histone demethylase activity. Accordingly, the substituted triazolylpyridine derivative compounds described herein are useful in methods and medicaments for treating cancer.
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公开(公告)号：US10208039B2
公开(公告)日：2019-02-19
申请号：US15891927
申请日：2018-02-08
发明人： Amogh Boloor , Toufike Kanouni , Jeffrey Alan Stafford , James Marvin Veal , Michael Brennan Wallace
IPC分类号： C07D239/70 , C07D471/04 , A61K31/505 , A61K31/395 , C07D227/00 , A61K31/519 , A61K31/404 , C07D209/04 , C07D239/00
摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer, melanoma, and the like.
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公开(公告)号：US10202360B2
公开(公告)日：2019-02-12
申请号：US15488674
申请日：2017-04-17
发明人： Michael John Bennett , Juan Manuel Betancort , Amogh Boloor , Toufike Kanouni , Jeffrey Alan Stafford , James Marvin Veal , Michael Brennan Wallace
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D515/08
摘要： The present disclosure relates to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease.
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公开(公告)号：US20180297999A1
公开(公告)日：2018-10-18
申请号：US16014885
申请日：2018-06-21
发明人： Amogh Boloor , Toufike Kanouni , Jeffrey Alan Stafford , James Marvin Veal , Michael Brennan Wallace
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/395 , A61K31/404 , A61K31/505 , A61K31/519 , C07D209/04 , C07D227/00 , C07D239/00 , C07D239/70 , C07D471/14
摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer, melanoma, and the like.
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公开(公告)号：US20180251458A1
公开(公告)日：2018-09-06
申请号：US15971749
申请日：2018-05-04
IPC分类号： C07D417/14 , C07D405/12 , C07D409/12 , C07D417/12 , C07D413/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D213/79 , C07D401/12 , C07D403/12
CPC分类号： C07D417/14 , A61P35/00 , C07D213/79 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
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公开(公告)号：US10059687B2
公开(公告)日：2018-08-28
申请号：US15391773
申请日：2016-12-27
IPC分类号： C07D401/12 , C07D409/14 , C07D401/14 , C07D407/14 , C12N9/02
CPC分类号： C07D401/12 , A61P35/00 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C12N9/0071 , C12Y114/11027
摘要： The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds, and compositions (including pharmaceutical compositions) that include these compounds. The subject compounds and compositions are useful for inhibition of at least one histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer or neoplastic disease, such as prostate cancer, breast cancer, bladder cancer, lung cancer, melanoma, retinoblastoma, or multiple endocrine neoplasia type 1.
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公开(公告)号：US10016401B2
公开(公告)日：2018-07-10
申请号：US15667553
申请日：2017-08-02
IPC分类号： C07D471/04 , A61K31/437 , C07D487/04 , A61P35/00
CPC分类号： A61K31/437 , A61P35/00 , C07D471/04 , C07D487/04
摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
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