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    METHOD AND APPARATUS FOR ANALYZING ACETONE IN BREATH
    3.
    发明申请
    METHOD AND APPARATUS FOR ANALYZING ACETONE IN BREATH 审中-公开

    公开(公告)号：US20170176447A1

    公开(公告)日：2017-06-22

    申请号：US15366309

    申请日：2016-12-01

    申请人： Invoy Technologies, LLC

    发明人： Lubna M. Ahmad ,  Brent C. Satterfield ,  Rhett L. Martineau

    IPC分类号： G01N33/64 ,  G01N21/78 ,  A61B5/08 ,  G01N33/497

    CPC分类号： G01N33/64 ,  A61B5/0059 ,  A61B5/082 ,  A61B5/097 ,  A61B2010/0087 ,  A61B2560/0233 ,  G01N21/783 ,  G01N33/497 ,  G01N2033/4975 ,  Y10T436/202499

    摘要： Methods and devices are provided for analyzing acetone in breath. One such method comprises disposing a reactant in a reaction zone within the breath analysis device, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic that is at a reference level. It also comprises pre-storing a liquid nitroprusside solution within the breath analysis device separately from the reactant. The method further comprises using the breath analysis device to cause the breath to contact the reactant in the reaction zone so that the acetone in the breath reacts with the reactant to form a reaction product and, after the reaction product has been formed, using the breath analysis device to cause the nitroprusside solution to contact and react with the reaction product and to facilitate a change in the optical characteristic of the reaction zone relative to the reference level. The method also comprises using the breath analysis device to detect the change in the optical characteristic to sense the acetone in the breath. Apparatuses that use these methods are also described.

    NONINVASIVE DETECTION OF CANCER ORIGINATING IN TISSUE OUTSIDE OF THE LUNG USING EXHALED BREATH
    5.
    发明申请
    NONINVASIVE DETECTION OF CANCER ORIGINATING IN TISSUE OUTSIDE OF THE LUNG USING EXHALED BREATH 审中-公开
    使用呼吸道呼吸的肺部外侧组织检测癌症的非侵袭性检测

    公开(公告)号：US20170030892A1

    公开(公告)日：2017-02-02

    申请号：US15223756

    申请日：2016-07-29

    申请人： University of Louisville Research Foundation, Inc.

    发明人： Xiaoan Fu ,  Michael Nantz ,  Michael Bousamra ,  Victor van Berkel

    IPC分类号： G01N33/497 ,  H01J49/38 ,  G01N30/72 ,  H01J49/00

    CPC分类号： G01N33/497 ,  A61B5/082 ,  A61B5/091 ,  A61B2505/03 ,  G01N30/72 ,  G01N33/543 ,  G01N33/574 ,  G01N33/57484 ,  G01N33/64 ,  G01N2033/4975 ,  G01N2800/7028 ,  H01J49/0031 ,  H01J49/38

    摘要： Provided is a non-invasive method of detecting or screening for a cancer in a subject specimen originating in a tissue outside of the lung. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for the cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for the cancer in the subject specimen.

    摘要翻译： 本发明提供一种检测或筛选来自肺外组织的受试者标本中的癌症的非侵入性方法。 该方法包括检测作为来自受检标本的呼出气中癌症的生物标志物的一种或多种含羰基的挥发性有机化合物（VOC）的升高水平。 该方法可以进一步包括从主体样本获得呼出的呼吸; 形成含羰基VOCs与反应性化合物的加成物; 量化含羰基VOC的加合物以建立每种加合物的主题值; 并将每个受试者值与含羰基VOC的加合物的阈值健康标本值进行比较。 一个或多个数量大于阈值健康标本值的受试者值也可用于筛选受检标本中的癌症。

    KETONE MEASUREMENT SYSTEM AND RELATED METHOD WITH ACCURACY AND REPORTING ENHANCEMENT FEATURES
    6.
    发明申请
    KETONE MEASUREMENT SYSTEM AND RELATED METHOD WITH ACCURACY AND REPORTING ENHANCEMENT FEATURES 审中-公开
    KETONE测量系统及其相关方法与准确性和报告增强功能

    公开(公告)号：US20160370377A1

    公开(公告)日：2016-12-22

    申请号：US15136629

    申请日：2016-04-22

    申请人： Invoy Technologies, LLC

    发明人： Lubna M. Ahmad

    IPC分类号： G01N33/64 ,  A61B5/097 ,  A61B5/00 ,  A61B5/15 ,  A61B5/145 ,  A61B5/08

    CPC分类号： G01N33/64 ,  A61B5/0022 ,  A61B5/082 ,  A61B5/097 ,  A61B5/14546 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/4866 ,  A61B5/6898 ,  A61B5/742 ,  G01N33/49 ,  G01N33/497

    摘要： A portable ketone measurement device measures ketone levels in breath samples or other bodily fluid samples of a user, and communicates the ketone measurements to an application that runs on a smartphone or other mobile device of the user. The application may communicate with, and report the measurements to, a remote server. One or more components of the system (e.g., the portable ketone measurement device, the mobile application, and/or the server) may, where appropriate, adjust the ketone measurements to compensate for ketone variations resulting from, e.g., the age of the user, a medical condition of the user, a missed medication event, or an interrupted sleep event. The application may, in some scenarios, withhold the display of a ketone measurement from the user until an authorization has been received from the server.

