公开(公告)号：US08086154B2

公开(公告)日：2011-12-27

申请号：US12257015

申请日：2008-10-23

申请人： Kock-Yee Law ,  Hong Zhao ,  Bryan Roof ,  Michael F. Zona ,  David J. Gervasi

发明人： Kock-Yee Law ,  Hong Zhao ,  Bryan Roof ,  Michael F. Zona ,  David J. Gervasi

IPC分类号： G03G15/20

CPC分类号： G03G15/2007 ,  G03G2215/2025 ,  G03G2215/2048

摘要： In accordance with the invention, there are printing apparatuses and methods of forming an image. An exemplary printing apparatus can include a fuser subsystem including one or more light induced heating elements, each of the one or more light induced heating elements including plurality of nanomaterials, wherein the nanomaterials are selected from the group consisting of carbon nanotubes and metal nanoshells. The exemplary printing apparatus can also include one or more light sources disposed in close proximity to the one or more light induced heating elements, each of the one or more light sources having an emission in the absorption range of the plurality of nanomaterials and disposed to produce heat in the fuser subsystem by light absorption by the plurality of nanomaterials.

摘要翻译： 根据本发明，存在形成图像的印刷装置和方法。 示例性印刷设备可以包括定影子系统，其包括一个或多个光感应加热元件，所述一个或多个光诱导加热元件中的每一个包括多个纳米材料，其中所述纳米材料选自碳纳米管和金属纳米壳。 该示例性打印设备还可以包括一个或多个光源，其设置在一个或多个光感应加热元件附近，所述一个或多个光源中的每一个具有在多个纳米材料的吸收范围内的发射并且被设置成产生 通过多个纳米材料的光吸收，定影子系统中的热量。

公开(公告)号：US20110234106A1

公开(公告)日：2011-09-29

申请号：US13128936

申请日：2010-07-26

申请人： Jian Wang ,  Hong Zhao

发明人： Jian Wang ,  Hong Zhao

IPC分类号： H05B37/02 ,  H02M3/22

CPC分类号： H05B33/0815

摘要： A three phase rectifier rectifies received three phase a.c. power to generate a ripple d.e. voltage. A power distribution bus conveys distribution panel conveys distribution power comprising the ripple d.c. voltage or an a.c. voltage derived therefrom to a location of an LED based lamp that is distal from the three phase rectifier. Additional circuitry disposed with the LED based lamp drives the LED based lamp using the distribution power.

摘要翻译： 三相整流器对接收的三相交流整流器进行整流。 产生波纹的能力 电压。 配电总线传送配电面板传送包括波纹直流的配电功率。 电压或电流 电压源于距离三相整流器远的LED基灯的位置。 配有基于LED的灯的附加电路使用分配功率驱动基于LED的灯。

公开(公告)号：US20110229581A1

公开(公告)日：2011-09-22

申请号：US13129611

申请日：2009-11-17

申请人： Hong Zhao ,  Weili Yan ,  Lianjun Shi ,  Dechun Wu ,  Maksim Royzen

发明人： Hong Zhao ,  Weili Yan ,  Lianjun Shi ,  Dechun Wu ,  Maksim Royzen

IPC分类号： A61K9/14 ,  C12N5/071 ,  C12N5/09 ,  C07J31/00 ,  C07J43/00 ,  A61K47/20 ,  A61K47/24 ,  A61K47/22 ,  A61K31/7088 ,  A61K31/713 ,  A61K38/14 ,  A61P35/00 ,  A61P29/00 ,  A61P31/12 ,  B82Y5/00

CPC分类号： C07J41/0055 ,  C07J51/00

摘要： The present invention is directed to releasable cationic lipids and nanoparticle compositions for the delivery of nucleic acids and methods of modulating an expression of a target gene using the same. In particular, the invention relates to cationic lipids including an acid labile linker, and nanoparticle compositions containing the same.

摘要翻译： 本发明涉及用于递送核酸的可释放阳离子脂质和纳米颗粒组合物以及使用其调节靶基因表达的方法。 特别地，本发明涉及包括酸不稳定接头的阳离子脂质和含有它的纳米颗粒组合物。

公开(公告)号：US20110223257A1

公开(公告)日：2011-09-15

申请号：US13129546

申请日：2009-11-17

申请人： Hong Zhao ,  Weili Yan ,  Lianjun Shi ,  Dechun Wu ,  Maksim Royzen

发明人： Hong Zhao ,  Weili Yan ,  Lianjun Shi ,  Dechun Wu ,  Maksim Royzen

IPC分类号： A61K9/50 ,  C07C229/34 ,  C07C233/87 ,  C07F9/02 ,  C12N5/00 ,  A61K47/00 ,  A61K31/7088 ,  A61K31/56 ,  B82Y5/00

CPC分类号： A61K9/1272

摘要： The present invention relates to releasable fusogenic lipids and nanoparticle compositions containing the same for the delivery of oligonucleotides and methods of modulating gene expression using the same. In particular, this invention relates to releasable fusogenic lipids containing an imine linker and a zwitterionic moiety.

