公开(公告)号：US20110005977A1

公开(公告)日：2011-01-13

申请号：US12832771

申请日：2010-07-08

申请人： Edward T. Maggio

发明人： Edward T. Maggio

IPC分类号： B07C5/34 ,  B65D85/00 ,  B65D71/00

CPC分类号： B07C5/3412 ,  B07C5/3404 ,  B07C2501/0054 ,  B65D33/2508

摘要： The present invention provides devices and methods for facilitating the single stream recycling of toxic substance-containing products. A toxin impermeable container designed to enclose the product containing toxic substances incorporates graphic markings or radiofrequency tags to facilitate automated or manual sorting from single stream recycling processes, identification of the toxic component, identification of the person or entity recycling the toxic to allow verification and documentation of compliance with government regulations or reimbursement of a recycling deposit that may be associated with the particular product.

摘要翻译： 本发明提供用于促进含有毒物质的产品的单流回收的装置和方法。 设计用于封闭含有毒物质的产品的毒素不渗透容器包含图形标记或射频标签，以便于从单流回收过程进行自动或手动分选，识别有毒成分，鉴定人员或实体回收有毒物质，以便验证和记录 遵守政府规定或偿还可能与特定产品相关的回收存款。

公开(公告)号：US07392199B2

公开(公告)日：2008-06-24

申请号：US10138068

申请日：2002-05-01

申请人： Valeri I. Karlov ,  Bernard Kasten ,  Carlos E. Padilla ,  Edward T. Maggio ,  Frank Billingsley

发明人： Valeri I. Karlov ,  Bernard Kasten ,  Carlos E. Padilla ,  Edward T. Maggio ,  Frank Billingsley

IPC分类号： G06Q10/00

CPC分类号： G06Q50/22 ,  G06F19/00 ,  G16H10/20 ,  G16H10/60 ,  G16H15/00 ,  G16H50/20 ,  G16H50/30 ,  G16H50/70 ,  G16H50/80 ,  Y02A90/22 ,  Y02A90/24 ,  Y02A90/26

摘要： A system and method of diagnosing diseases from biological data is disclosed. A system for automated disease diagnostics prediction can be generated using a database of clinical test data. The diagnostics prediction can also be used to develop screening tests to screen for one or more inapparent diseases. The prediction method can be implemented with Bayesian probability estimation techniques. The system and method permit clinical test data to be analyzed and mined for improved disease diagnosis.

摘要翻译： 公开了从生物数据诊断疾病的系统和方法。 可以使用临床测试数据的数据库生成用于自动疾病诊断预测的系统。 诊断预测也可用于开发筛查测试以筛选一种或多种不明显的疾病。 该预测方法可以用贝叶斯概率估计技术来实现。 系统和方法允许对临床测试数据进行分析和开采，以改善疾病诊断。

公开(公告)号：US20070298010A1

公开(公告)日：2007-12-27

申请号：US11474055

申请日：2006-06-23

申请人： Edward T. Maggio

发明人： Edward T. Maggio

IPC分类号： A61K38/28 ,  A61K38/21 ,  A61K38/22 ,  A61K38/18 ,  A61K31/70

CPC分类号： A61K31/70 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/127 ,  A61K9/19 ,  A61K38/162 ,  A61K38/1816 ,  A61K38/21 ,  A61K38/27 ,  A61K38/28 ,  A61K38/29 ,  A61K45/06 ,  A61K47/26 ,  A61K2300/00

摘要： The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a peptide, polypeptide, or variant thereof, for example insulin and Peptide T or analog thereof.

