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61.发明授权
公开(公告)号：US5795575A
公开(公告)日：1998-08-18
申请号：US763925
申请日：1996-12-12
IPC分类号： A61K9/00 , A61K31/00 , A61K31/20 , A61K31/202 , A61K31/35 , A61K31/352 , A61K31/365 , A61K31/37 , A61K31/40 , A61K31/4375 , A61K31/475 , A61K31/48 , A61K36/16 , A61K45/06 , A61P9/00 , A61K39/385
CPC分类号： A61K31/48 , A61K31/20 , A61K31/202 , A61K31/35 , A61K31/352 , A61K31/365 , A61K31/37 , A61K31/40 , A61K31/4375 , A61K31/475 , A61K45/06 , Y10S514/886 , Y10S514/887
摘要： A method for increasing the number of capillaries in damaged skin during healing of the skin is disclosed. The method includes the application of a skin composition to the damaged skin which comprises an active compound having peripheral vasokinetic activity and a pharmaceutically acceptable carrier. The active compound is selected from compounds such as Amni visnaga coumarins, Vinca alkaloids, Ergot alkaloids, polyunsaturated fatty acid derivatives, a buflomedil bioflavinoid, Ginkgo bioflavonoids, and Cratageus bioflavonoids. The composition is applied in amount to increase the number of capillaries in new tissue which forms during healing of the damaged skin. Furthermore, a method of treating bedsores is also disclosed.
摘要翻译： 公开了一种在皮肤愈合过程中增加受损皮肤毛细血管数量的方法。 该方法包括将皮肤组合物施用于损伤的皮肤，其包含具有外周血管动力学活性的活性化合物和药学上可接受的载体。 活性化合物选自化合物如Amni visnaga香豆素，长春花生物碱，微生物碱，多不饱和脂肪酸衍生物，buflomedil生物黄素，银杏生物类黄酮和Cratageus生物类黄酮。 该组合物的量应用于增加损伤皮肤愈合过程中形成的新组织中毛细管的数量。 此外，还公开了治疗褥疮的方法。
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公开(公告)号：US09687468B2
公开(公告)日：2017-06-27
申请号：US14342593
申请日：2012-09-13
申请人： Ezio Bombardelli
发明人： Ezio Bombardelli
IPC分类号： A01N43/16 , A61K31/35 , A61K31/352 , A61K36/28 , A61K31/216 , A61K31/365
CPC分类号： A61K31/352 , A61K31/216 , A61K31/365 , A61K36/28
摘要： The present invention relates to the preparation of Cynara scolymus leaf extracts, which are useful for the prevention and treatment of dyslipidaemia, in particular to increase HDL cholesterol in patients at cardiovascular risk. Said extracts are useful to normalize the lipid and carbohydrate balances and significantly increase the value of HDL cholesterol by favorably changing the LDL/HDL ratio, especially in post-infarction patients with drug-induced dyslipidaemia.
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63.发明授权公开(公告)号：US09101604B2
公开(公告)日：2015-08-11
申请号：US12996159
申请日：2009-05-25
申请人： Ezio Bombardelli
发明人： Ezio Bombardelli
IPC分类号： A61K36/28 , A61K9/68 , A61K36/66 , A61K36/45 , A61K36/36 , A61K31/473 , A61K36/185
CPC分类号： A61K36/36 , A61K31/473 , A61K36/185 , A61K36/28
摘要： The present invention relates to compositions based on benzophenanthridine alkaloids, extract of Hippophae rhamnoides and extract of Echinacea angustifolia which possess antibacterial, antiviral and anti-inflammatory activity, and are useful in the treatment of bacterial and viral infections of the upper respiratory tract, and in the treatment of influenza.
摘要翻译： 本发明涉及具有抗菌，抗病毒和抗炎活性的苯并菲啶生物碱，沙棘提取物和松果菊提取物的组合物，可用于治疗上呼吸道的细菌和病毒感染， 治疗流行性感冒。
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64.发明授权公开(公告)号：US08361521B2
公开(公告)日：2013-01-29
申请号：US13145153
申请日：2010-01-15
申请人： Ezio Bombardelli
发明人： Ezio Bombardelli
IPC分类号： A61K36/28 , A61K36/9068
CPC分类号： A61K36/9068 , A61K36/28
摘要： The present invention relates to compositions consisting of a combination of lipophilic extracts of Zingiber officinale and Echinacea angustifolia, obtained by extraction with carbon dioxide under supercritical conditions, which are useful for the prevention and treatment of oesophageal reflux and chemotherapy-induced emesis.
摘要翻译： 本发明涉及通过在超临界条件下用二氧化碳萃取而获得的姜黄的亲脂性提取物和松果菊的组合物，其可用于预防和治疗食管反流和化疗诱发的呕吐。
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公开(公告)号：US08076351B2
公开(公告)日：2011-12-13
申请号：US12374799
申请日：2007-07-12
申请人： Gabriele Fontana , Ezio Bombardelli , Carla Manzotti , Arturo Battaglia , Maria Grazia Allegri, legal representative , Cristian Samori
IPC分类号： A61K31/4745 , C07D491/22
CPC分类号： Y02P20/55
摘要： Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
摘要翻译： 具有抗肿瘤活性的新型喜树碱衍生物，其制备方法，其作为抗肿瘤药物的用途和含有它们的药物组合物。
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66.发明授权Combinations of vasoactive agents, their use in the pharmaceutical and cosmetic field, and formulations containing them 有权血管活性剂的组合，它们在药物和化妆品领域的用途，以及含有它们的制剂公开(公告)号：US07976881B2
公开(公告)日：2011-07-12
申请号：US10563965
申请日：2004-07-06
申请人： Ezio Bombardelli
发明人： Ezio Bombardelli
CPC分类号： A61Q19/06 , A61K8/97 , A61K31/37 , A61K31/70 , A61K31/7048 , A61K36/16 , A61K36/23 , A61K2300/00
摘要： Combinations of vasoactive substances which act at venous or arterial level with phosphodiesterase inhibitors including phosphodiesterase V, in particular: visnadin or esculoside; at least one compound selected from icarin or derivatives thereof or extracts containing it, Gingko biloba dimeric flavones either in the free form or complexed with phospholipids, amentoflavone; at least one compound selected from escin, escin beta-sitosterol complexed with phospholipids, sericoside, sericoside complexed with phospholipids or Centella asiatica extract in the free form or complexed with phospholipids. The formulations are useful in reducing parmiculopathy and problems associated with venous insufficiency of the lower limbs.