摘要翻译： 本发明涉及可释放的融合脂质和含有其的用于递送寡核苷酸的纳米颗粒组合物和使用其衍生调节基因表达的方法。 特别地，本发明涉及含有亚胺接头和两性离子部分的可释放的融合脂质。

公开(公告)号：US20110157278A1

公开(公告)日：2011-06-30

申请号：US12648004

申请日：2009-12-28

申请人： Peter Michael Gulvin ,  Hong Zhao

发明人： Peter Michael Gulvin ,  Hong Zhao

IPC分类号： B41J2/135 ,  G03F7/20

CPC分类号： B41J2/1645 ,  B41J2/1606 ,  B41J2/162 ,  B41J2/1628 ,  B41J2/1631 ,  B41J2/1632 ,  B41J2/1642 ,  B41J2/1646

摘要： A process for preparing an ink jet print head front face or nozzle plate having a textured superoleophobic surface comprising providing a silicon substrate; using photolithography to create a textured pattern in the silicon substrate; optionally, modifying the textured silicon surface by disposing a conformal oleophobic coating thereon; and forming an ink jet print head front face or nozzle plate from the textured oleophobic silicon material to provide an ink jet print head front face or nozzle plate having a textured superoleophobic surface.

摘要翻译： 一种用于制备具有纹理化超疏油表面的喷墨打印头前面或喷嘴板的方法，包括提供硅衬底; 使用光刻法在硅衬底中产生纹理图案; 任选地，通过在其上设置共形疏油涂层来改变织构的硅表面; 以及从织构化疏油硅材料形成喷墨打印头前面或喷嘴板，以提供具有织构化的超疏油表面的喷墨打印头前面或喷嘴板。

公开(公告)号：US20110130850A1

公开(公告)日：2011-06-02

申请号：US12786052

申请日：2010-05-24

申请人： Qingsheng Quinn Zheng ,  Hong Zhao

发明人： Qingsheng Quinn Zheng ,  Hong Zhao

IPC分类号： G05B13/04

CPC分类号： G05B13/048

摘要： Apparatuses and methods for model quality estimation and model adaptation in multivariable process control are disclosed. A method for updating a multiple input multiple output (MIMO) dynamical model of a process includes perturbing the process, auditing the controller model, identifying poor performing submodels and re-testing the relevant process variables, re-identifying submodels and adapting the model online while the process continues to operate within normal operating parameters. An apparatus comprises an online multivariable controller, a tester, a database to store data corresponding to manipulated variables and controlled variables, and a performance diagnosis module configured to identify problematic submodels and adapt a model used by the controller.

摘要翻译： 公开了多变量过程控制中的模型质量估计和模型适应的装置和方法。 用于更新过程的多输入多输出（MIMO）动态模型的方法包括扰动过程，审核控制器模型，识别执行不良的子模型并重新测试相关过程变量，重新识别子模型并在线适配模型 该过程继续在正常操作参数内运行。 一种装置包括在线多变量控制器，测试器，用于存储与操作变量和受控变量相对应的数据的数据库，以及性能诊断模块，被配置为识别有问题的子模型并适应控制器使用的模型。

公开(公告)号：US20110122195A1

公开(公告)日：2011-05-26

申请号：US12625442

申请日：2009-11-24

申请人： Gregory J. Kovacs ,  Kock-Yee Law ,  Hong Zhao ,  Varun Sambhy

发明人： Gregory J. Kovacs ,  Kock-Yee Law ,  Hong Zhao ,  Varun Sambhy

IPC分类号： B41J2/135 ,  C08G18/42

CPC分类号： B41J2/14008 ,  B41J2/1433 ,  B41J2/1606 ,  B41J2/162 ,  B41J2/1645 ,  C08G18/5015 ,  C08G18/6216 ,  C08G18/73

摘要： A coating for an ink jet printhead front face, wherein the coating comprises a low adhesion coating, wherein when the low adhesion coating is disposed on an ink jet printhead front face surface, jetted drops of ultra-violet gel ink or jetted drops of solid ink exhibit a low sliding angle with the printhead front face surface, wherein the low sliding angle is less than about 1° to less than about 30°. In embodiments, the low adhesion coating is an oleophobic coating that exhibits a contact angle of greater than about 35° with ultra-violet gel ink or solid ink.

摘要翻译： 用于喷墨打印头前面的涂层，其中所述涂层包括低粘附性涂层，其中当所述低粘附性涂层设置在喷墨打印头前表面上时，喷射的紫外线凝胶墨滴或固体墨水的喷射滴 与打印头前表面呈现低滑动角，其中低滑动角小于约1°至小于约30°。 在实施方案中，低粘附性涂层是疏油涂层，其与紫外线凝胶油墨或固体油墨呈现大于约35°的接触角。

公开(公告)号：US20100048489A1

公开(公告)日：2010-02-25

申请号：US12541410

申请日：2009-08-14

申请人： Angelika Fretzen ,  Steven Witowski ,  Alfredo Grossi ,  Hong Zhao ,  Mahendra Dedhiya ,  Yun Mo

发明人： Angelika Fretzen ,  Steven Witowski ,  Alfredo Grossi ,  Hong Zhao ,  Mahendra Dedhiya ,  Yun Mo

IPC分类号： A61K38/10 ,  A61P1/00

CPC分类号： A61J3/00 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/167 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/5078 ,  A61K38/10

摘要： Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.

