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公开(公告)号：US4681896A
公开(公告)日：1987-07-21
申请号：US575744
申请日：1984-01-31
Applicant: David F. Horrobin
Inventor： David F. Horrobin
IPC: A61K31/19 , A23D9/00 , A23L1/30 , A23L1/325 , A23L1/48 , A61K31/16 , A61K31/20 , A61K31/22 , A61K31/23 , A61K31/557 , A61K35/56 , A61K35/60 , A61K36/00 , A61K36/185 , A61K38/00 , A61P3/08 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/30 , A61P27/16 , A61P35/00 , A61P37/08
CPC classification number: A61K35/60 , A23D9/00 , A61K31/20 , A61K31/23 , A61K31/557 , A61K36/185 , Y10S514/861 , Y10S514/866
Abstract: A method of treatment of atopic disorders, including eczema, asthma, allergies (especially allergic rhinitis), migraine and disorders associated with atopy including Crohn's disease, ulcerative colitis, otitis media, nephrotic syndrome, or benign breast disease, or breast or other cancer, or diabetes, or alcoholism, with effective amounts of one or more of the metabolites of linoleic acid (GLA, DGLA, AA, 22:4n-6 or 22:5n-6) and one or more of the metabolites of .alpha.-linolenic acid (18:4n-3, 20:4n-3, 20:5n-3, 22:5n-3 or 22:6n-3) are administered as such or in the form of an ester, salt, amide or other derivative convertible in the body thereto alone or in an acceptable pharmaceutical carrier or diluent.
Abstract translation: 治疗特应性疾病的方法，包括湿疹，哮喘，过敏（特别是过敏性鼻炎），偏头痛和与特应性相关的疾病，包括克罗恩病，溃疡性结肠炎，中耳炎，肾病综合征或良性乳腺疾病或乳腺癌或其他癌症， 或糖尿病或酒精中毒，有效量的一种或多种亚油酸（GLA，DGLA，AA，22：4n-6或22：5n-6）的代谢物和一种或多种α-亚麻酸的代谢物 （18：4n-3,20：4n-3,20：5n-3,22：5n-3或22：6n-3）以这样的形式或以酯，盐，酰胺或其他可转换衍生物 在体内单独或在可接受的药物载体或稀释剂中。
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公开(公告)号：US4535093A
公开(公告)日：1985-08-13
申请号：US476708
申请日：1983-03-18
Applicant: David F. Horrobin
Inventor： David F. Horrobin
IPC: A23L1/302 , A23L1/30 , A61K31/13 , A61K31/165 , A61K31/195 , A61K31/20 , A61K31/202 , A61K31/215 , A61K31/23 , A61K31/375 , A61K31/43 , A61K31/485 , A61K33/30 , A61K45/06 , A61P1/00 , A61P29/00 , A61P37/00 , A61P39/02 , A61P43/00 , A01N37/02 , A01N37/00
CPC classification number: A61K31/43 , A61K31/20 , A61K31/23 , A61K31/375 , A61K31/485 , A61K33/30 , A61K45/06 , Y10S514/811 , Y10S514/889
Abstract: Composition and use of .gamma.-linolenic acid and related materials with ascorbic acid, or ethyl alcohol, or an opiate antagonist such as naloxone, nalorphine or levallorphan, for treating alcoholism or moderating the effects of taking alcohol.
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公开(公告)号：US4415554A
公开(公告)日：1983-11-15
申请号：US272083
申请日：1981-06-10
Applicant: David F. Horrobin
Inventor： David F. Horrobin
CPC classification number: A61K31/545 , A61K31/43 , A61K33/30 , Y10S514/825 , Y10S514/899 , Y10S514/909
Abstract: Use of .gamma.-linolenic acid and related materials alone or with zinc or .beta.-lactam antibiotics to treat menstrual disorders.
Abstract translation: 单独或与锌或β-内酰胺抗生素一起使用γ-亚麻酸和相关物质治疗月经失调。
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公开(公告)号：US4393049A
公开(公告)日：1983-07-12
申请号：US272082
申请日：1981-06-10
Applicant: David F. Horrobin
Inventor： David F. Horrobin
IPC: A61K31/43 , A61K31/545 , A61K33/30 , A61K31/20 , A61K31/315 , A61K31/33
CPC classification number: A61K31/545 , A61K31/43 , A61K33/30 , Y10S514/825 , Y10S514/899 , Y10S514/909
Abstract: Use of .gamma.-linolenic acid and related materials alone or with zinc or .beta.-lactam antibiotics to treat obesity.
Abstract translation: 单独或与锌或β-内酰胺抗生素一起使用γ-亚麻酸和相关物质治疗肥胖。
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公开(公告)号：US4388324A
公开(公告)日：1983-06-14
申请号：US150402
申请日：1980-05-15
Applicant: David F. Horrobin
Inventor： David F. Horrobin
IPC: A23L1/302 , A23L1/30 , A61K31/13 , A61K31/165 , A61K31/195 , A61K31/20 , A61K31/202 , A61K31/215 , A61K31/23 , A61K31/375 , A61K31/43 , A61K31/485 , A61K33/30 , A61K45/06 , A61P1/00 , A61P29/00 , A61P37/00 , A61P39/02 , A61P43/00 , A01N37/02 , A01N37/00
CPC classification number: A61K31/43 , A61K31/20 , A61K31/23 , A61K31/375 , A61K31/485 , A61K33/30 , A61K45/06 , Y10S514/811 , Y10S514/889
Abstract: Composition and use of .gamma.-linolenic acid and related materials with ascorbic acid, or ethyl alcohol, or an opiate antagonist such as naloxone, nalorphine or levallorphan, for treating alcoholism or moderating the effects of taking alcohol.
