公开(公告)号：US10695170B2

公开(公告)日：2020-06-30

申请号：US15199743

申请日：2016-06-30

Applicant: Edwards Lifesciences Corporation

Inventor： Brian S. Conklin ,  Qinggang Zeng

IPC: A61F2/24

Abstract: A hybrid prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be expanded post implant in order to receive and/or support an expandable prosthetic heart valve therein (a valve-in-valve procedure). The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. An inflow stent frame is expandable for anchoring the valve in place, and may have an outflow end that is collapsible for delivery and expandable post-implant to facilitate a valve-in-valve procedure.

公开(公告)号：US10667906B2

公开(公告)日：2020-06-02

申请号：US15880181

申请日：2018-01-25

Applicant: Edwards Lifesciences Corporation

Inventor： Mark Chau ,  Travis Zenyo Oba ,  Tammy Huntley ,  Qinggang Zeng ,  August R. Yambao ,  Rafael Pintor

IPC: A61F2/24

Abstract: A system for expanding a device in a conduit or orifice of a human body includes a balloon member that is movable from a first configuration to a second configuration. External surfaces of the balloon member can collectively have a non-cylindrical cross-section relative to a main axis of the balloon member, such that the external surfaces of the balloon member generally conform to the anatomical shape of the conduit or orifice when the balloon member is in the second configuration.

公开(公告)号：US20200060815A1

公开(公告)日：2020-02-27

申请号：US16666331

申请日：2019-10-28

Applicant: Edwards Lifesciences Corporation

Inventor： Brian S. Conklin ,  Qinggang Zeng ,  Myron Howanec, JR. ,  Grace Myong Kim

IPC: A61F2/24

Abstract: A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. An inflow stent frame is expandable for anchoring the valve in place, and may have an outflow end that is collapsible to a limited degree for delivery and expandable post-implant to facilitate valve-in-valve (ViV) procedures. The hybrid heart valves eliminate earlier structural bands, which both reduces manufacturing time and facilitates ViV procedures.

公开(公告)号：US10456246B2

公开(公告)日：2019-10-29

申请号：US15199748

申请日：2016-06-30

Applicant: Edwards Lifesciences Corporation

Inventor： Brian S. Conklin ,  Qinggang Zeng ,  Myron Howanec, Jr. ,  Grace Myong Kim

IPC: A61F2/24

Abstract: A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. An inflow stent frame is expandable for anchoring the valve in place, and may have an outflow end that is collapsible to a limited degree for delivery and expandable post-implant to facilitate a valve-in-valve (ViV) procedure. The hybrid heart valves eliminate earlier structural bands, which both reduces manufacturing time and facilitates a ViV procedure.

公开(公告)号：US10182909B2

公开(公告)日：2019-01-22

申请号：US15423378

申请日：2017-02-02

Applicant: Edwards Lifesciences Corporation

Inventor： Rafael Pintor ,  Mark Chau ,  Travis Zenyo Oba ,  August R. Yambao ,  Louis A. Campbell ,  Tammy Huntley ,  Qinggang Zeng ,  Carey L. Cristea ,  Faisal Kalam

IPC: A61F2/24

Abstract: A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve has a base stent that is deployed at a treatment site, and a valve component configured to quickly connect to the base stent. The base stent may take the form of a self- or balloon-expandable stent that expands outward against the native valve with or without leaflet excision. The valve component has a non-expandable prosthetic valve and a self- or balloon-expandable coupling stent for attachment to the base stent, thereby fixing the position of the valve component relative to the base stent. The prosthetic valve may be a commercially available to valve with a sewing ring and the coupling stent attaches to the sewing ring. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment. A catheter-based system and method for deployment is provided.

公开(公告)号：US20180185146A1

公开(公告)日：2018-07-05

申请号：US15905625

申请日：2018-02-26

Applicant: Edwards Lifesciences Corporation

Inventor： Rafael Pintor ,  Mark Chau ,  Travis Zenyo Oba ,  August R. Yambao ,  Louis A. Campbell ,  Tammy Huntley ,  Qinggang Zeng ,  Carey L. Cristea ,  Faisal Kalam

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2439 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2220/0083 ,  A61F2230/005 ,  A61F2250/006

Abstract: A quick-connect heart valve prosthesis that can be quickly and easily implanted is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable coupling stent, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the coupling stent attached thereto. The coupling stent may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes a hollow two-piece handle through which a balloon catheter passes. A valve holder is stored with the heart valve and the handle easily attaches thereto to improve valve preparation steps.