摘要翻译： 本发明涉及含有烷基糖苷的组合物和增加其多肽，多肽或其变体（例如胰岛素和肽T）的稳定性，降低聚集和免疫原性，增加生物学活性以及降低或预防纤维状形成的方法， 其类似物。

公开(公告)号：US4789631A

公开(公告)日：1988-12-06

申请号：US581347

申请日：1984-02-17

申请人： Edward T. Maggio

发明人： Edward T. Maggio

IPC分类号： A61K35/56 ,  C07K16/20 ,  G01N33/53 ,  G01N33/543 ,  G01N33/545 ,  G01N33/569

CPC分类号： G01N33/5308 ,  C07K16/20 ,  G01N33/54313 ,  G01N33/54393 ,  Y10S435/81

摘要： A serum antibody assay for assaying a serum sample is described which has diagnostic value for determining the presence of a specific serum antibody which may be indicative of an infection by a specific microorganism. The serum antibody assay has an enhanced diagnostic value because it can eliminate interference by selected cross-reactive antibodies which are directed against one or more other microorganisms to which the assay is not directed and which may be present in the serum sample with a clinically significant frequency. The serum antibody assay uses an immunologically purified fraction of antigenic material derived from the specific microorganism to which assay is directed. The immunologically purified fraction of antigenic material includes immunologically distinguishable components of the antigenic material. These immunologically distinguishable components are reactive with the antibodies to be assayed and are nonreactive with certain antibodies not to be assayed, even where these certain antibodies not to be assayed are cross-reactive with antigen from the microorganism to be diagnosed. The immunologically distinguishable components are made using an immunoadsorption method. The immunoadsorption method may be specially screened monoclonal antibodies which bind only the immunologically distinguishable components. Alternatively, the immunoadsorption method may use polyclonal antibodies which bind immunologically cross-reactive components and leave the immunologically distinguishable components unbound.

摘要翻译： 描述了用于测定血清样品的血清抗体测定法，其具有确定可能指示特定微生物感染的特异性血清抗体的存在的诊断价值。 血清抗体测定具有增强的诊断价值，因为它可以消除所选择的交叉反应性抗体的干扰，所述交叉反应性抗体针对一种或多种其它微生物而不针对该测定法，并且可能以临床显着频率存在于血清样品中 。 血清抗体测定使用来自测定所针对的特异性微生物的免疫纯化的抗原物质部分。 抗原性材料的免疫纯化部分包括抗原性材料的免疫可区分组分。 这些免疫学上可区分的组分与待测定的抗体是反应性的，并且与某些不被测定的抗体不反应，即使这些不被测定的某些抗体与待诊断的微生物的抗原是交叉反应的。 使用免疫吸附法制备免疫学上可区分的组分。 免疫吸附方法可以是仅结合免疫可区分组分的特异性筛选的单克隆抗体。 或者，免疫吸附法可以使用结合免疫交叉反应性成分并使免疫可区分组分未结合的多克隆抗体。

公开(公告)号：US4397956A

公开(公告)日：1983-08-09

申请号：US329392

申请日：1981-12-10

申请人： Edward T. Maggio

发明人： Edward T. Maggio

IPC分类号： C12Q1/54 ,  G01N33/64 ,  G01N33/52 ,  G01N33/66

CPC分类号： C12Q1/54 ,  G01N33/64 ,  Y10T436/144444 ,  Y10T436/200833 ,  Y10T436/202499 ,  Y10T436/203332

摘要： Method and test system for monitoring the status of control of ketoacidosis-prone diabetics using pseudo-kinetic methods. Pseudo-kinetic clinical information is obtained by analysis of a single blood sample in which the blood glucose level is determined along with one or more additional indicator analytes present in patient blood, serum or plasma. The additional indicator analyte(s) provide a "historical" picture of recent events within the patient relating to glucose metabolism which, when analyzed in conjunction with the blood glucose level, provides, from a single sample, a holistic view of the degree of metabollic control in the diabetic patient which is otherwise obtainable at the present time only by the much less desirable process of drawing and analyzing multiple samples over a period of time. The additional indicator analyte may be ketone bodies.

