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    METHOD AND APPARATUS FOR ANALYZING ACETONE IN BREATH
    1.
    发明申请
    METHOD AND APPARATUS FOR ANALYZING ACETONE IN BREATH 审中-公开

    公开(公告)号：US20170176447A1

    公开(公告)日：2017-06-22

    申请号：US15366309

    申请日：2016-12-01

    申请人： Invoy Technologies, LLC

    发明人： Lubna M. Ahmad ,  Brent C. Satterfield ,  Rhett L. Martineau

    IPC分类号： G01N33/64 ,  G01N21/78 ,  A61B5/08 ,  G01N33/497

    CPC分类号： G01N33/64 ,  A61B5/0059 ,  A61B5/082 ,  A61B5/097 ,  A61B2010/0087 ,  A61B2560/0233 ,  G01N21/783 ,  G01N33/497 ,  G01N2033/4975 ,  Y10T436/202499

    摘要： Methods and devices are provided for analyzing acetone in breath. One such method comprises disposing a reactant in a reaction zone within the breath analysis device, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic that is at a reference level. It also comprises pre-storing a liquid nitroprusside solution within the breath analysis device separately from the reactant. The method further comprises using the breath analysis device to cause the breath to contact the reactant in the reaction zone so that the acetone in the breath reacts with the reactant to form a reaction product and, after the reaction product has been formed, using the breath analysis device to cause the nitroprusside solution to contact and react with the reaction product and to facilitate a change in the optical characteristic of the reaction zone relative to the reference level. The method also comprises using the breath analysis device to detect the change in the optical characteristic to sense the acetone in the breath. Apparatuses that use these methods are also described.

    METHOD AND DEVICE FOR CARBONYL DETECTION AND QUANTITATION
    5.
    发明申请
    METHOD AND DEVICE FOR CARBONYL DETECTION AND QUANTITATION 有权
    用于碳检测和量化的方法和装置

    公开(公告)号：US20150377858A1

    公开(公告)日：2015-12-31

    申请号：US14754567

    申请日：2015-06-29

    申请人： Gerald Thomas ,  Brian Young ,  Juven Lara ,  Charles Noll ,  James Ingle

    发明人： Gerald Thomas ,  Brian Young ,  Juven Lara ,  Charles Noll ,  James Ingle

    IPC分类号： G01N33/497

    CPC分类号： G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

    摘要： Fluorescence chromophores such as phenylene diamine derivatives can undergo oxidative coupling and polymerization to form optical, colorimetric and fluorogenic, multimers and polymers. The presence of carbonyl containing moieties such as aldehydes and ketones under favorable environmental conditions can initiate, catalyze, accelerate and modulate this reaction which in turn provides a mechanism for the detection and quantitation of such moieties. Selected phenylene diamine derivatives can be used for the detection and quantitation of aldehyde and ketones via measurement of the reaction and the associated spectroscopic transformation. In particular, the use of meta-phenylene diamine (mPDA) and related compounds for aldehyde detection and quantitation is described. The method provides a convenient means for monitoring aldehyde and ketone levels without use of separation steps. The method is applicable to kinetic and quasi-endpoint detection assay formats.

    摘要翻译： 荧光发色团如苯二胺衍生物可进行氧化偶联和聚合以形成光学，比色和荧光，多聚体和聚合物。 在有利的环境条件下，含有羰基的部分如醛和酮的存在可引发，催化，加速和调节该反应，而反应又提供了检测和定量这些部分的机理。 选择的苯二胺衍生物可用于通过测量反应和相关的光谱转化来检测和定量醛和酮。 特别地，描述了使用间苯二胺（mPDA）和相关化合物进行醛检测和定量。 该方法提供了在不使用分离步骤的情况下监测醛和酮水平的方便手段。 该方法适用于动力学和准终点检测测定方法。

    Method for quantitatively determining impurities in glycerin
    7.
    发明授权
    Method for quantitatively determining impurities in glycerin 有权
    定量测定甘油中杂质的方法

    公开(公告)号：US09097692B2

    公开(公告)日：2015-08-04

    申请号：US13249997

    申请日：2011-09-30

    申请人： Frank Milek ,  Rouven Josl

    发明人： Frank Milek ,  Rouven Josl

    IPC分类号： G01N33/15 ,  G01N30/06 ,  G01N30/34 ,  G01N30/74 ,  G01N30/88

    CPC分类号： G01N30/06 ,  G01N30/34 ,  G01N30/74 ,  G01N2030/8872 ,  Y10T436/200833 ,  Y10T436/202499

    摘要： The invention relates to a method for quantitatively determining impurities in the form of aldehydes and ketones in glycerin serving for preparing pharmaceuticals, in which the glycerin containing impurities is reacted with a derivatization reagent in a sample solution and the quantity of derivatized impurities is determined. Said method is characterized in that PFBHA, O-(2,3,4,5,6-pentafluorobenzyl)-hydroxylamine hydrochloride, is used as the derivatization reagent, the derivatizing is conducted in the presence of a solubilizer in the form of a polar organic solvent, and liquid chromatographic separation and UV detection are performed. A subject matter of the invention is also the use of glycerin, in which the content of impurities of 9 ppm or less has been determined by means of the described method in a pharmaceutical preparation. According to the invention, impurities in glycerin can be better determined.