公开(公告)号：US09918836B2

公开(公告)日：2018-03-20

申请号：US15068324

申请日：2016-03-11

Applicant: Edwards Lifesciences Corporation

Inventor： Fred Hodshon ,  Rafael Pintor ,  August R. Yambao ,  Abishek Gautam ,  Louis A. Campbell ,  Lawrence J. Farhat ,  Tammy Huntley ,  Faisal Kalam ,  Travis Zenyo Oba ,  Qinggang Zeng

IPC: A61F2/24 ,  A61F2/00

CPC classification number: A61F2/2427 ,  A61F2/0095 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2220/0075

Abstract: Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. Contrary to previous designs, in one embodiment the valve holder is directed downward into the jar, and the valve is retained with an inflow end upward. The valve may have flexible leaflets, and a leaflet parting member on the end of the shaft extends through the leaflets and couples with the valve holder. The assembly of the packaging sleeve, valve, and holder can then be removed from the jar and a valve delivery tube connected with the holder, or to the leaflet parting member. The packaging sleeve may be bifurcated into two halves connected at a living hinge to facilitate removal from around the valve/holder subassembly.

公开(公告)号：US09877831B2

公开(公告)日：2018-01-30

申请号：US15097146

申请日：2016-04-12

Applicant: Edwards Lifesciences Corporation

Inventor： Mark Chau ,  Travis Zenyo Oba ,  Tammy Huntley ,  Qinggang Zeng ,  August R. Yambao ,  Rafael Pintor

IPC: A61F2/06 ,  A61F2/24

CPC classification number: A61F2/2433 ,  A61F2/2418 ,  A61F2/243 ,  A61F2220/0008 ,  A61F2230/0054 ,  A61F2250/0003

Abstract: A system for expanding a device in a conduit or orifice of a human body includes a balloon member that is movable from a first configuration to a second configuration. External surfaces of the balloon member can collectively have a non-cylindrical cross-section relative to a main axis of the balloon member, such that the external surfaces of the balloon member generally conform to the anatomical shape of the conduit or orifice when the balloon member is in the second configuration.

公开(公告)号：US09675453B2

公开(公告)日：2017-06-13

申请号：US15362472

申请日：2016-11-28

Applicant: Edwards Lifesciences Corporation

Inventor： Jessica Guttenberg ,  Da-Yu Chang ,  Derrick Johnson ,  Brian S. Conklin ,  Qinggang Zeng ,  Myron Howanec, Jr. ,  Grace Myong Kim

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2250/0085 ,  A61F2250/0089 ,  A61F2250/0098

Abstract: A prosthetic heart valve configured to replace a native heart valve and for post-implant expansion and having a valve-type indicator thereon visible from outside the body post-implant. The indicator communicates information about the valve, such as the size or orifice diameter of the valve, and/or that the valve has the capacity for post-implant expansion. The indicator can be an alphanumeric symbol or other symbol or combination of symbols that represent information about the characteristics of the valve such as the valve size. The capacity for post-implant expansion facilitates a valve-in-valve procedure, where the valve-type indicator conveys information to the surgeon about whether the implanted valve is suitable for the procedure and informs the choice of the secondary valve.

公开(公告)号：US20170071735A1

公开(公告)日：2017-03-16

申请号：US15362472

申请日：2016-11-28

Applicant: Edwards Lifesciences Corporation

Inventor： Jessica Guttenberg ,  Da-Yu Chang ,  Derrick Johnson ,  Brian S. Conklin ,  Qinggang Zeng ,  Myron Howanec, JR. ,  Grace Myong Kim

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2250/0085 ,  A61F2250/0089 ,  A61F2250/0098

Abstract: A prosthetic heart valve configured to replace a native heart valve and for post-implant expansion and having a valve-type indicator thereon visible from outside the body post-implant. The indicator communicates information about the valve, such as the size or orifice diameter of the valve, and/or that the valve has the capacity for post-implant expansion. The indicator can be an alphanumeric symbol or other symbol or combination of symbols that represent information about the characteristics of the valve such as the valve size. The capacity for post-implant expansion facilitates a valve-in-valve procedure, where the valve-type indicator conveys information to the surgeon about whether the implanted valve is suitable for the procedure and informs the choice of the secondary valve.

Abstract translation: 一种假体心脏瓣膜，其构造成代替天然心脏瓣膜并用于植入后扩张，并且在体外植入后可从外部观察到瓣膜型指示器。 指示器传达关于阀的信息，例如阀的尺寸或孔直径，和/或阀具有用于植入物扩张的能力。 指示符可以是代表关于阀的特性的信息的字母数字符号或其他符号或符号的组合，例如阀的尺寸。 植入后扩张的能力有利于瓣膜瓣膜手术，其中瓣膜型指示器向外科医生传达关于植入的瓣膜是否适于手术并且通知二次瓣膜的选择的信息。