摘要翻译： 使用假动力学方法监测易酮糖酸酯糖尿病患者的控制状态的方法和测试系统。 通过分析其中测定血糖水平的一个血液样本以及存在于患者血液，血清或血浆中的一种或多种另外的指示剂分析物来获得伪动力学临床信息。 额外的指示剂分析物提供了患者内关于葡萄糖代谢的最近事件的“历史”图，当葡萄糖代谢结合血糖水平进行分析时，从单个样本中提供代谢程度的整体视图 糖尿病患者目前只能通过在一段时间内绘制和分析多个样品的不太理想的过程来控制糖尿病患者。 另外的指示剂分析物可以是酮体。

公开(公告)号：US4277437A

公开(公告)日：1981-07-07

申请号：US101935

申请日：1979-12-10

申请人： Edward T. Maggio

发明人： Edward T. Maggio

IPC分类号： G01N33/542 ,  G01N33/58 ,  G01N33/54

CPC分类号： G01N33/581 ,  G01N33/542 ,  G01N33/582 ,  Y10S435/81 ,  Y10S435/968 ,  Y10S435/975 ,  Y10S436/80 ,  Y10S436/808 ,  Y10S436/811 ,  Y10S436/815 ,  Y10S436/82

摘要： A competitive protein binding method is provided for the determination of an analyte which is a member of an immunological pair consisting of ligand and receptor for the ligand. A chemiluminescent source is employed comprised of one or more individual members, one chemiluminescent source member being conjugated to one of the members of the immunological pair, so as to provide chemiluminescence adjacent to the site of conjugation. A quencher molecule is conjugated to a member of the immunological pair. When the members of the immunological pair bind, the quencher molecule is brought within quenching distance of the chemiluminescent source so as to inhibit the emission of light by the chemiluminescent source. The amount of analyte present in the assay medium affects the amount of binding between the members of the immunological pair which results in quenching of the chemiluminescence. By observing the light emitted from the assay medium, either from the chemiluminescent source or the quencher, the change in light emission in relation to the concentration of analyte present in the assay medium can be used to determine the amount of analyte present in the assay medium. By employing standards having known amounts of analyte, the amount of analyte in an unknown sample can be quantitatively determined.Reagent kits can be provided having predetermined amounts of the reagents, so as to substantially optimize the sensitivity of the assay.

摘要翻译： 提供竞争性蛋白质结合方法用于测定作为配体的配体和受体的免疫对的成员的分析物。 使用化学发光源由一个或多个单独的成员组成，一个化学发光源成员与免疫对的一个成员缀合，以提供与缀合位点相邻的化学发光。 猝灭剂分子与免疫对的成员缀合。 当免疫学对的成员结合时，淬灭剂分子被置于化学发光源的淬灭距离内，以便抑制化学发光源的光的发射。 测定培养基中存在的分析物的量影响免疫对的成员之间的结合量，导致化学发光的猝灭。 通过从化学发光源或猝灭剂观察从测定介质发射的光，可以使用与测定介质中存在的分析物浓度相关的光发射变化来确定测定介质中存在的分析物的量 。 通过使用具有已知量的分析物的标准品，可以定量测定未知样品中的分析物的量。 可以提供具有预定量的试剂的试剂盒，以便基本上优化测定的灵敏度。

公开(公告)号：US4233401A

公开(公告)日：1980-11-11

申请号：US815487

申请日：1977-07-14

申请人： Robert A. Yoshida ,  Edward T. Maggio

发明人： Robert A. Yoshida ,  Edward T. Maggio

IPC分类号： C07J41/00 ,  G01N33/542 ,  G01N31/14 ,  G01N33/16

CPC分类号： C07J41/0016 ,  G01N33/542 ,  Y10S435/81 ,  Y10S435/963

摘要： Methods and reagent combinations are provided for competitive protein binding assays for determining a member of an immunological pair (ligand and receptor) whereby an enzyme-ligand conjugate is employed in combination with an enzyme inhibitor, conveniently an antibody to said enzyme. When ligand is the analyte, receptor for ligand is also included in the assay medium, while supplemental amounts of receptor need not be added when receptor is the analyte. The assay is carried out in an aqueous buffered medium, normally at constant temperature, by combining in the assay medium the unknown sample suspected of containing the analyte, enzyme-bound-ligand, ligand receptor (antiligand), enzyme inhibitor (antienzyme), and enzyme substrates, and the enzymatic activity in the assay medium determined. By comparing the observed enzymatic activity with an unknown to the enzymatic activity observed in an assay medium with a known amount of analyte, the amount of analyte can be quantitatively determined.Kits are provided having matched amounts of enzyme-bound-ligand, antienzyme and, when appropriate, antiligand for use in the subject assay.