    摘要翻译： 便携式酮测量装置测量使用者的呼吸样本或其他体液样品中的酮水平，并将酮测量值传送到在用户的智能电话或其他移动设备上运行的应用。 应用程序可以与远程服务器通信并向远程服务器报告测量结果。 在适当的情况下，系统的一个或多个组件（例如，便携式酮测量装置，移动应用和/或服务器）可以调整酮测量值以补偿由例如用户的年龄引起的酮变化 ，用户的医疗状况，错过的药物事件或中断的睡眠事件。 在某些情况下，应用程序可以保留从用户显示酮测量值，直到从服务器接收到授权。

    Sensor composition for acetone detection in breath
    7.
    发明授权
    Sensor composition for acetone detection in breath 有权
    用于呼吸中丙酮检测的传感器组成

    公开(公告)号：US09470675B2

    公开(公告)日：2016-10-18

    申请号：US14356127

    申请日：2013-03-04

    申请人： Council of Scientific & Industrial Research

    发明人： Amarnath Sen ,  Subhasis Rana

    IPC分类号： G01N33/497 ,  G01N33/48 ,  G01N33/00 ,  B01J19/10 ,  B01J19/08 ,  A61B5/083 ,  G01N33/64 ,  A61B5/08 ,  A61B5/145

    CPC分类号： G01N33/497 ,  A61B5/082 ,  A61B5/083 ,  A61B5/14532 ,  B01J19/10 ,  G01N33/64 ,  G01N2033/4975

    摘要： The present invention provides a composition for acetone detection and a process of preparation thereof. The composition comprises γ-ferric oxide (γ-Fe2O3), antimony (Sb) salt, and platinum (Pt). The sensor fabricated using the said composition is selective to low concentration of breath acetone, the biomarker of diabetes, in presence of high amount of moisture normally present in breath. Such semiconductor sensors for diabetes monitoring are inexpensive, rugged, patient-friendly and on the top, non-invasive.

    摘要翻译： 本发明提供了用于丙酮检测的组合物及其制备方法。 该组合物包含γ-氧化铁（γ-Fe 2 O 3），锑（Sb）盐和铂（Pt）。 使用所述组合物制造的传感器对呼吸中通常存在大量水分存在的低浓度呼吸丙酮是糖尿病的生物标志物是选择性的。 用于糖尿病监测的这种半导体传感器是廉价的，坚固的，耐心友好的，并且在顶部，非侵入性的。

    GENETICALLY ENCODED PROBE FOR QUANTIFICATION OF PYRUVATE CONCENTRATION AND METHODS OF USING THE SAME
    8.
    发明申请
    GENETICALLY ENCODED PROBE FOR QUANTIFICATION OF PYRUVATE CONCENTRATION AND METHODS OF USING THE SAME 审中-公开
    用于定量聚合浓缩的基因编码探针及其使用方法

    公开(公告)号：US20160209402A1

    公开(公告)日：2016-07-21

    申请号：US14912779

    申请日：2013-08-20

    申请人： CENTRO DE ESTUDIOS CLENTIFICOS DE VALDIVIA

    发明人： Luis Felipe BARROS ,  Sebastian CEBALLO ,  Alejandro SAN MARTIN

    IPC分类号： G01N33/50 ,  G01N21/64 ,  G01N33/64 ,  G01N33/58

    CPC分类号： G01N33/5038 ,  C12Q1/02 ,  G01N21/6428 ,  G01N33/5079 ,  G01N33/542 ,  G01N33/582 ,  G01N33/64 ,  G01N2021/6432 ,  G01N2201/06113 ,  G01N2201/12

    摘要： The present invention relates to a new optical tool for detecting and quantifying pyruvate in samples, in tissues and in cellular and subcellular compartments, with high spatial and temporal resolution, this is a Forster Resonance Energy Transfer (FRET)-based pyruvate sensor comprising a bacterial PdhR transcription factor between any suitable donor and acceptor fluorescent proteins moieties. The invention also relates to methods of use of this novel optical tool for the quantification of the activity of pyruvate transporters, for the quantification of the rates of cellular pyruvate production and consumption, and for the direct quantification of the rate of mitochondrial pyruvate consumption in intact cells.

    摘要翻译： 本发明涉及用于在样品，组织和细胞和亚细胞室中检测和定量丙酮酸的新的光学工具，具有高空间和时间分辨率，这是基于福斯特共振能量转移（FRET）的丙酮酸传感器，其包含细菌 任何合适的供体和受体荧光蛋白部分之间的PdhR转录因子。 本发明还涉及使用这种新型光学工具来量化丙酮酸转运蛋白活性的方法，用于定量细胞丙酮酸生产和消耗的速率，以及直接定量完整的线粒体丙酮酸消耗速率 细胞。