Abstract translation: 用抗坏血酸或乙醇或鸦片拮抗剂如纳洛酮，纳洛芬或左旋啡喃组成和使用γ-亚麻酸及其相关物质，用于治疗酒精中毒或缓和服用酒精的作用。
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Patent Agency Ranking66.发明授权
公开(公告)号：US4386072A
公开(公告)日：1983-05-31
申请号：US345214
申请日：1982-02-03
Applicant: David F. Horrobin , Julian Lieb
Inventor： David F. Horrobin , Julian Lieb
Abstract: A method for the treatment or prophylaxis of disorders of inflammation and immunity and disorders associated with smooth muscle spasm, by administering dihomo-.gamma.-linolenic acid or a bioprecursor thereof conjointly with a physiologically acceptable lithium salt. Vitamin E and related tocopherols may optionally be also administered.
Abstract translation: 通过与生理上可接受的锂盐联合给予二 - γ-亚麻酸或其生物前体，治疗或预防与平滑肌痉挛相关的炎症和免疫疾病和紊乱的方法。 还可以任选地施用维生素E和相关的生育酚。
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公开(公告)号：US5990164A
公开(公告)日：1999-11-23
申请号：US930701
申请日：1998-03-17
Applicant: David F. Horrobin , Philip Knowles , Mehar Manku , John C. Stewart
Inventor： David F. Horrobin , Philip Knowles , Mehar Manku , John C. Stewart
IPC: A23L1/30 , A61K8/00 , A61K8/30 , A61K8/33 , A61K8/36 , A61K8/41 , A61K31/20 , A61K31/202 , A61Q5/02 , C07C57/03 , C07C215/10 , A61K31/215
CPC classification number: C07C57/03 , C07C215/10
Abstract: An N-alkylpolyhydroxyamine salt of an n-6 or n-3 essential fatty acid (EFA) that is beyond the 6-desaturation step, or of any polyunsaturated fatty acid, other than those belonging to the n-6 and n-3 series, having 16 to 26 carbon atoms and up to six double bonds, the double bonds being in the cis or trans configuration, the salt being formed with the fatty acid either as such or in the form of a covalent derivative, through the carboxyl group, of a bifunctional compound itself having a free acid function.
Abstract translation: PCT No.PCT / GB96 / 00952 Sec。 371日期：1998年3月17日 102（e）1998年3月17日PCT 1996年4月19日PCT PCT。 出版物WO96 / 33155 日期1996年10月24日除了6-去饱和步骤以外的n-6或n-3必需脂肪酸（EFA）的N-烷基多羟基胺盐或任何多不饱和脂肪酸，属于n-6 和n-3系，具有16至26个碳原子和多至六个双键，双键呈顺式或反式构型，盐与脂肪酸形成或者以共价衍生物形式， 通过羧基，具有游离酸功能的双官能化合物本身。
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公开(公告)号：US5922345A
公开(公告)日：1999-07-13
申请号：US584426
申请日：1996-01-11
Applicant: David F. Horrobin , Lars Lindmark
Inventor： David F. Horrobin , Lars Lindmark
IPC: A23L1/29 , A23L1/30 , A61K31/202 , A61K31/23
CPC classification number: A61K31/202 , A23L33/12 , A23L33/40
Abstract: Countering side effects of parenteral or fluid-diet enteral nutrition by adding one or more 6-desaturated essential fatty acids (EFAs) to parenteral or enteral composition (particularly low-fat compositions) being given, or giving them in addition to the compositions.
Abstract translation: 通过向给予的肠胃外或肠内组合物（特别是低脂肪组合物）中加入一种或多种6-去饱和必需脂肪酸（EFAs）或给予它们以补充组合物来抵抗肠胃外或流体饮食肠内营养的副作用。
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公开(公告)号：US5859055A
公开(公告)日：1999-01-12
申请号：US557545
申请日：1995-11-14
Applicant: David F. Horrobin , John C. M. Stewart
Inventor： David F. Horrobin , John C. M. Stewart
CPC classification number: A61K31/20 , Y10S514/824
Abstract: Gamma-linolenic acid and/or dihomo-gamma-linolenic acid is used in the preparation of a medicament for inhibiting reocclusion of an artery from which an occlusion or other blockage has been removed, or for preventing occlusion of peripheral or coronary arteries. The medicament may also comprise eicosapentaenoic acid.
Abstract translation: γ-亚麻酸和/或二 - γ-亚麻酸用于制备用于抑制已经从其中除去闭塞或其它阻塞的动脉再闭塞或用于防止外周或冠状动脉闭塞的药物中的用途。 药物还可以包含二十碳五烯酸。
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公开(公告)号：US5663202A
公开(公告)日：1997-09-02
申请号：US690545
申请日：1996-07-31
Applicant: David F. Horrobin , Catherine A. Scott
Inventor： David F. Horrobin , Catherine A. Scott
IPC: A61K31/20 , A61K31/202 , A61P25/00 , A61P43/00
CPC classification number: A61K31/202 , A61K31/20
Abstract: Damage to the gastrointestinal tract as a consequence of exposure to ionising radiation is prevented or treated by administration of GLA and/or DGLA. Medicaments containing GLA and/or DGLA for such treatment or prevention may also further comprise EPA and/or DHA.
Abstract translation: 由于暴露于电离辐射而导致的胃肠道损伤通过施用GLA和/或DGLA来预防或治疗。 含有GLA和/或DGLA用于治疗或预防的药物还可以进一步包含EPA和/或DHA。
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