摘要翻译： 提供了用于确定免疫对（配体和受体）成员的竞争性蛋白质结合测定法的方法和试剂组合，由此酶 - 配体缀合物与酶抑制剂组合使用，方便地是所述酶的抗体。 当配体是分析物时，配体受体也包括在测定培养基中，而当受体是分析物时，不需要加入补充量的受体。 通常在恒定温度下通过在测定培养基中结合怀疑含有分析物的未知样品，酶结合配体，配体受体（抗配体），酶抑制剂（抗酶）和 酶底物，并测定测定培养基中的酶活性。 通过将观察到的酶活性与未知的酶活性与在已知量的分析物的测定培养基中观察到的酶活性进行比较，可以定量测定分析物的量。 提供的试剂盒具有匹配量的酶结合配体，抗酶，并且在合适的情况下，用于本发明测定中的配体配体。

公开(公告)号：US4220450A

公开(公告)日：1980-09-02

申请号：US893910

申请日：1978-04-05

申请人： Edward T. Maggio

发明人： Edward T. Maggio

IPC分类号： G01N33/542 ,  G01N33/58 ,  G01N33/16 ,  C09K11/00 ,  G01N31/14

CPC分类号： G01N33/581 ,  G01N33/582 ,  Y10S435/966 ,  Y10S435/968 ,  Y10S436/80 ,  Y10S436/816 ,  Y10S436/817

摘要： A competitive protein binding method is provided for the determination of an analyte which is a member of an immunological pair consisting of ligand and receptor for the ligand. A chemiluminescent source is employed comprised of one or more individual members, one chemiluminescent source member being conjugated to one of the members of the immunological pair, so as to provide chemiluminescence adjacent to the site of conjugation. A quencher molecule is conjugated to a member of the immunological pair. When the members of the immunological pair bind, the quencher molecule is brought within quenching distance of the chemiluminescent source so as to inhibit the emission of light by the chemiluminescent source. The amount of analyte present in the assay medium affects the amount of binding between the members of the immunological pair which results in quenching of the chemiluminescence. By observing the light emitted from the assay medium, either from the chemiluminescent source of the quencher, the change in light emission in relation to the concentration of analyte present in the assay medium can be used to determine the amount of analyte present in the assay medium. By employing standards having known amounts of analyte, the amount of analyte in an unknown sample can be quantitatively determined.Reagent kits can be provided having predetermined amounts of the reagents, so as to substantially optimize the sensitivity of the assay.

摘要翻译： 提供竞争性蛋白质结合方法用于测定作为配体的配体和受体的免疫对的成员的分析物。 使用化学发光源由一个或多个单独的成员组成，一个化学发光源成员与免疫对的一个成员缀合，以提供与缀合位点相邻的化学发光。 猝灭剂分子与免疫对的成员缀合。 当免疫学对的成员结合时，淬灭剂分子被置于化学发光源的淬灭距离内，以便抑制化学发光源的光的发射。 测定培养基中存在的分析物的量影响免疫对的成员之间的结合量，导致化学发光的猝灭。 通过从猝灭剂的化学发光源观察从测定介质发射的光，可以使用与测定培养基中存在的分析物浓度相关的光发射变化来确定测定培养基中存在的分析物的量 。 通过使用具有已知量的分析物的标准品，可以定量测定未知样品中的分析物的量。 可以提供具有预定量的试剂的试剂盒，以便基本上优化测定的灵敏度。