摘要翻译： 在静脉或动脉层上与磷酸二酯酶抑制剂（包括磷酸二酯酶V）特别是visnadin或esculoside作用的血管活性物质的组合; 至少一种选自酰胺或其衍生物的化合物或含有它的提取物，游离形式或与磷脂络合的银杏叶二聚黄酮，黄酮黄酮; 至少一种选自与磷脂络合的七叶皂苷，七叶皂苷β-谷甾醇，与磷脂络合的丝氨酸或积雪草积雪草提取物与游离形式或与磷脂络合的化合物。 该制剂可用于减少与下肢静脉功能不全相关的副反应和问题。
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67.发明授权公开(公告)号：US07910139B2
公开(公告)日：2011-03-22
申请号：US10580190
申请日：2004-11-04
申请人： Ezio Bombardelli
发明人： Ezio Bombardelli
CPC分类号： A61K45/06 , A61K31/35 , A61K36/185 , A61K36/38 , A61K36/45 , A61K36/61 , A61K36/82 , A61K36/87 , A61K2300/00
摘要： Compositions for the treatment of the affections of the oral cavity and upper respiratory tract include anthocyanosides, procyanidins and phloroglucinols. The anthocyanosides are derived from Vaccinium myrtillus extract, the procyanidins are derived from a Vitus vinifera extract, a Camellia sinensis extract or from other edible plants containing procyanidins, and the phloroglucinols are derived from Hypericum spp., Myrtus spp. or Humulus lupulus extracts.
摘要翻译： 用于治疗口腔和上呼吸道感染的组合物包括花青素，原花青素和间苯三酚。 花青素衍生自牛痘提取物，原花青素衍生自维他龙提取物，山茶提取物或其他含有原花青素的食用植物，间苯三酚衍生自金丝桃属（Myrtus spp。）。 或葎草提取物。
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68.发明申请COMPOSITIONS FOR THE TREATMENT OF BENIGN PROSTATE HYPERTROPHY, PROSTATITIS, PROSTATOSIS AND PROSTATE CANCER 审中-公开治疗前列腺增生症，前列腺癌，前列腺癌和前列腺癌的组合物公开(公告)号：US20100316740A1
公开(公告)日：2010-12-16
申请号：US12918393
申请日：2009-02-17
申请人： Ezio Bombardelli
发明人： Ezio Bombardelli
IPC分类号： A61K9/02 , A61K36/889 , A61P35/00 , A61P13/08 , A61M31/00
CPC分类号： A61K36/889 , A61K36/28 , A61K36/38
摘要： Compositions including Serenoa repens, Echinacea and Hypericum perforatum extracts and selenium compounds for the treatment of prostate disorders, in particular for the treatment of prostate cancer, prostatitis, prostatosis and urinary incontinence.
摘要翻译： 组合物包括Serenoa repens，Echinacea和贯叶连翘提取物和用于治疗前列腺疾病的硒化合物，特别是用于治疗前列腺癌，前列腺炎，前列腺症和尿失禁。
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69.发明申请FORMULATIONS FOR THE TREATMENT OF MUCOSITIS INDUCED BY ANTITUMOR OR IMMUNOSUPPRESSIVE THERAPY 有权治疗由抗肿瘤药物或免疫抑制治疗诱发的肌瘤的制剂公开(公告)号：US20100284945A1
公开(公告)日：2010-11-11
申请号：US12812065
申请日：2009-01-08
申请人： Ezio Bombardelli , Gabriele Fontana
发明人： Ezio Bombardelli , Gabriele Fontana
IPC分类号： A61K31/4355 , A61K9/68 , C07D491/22 , A61P1/04 , A61P29/00 , A61P15/02
CPC分类号： B60S3/063
摘要： Formulations containing sanguinarine or chelerythrine or the salts thereof or extracts containing them in admixture with suitable carriers and/or excipients for the treatment and/or prevention of mucositis.
摘要翻译： 含有血根碱或白藜芦醇或其盐的制剂或含有它们的提取物与适合的载体和/或赋形剂的混合物用于治疗和/或预防粘膜炎。
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公开(公告)号：US07683163B2
公开(公告)日：2010-03-23
申请号：US10559462
申请日：2004-05-26
申请人： Ezio Bombardelli , Gabriele Fontana
发明人： Ezio Bombardelli , Gabriele Fontana
CPC分类号： C07H15/248
摘要： The present invention relates to colchicine derivatives, in particular to the 3-demethyl and 3-demethylthio-colchicine of the general formula (I) in which X is oxygen or sulfur, a method for the preparation thereof and pharmaceutical compositions containing them. The compounds of formula (I) have muscle relaxing, anti-inflammatory and anti-gout activity.
摘要翻译： 本发明涉及秋水仙素衍生物，特别涉及其中X为氧或硫的通式（I）的3-去甲基和3-脱甲基硫代秋水仙碱，其制备方法和含有它们的药物组合物。 式（I）化合物具有肌肉松弛，抗炎和抗痛风活性。
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