    摘要翻译： 本发明涉及一种用于定量测定用于制备药物的甘油中醛和酮形式的杂质的方法，其中含有杂质的甘油与样品溶液中的衍生试剂反应，并测定衍生化杂质的量。 所述方法的特征在于使用PFBHA，O-（2,3,4,5,6-五氟苄基） - 羟胺盐酸盐作为衍生试剂，衍生化在极性形式的增溶剂存在下进行 有机溶剂，液相色谱分离和UV检测。 本发明的主题也是在药物制剂中通过所述方法测定了9ppm以下的杂质含量的甘油的用途。 根据本发明，可以更好地测定甘油中的杂质。

    METHOD AND APPARATUS FOR ANALYZING ACETONE IN BREATH
    8.
    发明申请
    METHOD AND APPARATUS FOR ANALYZING ACETONE IN BREATH 有权
    用于分析呼吸道中乙酰胆碱的方法和装置

    公开(公告)号：US20150132858A1

    公开(公告)日：2015-05-14

    申请号：US14400911

    申请日：2013-05-15

    申请人： INVOY TECHNOLOGIES, LLC

    发明人： Lubna M. Ahmad ,  Brent Satterfield ,  Rhett Martineau

    IPC分类号： G01N33/64 ,  G01N21/78

    CPC分类号： G01N33/64 ,  A61B5/0059 ,  A61B5/082 ,  A61B5/097 ,  A61B2010/0087 ,  A61B2560/0233 ,  G01N21/783 ,  G01N33/497 ,  G01N2033/4975 ,  Y10T436/202499

    摘要： Methods and devices are provided for analyzing acetone in breath. One such method comprises disposing a reactant in a reaction zone within the breath analysis device, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic that is at a reference level. It also comprises pre-storing a liquid nitroprusside solution within the breath analysis device separately from the reactant. The method further comprises using the breath analysis device to cause the breath to contact the reactant in the reaction zone so that the acetone in the breath reacts with the reactant to form a reaction product and, after the reaction product has been formed, using the breath analysis device to cause the nitroprusside solution to contact and react with the reaction product and to facilitate a change in the optical characteristic of the reaction zone relative to the reference level.

    摘要翻译： 提供方法和装置用于分析呼吸中的丙酮。 一种这样的方法包括将反应物设置在呼吸分析装置内的反应区中，其中反应物包含设置在表面上的伯胺，并且其中反应区具有基准水平的光学特性。 它还包括将液氮硝普钠溶液与反应物分开预先储存在呼吸分析装置内。 该方法还包括使用呼吸分析装置使呼吸与反应区中的反应物接触，使得呼吸中的丙酮与反应物反应形成反应产物，并且在反应产物形成之后，使用呼吸 分析装置使硝普钠溶液与反应产物接触并反应，并促进反应区相对于参考水平的光学特性的变化。

    NANOPOROUS DETECTORS OF MONOCYCLIC AROMATIC COMPOUNDS AND OTHER POLLUTANTS
    9.
    发明申请
    NANOPOROUS DETECTORS OF MONOCYCLIC AROMATIC COMPOUNDS AND OTHER POLLUTANTS 有权
    单体芳族化合物和其他污染物的纳米探测器

    公开(公告)号：US20140242713A1

    公开(公告)日：2014-08-28

    申请号：US14270459

    申请日：2014-05-06

    申请人： CEA - COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  CNRS - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQU E

    发明人： Sabine Crunaire ,  Thu-Hoa Tran-Thi

    IPC分类号： G01N33/00

    CPC分类号： G01N33/0004 ,  B01J20/10 ,  B01J20/26 ,  B01J20/28047 ,  B01J20/2808 ,  C03B19/12 ,  C08L83/08 ,  Y02P40/57 ,  Y10T436/20 ,  Y10T436/200833 ,  Y10T436/201666 ,  Y10T436/202499 ,  Y10T436/21 ,  Y10T436/212 ,  Y10T436/214 ,  Y10T436/216 ,  Y10T436/25375 ,  Y10T436/255

    摘要： Porous sol-gel material essentially consisting of units of one or more first polyalkoxysilanes chosen from the following compounds: (chloromethyl)triethoxysilane; 1,3-dimethyltetramethoxydisiloxane; ethyltrimethoxysilane; triethoxy(ethyl)silane; triethoxymethylsilane; triethoxy(vinyl)silane; trimethoxymethylsilane; trimethoxy(vinyl)silane; tetraethoxysilane or tetramethoxysilane (TMOS) and of units of one or more second polyalkoxysilanes chosen from the following compounds: (N-(3-(trimethoxysilyl)propyl)ethylenediamine; 3-aminopropyltriethoxysilane (APTES) and 3-aminopropyltrimethoxysilane, in a first polyalkoxysilane/second polyalkoxysilane molar ratio of 1/0.01 to 1/1, optionally comprising a probe molecule, method of preparation and applications in the trapping of monocyclic aromatic hydrocarbons and other pollutants or in their detection.

    摘要翻译： 多孔溶胶凝胶材料主要由选自以下化合物的一种或多种第一聚烷氧基硅烷的单元组成：（氯甲基）三乙氧基硅烷; 1,3-二甲基四甲氧基二硅氧烷; 乙基三甲氧基硅烷; 三乙氧基（乙基）硅烷; 三乙氧基甲基硅烷; 三乙氧基（乙烯基）硅烷; 三甲氧基甲基硅烷; 三乙氧基（乙烯基）硅烷; 四乙氧基硅烷或四甲氧基硅烷（TMOS）以及选自以下化合物的一种或多种第二聚烷氧基硅烷的单元：（N-（3-（三甲氧基甲硅烷基）丙基）乙二胺; 3-氨基丙基三乙氧基硅烷（APTES）和3-氨基丙基三甲氧基硅烷，在第一聚烷氧基硅烷/ 第二聚烷氧基硅烷的摩尔比为1 / 0.01至1/1，任选地包含探针分子，制备方法和捕获单环芳烃和其它污染物或其检测中的应用。