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公开(公告)号：US20230027394A1
公开(公告)日：2023-01-26
申请号：US17739934
申请日：2022-05-09
Applicant: GENMAB A/S
Inventor： Rik RADEMAKER , Isil Altintas , Patrick Engelberts , Janine Schuurman , Paul Parren
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：US11440966B2
公开(公告)日：2022-09-13
申请号：US17345628
申请日：2021-06-11
Applicant: GENMAB A/S , BioNTech SE
Inventor： Isil Altintas , David Satijn , Rik Rademaker , Paul Parren , Friederike Gieseke , Ugur Sahin
IPC: C07K16/28 , A61K39/395 , G01N33/569
Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
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公开(公告)号：US11230604B2
公开(公告)日：2022-01-25
申请号：US15909540
申请日：2018-03-01
Applicant: GENMAB A/S
Inventor： Michel De Weers , Tim Walseth , Jan Van De Winkel , Tom Vink , Paul Parren
IPC: C07K16/28 , A61K39/395 , A61K45/06 , G01N33/573
Abstract: Isolated monoclonal antibodies which bind to human CD38 and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies.
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公开(公告)号：US11091557B2
公开(公告)日：2021-08-17
申请号：US16316534
申请日：2017-07-14
Applicant: GENMAB A/S , BioNTech SE
Inventor： Isil Altintas , David Satijn , Rik Rademaker , Paul Parren , Friederike Gieseke , Ugur Sahin
IPC: A61K39/395 , C07K16/28 , G01N33/569
Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
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公开(公告)号：US10927181B2
公开(公告)日：2021-02-23
申请号：US16582534
申请日：2019-09-25
Applicant: BIONTECH SE , GENMAB A/S
Inventor： Ugur Sahin , Friederike Gieseke , Isil Altintas , David Satijn , Paul Parren
IPC: C07K16/28
Abstract: The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.
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Patent Agency Ranking
公开(公告)号：US10882913B2
公开(公告)日：2021-01-05
申请号：US16451714
申请日：2019-06-25
Applicant: GENMAB B.V.
Inventor： Marije Overdijk , Kristin Strumane , Rik Rademaker , Esther Breij , Janine Schuurman , Paul Parren
Abstract: The present invention relates to monospecific or bispecific antibody molecules that specifically bind the human DR5 antigen. The invention relates in particular to DR5-specific antibody molecules of the IgG1 isotype having a mutation in the Fc region that enhances clustering of IgG molecules after cell-surface antigen binding leading to the induction of DR5 signaling, apoptosis and cell death. The invention further relates to a combination of antibody molecules binding different epitopes on DR5. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer using these compositions.
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公开(公告)号：US20200317799A1
公开(公告)日：2020-10-08
申请号：US16689361
申请日：2019-11-20
Applicant: Genmab A/S
Inventor： Jessica Teeling , Sigrid Ruuls , Martin Glennie , Jan G.J. van de Winkel , Paul Parren , Jørgen Petersen , Ole Baadsgaard , Haichun Huang
IPC: C07K16/28 , C07K16/42 , A61K39/395 , A61K45/06 , G01N33/68
Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：US10512688B2
公开(公告)日：2019-12-24
申请号：US15325364
申请日：2015-07-10
Applicant: GENMAB A/S
Inventor： Esther Breij , David Satijn , Edward Norbert Van Den Brink , Dennis Verzijl , Rob N. De Jong , Paul Parren , Riemke Van Dijkhuizen Radersma
IPC: A61K39/395 , C07K16/28 , A61K47/68 , A61K39/00 , C07K16/30
Abstract: The present disclosure relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.
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公开(公告)号：US20180194849A1
公开(公告)日：2018-07-12
申请号：US15538419
申请日：2016-01-08
Applicant: BIONTECH AG , GENMAB A/S
Inventor： Ugur Sahin , Friederike Gieseke , Isil Altintas , David Satijn , Paul Parren
IPC: C07K16/28
Abstract: The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.
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公开(公告)号：US10000570B2
公开(公告)日：2018-06-19
申请号：US14739768
申请日：2015-06-15
Applicant: Genmab A/S
Inventor： Aran Frank Labrijn , Stefan Loverix , Paul Parren , Jan Van De Winkel , Janine Schuurman , Ignace Lasters
Abstract: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
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