摘要翻译： 适用于口服给药的利那洛肽的固体稳定制剂在本文中描述为制备这些制剂的方法。 本文描述的制剂含有由氨基酸序列Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr（“linaclotide”）或其药学上可接受的盐组成的多肽。 本文所述的利那洛肽制剂是稳定的并且具有用于制造，储存和分配药物的足够的保质期。

公开(公告)号：US20090301963A1

公开(公告)日：2009-12-10

申请号：US12135394

申请日：2008-06-09

申请人： Martin Brockmann ,  Heribert Moeslang ,  Dietmar Schnuell ,  Hong Zhao ,  David Thaure ,  Pierre Girodet

发明人： Martin Brockmann ,  Heribert Moeslang ,  Dietmar Schnuell ,  Hong Zhao ,  David Thaure ,  Pierre Girodet

IPC分类号： C02F3/06 ,  C02F9/02 ,  C02F9/14

CPC分类号： B01D61/18 ,  B01D2315/06 ,  C02F3/1273 ,  C02F3/223 ,  C02F3/286 ,  C02F3/302 ,  C02F3/308 ,  C02F2303/16 ,  Y02W10/15

摘要： A method and system is provided for treating wastewater. In one process, wastewater is directed into a treatment tank and biologically treated. The biologically treated wastewater is directed as mixed liquor from the treatment tank to a bottom portion of a downstream filtration tank having at least one submerged membrane module that extends across substantially the entire cross sectional area of the filtration tank mixed liquor is directed from the bottom of the filtration tank upwardly into the membrane module such that substantially all of the mixed liquor received in the bottom of the filtration tank flows through the membrane module. As the mixed liquor flows vertically through the membrane module, the method includes inducing at least some of the mixed liquor through walls of one or more membrane filters that form a part of the membrane module, producing a permeate stream. The remaining mixed liquor passing through and from the membrane module is referred to as a non-permeate stream and the non-permeate stream, or at least a substantial portion thereof, is recirculated to the treatment tank. The filtration tank is sized relative to the membrane module and the process is carried out such that there is no substantial recycle of mixed liquor in the filtration tank itself. Although mixed liquor may be recirculated from the filtration tank back to the treatment tank and then back to the filtration tank and so forth and so on, once the mixed liquor in the filtration tank makes one pass through the membrane module the mixed liquor is recycled back to the treatment tank and generally not permitted to be recycled back through the membrane module without first returning to the treatment tank.

摘要翻译： 提供了一种处理废水的方法和系统。 在一个过程中，将废水引入处理槽并进行生物处理。 生物处理的废水作为混合液从处理槽引导到具有至少一个浸没膜组件的下游过滤槽的底部，该膜组件延伸穿过过滤罐的整个横截面积，混合液从 过滤罐向上进入膜组件，使得接收在过滤罐底部的基本上所有的混合液体都流过膜组件。 当混合液体垂直流过膜组件时，该方法包括通过形成膜组件的一部分的一个或多个膜过滤器的壁诱导至少一些混合液体，产生渗透物流。 将通过膜组件的剩余混合液称为非渗透物流，将非渗透物流或其至少大部分再循环至处理槽。 过滤罐相对于膜组件尺寸设定，并且进行该过程，使得过滤罐本身中没有混合液体的实质再循环。 虽然混合液体可以从过滤罐再循环回处理槽，然后回到过滤槽等等，一旦过滤罐中的混合液体一次通过膜组件，混合液体再循环回来 并且通常不允许通过膜组件再循环回到处理槽中，而不首先返回到处理槽。

公开(公告)号：US07601798B2

公开(公告)日：2009-10-13

申请号：US11242656

申请日：2005-10-04

申请人： Hong Zhao ,  Belen Rubio

发明人： Hong Zhao ,  Belen Rubio

IPC分类号： C08F6/06 ,  C08F6/10 ,  C08G73/00

CPC分类号： C08G65/33303 ,  C08G65/3348

摘要： The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal tosylate with a protected amine salt to form a polymer containing a terminal protected amine and thereafter deprotecting the polymer containing the terminal protected amine to form the polymer having a terminal amine. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

摘要翻译： 本发明涉及制备高纯度的含有末端胺的聚环氧烷的线性聚合物的方法。 一种优选的方法包括使聚环氧烷如含有甲苯磺酸末端的聚乙二醇与受保护的胺盐反应形成含有末端保护的胺的聚合物，然后使包含末端被保护的胺的聚合物脱保护，形成具有末端胺的聚合物。 得到的聚合物胺具有足够的纯度，因此避免了医药级聚合物所需的昂贵且耗时的纯化步骤。